{"id":"https://openalex.org/W2287688445","doi":null,"title":"Papel de las prote\u00ednas oxidadas sobre el da\u00f1o endotelial asociado a la enfermedad renal cr\u00f3nica : aproximaci\u00f3n \u201cin vivo\u201d e \u201cin vitro\u201d","display_name":"Papel de las prote\u00ednas oxidadas sobre el da\u00f1o endotelial asociado a la enfermedad renal cr\u00f3nica : aproximaci\u00f3n \u201cin vivo\u201d e \u201cin vitro\u201d","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2287688445","mag":"2287688445"},"language":"es","primary_location":{"id":"pmh:oai:ebuah.uah.es:10017/22937","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10017/22937","pdf_url":"https://ebuah.uah.es/dspace/bitstream/10017/22937/1/papel_navalmoral_2014_DIANAS.pdf","source":{"id":"https://openalex.org/S7407055200","display_name":"e_Buah","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/submittedVersion"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ebuah.uah.es/dspace/bitstream/10017/22937/1/papel_navalmoral_2014_DIANAS.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083005148","display_name":"Estefania Navalmoral","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Estefan\u00eda Navalmoral Arenas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065217538","display_name":"Carlos Luna Ruiz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Luna Ruiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030578631","display_name":"Matilde Alique Aguilar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matilde Alique Aguilar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004583419","display_name":"Manuel Rafael Ram\u00edrez Chamond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Rafael Ram\u00edrez Chamond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidized-proteins","display_name":"oxidized proteins","score":0.7720000147819519},{"id":"https://openalex.org/keywords/advanced-oxidation-protein-products","display_name":"advanced oxidation protein products","score":0.7730000019073486},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9419999718666077},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.5669999718666077},{"id":"https://openalex.org/keywords/oxidative-modification","display_name":"oxidative modification","score":0.4390000104904175},{"id":"https://openalex.org/keywords/premature-senescence","display_name":"premature senescence","score":0.7979999780654907},{"id":"https://openalex.org/keywords/endothelial-microparticles","display_name":"endothelial microparticles","score":0.9150000214576721},{"id":"https://openalex.org/keywords/re-endothelialization","display_name":"re-endothelialization","score":0.8230000138282776},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cardiovascular-complications","display_name":"cardiovascular complications","score":0.5809999704360962},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.6729999780654907},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.6460000276565552},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3240000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.46000000834465027},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.496634304523468}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ebuah.uah.es:10017/22937","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10017/22937","pdf_url":"https://ebuah.uah.es/dspace/bitstream/10017/22937/1/papel_navalmoral_2014_DIANAS.pdf","source":{"id":"https://openalex.org/S7407055200","display_name":"e_Buah","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/submittedVersion"},{"id":"pmh:oai:dnet:ebuahbibliot::fd4bacf7b9408240849474b5944f2d51","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10017/22937","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2287688445","doi":null,"is_oa":false,"landing_page_url":"https://ebuah.uah.es/dspace/handle/10017/22937","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ebuah.uah.es:10017/22937","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10017/22937","pdf_url":"https://ebuah.uah.es/dspace/bitstream/10017/22937/1/papel_navalmoral_2014_DIANAS.pdf","source":{"id":"https://openalex.org/S7407055200","display_name":"e_Buah","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/submittedVersion"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323755","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2287688445.pdf","grobid_xml":"https://content.openalex.org/works/W2287688445.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2016946333","https://openalex.org/W2050690509","https://openalex.org/W2095808083","https://openalex.org/W2120833123","https://openalex.org/W2126525177","https://openalex.org/W2137310032","https://openalex.org/W2141770297"],"related_works":["https://openalex.org/W3024116393","https://openalex.org/W139222633","https://openalex.org/W4241575590","https://openalex.org/W2278526417","https://openalex.org/W2902855910","https://openalex.org/W2952590955","https://openalex.org/W2298898938","https://openalex.org/W1534439578","https://openalex.org/W7064932183","https://openalex.org/W1572117636"],"abstract_inverted_index":{"Una":[0],"manifestaci\u00f3n":[1],"temprana":[2],"de":[3,17,46,72,80,88,106,118,121,152,160,169,177,197,207,218,228,235,241,252,264,267,272,280,284,291],"las":[4,37,131,182,288],"enfermedades":[5],"cardiovasculares":[6,56],"es":[7],"la":[8,21,30,41,116,142,149,208,250,273,296],"disfunci\u00f3n":[9],"endotelial,":[10],"asociada":[11],"a":[12,58,115,287],"un":[13,48],"entorno":[14],"inflamatorio":[15],"propio":[16],"patolog\u00edas":[18],"cr\u00f3nicas":[19],"como":[20,40,52,199,211,232,262],"insuficiencia":[22],"renal":[23],"cr\u00f3nica":[24],"(IRC).":[25,61],"Est\u00e1":[26],"descrito":[27],"que":[28,43,249],"en":[29,36,66,77,91,104,113,127,141,158,181,238,258],"IRC":[31],"se":[32,147,173,190,247],"producen":[33],"modificaciones":[34],"pos-traduccionales":[35],"prote\u00ednas,":[38],"tales":[39],"oxidaci\u00f3n,":[42],"ser\u00edan":[44],"capaces":[45],"generar":[47],"da\u00f1o":[49,122,187,214],"endotelial":[50],"y":[51,68,109,123,213,221,275],"consecuencia":[53],"producir":[54],"eventos":[55],"asociados":[57],"esta":[59],"patolog\u00eda":[60],"Por":[62],"ello,":[63],"nos":[64],"centramos":[65],"caracterizar":[67],"determinar":[69],"el":[70,128,175,186,245,259],"papel":[71],"estas":[73,100],"prote\u00ednas":[74,229],"oxidadas":[75,230],"presentes":[76,103],"los":[78,86,203,239,242],"plasmas":[79,105,159,240],"pacientes":[81],"con":[82,130,163,295],"IRC.":[83],"Adem\u00e1s,":[84],"valoramos":[85],"efectos":[87,205],"una":[89,137,225,281],"prote\u00edna":[90,111,293],"concreto,":[92],"alb\u00famina":[93,253],"humana,":[94],"sobre":[95],"cultivos":[96],"endoteliales,":[97],"para":[98,184,201],"relacionar":[99],"mol\u00e9culas":[101],"alteradas":[102],"sujetos":[107,161,243],"patol\u00f3gicos":[108],"nuestra":[110],"modificada":[112],"cuanto":[114],"capacidad":[117],"provocar":[119],"fen\u00f3menos":[120],"senescencia":[124,212,256,297],"prematura":[125,257],"inducida":[126],"endotelio,":[129,260],"consiguientes":[132],"complicaciones":[133],"fisiopatol\u00f3gicas.":[134],"Se":[135,223],"realiz\u00f3":[136],"aproximaci\u00f3n":[138],"in":[139],"vivo,":[140],"cual,":[143],"mediante":[144],"t\u00e9cnica":[145],"ELISA,":[146],"determin\u00f3":[148],"cantidad":[150,227],"(ng/mL)":[151],"AOPP":[153],"(Advance":[154],"Oxidized":[155],"Protein":[156],"Products)":[157],"(n=18)":[162],"IRC,":[164],"procedentes":[165],"del":[166,277],"Hospital":[167],"Puerta":[168],"Hierro,":[170],"Majadahonda.":[171],"Paralelamente,":[172],"cuantific\u00f3":[174],"n\u00famero":[176,234,266],"micropart\u00edculas":[178],"(MPs)":[179],"endoteliales":[180,237],"muestras":[183],"observar":[185],"endotelial.\u201dIn":[188],"Vitro\u201d,":[189],"utiliz\u00f3":[191],"Alb\u00famina":[192],"Humana":[193],"Oxidada":[194],"(mediante":[195],"sulfato":[196],"cobre)":[198],"tratamiento,":[200,292],"ver":[202],"posibles":[204],"delet\u00e9reos":[206],"misma,":[209],"medidos":[210],"(actividad":[215],"B-gal,":[216],"producci\u00f3n":[217],"MPs,":[219],"reendotelizaci\u00f3n":[220,276],"proliferaci\u00f3n).":[222],"observ\u00f3":[224],"mayor":[226,233,265,282],"as\u00ed":[231,261],"MPs":[236,268],"respecto":[244],"control;":[246],"valor\u00f3":[248],"presencia":[251],"oxidada":[254],"induce":[255],"expresi\u00f3n":[263,283],"e":[269],"inhibici\u00f3n":[270],"parcial":[271],"proliferaci\u00f3n":[274],"mismo,":[278],"adem\u00e1s":[279],"ciclina":[285],"D1":[286],"6":[289],"horas":[290],"relacionada":[294]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}