{"id":"https://openalex.org/W2286682849","doi":null,"title":"Patterns of Archaic Hominin DNA in Modern Human Genomes","display_name":"Patterns of Archaic Hominin DNA in Modern Human Genomes","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2286682849","mag":"2286682849"},"language":"en","primary_location":{"id":"pmh:oai:digital.lib.washington.edu:1773/33939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/33939","pdf_url":"http://hdl.handle.net/1773/33939","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1773/33939","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008182805","display_name":"Benjamin Vernot","orcid":"https://orcid.org/0000-0002-6820-2181","observed_orcids":["https://orcid.org/0000-0002-6820-2181"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin Vernot","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6820-2181","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008182805"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10421","display_name":"Pleistocene-Era Hominins and Archaeology","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10421","display_name":"Pleistocene-Era Hominins and Archaeology","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.11760000139474869,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neanderthal-introgression","display_name":"Neanderthal introgression","score":0.9160000085830688},{"id":"https://openalex.org/keywords/denisovan-introgression","display_name":"Denisovan introgression","score":0.996999979019165},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.7419999837875366},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C189338579","wikidata":"https://www.wikidata.org/wiki/Q290447","display_name":"Ancient DNA","level":3,"score":0.7041120529174805},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.645794689655304},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5527889132499695},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5137782692909241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43939024209976196},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.4328550100326538},{"id":"https://openalex.org/C2779987252","wikidata":"https://www.wikidata.org/wiki/Q635162","display_name":"Hominidae","level":3,"score":0.4219197630882263},{"id":"https://openalex.org/C53553401","wikidata":"https://www.wikidata.org/wiki/Q47307","display_name":"Genealogy","level":1,"score":0.3581469655036926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2552921772003174},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.20642608404159546},{"id":"https://openalex.org/C2988562018","wikidata":"https://www.wikidata.org/wiki/Q1063","display_name":"Biological evolution","level":2,"score":0.1901213824748993},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.1020718514919281},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09475085139274597},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.06442233920097351},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digital.lib.washington.edu:1773/33939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/33939","pdf_url":"http://hdl.handle.net/1773/33939","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2286682849","doi":null,"is_oa":false,"landing_page_url":"https://digital.lib.washington.edu:443/researchworks/handle/1773/33939","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.lib.washington.edu:1773/33939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/33939","pdf_url":"http://hdl.handle.net/1773/33939","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3857611472","display_name":"Collaborative Research: Genetic Bases for the Evolution of Human Diet","funder_award_id":"0827436","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337949","display_name":"Center of Excellence\u00a0in\u00a0Environmental Toxicology, University of Pennsylvania","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2286682849.pdf","grobid_xml":"https://content.openalex.org/works/W2286682849.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1507075706","https://openalex.org/W1533942137","https://openalex.org/W1967279698","https://openalex.org/W1975749505","https://openalex.org/W1981283697","https://openalex.org/W1988957060","https://openalex.org/W2009494639","https://openalex.org/W2019589543","https://openalex.org/W2021736445","https://openalex.org/W2022293111","https://openalex.org/W2023172335","https://openalex.org/W2023607662","https://openalex.org/W2027283031","https://openalex.org/W2033913430","https://openalex.org/W2047998066","https://openalex.org/W2050967443","https://openalex.org/W2056921607","https://openalex.org/W2057055150","https://openalex.org/W2065397738","https://openalex.org/W2091516786","https://openalex.org/W2098187463","https://openalex.org/W2105894702","https://openalex.org/W2105990937","https://openalex.org/W2111310368","https://openalex.org/W2111408573","https://openalex.org/W2111859817","https://openalex.org/W2135370544","https://openalex.org/W2142215232","https://openalex.org/W2145345672","https://openalex.org/W2145480785","https://openalex.org/W2149683346"],"related_works":["https://openalex.org/W793752290","https://openalex.org/W2603025299","https://openalex.org/W2972801206","https://openalex.org/W2330291512","https://openalex.org/W1935056412","https://openalex.org/W2762461669","https://openalex.org/W2410837016","https://openalex.org/W4392302720","https://openalex.org/W7051528105","https://openalex.org/W3127003835"],"abstract_inverted_index":{"In":[0,26,58,133,171],"this":[1,21,93,191],"dissertation":[2],"I":[3,15,31,69,89,112,137,182],"describe":[4],"the":[5,18,53,86,106,109,140,144,165,168,200,214,223],"development":[6],"of":[7,20,34,56,61,74,83,85,92,108,116,143,153,167,174,193,199,205,216,225],"a":[8,59,81,134,172],"method":[9,22],"for":[10,128,164],"identifying":[11],"introgressed":[12,77],"archaic":[13,39,194,206],"haplotypes.":[14],"then":[16],"present":[17,114],"application":[19],"to":[23,52,95,196],"several":[24],"populations.":[25],"15":[27],"African":[28],"hunter-gatherer":[29],"genomes,":[30,68],"identify":[32,70,183,197],"signatures":[33,115],"introgression":[35,110,145,169,195,211],"from":[36,178,208],"an":[37,42],"unknown":[38],"hominin":[40],"with":[41,46],"apparent":[43],"divergence":[44,54],"time":[45,55],"modern":[47,124],"humans":[48],"that":[49,139,202],"is":[50],"similar":[51],"Neanderthals.":[57],"sample":[60,173],"379":[62],"European":[63],"and":[64,105,126,157,160,186,189],"279":[65],"East":[66,158],"Asian":[67],"on":[71],"average":[72],"1/4":[73],"each":[75],"individual's":[76],"Neanderthal":[78,87,121,131,185],"sequence,":[79],"composing":[80],"total":[82],"600Mb":[84],"genome.":[88],"use":[90,190],"characteristics":[91],"sequence":[94,122,207],"estimate":[96],"demographic":[97],"parameters,":[98],"including":[99],"ancestral":[100],"effective":[101],"population":[102],"size":[103],"(Ne),":[104],"complexity":[107,166],"event.":[111,170],"also":[113],"both":[117,184],"purifying":[118],"selection":[119,127,154,221],"against":[120],"in":[123,222],"humans,":[125],"other,":[129],"beneficial":[130],"alleles.":[132],"separate":[135],"analysis,":[136],"show":[138],"inferred":[141],"parameters":[142],"event":[146],"are":[147,203],"not":[148],"influenced":[149],"by":[150],"differing":[151],"efficiency":[152],"between":[155],"Europeans":[156],"Asians,":[159],"explore":[161],"alternative":[162],"models":[163],"35":[175],"Melanesian":[176],"individuals":[177],"Papua":[179],"New":[180],"Guinea,":[181],"Denisovan":[187],"introgression,":[188],"map":[192],"regions":[198],"genome":[201],"depleted":[204],"two":[209],"independent":[210],"events,":[212],"implying":[213],"presence":[215],"non-random":[217],"forces":[218],"such":[219,226],"as":[220],"creation":[224],"regions.":[227]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}