{"id":"https://openalex.org/W2289037553","doi":"https://doi.org/10.1038/ncomms10816","title":"Structural hot spots for the solubility of globular proteins","display_name":"Structural hot spots for the solubility of globular proteins","publication_year":2016,"publication_date":"2016-02-24","ids":{"openalex":"https://openalex.org/W2289037553","doi":"https://doi.org/10.1038/ncomms10816","mag":"2289037553","pmid":"https://pubmed.ncbi.nlm.nih.gov/26905391","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4770091"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms10816","doi":"https://doi.org/10.1038/ncomms10816","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms10816","pdf_url":"https://www.nature.com/articles/ncomms10816.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/ncomms10816.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110834528","display_name":"Ashok Ganesan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ashok Ganesan","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080234805","display_name":"Aleksandra Siekierska","orcid":"https://orcid.org/0000-0003-4907-605X","observed_orcids":["https://orcid.org/0000-0003-4907-605X"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Aleksandra Siekierska","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103905022","display_name":"Jacinte Beerten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jacinte Beerten","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041531714","display_name":"Marijke Brams","orcid":"https://orcid.org/0000-0002-1830-7620","observed_orcids":["https://orcid.org/0000-0002-1830-7620"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marijke Brams","raw_affiliation_strings":["KU Leuven, Laboratory for Structural Neurobiology, Department of Cellular and Molecular Medicine, Herestraat 49, PB 601, B-3000 Leuven, Belgium","Department of Cellular and Molecular Medicine, KU Leuven, Laboratory for Structural Neurobiology, Herestraat 49, PB 601, Leuven, B-3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Laboratory for Structural Neurobiology, Department of Cellular and Molecular Medicine, Herestraat 49, PB 601, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, KU Leuven, Laboratory for Structural Neurobiology, Herestraat 49, PB 601, Leuven, B-3000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070924824","display_name":"Joost Van Durme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Joost Van Durme","raw_affiliation_strings":["VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039155418","display_name":"Greet De Baets","orcid":"https://orcid.org/0000-0001-8844-800X","observed_orcids":["https://orcid.org/0000-0001-8844-800X"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Greet De Baets","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053523332","display_name":"Rob van der Kant","orcid":"https://orcid.org/0000-0003-3639-9749","observed_orcids":["https://orcid.org/0000-0003-3639-9749"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rob Van der Kant","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018247276","display_name":"Rodrigo U. Gallardo","orcid":"https://orcid.org/0000-0003-1584-3564","observed_orcids":["https://orcid.org/0000-0003-1584-3564"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rodrigo Gallardo","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026197000","display_name":"Meine Ramakers","orcid":"https://orcid.org/0000-0002-9417-4196","observed_orcids":["https://orcid.org/0000-0002-9417-4196"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Meine Ramakers","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078196831","display_name":"Tobias Langenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tobias Langenberg","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005478274","display_name":"Hannah Roslyne Wilkinson","orcid":"https://orcid.org/0000-0002-8888-2882","observed_orcids":["https://orcid.org/0000-0002-8888-2882"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hannah Wilkinson","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046557285","display_name":"Frederik De Smet","orcid":"https://orcid.org/0000-0002-6669-3335","observed_orcids":["https://orcid.org/0000-0002-6669-3335"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frederik De Smet","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050669467","display_name":"Chris Ulens","orcid":"https://orcid.org/0000-0002-8202-5281","observed_orcids":["https://orcid.org/0000-0002-8202-5281"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Chris Ulens","raw_affiliation_strings":["KU Leuven, Laboratory for Structural Neurobiology, Department of Cellular and Molecular Medicine, Herestraat 49, PB 601, B-3000 Leuven, Belgium","Department of Cellular and Molecular Medicine, KU Leuven, Laboratory for Structural Neurobiology, Herestraat 49, PB 601, Leuven, B-3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Laboratory for Structural Neurobiology, Department of Cellular and Molecular Medicine, Herestraat 49, PB 601, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, KU Leuven, Laboratory for Structural Neurobiology, Herestraat 49, PB 601, Leuven, B-3000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008256216","display_name":"Fr\u00e9d\u00e9ric Rousseau","orcid":"https://orcid.org/0000-0002-9189-7399","observed_orcids":["https://orcid.org/0000-0002-9189-7399"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Frederic Rousseau","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","Department of Cellular and Molecular Medicine, KU Leuven, Switch Laboratory, Herestraat 49, PB 802, 3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, KU Leuven, Switch Laboratory, Herestraat 49, PB 802, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost W. H. Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168","observed_orcids":["https://orcid.org/0000-0003-2020-0168"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Joost Schymkowitz","raw_affiliation_strings":["KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Switch Laboratory, Department of Cellular and Molecular Medicine, Herestraat 49, PB 802, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950"]},{"raw_affiliation_string":"VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB), Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I2802017950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008256216","https://openalex.org/A5031589452"],"corresponding_institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I99464096"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":2.1332,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.87647394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"10816","last_page":"10816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.30809998512268066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-solubility","display_name":"protein solubility","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aggregation-prone-regions","display_name":"aggregation-prone regions","score":0.8920000195503235},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7080000042915344},{"id":"https://openalex.org/keywords/globular-proteins","display_name":"globular proteins","score":0.7670000195503235},{"id":"https://openalex.org/keywords/alpha-galactosidase","display_name":"alpha-galactosidase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bacillus-anthracis-protective-antigen","display_name":"Bacillus anthracis protective antigen","score":0.9769999980926514},{"id":"https://openalex.org/keywords/solubility-prediction","display_name":"solubility prediction","score":0.7210000157356262},{"id":"https://openalex.org/keywords/natural-selection","display_name":"natural selection","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.9015201330184937},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.5501915216445923},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4918477535247803},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4823690950870514},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.457773894071579},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4316861927509308},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4188041687011719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4144803285598755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3681112825870514},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3567792773246765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34122055768966675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11525630950927734},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07054629921913147}],"mesh":[{"descriptor_ui":"D000519","descriptor_name":"alpha-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000519","descriptor_name":"alpha-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000519","descriptor_name":"alpha-Galactosidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/ncomms10816","doi":"https://doi.org/10.1038/ncomms10816","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms10816","pdf_url":"https://www.nature.com/articles/ncomms10816.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:26905391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26905391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4770091","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4770091/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:dora:psi_5693","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:5693","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:5693/PDF/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/533149","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/533149","pdf_url":"https://lirias.kuleuven.be/retrieve/cbd4fe8f-d32d-41a5-aa6e-5f5f87cac44d","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol. 7, Art.No. ARTN 10816, (10816-10816)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10816","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms10816","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:83b3c708399847f480f311a4edf53932","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/83b3c708399847f480f311a4edf53932","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms10816","doi":"https://doi.org/10.1038/ncomms10816","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms10816","pdf_url":"https://www.nature.com/articles/ncomms10816.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G457760290","display_name":null,"funder_award_id":"G.0939.11","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5498576345","display_name":null,"funder_award_id":"647458","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5685691454","display_name":null,"funder_award_id":"647458","funder_id":"https://openalex.org/F4320322837","funder_display_name":"Vlaams Instituut voor Biotechnologie"},{"id":"https://openalex.org/G5694002358","display_name":"The determinants of cross-seeding of protein aggregation: a Multiple TANGO","funder_award_id":"647458","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G7512698666","display_name":null,"funder_award_id":"G.0762.13","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322837","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2289037553.pdf","grobid_xml":"https://content.openalex.org/works/W2289037553.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1966406470","https://openalex.org/W1973268693","https://openalex.org/W1976513749","https://openalex.org/W1980123055","https://openalex.org/W1985267699","https://openalex.org/W1993282040","https://openalex.org/W2005157268","https://openalex.org/W2012108346","https://openalex.org/W2012310616","https://openalex.org/W2014297210","https://openalex.org/W2015148410","https://openalex.org/W2018838993","https://openalex.org/W2023490488","https://openalex.org/W2024981220","https://openalex.org/W2026507072","https://openalex.org/W2027839322","https://openalex.org/W2027856172","https://openalex.org/W2040721946","https://openalex.org/W2044683923","https://openalex.org/W2045725488","https://openalex.org/W2045831415","https://openalex.org/W2047721234","https://openalex.org/W2051349181","https://openalex.org/W2066983873","https://openalex.org/W2078005095","https://openalex.org/W2084073404","https://openalex.org/W2088593433","https://openalex.org/W2099099776","https://openalex.org/W2101520669","https://openalex.org/W2102796372","https://openalex.org/W2105196725","https://openalex.org/W2107803104","https://openalex.org/W2107904341","https://openalex.org/W2108078395","https://openalex.org/W2108921801","https://openalex.org/W2109302654","https://openalex.org/W2110498021","https://openalex.org/W2116633256","https://openalex.org/W2121543180","https://openalex.org/W2124026197","https://openalex.org/W2124561962","https://openalex.org/W2129507901","https://openalex.org/W2131187223","https://openalex.org/W2139418286","https://openalex.org/W2141013260","https://openalex.org/W2154714625","https://openalex.org/W2162390984","https://openalex.org/W2171533950","https://openalex.org/W2180229411","https://openalex.org/W2322685908","https://openalex.org/W2415636511","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W2896777916","https://openalex.org/W2411303265","https://openalex.org/W2098600151","https://openalex.org/W2883869520","https://openalex.org/W2748995151","https://openalex.org/W7070635416","https://openalex.org/W2613688952","https://openalex.org/W2795330179","https://openalex.org/W2052157693","https://openalex.org/W1966548097"],"abstract_inverted_index":{"Natural":[0],"selection":[1],"shapes":[2],"protein":[3,14,28,48,65,76,85,91,134],"solubility":[4,25,92,135],"to":[5,63,132],"physiological":[6],"requirements":[7],"and":[8,50,96,114,139],"recombinant":[9],"applications":[10],"that":[11,54,69,125],"require":[12],"higher":[13],"concentrations":[15],"are":[16,93],"often":[17],"problematic.":[18],"This":[19],"raises":[20],"the":[21,24,39,109],"question":[22],"whether":[23],"of":[26,41,57,111,117,137],"natural":[27],"sequences":[29],"can":[30,78,100],"be":[31,101],"improved.":[32],"We":[33,67,104],"here":[34],"show":[35,68],"an":[36],"anti-correlation":[37],"between":[38],"number":[40],"aggregation":[42,110],"prone":[43],"regions":[44],"(APRs)":[45],"in":[46],"a":[47,60,75],"sequence":[49,97],"its":[51],"solubility,":[52],"suggesting":[53],"mutational":[55],"suppression":[56],"APRs":[58],"provides":[59],"simple":[61],"strategy":[62],"increase":[64],"solubility.":[66],"mutations":[70],"at":[71],"specific":[72],"positions":[73],"within":[74],"structure":[77,95,138],"act":[79],"as":[80],"APR":[81],"suppressors":[82],"without":[83],"affecting":[84],"stability.":[86],"These":[87],"hot":[88,129],"spots":[89,130],"for":[90],"both":[94],"dependent":[98],"but":[99],"computationally":[102],"predicted.":[103],"demonstrate":[105],"this":[106],"by":[107],"reducing":[108],"human":[112],"\u03b1-galactosidase":[113],"protective":[115],"antigen":[116],"Bacillus":[118],"anthracis":[119],"through":[120],"mutation.":[121],"Our":[122],"results":[123],"indicate":[124],"many":[126],"proteins":[127],"possess":[128],"allowing":[131],"adapt":[133],"independently":[136],"function.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
