{"id":"https://openalex.org/W2287124181","doi":null,"title":"NRTI-associated mitochondrial toxicity.","display_name":"NRTI-associated mitochondrial toxicity.","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2287124181","mag":"2287124181","pmid":"https://pubmed.ncbi.nlm.nih.gov/11682785"},"language":"en","primary_location":{"id":"pmid:11682785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11682785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS clinical care","raw_type":"Newspaper Article"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045910681","display_name":"Raphael J. Landovitz","orcid":"https://orcid.org/0000-0002-1442-714X","observed_orcids":["https://orcid.org/0000-0002-1442-714X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Landovitz","raw_affiliation_strings":["Division of Infectious Diseases, Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000473129","display_name":"Paul Edward Sax","orcid":"https://orcid.org/0000-0001-8434-174X","observed_orcids":["https://orcid.org/0000-0001-8434-174X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Sax","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"5","first_page":"43","last_page":"5, 48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.6650000214576721},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.7973330020904541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.655882716178894},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4917598068714142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2159598469734192}],"mesh":[{"descriptor_ui":"D000140","descriptor_name":"Acidosis, Lactic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008060","descriptor_name":"Lipodystrophy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11682785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11682785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS clinical care","raw_type":"Newspaper Article"},{"id":"mag:2287124181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11682785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W81622017","https://openalex.org/W144505945","https://openalex.org/W1870866330","https://openalex.org/W1978724449","https://openalex.org/W1978902758","https://openalex.org/W1980733232","https://openalex.org/W1989206970","https://openalex.org/W1990618679","https://openalex.org/W2004602615","https://openalex.org/W2023242450","https://openalex.org/W2031274178","https://openalex.org/W2034544937","https://openalex.org/W2038161589","https://openalex.org/W2041841997","https://openalex.org/W2048229179","https://openalex.org/W2048578521","https://openalex.org/W2073056291","https://openalex.org/W2076562284","https://openalex.org/W2083600593","https://openalex.org/W2116315449","https://openalex.org/W2117858206","https://openalex.org/W2162705413","https://openalex.org/W2163221081","https://openalex.org/W2163492123","https://openalex.org/W2327070670","https://openalex.org/W2679757027"],"related_works":["https://openalex.org/W2409373368","https://openalex.org/W2051866662","https://openalex.org/W7098469571","https://openalex.org/W2135249194","https://openalex.org/W7098753203","https://openalex.org/W2132961893","https://openalex.org/W2033327454","https://openalex.org/W2045592358","https://openalex.org/W2070873543","https://openalex.org/W7095585844"],"abstract_inverted_index":{"Potent":[0],"combination":[1],"antiretroviral":[2],"therapy":[3],"has":[4],"resulted":[5],"in":[6,9],"sharp":[7],"declines":[8],"HIV-related":[10],"morbidity":[11],"and":[12],"mortality":[13],"--":[14],"advances":[15],"that":[16],"have,":[17],"however,":[18],"come":[19],"at":[20]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}