{"id":"https://openalex.org/W2288231963","doi":null,"title":"Iron overload in Chang cell cultures: biochemical and morphological studies.","display_name":"Iron overload in Chang cell cultures: biochemical and morphological studies.","publication_year":1978,"publication_date":"1978-10-01","ids":{"openalex":"https://openalex.org/W2288231963","mag":"2288231963","pmid":"https://pubmed.ncbi.nlm.nih.gov/214097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041387"},"language":"en","primary_location":{"id":"pmid:214097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/214097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2041387/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Jacobs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Jacobs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111870028","display_name":"T. G. Hoy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083418917","display_name":"J. Humphrys","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Humphrys","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"P Perera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Perera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.857,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88992582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"5","first_page":"489","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9909999966621399},{"id":"https://openalex.org/keywords/iron-toxicity","display_name":"iron toxicity","score":0.777999997138977},{"id":"https://openalex.org/keywords/siderosomes","display_name":"siderosomes","score":0.7039999961853027},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/chang-cells","display_name":"Chang cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.8088868856430054},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.756580114364624},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6506868600845337},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5722741484642029},{"id":"https://openalex.org/C2780534640","wikidata":"https://www.wikidata.org/wiki/Q3233795","display_name":"Ferric","level":2,"score":0.5470266938209534},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47634103894233704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4758051335811615},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4251846969127655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4014270007610321},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4009351134300232},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38629692792892456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3516136705875397},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.06926751136779785},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06438702344894409},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:214097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/214097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2041387","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2041387/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},{"id":"mag:2288231963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/214097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2041387","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2041387/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W157133164","https://openalex.org/W185325478","https://openalex.org/W193854866","https://openalex.org/W204902447","https://openalex.org/W340035290","https://openalex.org/W1551118417","https://openalex.org/W2018325652","https://openalex.org/W2027749968","https://openalex.org/W2048187323","https://openalex.org/W2074602083","https://openalex.org/W2089218325","https://openalex.org/W2289323201","https://openalex.org/W2297117042","https://openalex.org/W2324682807","https://openalex.org/W2337040997","https://openalex.org/W2411964769","https://openalex.org/W2413703934"],"related_works":["https://openalex.org/W2164924092","https://openalex.org/W1460235955","https://openalex.org/W204902447","https://openalex.org/W160548577","https://openalex.org/W2020656528","https://openalex.org/W163798240","https://openalex.org/W2411199534","https://openalex.org/W2066252136","https://openalex.org/W1605447271","https://openalex.org/W2119051395"],"abstract_inverted_index":{"Cultures":[0,169],"of":[1,17,45,77,104,114,121,137,141,182,189,203],"Chang":[2],"cells":[3,19,88,142],"have":[4,170],"been":[5,160,171],"studied":[6],"during":[7],"growth":[8],"in":[9,29,35,41,60,68,81,92],"media":[10],"supplemented":[11],"with":[12,97,118,178],"ferric":[13],"nitriloacetate.":[14],"Iron":[15,84],"loading":[16],"the":[18,26,30,46,82,87,93,100,119,204,208],"occurs":[20],"rapidly":[21],"and":[22,51,95,156],"is":[23,49,52,64,79,89,110,166,186,196,201],"related":[24],"to":[25,57,74,132,143,175],"iron":[27,37,48,116,145,164,193,211],"concentration":[28],"medium.":[31],"A":[32],"50-fold":[33],"increase":[34],"cellular":[36,69],"content":[38,71],"was":[39],"obtained":[40],"some":[42,187],"cultures.":[43],"Most":[44,76],"intracellular":[47],"membrane-bound":[50,115],"seen":[53],"on":[54],"electron":[55],"microscopy":[56],"be":[58],"concentrated":[59],"discrete":[61],"bodies.":[62],"There":[63],"a":[65,111],"rapid":[66,112,148],"rise":[67,113],"ferritin":[70,126,154],"after":[72,153],"exposure":[73,140,152],"iron.":[75,138],"this":[78,107],"found":[80,90],"cytosol.":[83],"taken":[85],"into":[86],"equally":[91],"cytosol":[94],"associated":[96,117],"membranes":[98],"for":[99,173],"first":[101],"4":[102],"days":[103],"culture.":[105],"After":[106],"time":[108],"there":[109,185],"formation":[120,158,200],"siderosomes":[122,129],"which":[123],"contain":[124,133],"iron-rich":[125],"cores.":[127],"These":[128],"later":[130],"evolve":[131],"irregular,":[134],"electron-dense":[135],"accumulations":[136],"Initial":[139],"high":[144,192],"concentrations":[146,165],"causes":[147],"death":[149],"but":[150],"similar":[151],"synthesis":[155],"siderosome":[157,199],"has":[159],"stimulated":[161],"by":[162],"low":[163],"well":[167],"tolerated.":[168],"maintained":[172],"up":[174],"26":[176],"weeks":[177],"no":[179],"morphological":[180],"signs":[181],"toxicity,":[183],"though":[184],"impairment":[188],"proliferation":[190],"at":[191],"concentrations.":[194],"It":[195],"suggested":[197],"that":[198,206],"part":[202],"mechanism":[205],"protects":[207],"cell":[209],"against":[210],"toxicity.":[212]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}