{"id":"https://openalex.org/W2288442136","doi":"https://doi.org/10.1021/acs.jnatprod.5b00662","title":"Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes","display_name":"Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes","publication_year":2015,"publication_date":"2015-11-05","ids":{"openalex":"https://openalex.org/W2288442136","doi":"https://doi.org/10.1021/acs.jnatprod.5b00662","mag":"2288442136","pmid":"https://pubmed.ncbi.nlm.nih.gov/26539973"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jnatprod.5b00662","doi":"https://doi.org/10.1021/acs.jnatprod.5b00662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.5b00662","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044647383","display_name":"Shinichiro Okamoto","orcid":"https://orcid.org/0000-0002-6257-4152","observed_orcids":["https://orcid.org/0000-0002-6257-4152"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Okamoto","raw_affiliation_strings":["Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087136290","display_name":"Arihiro Iwasaki","orcid":"https://orcid.org/0000-0002-3775-5066","observed_orcids":["https://orcid.org/0000-0002-3775-5066"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Arihiro Iwasaki","raw_affiliation_strings":["Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074087265","display_name":"Osamu Ohno","orcid":"https://orcid.org/0000-0002-8147-6857","observed_orcids":["https://orcid.org/0000-0002-8147-6857"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Ohno","raw_affiliation_strings":["Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020010288","display_name":"Kiyotake Suenaga","orcid":"https://orcid.org/0000-0001-5343-5890","observed_orcids":["https://orcid.org/0000-0001-5343-5890"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kiyotake Suenaga","raw_affiliation_strings":["Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry,\rFaculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama, Kanagawa 223-8522, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020010288"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.92,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.83840464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"78","issue":"11","first_page":"2719","last_page":"2725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.39750000834465027,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marine-cyanobacteria","display_name":"marine cyanobacteria","score":0.7950000166893005},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.8340522646903992},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7546764612197876},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7280213236808777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48485812544822693},{"id":"https://openalex.org/C25170562","wikidata":"https://www.wikidata.org/wiki/Q2052053","display_name":"Absolute configuration","level":2,"score":0.4846230447292328},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.44401097297668457},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20498564839363098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16981086134910583}],"mesh":[{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008386","descriptor_name":"Marine Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jnatprod.5b00662","doi":"https://doi.org/10.1021/acs.jnatprod.5b00662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.5b00662","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:26539973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26539973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G159198709","display_name":null,"funder_award_id":"20436992","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G183214208","display_name":null,"funder_award_id":"24310160","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4152071780","display_name":"Elucidation of the mode of action of kurahyne, an ER-stress inducer","funder_award_id":"15H06584","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1976793055","https://openalex.org/W1994162165","https://openalex.org/W2002587435","https://openalex.org/W2049378145","https://openalex.org/W2049896972","https://openalex.org/W2058623521","https://openalex.org/W2078210355","https://openalex.org/W2109947553","https://openalex.org/W2142207867","https://openalex.org/W2320738396","https://openalex.org/W4211040155"],"related_works":["https://openalex.org/W2886590683","https://openalex.org/W2042181423","https://openalex.org/W2169188755","https://openalex.org/W2951677130","https://openalex.org/W2099677307","https://openalex.org/W2125675228","https://openalex.org/W2586008329","https://openalex.org/W2950046323","https://openalex.org/W2952915532","https://openalex.org/W4283066160"],"abstract_inverted_index":{"Kurahyne":[0,35],"B":[1,36,61],"(2),":[2],"a":[3],"new":[4],"analogue":[5],"of":[6,41,50,59,74],"kurahyne":[7,60,66,75],"(1),":[8],"was":[9,20,30,62,77],"isolated":[10],"from":[11],"the":[12,27,39,63,70],"marine":[13],"cyanobacterium":[14],"Okeania":[15],"sp.":[16],"Its":[17],"gross":[18],"structure":[19],"elucidated":[21],"based":[22],"on":[23],"spectroscopic":[24],"analyses,":[25],"and":[26,44,52],"absolute":[28],"configuration":[29],"established":[31],"by":[32],"total":[33,72],"synthesis.":[34],"(2)":[37],"inhibited":[38],"growth":[40],"both":[42],"HeLa":[43],"HL60":[45],"cells,":[46],"with":[47],"IC50":[48],"values":[49],"8.1":[51],"9.0":[53],"\u03bcM,":[54],"respectively.":[55],"The":[56],"growth-inhibitory":[57],"activity":[58],"same":[64],"as":[65],"(1).":[67],"In":[68],"parallel,":[69],"first":[71],"synthesis":[73],"(1)":[76],"also":[78],"achieved.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
