{"id":"https://openalex.org/W2287243199","doi":"https://doi.org/10.5897/ajpp2015.4389","title":"Effect of aqueous extract of Annona muricata seed on atherogenicity in streptozotocin-induced diabetic rats","display_name":"Effect of aqueous extract of Annona muricata seed on atherogenicity in streptozotocin-induced diabetic rats","publication_year":2015,"publication_date":"2015-08-15","ids":{"openalex":"https://openalex.org/W2287243199","doi":"https://doi.org/10.5897/ajpp2015.4389","mag":"2287243199"},"language":"en","primary_location":{"id":"doi:10.5897/ajpp2015.4389","doi":"https://doi.org/10.5897/ajpp2015.4389","is_oa":true,"landing_page_url":"https://doi.org/10.5897/ajpp2015.4389","pdf_url":"https://academicjournals.org/journal/AJPP/article-full-text-pdf/3905DCB54854.pdf","source":{"id":"https://openalex.org/S64826861","display_name":"African Journal of Pharmacy and Pharmacology","issn_l":"1996-0816","issn":["1996-0816"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://academicjournals.org/journal/AJPP/article-full-text-pdf/3905DCB54854.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090005971","display_name":"E O Agbai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E O Agbai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010097354","display_name":"Chinomso Juliet Njoku","orcid":"https://orcid.org/0009-0002-8780-9947","observed_orcids":["https://orcid.org/0009-0002-8780-9947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Njoku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058447646","display_name":"C O Nwanegwo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C O Nwanegwo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A Nwafor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nwafor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8693,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78812203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"30","first_page":"745","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12497","display_name":"Traditional and Medicinal Uses of Annonaceae","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annona-muricata","display_name":"Annona muricata","score":0.996999979019165},{"id":"https://openalex.org/keywords/seed-extract","display_name":"seed extract","score":0.5370000004768372},{"id":"https://openalex.org/keywords/atherogenicity","display_name":"atherogenicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6690000295639038},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7519999742507935},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9710000157356262},{"id":"https://openalex.org/keywords/aortic-histology","display_name":"aortic histology","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.75},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8517975807189941},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.8157483339309692},{"id":"https://openalex.org/C2779565439","wikidata":"https://www.wikidata.org/wiki/Q1709343","display_name":"Annona muricata","level":2,"score":0.7566507458686829},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5459959506988525},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.531383216381073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5259866118431091},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5025773048400879},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4952310621738434},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4673590660095215},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.41640493273735046},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.4138604402542114},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.4112914502620697},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39532363414764404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3637649714946747},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3597396910190582},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.350253164768219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2427321970462799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2060076892375946},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.20557156205177307},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.18617090582847595}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5897/ajpp2015.4389","doi":"https://doi.org/10.5897/ajpp2015.4389","is_oa":true,"landing_page_url":"https://doi.org/10.5897/ajpp2015.4389","pdf_url":"https://academicjournals.org/journal/AJPP/article-full-text-pdf/3905DCB54854.pdf","source":{"id":"https://openalex.org/S64826861","display_name":"African Journal of Pharmacy and Pharmacology","issn_l":"1996-0816","issn":["1996-0816"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},{"id":"mag:2287243199","doi":null,"is_oa":true,"landing_page_url":"https://www3.iupui.academicjournals.org/article/article1440232690_Agbai et al.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S64826861","display_name":"African Journal of Pharmacy and Pharmacology","issn_l":"1996-0816","issn":["1996-0816"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"African Journal of Pharmacy and Pharmacology","raw_type":null}],"best_oa_location":{"id":"doi:10.5897/ajpp2015.4389","doi":"https://doi.org/10.5897/ajpp2015.4389","is_oa":true,"landing_page_url":"https://doi.org/10.5897/ajpp2015.4389","pdf_url":"https://academicjournals.org/journal/AJPP/article-full-text-pdf/3905DCB54854.pdf","source":{"id":"https://openalex.org/S64826861","display_name":"African Journal of Pharmacy and Pharmacology","issn_l":"1996-0816","issn":["1996-0816"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321074","host_organization_name":"Academic Journals","host_organization_lineage":["https://openalex.org/P4310321074"],"host_organization_lineage_names":["Academic Journals"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"African Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2287243199.pdf","grobid_xml":"https://content.openalex.org/works/W2287243199.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1486328468","https://openalex.org/W1578728271","https://openalex.org/W1649785903","https://openalex.org/W1946263363","https://openalex.org/W1965247491","https://openalex.org/W1966640590","https://openalex.org/W1976938123","https://openalex.org/W1984618853","https://openalex.org/W1990089345","https://openalex.org/W1992153362","https://openalex.org/W1999434351","https://openalex.org/W2002242057","https://openalex.org/W2015686984","https://openalex.org/W2035576567","https://openalex.org/W2038846370","https://openalex.org/W2044507895","https://openalex.org/W2045414990","https://openalex.org/W2049227201","https://openalex.org/W2049878977","https://openalex.org/W2053680041","https://openalex.org/W2058773387","https://openalex.org/W2067789393","https://openalex.org/W2074758020","https://openalex.org/W2079248334","https://openalex.org/W2093623924","https://openalex.org/W2105425033","https://openalex.org/W2108824255","https://openalex.org/W2114783994","https://openalex.org/W2116404316","https://openalex.org/W2127272429","https://openalex.org/W2130218963","https://openalex.org/W2153759743","https://openalex.org/W2161034797","https://openalex.org/W2162334236","https://openalex.org/W2163289904","https://openalex.org/W2185049039","https://openalex.org/W2185512606","https://openalex.org/W2410447336","https://openalex.org/W2435745310","https://openalex.org/W2480422512","https://openalex.org/W4301501807"],"related_works":["https://openalex.org/W2074758020","https://openalex.org/W7097425099","https://openalex.org/W4205095611","https://openalex.org/W1965247491","https://openalex.org/W7073788675","https://openalex.org/W2045414990","https://openalex.org/W7065880798","https://openalex.org/W2242258924","https://openalex.org/W7162067528","https://openalex.org/W7100759512"],"abstract_inverted_index":{"Poorly":[0],"controlled":[1],"diabetes":[2],"has":[3],"been":[4],"implicated":[5],"in":[6,11,32,39,76],"lipoprotein":[7],"abnormalities":[8],"and":[9,14,51,91,95,104,133,141],"hypertriglyceridemia":[10],"both":[12],"human":[13],"experimental":[15],"animals,":[16],"which":[17],"increase":[18],"the":[19,54,154],"risk":[20],"of":[21,25,53,71,98,116,153],"artherogenicity.":[22],"The":[23,56],"effect":[24,175],"annona":[26],"muricata":[27],"seed":[28],"extract":[29,99,117,162],"was":[30,148],"studied":[31],"streptozotocin-induced":[33],"diabetic":[34],"rats":[35],"for":[36],"30":[37],"days":[38],"order":[40],"to":[41],"evaluate":[42],"its":[43],"anti-atherogenic":[44,122,187],"property":[45],"by":[46],"investigating":[47],"lipid":[48,185],"profile":[49],"malondialdehyde":[50],"histology":[52],"aorta.":[55],"animals":[57],"were":[58,170],"divided":[59],"into":[60],"four":[61],"groups":[62],"(I-IV).":[63],"Groups":[64,89],"II-IV":[65],"received":[66,85,93,106],"a":[67,77],"single":[68],"intraperitoneal":[69],"injection":[70],"streptozotocin":[72],"(65":[73],"mg/kg)":[74,119],"dissolved":[75],"citrate":[78,86],"buffer":[79,87],"(pH":[80],"4.5).":[81],"Group":[82],"I":[83,103],"(control)":[84],"only.":[88],"III":[90],"IV":[92],"500":[94,140],"750":[96,142],"mg/kg":[97,143],"orally,":[100],"whereas":[101,126],"group":[102],"II":[105],"rat":[107],"chow.":[108],"Result":[109],"showed":[110,156,166],"that":[111,167],"treatment":[112,138],"with":[113,139],"high":[114],"dose":[115],"(750":[118],"significantly":[120,135,149],"increased":[121],"percentage":[123],"(70.7":[124],"%),":[125],"total":[127],"cholesterol,":[128],"low":[129],"density":[130],"lipoprotein-cholesterol,":[131],"triglycerides":[132],"malondialdehydewere":[134],"reduced":[136],"after":[137],"respectively.":[144],"Low-density":[145],"lipoprotein-cholesterol":[146],"(LDL-C)":[147],"elevated.":[150],"Histological":[151],"assessment":[152],"aorta":[155],"widely":[157],"dilated,":[158],"moderately":[159],"thickened":[160],"wallin":[161],"treated":[163],"groups.":[164],"Data":[165],"biochemical":[168],"parameters":[169],"greatly":[171],"improved":[172],"without":[173],"significant":[174],"on":[176],"endothelial":[177],"thickness.":[178],"Key":[179],"words:":[180],"Annona":[181],"muricata,":[182],"streptozotocin,":[183],"malondialdehyde,":[184],"profile,":[186],"index.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}