{"id":"https://openalex.org/W2287808652","doi":"https://doi.org/10.1534/genetics.115.186122","title":"Differential Phosphorylation Provides a Switch to Control How \u03b1-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae","display_name":"Differential Phosphorylation Provides a Switch to Control How \u03b1-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae","publication_year":2016,"publication_date":"2016-02-27","ids":{"openalex":"https://openalex.org/W2287808652","doi":"https://doi.org/10.1534/genetics.115.186122","mag":"2287808652","pmid":"https://pubmed.ncbi.nlm.nih.gov/26920760","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858781"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.115.186122","doi":"https://doi.org/10.1534/genetics.115.186122","is_oa":false,"landing_page_url":"https://doi.org/10.1534/genetics.115.186122","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064817377","display_name":"Christopher G. Alvaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G Alvaro","raw_affiliation_strings":["Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051219984","display_name":"Ann Aindow","orcid":"https://orcid.org/0000-0001-8821-9493","observed_orcids":["https://orcid.org/0000-0001-8821-9493"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Aindow","raw_affiliation_strings":["Division of Biochemistry , Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry , Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048920959","display_name":"Jeremy W. Thorner","orcid":"https://orcid.org/0000-0002-2583-500X","observed_orcids":["https://orcid.org/0000-0002-2583-500X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremy Thorner","raw_affiliation_strings":["Division of Biochemistry , Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry , Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048920959"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.5606,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.90046775,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"203","issue":"1","first_page":"299","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mating-pheromone-response","display_name":"mating pheromone response","score":0.8970000147819519},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.7519999742507935},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/clathrin-independent-endocytosis","display_name":"clathrin-independent endocytosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7963262796401978},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6554495096206665},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5872687697410583},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.5587486028671265},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5479434132575989},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5313209891319275},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5079346299171448},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.4940996468067169},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.4464437961578369},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.43598172068595886},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42587733268737793},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.3478778004646301},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33395934104919434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32938480377197266},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.14260241389274597}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012100","descriptor_name":"Reproduction, Asexual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019703","descriptor_name":"Calcineurin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051964","descriptor_name":"Receptors, Mating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051964","descriptor_name":"Receptors, Mating Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1534/genetics.115.186122","doi":"https://doi.org/10.1534/genetics.115.186122","is_oa":false,"landing_page_url":"https://doi.org/10.1534/genetics.115.186122","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4858781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmid:26920760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26920760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3k9693wg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3k9693wg","pdf_url":"https://escholarship.org/content/qt3k9693wg/qt3k9693wg.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics, vol 203, iss 1","raw_type":"article"},{"id":"pmh:qt3k9693wg","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/3k9693wg","pdf_url":"http://www.escholarship.org/uc/item/3k9693wg","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alvaro, CG; Aindow, A; &amp; Thorner, J. (2016). Differential phosphorylation provides a switch to control how \u00ce\u00b1-arrestin Rod1 down-regulates mating pheromone response in saccharomyces cerevisiae. Genetics, 203(1), 299 - 317. doi: 10.1534/genetics.115.186122. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3k9693wg","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3k9693wg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3k9693wg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics, vol 203, iss 1","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4858781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G718078759","display_name":"The Molecular Basis of Cell Function","funder_award_id":"T32GM007232","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7496746108","display_name":"Yeast Protein Kinase Signaling Networks: Specificity, Regulation and Function","funder_award_id":"R01GM021841","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000211449","display_name":null,"funder_award_id":"GM21841","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2287808652.pdf","grobid_xml":"https://content.openalex.org/works/W2287808652.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W274181902","https://openalex.org/W585621270","https://openalex.org/W1486226554","https://openalex.org/W1500480452","https://openalex.org/W1526043578","https://openalex.org/W1534435141","https://openalex.org/W1540070193","https://openalex.org/W1599051410","https://openalex.org/W1600651336","https://openalex.org/W1604209299","https://openalex.org/W1608303629","https://openalex.org/W1909076506","https://openalex.org/W1938630352","https://openalex.org/W1964557313","https://openalex.org/W1965577544","https://openalex.org/W1974797908","https://openalex.org/W1981385111","https://openalex.org/W1984706267","https://openalex.org/W1985891940","https://openalex.org/W1987625771","https://openalex.org/W1989285948","https://openalex.org/W1990750768","https://openalex.org/W1991468122","https://openalex.org/W1991643627","https://openalex.org/W1998273363","https://openalex.org/W2003609221","https://openalex.org/W2004250476","https://openalex.org/W2004817469","https://openalex.org/W2006404990","https://openalex.org/W2008943739","https://openalex.org/W2018327145","https://openalex.org/W2024812887","https://openalex.org/W2029269187","https://openalex.org/W2030690279","https://openalex.org/W2032030313","https://openalex.org/W2032977708","https://openalex.org/W2037297990","https://openalex.org/W2041076630","https://openalex.org/W2041724231","https://openalex.org/W2043295482","https://openalex.org/W2047373064","https://openalex.org/W2047567287","https://openalex.org/W2049512843","https://openalex.org/W2051338800","https://openalex.org/W2053476250","https://openalex.org/W2054432610","https://openalex.org/W2054624670","https://openalex.org/W2060259273","https://openalex.org/W2065452543","https://openalex.org/W2068323301","https://openalex.org/W2069862589","https://openalex.org/W2070380343","https://openalex.org/W2070446531","https://openalex.org/W2073573051","https://openalex.org/W2078230826","https://openalex.org/W2081954164","https://openalex.org/W2086963800","https://openalex.org/W2087663632","https://openalex.org/W2093714495","https://openalex.org/W2094353613","https://openalex.org/W2094866737","https://openalex.org/W2095055516","https://openalex.org/W2100582146","https://openalex.org/W2102763490","https://openalex.org/W2103370167","https://openalex.org/W2103544547","https://openalex.org/W2104195793","https://openalex.org/W2104523985","https://openalex.org/W2108280966","https://openalex.org/W2111651553","https://openalex.org/W2113551110","https://openalex.org/W2114978834","https://openalex.org/W2122412269","https://openalex.org/W2122936428","https://openalex.org/W2123563726","https://openalex.org/W2125263833","https://openalex.org/W2128764621","https://openalex.org/W2135020156","https://openalex.org/W2135711463","https://openalex.org/W2135918106","https://openalex.org/W2136812039","https://openalex.org/W2139292247","https://openalex.org/W2139511297","https://openalex.org/W2140210268","https://openalex.org/W2141627667","https://openalex.org/W2143958516","https://openalex.org/W2144634347","https://openalex.org/W2147013899","https://openalex.org/W2147594695","https://openalex.org/W2148810638","https://openalex.org/W2149063573","https://openalex.org/W2150091336","https://openalex.org/W2154830357","https://openalex.org/W2157058776","https://openalex.org/W2157972644","https://openalex.org/W2165775221","https://openalex.org/W2166214044","https://openalex.org/W2168102576","https://openalex.org/W2168648974","https://openalex.org/W2169520827","https://openalex.org/W2181926368","https://openalex.org/W2190825436","https://openalex.org/W2201298412","https://openalex.org/W2314225431","https://openalex.org/W2323529956","https://openalex.org/W2413409105"],"related_works":["https://openalex.org/W2520276330","https://openalex.org/W7024205554","https://openalex.org/W2111651553","https://openalex.org/W7098151313","https://openalex.org/W2122412269","https://openalex.org/W83762184","https://openalex.org/W4252857205","https://openalex.org/W2060279438","https://openalex.org/W2128195122","https://openalex.org/W2083747145"],"abstract_inverted_index":{"G-protein-coupled":[0],"receptors":[1],"(GPCRs)":[2],"are":[3,217],"integral":[4],"membrane":[5],"proteins":[6],"that":[7,42,105,126,152,189,216],"initiate":[8],"stimulus-dependent":[9],"activation":[10],"of":[11,22,45,65,87,91,107,129,158,173,181,240],"cognate":[12],"heterotrimeric":[13],"G-proteins,":[14],"triggering":[15],"ensuing":[16],"downstream":[17],"cellular":[18],"responses.":[19],"Tight":[20],"regulation":[21,128],"GPCR-evoked":[23],"pathways":[24],"is":[25,54,114,133],"required":[26,115,210],"because":[27],"prolonged":[28],"stimulation":[29],"can":[30,177,191],"be":[31],"detrimental":[32],"to":[33,48,160,193,222],"an":[34,71],"organism.":[35],"Ste2,":[36],"a":[37,206,231],"GPCR":[38],"in":[39,120,147,150,170,203],"Saccharomyces":[40],"cerevisiae":[41],"mediates":[43],"response":[44],"MATa":[46],"haploids":[47],"the":[49,74,79,88,92,98,156,171,241],"peptide":[50],"mating":[51,162],"pheromone":[52],"\u03b1-factor,":[53],"down-regulated":[55],"by":[56,97,109,131,135,196,234],"both":[57,146,197],"constitutive":[58],"and":[59,94,142,144,149,199,220],"agonist-induced":[60],"endocytosis.":[61],"Efficient":[62],"agonist-stimulated":[63],"internalization":[64],"Ste2":[66,121],"requires":[67],"its":[68,95,174],"association":[69],"with":[70,186,224],"adaptor":[72],"protein,":[73],"\u03b1-arrestin":[75,237],"Rod1/Art4,":[76],"which":[77,235],"recruits":[78],"HECT-domain":[80],"ubiquitin":[81],"ligase":[82],"Rsp5,":[83],"allowing":[84],"for":[85,116,211],"ubiquitinylation":[86],"C-terminal":[89],"tail":[90],"receptor":[93,183],"engagement":[96],"clathrin-dependent":[99,198],"endocytic":[100],"machinery.":[101],"We":[102,123],"previously":[103],"showed":[104],"dephosphorylation":[106],"Rod1":[108,118,130,159,176,214],"calcineurin":[110],"(phosphoprotein":[111],"phosphatase":[112],"2B)":[113],"optimal":[117],"function":[119],"down-regulation.":[122],"show":[124],"here":[125],"negative":[127],"phosphorylation":[132],"mediated":[134],"two":[136],"distinct":[137],"stress-activated":[138],"protein":[139],"kinases,":[140],"Snf1/AMPK":[141],"Ypk1/SGK1,":[143],"demonstrate":[145],"vitro":[148],"vivo":[151],"this":[153,236],"phospho-regulation":[154],"impedes":[155],"ability":[157],"promote":[161,178,227],"pathway":[163],"desensitization.":[164],"These":[165],"studies":[166],"also":[167],"revealed":[168],"that,":[169],"absence":[172],"phosphorylation,":[175],"adaptation":[179],"independently":[180],"Rsp5-mediated":[182],"ubiquitinylation,":[184],"consistent":[185],"recent":[187],"evidence":[188],"\u03b1-arrestins":[190],"contribute":[192],"cargo":[194],"recognition":[195],"clathrin-independent":[200,212],"mechanisms.":[201],"However,":[202],"cells":[204],"lacking":[205],"component":[207],"(formin":[208],"Bni1)":[209],"entry,":[213],"derivatives":[215],"largely":[218],"unphosphorylated":[219],"unable":[221],"associate":[223],"Rsp5":[225],"still":[226],"efficient":[228],"adaptation,":[229],"indicating":[230],"third":[232],"mechanism":[233],"promotes":[238],"desensitization":[239],"pheromone-response":[242],"pathway.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
