{"id":"https://openalex.org/W2286337032","doi":null,"title":"Novel Photodynamic Therapy Agents: Biochemical Analysis","display_name":"Novel Photodynamic Therapy Agents: Biochemical Analysis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2286337032","mag":"2286337032"},"language":"en","primary_location":{"id":"mag:2286337032","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.georgiasouthern.edu/cgi/viewcontent.cgi?article=1077&context=honors-theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James Conner","orcid":"https://orcid.org/0000-0003-2227-6182","observed_orcids":["https://orcid.org/0000-0003-2227-6182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Conner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2227-6182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021535684","display_name":"Alex A. Cruce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex A. Cruce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047551105","display_name":"Patrick Axel Molina","orcid":"https://orcid.org/0000-0001-8855-0880","observed_orcids":["https://orcid.org/0000-0001-8855-0880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick A. Molina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8855-0880","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025348842","display_name":"C. Michele Davis McGibony","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Michele Davis McGibony","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25059953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.1688999980688095,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metalloporphyrins","display_name":"metalloporphyrins","score":0.9829999804496765},{"id":"https://openalex.org/keywords/manganese-porphyrin","display_name":"manganese porphyrin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/porphyrins","display_name":"porphyrins","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tetrapyrroles","display_name":"tetrapyrroles","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.8519999980926514},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7881734371185303},{"id":"https://openalex.org/C167816639","wikidata":"https://www.wikidata.org/wiki/Q803925","display_name":"Bioinorganic chemistry","level":2,"score":0.6013738512992859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5671257972717285},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.509587287902832},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4971154034137726},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.46382227540016174},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.34432417154312134},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.25699567794799805},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21343833208084106},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18250292539596558}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2286337032","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.georgiasouthern.edu/cgi/viewcontent.cgi?article=1077&context=honors-theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1966163722","https://openalex.org/W2000554196","https://openalex.org/W2091210609","https://openalex.org/W2143012419","https://openalex.org/W2286353351","https://openalex.org/W3133924569"],"related_works":["https://openalex.org/W2302903263","https://openalex.org/W2808460502","https://openalex.org/W4387041949","https://openalex.org/W2990485431","https://openalex.org/W2049479309","https://openalex.org/W7120582315","https://openalex.org/W2171963741","https://openalex.org/W2016312457","https://openalex.org/W2266156694","https://openalex.org/W2990407650"],"abstract_inverted_index":{"Bioinorganic":[0],"photochemistry":[1],"is":[2,90],"a":[3,175],"rapidly":[4],"advancing":[5],"research":[6],"area":[7],"in":[8,55,74,131,136,151,184,204],"the":[9,20,56,98,102,111,187,199],"field":[10,22,58],"of":[11,37,44,52,80,93,108,113,117,138,186],"bioinorganic":[12],"chemistry.":[13],"This":[14,162],"project":[15,163],"seeks":[16],"to":[17,60,97],"build":[18],"upon":[19],"growing":[21],"by":[23],"synthesizing":[24],"and":[25,67,70,87,119,144,159,170,189,196],"analyzing":[26],"new":[27],"photodynamic":[28,145],"therapy":[29],"(PDT)":[30],"agents.":[31,39,193],"There":[32],"are":[33,50,122,148,198],"three":[34],"major":[35],"generations":[36],"PDT":[38,109,192],"The":[40,76,105],"first":[41,103,188],"generation":[42,78,107,191],"consists":[43,79,116],"chemically":[45],"modified":[46],"natural":[47],"hematoporphyrins,":[48],"which":[49,134],"not":[51,92],"great":[53],"interest":[54,95],"phototherapeutic":[57],"due":[59,96],"their":[61,132],"low":[62],"distinguishability":[63],"between":[64],"tumor":[65],"cells":[66],"healthy":[68],"cells,":[69],"extended":[71],"skin":[72],"photosensitivity":[73],"patients.":[75],"second":[77,190],"organic":[81],"dyes,":[82],"aromatic":[83],"hydrocarbons,":[84],"polypyrolics":[85],"complexes,":[86],"semi-conductors,":[88],"but":[89],"also":[91,149],"much":[94],"same":[99],"issues":[100],"as":[101,156],"generation.":[104],"third":[106],"agents,":[110],"focus":[112],"this":[114,205],"project,":[115],"tetrapyrroles":[118],"porphyrins.":[120],"Porphyrins":[121,147],"essential":[123],"because":[124],"they":[125,180],"can":[126],"accept":[127],"many":[128],"different":[129],"metals":[130],"core,":[133],"result":[135],"changes":[137],"its":[139],"properties":[140],"for":[141],"both":[142],"therapeutic":[143],"purposes.":[146],"found":[150],"other":[152],"biological":[153],"molecules":[154],"such":[155],"heme,":[157],"chlorophyll,":[158],"vitamin":[160],"B12.":[161],"specifically":[164],"focuses":[165],"on":[166],"metalloporphyrins":[167,201],"encompassing":[168],"manganese,":[169],"if":[171],"these":[172],"porphyrins":[173],"display":[174],"high":[176],"DNA":[177],"cleavage":[178],"rate":[179],"could":[181],"be":[182],"used":[183],"place":[185],"MnTDCLPP,":[194],"MnTTFMPP,":[195],"MnTECP":[197],"specific":[200],"being":[202],"analyzed":[203],"project.":[206],"Thesis":[207],"Mentor:_____________________________":[208],"Dr.":[209,214],"Michele":[210],"McGibony":[211],"Honors":[212,222],"Director:___________________________":[213],"Steven":[215],"Engel":[216],"December":[217],"2014":[218],"Chemistry":[219],"Department":[220],"University":[221,226],"Program":[223],"Georgia":[224],"Southern":[225]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}