{"id":"https://openalex.org/W2289227135","doi":"https://doi.org/10.1158/1538-7445.am2015-5145","title":"Abstract 5145: Y-27632 inhibits Myc-induced apoptosis and cooperates with Myc to immortalize human keratinocytes","display_name":"Abstract 5145: Y-27632 inhibits Myc-induced apoptosis and cooperates with Myc to immortalize human keratinocytes","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2289227135","doi":"https://doi.org/10.1158/1538-7445.am2015-5145","mag":"2289227135"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-5145","doi":"https://doi.org/10.1158/1538-7445.am2015-5145","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-5145","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034842985","display_name":"Aleksandra Dakic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandra Dakic","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085976734","display_name":"Kyle A. DiVito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Divito","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108424722","display_name":"Shuang Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuang Fang","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009366054","display_name":"Nancy Palechor-Ceron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Palechor-Ceron","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079282125","display_name":"Vera Simi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vera Simic","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sujata Choudhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujata Choudhury","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078200537","display_name":"Songtao Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Songtao Yu","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108167484","display_name":"Cynthia Marie Simbulan-Rosenthal","orcid":"https://orcid.org/0000-0002-5070-0342","observed_orcids":["https://orcid.org/0000-0002-5070-0342"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia M. Simbulan-Rosenthal","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084704868","display_name":"Dean S. Rosenthal","orcid":"https://orcid.org/0000-0002-7624-0209","observed_orcids":["https://orcid.org/0000-0002-7624-0209"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Rosenthal","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867375","display_name":"Richard Schlegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Schlegel","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100400553","display_name":"Xuefeng Liu","orcid":"https://orcid.org/0000-0002-9922-9627","observed_orcids":["https://orcid.org/0000-0002-9922-9627"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuefeng Liu","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184565670"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"5145","last_page":"5145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.3285999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.12380000203847885,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/y-27632","display_name":"Y-27632","score":0.972000002861023},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8730000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/keratinocyte-immortalization","display_name":"keratinocyte immortalization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rock-inhibition","display_name":"ROCK inhibition","score":0.7440000176429749},{"id":"https://openalex.org/keywords/blebbing","display_name":"blebbing","score":0.6449999809265137},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6119999885559082},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.7110000252723694},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7497179508209229},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6336029171943665},{"id":"https://openalex.org/C2781140480","wikidata":"https://www.wikidata.org/wiki/Q673203","display_name":"Foreskin","level":3,"score":0.6026427149772644},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5059391856193542},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.46313101053237915},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4466613531112671},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38751691579818726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35728585720062256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3326342701911926},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32534176111221313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3132086396217346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14755165576934814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-5145","doi":"https://doi.org/10.1158/1538-7445.am2015-5145","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-5145","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046921917","https://openalex.org/W1588456924","https://openalex.org/W2357089519","https://openalex.org/W2605133025","https://openalex.org/W1858971253","https://openalex.org/W2404206464","https://openalex.org/W3203356408","https://openalex.org/W2347223537","https://openalex.org/W2077883236","https://openalex.org/W2392601632"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"high-risk":[2],"HPV":[3,48],"E6":[4,41],"and":[5,20,42,58,88,101,154],"E7":[6],"genes":[7],"are":[8,123],"sufficient":[9],"to":[10,158],"immortalize":[11,43,159],"human":[12,78,91,160],"foreskin":[13,79],"keratinocytes":[14,92],"(HFKs)":[15],"through":[16],"activation":[17],"of":[18,22,36,77,90,116,165,170],"telomerase":[19],"inactivation":[21],"the":[23,61,71,166,171],"RB/p16":[24],"pathway,":[25],"respectively.":[26],"Our":[27,81],"previous":[28],"work":[29],"has":[30],"shown":[31],"that":[32,66,84,102,112],"Myc":[33,54,85,113,157],"(via":[34],"induction":[35],"hTERT)":[37],"may":[38],"substitute":[39],"for":[40,174],"HFKs":[44,119],"when":[45,93,120],"combined":[46],"with":[47,70,156],"E7.":[49],"When":[50],"expressed":[51],"alone,":[52],"however,":[53],"induced":[55,86],"p53":[56],"expression":[57],"apoptosis.":[59],"In":[60],"current":[62],"study":[63],"we":[64],"found":[65],"Myc,":[67],"in":[68,95],"combination":[69],"ROCK":[72],"inhibitor":[73],"(Y-27632),":[74],"led":[75],"immortalization":[76],"keratinocytes.":[80,161],"data":[82,110],"confirmed":[83],"apoptosis":[87,121,153],"blebbing":[89],"cultured":[94],"serum":[96],"free":[97],"synthetic":[98],"medium":[99],"(KGM)":[100],"Y-27632":[103,150],"rapidly":[104],"inhibits":[105,151],"this":[106],"process.":[107],"Thus,":[108],"our":[109],"demonstrate":[111],"is":[114],"capable":[115],"independently":[117],"immortalizing":[118],"pathways":[122],"blocked.":[124],"Citation":[125],"Format:":[126],"Aleksandra":[127],"Dakic,":[128],"Kyle":[129],"Divito,":[130],"Shuang":[131],"Fang,":[132],"Nancy":[133],"Palechor-Ceron,":[134],"Vera":[135],"Simic,":[136],"Sujata":[137],"Choudhury,":[138],"Songtao":[139],"Yu,":[140],"Cynthia":[141],"M.":[142],"Simbulan-Rosenthal,":[143],"Dean":[144],"Rosenthal,":[145],"Richard":[146],"Schlegel,":[147],"Xuefeng":[148],"Liu.":[149],"Myc-induced":[152],"cooperates":[155],"[abstract].":[162],"In:":[163],"Proceedings":[164],"106th":[167],"Annual":[168],"Meeting":[169],"American":[172],"Association":[173],"Cancer":[175,185],"Research;":[176],"2015":[177],"Apr":[178],"18-22;":[179],"Philadelphia,":[180],"PA.":[181],"Philadelphia":[182],"(PA):":[183],"AACR;":[184],"Res":[186],"2015;75(15":[187],"Suppl):Abstract":[188],"nr":[189],"5145.":[190],"doi:10.1158/1538-7445.AM2015-5145":[191]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}