{"id":"https://openalex.org/W2286973531","doi":null,"title":"In utero exposure to di-(2-ethylhexyl) phthalate reveals the presence of an adrenal-testis axis regulating androgen formation","display_name":"In utero exposure to di-(2-ethylhexyl) phthalate reveals the presence of an adrenal-testis axis regulating androgen formation","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2286973531","mag":"2286973531"},"language":"en","primary_location":{"id":"pmh:oai:repository.library.georgetown.edu:10822/552848","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/552848","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dept. of Biochemistry and Molecular & Cellular Biology, Doctoral dissertations, 2011.","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061495997","display_name":"M. A. Arguelles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. A. Arguelles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110109746","display_name":"Daniel Benjamin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Benjamin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/di-2-ethylhexyl-phthalate","display_name":"DEHP","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.75},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antiandrogenic-effects","display_name":"antiandrogenic effects","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/testosterone-production","display_name":"testosterone production","score":0.7289999723434448},{"id":"https://openalex.org/keywords/aldosterone-biosynthesis","display_name":"aldosterone biosynthesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/angiotensin-ii-receptor","display_name":"angiotensin II receptor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.43799999356269836},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.6970000267028809},{"id":"https://openalex.org/keywords/kcnk5","display_name":"KCNK5","score":0.972000002861023},{"id":"https://openalex.org/keywords/kcnn2","display_name":"KCNN2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/zona-glomerulosa","display_name":"zona glomerulosa","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mono-2-ethylhexyl-phthalate","display_name":"mono(2-ethylhexyl) phthalate","score":0.871999979019165},{"id":"https://openalex.org/keywords/developmental-programming","display_name":"developmental programming","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8508708477020264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8473228812217712},{"id":"https://openalex.org/C2781005124","wikidata":"https://www.wikidata.org/wiki/Q84483575","display_name":"Phthalate","level":2,"score":0.8261572122573853},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8180794715881348},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.6618231534957886},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6028984785079956},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.5981127619743347},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.595561683177948},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5399110317230225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4962940812110901},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.495140939950943},{"id":"https://openalex.org/C3020590458","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid biosynthesis","level":4,"score":0.49440884590148926},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.44740086793899536},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.4213564991950989},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.4174690842628479},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4118478298187256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3710923492908478},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3527570366859436},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.2695308029651642},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17004168033599854},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.08682256937026978},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.06461343169212341},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.06120330095291138},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.library.georgetown.edu:10822/552848","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/552848","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dept. of Biochemistry and Molecular & Cellular Biology, Doctoral dissertations, 2011.","raw_type":"thesis"},{"id":"mag:2286973531","doi":null,"is_oa":false,"landing_page_url":"https://repository.library.georgetown.edu/bitstream/10822/552848/1/martinezDaniel.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":194,"referenced_works":["https://openalex.org/W21746425","https://openalex.org/W1486257535","https://openalex.org/W1512986957","https://openalex.org/W1537498059","https://openalex.org/W1576839117","https://openalex.org/W1577875429","https://openalex.org/W1752198036","https://openalex.org/W1760461988","https://openalex.org/W1765845624","https://openalex.org/W1784857457","https://openalex.org/W1964239883","https://openalex.org/W1964638404","https://openalex.org/W1966033354","https://openalex.org/W1967018540","https://openalex.org/W1968874083","https://openalex.org/W1970265465","https://openalex.org/W1972270992","https://openalex.org/W1973102900","https://openalex.org/W1973167599","https://openalex.org/W1973220977","https://openalex.org/W1973465628","https://openalex.org/W1974233507","https://openalex.org/W1974367155","https://openalex.org/W1974641745","https://openalex.org/W1976584931","https://openalex.org/W1976596494","https://openalex.org/W1977087590","https://openalex.org/W1977683262","https://openalex.org/W1977772936","https://openalex.org/W1977873240","https://openalex.org/W1978100432","https://openalex.org/W1979032853","https://openalex.org/W1980111995","https://openalex.org/W1982139221","https://openalex.org/W1982728225","https://openalex.org/W1983254116","https://openalex.org/W1984004239","https://openalex.org/W1985018784","https://openalex.org/W1985807498","https://openalex.org/W1986418939","https://openalex.org/W1988772913","https://openalex.org/W1989030284","https://openalex.org/W1989517537","https://openalex.org/W1990375252","https://openalex.org/W1992774226","https://openalex.org/W1993229871","https://openalex.org/W1993704473","https://openalex.org/W1993833615","https://openalex.org/W1994035761","https://openalex.org/W1995153983","https://openalex.org/W1998023875","https://openalex.org/W1999924432","https://openalex.org/W2000617798","https://openalex.org/W2001384492","https://openalex.org/W2002892575","https://openalex.org/W2003235222","https://openalex.org/W2003669217","https://openalex.org/W2004023747","https://openalex.org/W2005311687","https://openalex.org/W2005941318","https://openalex.org/W2007811800","https://openalex.org/W2010471712","https://openalex.org/W2011118373","https://openalex.org/W2011835584","https://openalex.org/W2014424488","https://openalex.org/W2015275965","https://openalex.org/W2018304597","https://openalex.org/W2019095198","https://openalex.org/W2021411448","https://openalex.org/W2022487066","https://openalex.org/W2022667194","https://openalex.org/W2023426559","https://openalex.org/W2023898611","https://openalex.org/W2023955385","https://openalex.org/W2024322918","https://openalex.org/W2024596480","https://openalex.org/W2026559515","https://openalex.org/W2027259130","https://openalex.org/W2028595868","https://openalex.org/W2030020451","https://openalex.org/W2030671980","https://openalex.org/W2032131268","https://openalex.org/W2032757820","https://openalex.org/W2033941796","https://openalex.org/W2034470409","https://openalex.org/W2035362985","https://openalex.org/W2038445778","https://openalex.org/W2039299884","https://openalex.org/W2040149948","https://openalex.org/W2040462127","https://openalex.org/W2041846642","https://openalex.org/W2045969670","https://openalex.org/W2046241907","https://openalex.org/W2046316415","https://openalex.org/W2049341175","https://openalex.org/W2050321497","https://openalex.org/W2051136909","https://openalex.org/W2053091633","https://openalex.org/W2055046903","https://openalex.org/W2055999269","https://openalex.org/W2056618157","https://openalex.org/W2057594856","https://openalex.org/W2058567701","https://openalex.org/W2058759573","https://openalex.org/W2058981622","https://openalex.org/W2060446375","https://openalex.org/W2064180864","https://openalex.org/W2064775435","https://openalex.org/W2064819791","https://openalex.org/W2067276759","https://openalex.org/W2068882633","https://openalex.org/W2070374666","https://openalex.org/W2071591569","https://openalex.org/W2072406021","https://openalex.org/W2074230554","https://openalex.org/W2076494331","https://openalex.org/W2078143543","https://openalex.org/W2078362264","https://openalex.org/W2079847745","https://openalex.org/W2081087045","https://openalex.org/W2083690559","https://openalex.org/W2084118479","https://openalex.org/W2084491739","https://openalex.org/W2084744450","https://openalex.org/W2085511343","https://openalex.org/W2085615781","https://openalex.org/W2085627287","https://openalex.org/W2087435963","https://openalex.org/W2089076664","https://openalex.org/W2090098866","https://openalex.org/W2090853832","https://openalex.org/W2091919352","https://openalex.org/W2095279324","https://openalex.org/W2096787550","https://openalex.org/W2097127734","https://openalex.org/W2097568021","https://openalex.org/W2097633545","https://openalex.org/W2098744753","https://openalex.org/W2098953148","https://openalex.org/W2099955017","https://openalex.org/W2101037833","https://openalex.org/W2103191975","https://openalex.org/W2103269496","https://openalex.org/W2105767037","https://openalex.org/W2106996349","https://openalex.org/W2107743828","https://openalex.org/W2107948749","https://openalex.org/W2112352676","https://openalex.org/W2113328569","https://openalex.org/W2116785812","https://openalex.org/W2117843333","https://openalex.org/W2117897211","https://openalex.org/W2118008591","https://openalex.org/W2118790060","https://openalex.org/W2119805009","https://openalex.org/W2121836743","https://openalex.org/W2122488988","https://openalex.org/W2123465466","https://openalex.org/W2124108262","https://openalex.org/W2125734610","https://openalex.org/W2126846194","https://openalex.org/W2127150492","https://openalex.org/W2129392163","https://openalex.org/W2129578663","https://openalex.org/W2130235559","https://openalex.org/W2130430758","https://openalex.org/W2130590450","https://openalex.org/W2130891446","https://openalex.org/W2133940765","https://openalex.org/W2134779214","https://openalex.org/W2137516638","https://openalex.org/W2139122477","https://openalex.org/W2139384923","https://openalex.org/W2141129348","https://openalex.org/W2141368739","https://openalex.org/W2143459819","https://openalex.org/W2144789363","https://openalex.org/W2145546233","https://openalex.org/W2145820822","https://openalex.org/W2150402790","https://openalex.org/W2152253844","https://openalex.org/W2154183258","https://openalex.org/W2155208844","https://openalex.org/W2157936339","https://openalex.org/W2158225497","https://openalex.org/W2159655200","https://openalex.org/W2160894249","https://openalex.org/W2166972916","https://openalex.org/W2167864792","https://openalex.org/W2171057075","https://openalex.org/W2171423639","https://openalex.org/W2312824801","https://openalex.org/W2432941869","https://openalex.org/W4299564444"],"related_works":["https://openalex.org/W2164480589","https://openalex.org/W2030671980","https://openalex.org/W2052473671","https://openalex.org/W2055464151","https://openalex.org/W2122488988","https://openalex.org/W2626943788","https://openalex.org/W2148733715","https://openalex.org/W7043897421","https://openalex.org/W2067341730","https://openalex.org/W2103178523"],"abstract_inverted_index":{"Thesis":[0],"(Ph.D.)--Georgetown":[1],"University,":[2],"2011.;":[3],"Includes":[4],"bibliographical":[5],"references.;":[6],"Text":[7],"(Electronic":[8],"thesis)":[9],"in":[10,27,35,49,97,104,116,122,129,135,186,211,228,234,258,283,323,334,342,355],"PDF":[11],"format.":[12],"Phthalates":[13],"are":[14,60],"endocrine":[15,353],"disruptors":[16],"with":[17,206,317],"short-":[18],"and":[19,46,52,93,126,169,183,195,203,232,242,306,358],"long-":[20],"term":[21],"antiadrogenic":[22],"properties.":[23],"In":[24,137],"the":[25,56,63,77,123,132,140,143,152,164,181,190,212,229,235,238,269,295,329,352,356,360],"adult,":[26],"utero":[28,98,343],"exposure":[29,99,344],"to":[30,75,100,131,268,290,300,345],"di-(2-ethylhexyl)":[31],"phthalate":[32,274],"(DEHP)":[33],"results":[34,339],"decreased":[36],"testosterone":[37,91],"levels":[38,42,118,162,315,322],"despite":[39,159],"normal":[40,160],"serum":[41,161],"of":[43,58,62,69,72,83,119,139,154,163,208,218,225,237,247,252,294,302,308,312,320,332,362],"LH,":[44],"proteins":[45,182],"enzymes":[47,184],"involved":[48,185,227],"cholesterol":[50,194,198],"transport,":[51],"biosynthesis":[53],"suggesting":[54],"that":[55,96,149,280,341],"effects":[57,331,350],"DEHP":[59,101,150,248,271,333,346],"independent":[61],"classic":[64],"steroidogenic":[65],"pathway.":[66],"The":[67,85,107,171,250,276],"purpose":[68],"this":[70,80],"body":[71],"work":[73],"is":[74],"identify":[76],"mechanism":[78,141],"mediating":[79],"antiandrogenic":[81,330],"effect":[82],"DEHP.":[84],"mineralocorticoid":[86],"receptor":[87,173,304],"(NR3C2;":[88],"MR)":[89],"mediates":[90],"production":[92],"we":[94,147],"show":[95],"decreases":[102,151],"MR-expression":[103],"Leydig":[105,324],"cells.":[106],"reduced":[108,144],"MR":[109,321],"expression":[110,153,217,287,305],"was":[111,127,256],"accompanied":[112,205],"by":[113],"a":[114,281,291,318],"decrease":[115,133,174,319],"circulating":[117,313],"aldosterone":[120,145,166,187,309,314],"biosynthesized":[121],"adrenal":[124,263,296],"gland":[125],"similar":[128],"magnitude":[130],"seen":[134],"testosterone.":[136],"search":[138],"underlying":[142],"formation,":[146],"observed":[148],"angiotensin":[155],"II":[156],"(ATII)":[157],"receptors":[158],"main":[165],"stimulants,":[167],"ATII":[168,172,303],"potassium.":[170],"did":[175],"not":[176],"have":[177],"an":[178,222],"impact":[179],"on":[180,351],"biosynthesis.":[188],"Paradoxically,":[189],"pathways":[191],"for":[192,328],"extracellular":[193],"de":[196],"novo":[197],"synthesis":[199],"were":[200,204],"up":[201,223],"regulated":[202],"accumulation":[207],"lipid":[209],"droplets":[210],"zona":[213,297],"glomerulosa.;":[214],"Global":[215],"gene":[216,286],"PND60":[219],"adrenals":[220],"showed":[221],"regulation":[224],"genes":[226],"potassium":[230,239,253,284],"response":[231],"resulted":[233],"identification":[236],"channels":[240],"Kcnk5":[241],"Kcnn2":[243],"as":[244],"novel":[245],"targets":[246],"exposure.":[249],"deregulation":[251,282],"sensing":[254],"pathway":[255],"confirmed":[257],"vitro":[259],"using":[260],"NCI-H295R":[261],"human":[262],"cortical":[264],"tumor":[265],"cells":[266,325],"exposed":[267],"bioactive":[270],"metabolite":[272],"mono-2-ethylhexyl":[273],"(MEHP).;":[275],"data":[277],"obtained":[278],"suggest":[279],"channel":[285],"can":[288],"lead":[289],"chronic":[292],"activation":[293],"glomerulosa,":[298],"leading":[299],"reduction":[301],"inhibition":[307],"production.":[310],"Reduction":[311],"together":[316,337],"could":[326],"account":[327],"testis.;":[335],"Taken":[336],"these":[338],"demonstrate":[340],"induces":[347],"long":[348],"lasting":[349],"system":[354],"rat":[357],"unveiled":[359],"presence":[361],"adrenal-testis":[363],"interactions":[364],"driving":[365],"androgen":[366],"formation.":[367]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}