{"id":"https://openalex.org/W2289194978","doi":"https://doi.org/10.4049/jimmunol.184.supp.145.7","title":"Donor-specific B cell quiescence following desensitization and transplantation (145.7)","display_name":"Donor-specific B cell quiescence following desensitization and transplantation (145.7)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2289194978","doi":"https://doi.org/10.4049/jimmunol.184.supp.145.7","mag":"2289194978"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.145.7","doi":"https://doi.org/10.4049/jimmunol.184.supp.145.7","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.145.7","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013219628","display_name":"Annette M. Jackson","orcid":"https://orcid.org/0000-0003-2648-2944","observed_orcids":["https://orcid.org/0000-0003-2648-2944"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette Jackson","raw_affiliation_strings":["Johns Hopkins University Department of Medicine , Baltimore, MD","1Johns Hopkins University Department of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University Department of Medicine , Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Johns Hopkins University Department of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032906001","display_name":"Robert A. Montgomery","orcid":"https://orcid.org/0000-0003-2728-4552","observed_orcids":["https://orcid.org/0000-0003-2728-4552"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Montgomery","raw_affiliation_strings":["Johns Hopkins University Department of Surgery , Baltimore, MD","2Johns Hopkins University Department of Surgery, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University Department of Surgery , Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"2Johns Hopkins University Department of Surgery, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"145.7","last_page":"145.7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-anergy","display_name":"B cell anergy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.8090000152587891},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/anti-hla-antibodies","display_name":"HLA antibodies","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hla-tetramers","display_name":"HLA tetramers","score":0.75},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.5460000038146973},{"id":"https://openalex.org/keywords/antibody-secreting-cells","display_name":"antibody-secreting cells","score":0.5429999828338623},{"id":"https://openalex.org/keywords/sensitized-transplant-recipients","display_name":"sensitized transplant recipients","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6802821159362793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6753425598144531},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.6376830339431763},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6297857165336609},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6201151609420776},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4456852674484253},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.43340784311294556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38134127855300903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36751145124435425},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21786633133888245},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.17265745997428894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10411134362220764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06512701511383057},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.145.7","doi":"https://doi.org/10.4049/jimmunol.184.supp.145.7","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.145.7","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029717704","https://openalex.org/W2574946218","https://openalex.org/W4402797615","https://openalex.org/W2317849922","https://openalex.org/W3119761841","https://openalex.org/W4200141394","https://openalex.org/W2007162526","https://openalex.org/W1987486991","https://openalex.org/W3178649094","https://openalex.org/W4400431019"],"abstract_inverted_index":{"Abstract":[0],"Transplantation":[1],"improves":[2],"the":[3,116,127,193],"health":[4],"and":[5,38,53,64,81,148,163],"quality":[6],"of":[7,88,118,129],"life":[8],"for":[9,16,20,95,107,126,153,168,182],"patients":[10,144,204],"suffering":[11],"from":[12,142],"renal":[13],"failure,":[14],"but":[15],"many,":[17],"antibodies":[18,37,93],"specific":[19,94,106,167,181],"HLA":[21,71,90,98,109,146,170,185],"antigens":[22],"create":[23],"a":[24,31,57,66,85],"substantial":[25],"barrier.":[26],"Our":[27],"center":[28],"has":[29],"developed":[30,65],"desensitization":[32,80,123],"protocol":[33,45],"to":[34,60,74,100,121,191],"remove":[35],"HLA-specific":[36,62,76,138],"successfully":[39],"transplant":[40],"these":[41,203],"sensitized":[42],"patients.":[43],"This":[44],"involves":[46],"alternate":[47],"day":[48],"plasmapheresis,":[49],"intravenous":[50],"immunoglobulin":[51],"(IvIg),":[52],"immunosuppressants.":[54],"We":[55,111,135],"use":[56],"Luminex":[58],"assay":[59],"detect":[61],"antibody":[63,175],"flow":[67],"cytometric":[68],"technique":[69],"using":[70,145,156],"tetramer":[72],"molecules":[73],"quantitate":[75],"B":[77,104,130,139,165,179,199],"cells.":[78],"Following":[79],"transplantation,":[82],"we":[83],"observe":[84],"sustained":[86],"loss":[87],"donor-specific":[89,108,198],"antibodies,":[91],"while":[92,178],"3rd":[96,183],"party":[97,184],"return":[99],"pre-treatment":[101],"levels.":[102],"Interestingly,":[103],"cells":[105,140,166,180,200],"persist.":[110],"hypothesize":[112],"that":[113],"transplantation":[114],"in":[115,150,196,202],"absence":[117],"inflammation,":[119],"due":[120],"continued":[122],"treatment,":[124],"allows":[125],"induction":[128],"cell":[131],"anergy":[132],"toward":[133],"donor-HLA.":[134],"have":[136],"isolated":[137],"post-transplant":[141],"desensitized":[143],"tetramers":[147],"performed":[149],"vitro":[151],"cultures":[152],"10-12":[154],"days":[155],"media":[157],"containing":[158],"CD40L,":[159],"IL2,":[160],"IL21,":[161],"IL10,":[162],"CpG.":[164],"donor":[169],"did":[171],"not":[172],"differentiate":[173],"into":[174],"secreting":[176],"cells,":[177],"did.":[186],"Further":[187],"research":[188],"is":[189],"underway":[190],"understand":[192],"mechanisms":[194],"involved":[195],"keeping":[197],"quiescent":[201],"post-transplant.":[205]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
