{"id":"https://openalex.org/W2288718083","doi":null,"title":"Effects of various inducers on the expression of P2X7 receptor in human peripheral blood mononuclear cells.","display_name":"Effects of various inducers on the expression of P2X7 receptor in human peripheral blood mononuclear cells.","publication_year":2005,"publication_date":"2005-04-25","ids":{"openalex":"https://openalex.org/W2288718083","mag":"2288718083","pmid":"https://pubmed.ncbi.nlm.nih.gov/15830104"},"language":"en","primary_location":{"id":"pmid:15830104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15830104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100720559","display_name":"Xiujun Zhang","orcid":"https://orcid.org/0000-0001-8041-0592","observed_orcids":["https://orcid.org/0000-0001-8041-0592"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391768267","display_name":"State Key Laboratory of Experimental Hematology","ror":"https://ror.org/0093mkr06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768267"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiu-Jun Zhang","raw_affiliation_strings":["State Key Laboratory for Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391768267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052076760","display_name":"Guoguang Zheng","orcid":"https://orcid.org/0000-0002-0829-3501","observed_orcids":["https://orcid.org/0000-0002-0829-3501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo-Guang Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101513801","display_name":"Xiaotong Ma","orcid":"https://orcid.org/0009-0009-7892-4143","observed_orcids":["https://orcid.org/0009-0009-7892-4143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Tong Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100513158","display_name":"Yong\u2010Min Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Min Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036680742","display_name":"Yuhua Song","orcid":"https://orcid.org/0000-0002-2583-850X","observed_orcids":["https://orcid.org/0000-0002-2583-850X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Hua Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081950834","display_name":"Ke\u2010Fu Wu","orcid":"https://orcid.org/0009-0005-6898-4995","observed_orcids":["https://orcid.org/0009-0005-6898-4995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ke-Fu Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6204,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.54853161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"57","issue":"2","first_page":"193","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":1.0},{"id":"https://openalex.org/keywords/receptor-regulation","display_name":"receptor regulation","score":0.703000009059906},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.968999981880188},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.878000020980835},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9700000286102295},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/inflammatory-stimuli","display_name":"inflammatory stimuli","score":0.503000020980835},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.7450000047683716},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.755630612373352},{"id":"https://openalex.org/C2993002077","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Receptor expression","level":3,"score":0.6467251777648926},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.611764132976532},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5992661714553833},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5964257717132568},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5747031569480896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5359120965003967},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4121149182319641},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3858412206172943},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10715055465698242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07188832759857178}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15830104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15830104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:2288718083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15830104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W54236526","https://openalex.org/W1500372714","https://openalex.org/W1815757713","https://openalex.org/W1902132075","https://openalex.org/W1910149072","https://openalex.org/W2000852234","https://openalex.org/W2066784771","https://openalex.org/W2075771764","https://openalex.org/W2095829875","https://openalex.org/W2113828544","https://openalex.org/W2122685998","https://openalex.org/W2156991534","https://openalex.org/W2248033023","https://openalex.org/W2266650223","https://openalex.org/W2370041414"],"related_works":["https://openalex.org/W2095829875","https://openalex.org/W2072243442","https://openalex.org/W2948204500","https://openalex.org/W2123610543","https://openalex.org/W2080766736","https://openalex.org/W2078395354","https://openalex.org/W3168257071","https://openalex.org/W4285182981","https://openalex.org/W7014547852","https://openalex.org/W2156552535"],"abstract_inverted_index":{"Regulation":[0],"of":[1,6,10,20,49,127],"P2X7":[2,50,70,79,128,136,159,172,179],"receptor":[3,12,51,71,80,137,160,180],"expression":[4,27,81,126,138,161],"is":[5],"interest":[7],"because":[8],"activation":[9],"this":[11],"by":[13,86],"extracellular":[14],"ATP":[15],"triggers":[16],"a":[17,183],"wide":[18],"variety":[19],"cell":[21],"functions":[22],"in":[23,30,65,75,82,139,162,185],"leukocytes.":[24],"However,":[25,107],"its":[26],"and":[28,37,52,62,68,77,99,118,132,144],"modulation":[29],"human":[31,66],"peripheral":[32],"blood":[33],"mononuclear":[34],"cells":[35],"(PBMC)":[36],"monocytes":[38],"remain":[39],"unclear.":[40],"RT-PCR":[41],"was":[42,73,84],"used":[43],"to":[44],"detect":[45],"the":[46,53,125,176,186],"constitutive":[47],"level":[48],"levels":[54],"upon":[55],"stimulation":[56],"with":[57,151],"bacteria,":[58],"bacterial":[59],"product,":[60],"mitogen":[61],"various":[63],"cytokines":[64],"PBMC":[67,76,83],"monocytes.":[69,78,163],"mRNA":[72],"detected":[74],"up-regulated":[85],"interleukin-2,":[87],"-4,":[88],"-6":[89],"(IL-2,":[90],"IL-4,":[91],"IL-6)":[92],"tumour":[93],"necrosis":[94],"factor-alpha":[95],"(TNF-alpha),":[96],"lipopolysaccharide":[97],"(LPS)":[98],"heat-inactivated":[100],"Staphylococcus":[101],"aureus":[102],"Cowan":[103],"strain":[104],"I":[105],"(SAC).":[106],"interferon-gamma":[108],"(IFN-gamma),":[109],"granulocyte-macrophage":[110],"colony-stimulating":[111,115],"factor":[112,116],"(GM-CSF),":[113],"macrophage":[114],"(M-CSF)":[117],"phytohemagglutinin-M":[119],"(PHA-M)":[120],"had":[121,146],"little":[122],"effect":[123],"on":[124],"receptor.":[129],"Furthermore,":[130],"LPS":[131],"M-CSF":[133],"could":[134,154],"up-regulate":[135],"monocytes,":[140],"while":[141],"IFN-gamma,":[142],"TNF-alpha":[143],"GM-CSF":[145],"weak":[147],"effects,":[148],"but":[149],"pretreatment":[150],"these":[152],"inducers":[153],"not":[155],"further":[156,194],"enhance":[157],"LPS-stimulated":[158],"The":[164],"results":[165],"obtained":[166],"demonstrate":[167],"that":[168,178],"inflammatory":[169,187],"stimuli":[170],"drive":[171],"expression,":[173],"thus":[174],"supporting":[175],"hypothesis":[177],"may":[181],"play":[182],"role":[184],"responses":[188],"against":[189],"bacteria":[190],"infection,":[191],"which":[192],"need":[193],"verification.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}