{"id":"https://openalex.org/W2286413616","doi":"https://doi.org/10.1002/cpt1978244439","title":"Kinetics of norethindrone in women; I. Radioimmunoassay and concentrations during multiple dosing","display_name":"Kinetics of norethindrone in women; I. Radioimmunoassay and concentrations during multiple dosing","publication_year":1978,"publication_date":"1978-10-01","ids":{"openalex":"https://openalex.org/W2286413616","doi":"https://doi.org/10.1002/cpt1978244439","mag":"2286413616","pmid":"https://pubmed.ncbi.nlm.nih.gov/567550"},"language":"en","primary_location":{"id":"doi:10.1002/cpt1978244439","doi":"https://doi.org/10.1002/cpt1978244439","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt1978244439","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042249868","display_name":"David J. Back","orcid":"https://orcid.org/0000-0002-7381-4799","observed_orcids":["https://orcid.org/0000-0002-7381-4799"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. J. Back","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110325039","display_name":"AM Breckenridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. M. Breckenridge","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110555317","display_name":"Francesca E. Crawford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesca E. Crawford","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. McIver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. McIver","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110576086","display_name":"Michael L'E. Orme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. L'E. Orme","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112375458","display_name":"B. K. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. K. Park","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111552079","display_name":"P.H. Rowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. H. Rowe","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019231746","display_name":"Eileen Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eileen Smith","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, England","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":13.1122,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.98406908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"4","first_page":"439","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norethisterone","display_name":"norethisterone","score":0.9829999804496765},{"id":"https://openalex.org/keywords/norethindrone-acetate","display_name":"norethindrone acetate","score":0.9739999771118164},{"id":"https://openalex.org/keywords/plasma-pharmacokinetics","display_name":"plasma pharmacokinetics","score":0.6010000109672546},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.8769999742507935},{"id":"https://openalex.org/keywords/ethinyl-estradiol","display_name":"ethinyl estradiol","score":0.8059999942779541},{"id":"https://openalex.org/keywords/contraceptive-steroids","display_name":"contraceptive steroids","score":0.8159999847412109},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.8510000109672546},{"id":"https://openalex.org/keywords/postpartum-period","display_name":"postpartum period","score":0.6050000190734863},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.6309999823570251},{"id":"https://openalex.org/keywords/repeated-dosing","display_name":"repeated dosing","score":0.6539999842643738},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.7796818017959595},{"id":"https://openalex.org/C2777956591","wikidata":"https://www.wikidata.org/wiki/Q415563","display_name":"Ethinylestradiol","level":4,"score":0.6705610752105713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6704586744308472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6389102935791016},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6173326373100281},{"id":"https://openalex.org/C2781039349","wikidata":"https://www.wikidata.org/wiki/Q421352","display_name":"Norethisterone","level":4,"score":0.6074284911155701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5631942749023438},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5494250655174255},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.441596120595932},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3861364424228668},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.32877540588378906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31425029039382935},{"id":"https://openalex.org/C2986817661","wikidata":"https://www.wikidata.org/wiki/Q185698","display_name":"Research methodology","level":3,"score":0.10270538926124573},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.06208670139312744},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003277","descriptor_name":"Contraceptives, Oral, Combined","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008598","descriptor_name":"Menstruation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009640","descriptor_name":"Norethindrone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009640","descriptor_name":"Norethindrone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cpt1978244439","doi":"https://doi.org/10.1002/cpt1978244439","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt1978244439","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:567550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/567550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1475527337","https://openalex.org/W2051503974","https://openalex.org/W2175662846","https://openalex.org/W2009997600","https://openalex.org/W2035861548","https://openalex.org/W2088207963","https://openalex.org/W2029228645","https://openalex.org/W2162194285","https://openalex.org/W2169071863","https://openalex.org/W2120127545"],"abstract_inverted_index":{"A":[0],"radioimmunoassay":[1],"for":[2,130],"norethindrone":[3,40,47,74,92,113,137,171,201,233,238,253],"has":[4],"been":[5],"developed":[6],"with":[7,49,76,106,203,214],"the":[8,17,80,86,109,118,131,141,167,173,189,218,235],"use":[9],"of":[10,19,39,70,73,85,91,112,136,170,199],"an":[11],"antiserum":[12],"raised":[13],"in":[14,41,100,182,217,248],"rabbits":[15],"after":[16,61,120],"injection":[18],"norethindrone\u20103\u2010carboxymethyloxime":[20],"linked":[21],"to":[22,30,144],"bovine":[23],"serum":[24],"albumin.":[25],"The":[26,153],"immunoassay":[27],"is":[28],"sensitive":[29],"30":[31],"pg/ml":[32],"norethindrone.":[33],"With":[34],"this":[35,212],"assay":[36],"plasma":[37,81,110,134,168,200,237],"concentrations":[38,135,145],"40":[42],"women":[43,126,187,226,249],"receiving":[44,127],"1":[45,71,251],"mg":[46,72,78,232,252],"acetate":[48,75],"50":[50,77],"\u00b5g":[51],"ethinylestradiol":[52],"were":[53],"between":[54,95,166,178],"1.6":[55],"and":[56,97,160,172,180,211],"15.2":[57],"ng/ml":[58],"12":[59],"hr":[60,99],"dosing":[62],"during":[63,140],"multiple":[64],"dosing.":[65],"After":[66],"a":[67,121,163,197,215,228],"single":[68,122],"dose":[69],"ethinylestradiol,":[79],"half":[82],"life":[83],"(t\u00bd)":[84],"terminal":[87],"apparently":[88],"monoexponential":[89],"phase":[90],"decay":[93],"was":[94,162,196,240],"6.1":[96],"12.3":[98],"6":[101],"patients.":[102],"During":[103],"long\u2010term":[104],"therapy":[105],"contraceptive":[107,128,190],"steroids":[108,129],"t\u00bd":[111,119],"did":[114],"not":[115],"differ":[116],"from":[117,149],"dose.":[123],"In":[124,185,225],"4":[125,183,192],"first":[132,142],"time.":[133],"rose":[138],"progressively":[139],"cycle":[143],"higher":[146],"than":[147],"predicted":[148],"simple":[150],"accumulation":[151],"pharmacokinetics.":[152],"sex":[154,174,219],"hormone\u2010binding":[155,175,220],"globulin":[156],"capacity":[157,176,221],"also":[158],"increased":[159],"there":[161,195],"good":[164],"correlation":[165],"concentration":[169,202,239],"(r":[177,205],"0.695":[179],"0.910":[181],"patients).":[184],"3":[186,231],"starting":[188],"steroid":[191],"wk":[193],"postpartum":[194],"reduction":[198],"time":[204],"=":[206],"0.528":[207],"p":[208],"<":[209,223],"0.01)":[210],"correlated":[213],"fall":[216],"(p":[222],"0.05).":[224],"taking":[227,250],"preparation":[229],"containing":[230],"acetate.":[234,254],"mean":[236],"only":[241],"1.4":[242],"times":[243],"as":[244,246],"high":[245],"that":[247]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}