{"id":"https://openalex.org/W2286306316","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.589","title":"Functional C3a\u2010 and C5a\u2010Receptors on human Mesenchymal Stem Cells","display_name":"Functional C3a\u2010 and C5a\u2010Receptors on human Mesenchymal Stem Cells","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2286306316","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.589","mag":"2286306316"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.2_supplement.589","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.589","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.2_supplement.589","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062097565","display_name":"Ingrid U. Schraufst\u00e4tter","orcid":"https://orcid.org/0000-0003-2084-9063","observed_orcids":["https://orcid.org/0000-0003-2084-9063"]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingrid U. Schraufstatter","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005894734","display_name":"Sophia K. Khaldoyanidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia K. Khaldoyanidi","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103207811","display_name":"Ming Zhao","orcid":"https://orcid.org/0000-0003-3411-8704","observed_orcids":["https://orcid.org/0000-0003-3411-8704"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["Burnham Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnham Institute, La Jolla, CA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110966862","display_name":"Richard G. DiScipio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40399489","display_name":"Torrey Pines Institute For Molecular Studies","ror":"https://ror.org/01grq2104","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I40399489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Discipio","raw_affiliation_strings":["Torrey Pines Institute for Molecular Studies, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torrey Pines Institute for Molecular Studies, San Diego, CA","institution_ids":["https://openalex.org/I40399489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S2","first_page":"589","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.44999998807907104,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.44999998807907104,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.3813000023365021,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3a-receptor","display_name":"C3a receptor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/c5a-receptor","display_name":"C5a receptor","score":1.0},{"id":"https://openalex.org/keywords/anaphylatoxin-receptors","display_name":"anaphylatoxin receptors","score":0.871999979019165},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.953000009059906},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-activation","display_name":"cell activation","score":0.5149999856948853},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7859020829200745},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7821056842803955},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5905845761299133},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5621621608734131},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5470037460327148},{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.4883112907409668},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.46885451674461365},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4572124481201172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43557724356651306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3215113878250122},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1873457431793213},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.15687698125839233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08462196588516235},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.2_supplement.589","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.589","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.2_supplement.589","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116918434","https://openalex.org/W180191204","https://openalex.org/W2070115530","https://openalex.org/W2574686074","https://openalex.org/W2123815050","https://openalex.org/W1828912712","https://openalex.org/W2125011111","https://openalex.org/W1486872989","https://openalex.org/W2053593582","https://openalex.org/W1978959609"],"abstract_inverted_index":{"The":[0,113],"anaphylatoxin":[1],"receptors,":[2],"C3a\u2010receptor":[3],"(C3aR)":[4],"and":[5,36,45,65,164],"C5a\u2010receptor":[6],"(C5aR)":[7],"are":[8,18,27],"best":[9],"known":[10],"as":[11,59,144],"receptors":[12],"involved":[13],"in":[14,75,83,92,104,108,122,127,153,158,172,187],"leukocyte":[15],"trafficking,":[16],"but":[17,77,106,124,156],"much":[19],"more":[20],"widely":[21],"expressed.":[22],"Mesenchymal":[23],"stem":[24],"cells":[25],"(MSCs)":[26],"among":[28],"the":[29,40,99,102,120,149,185,192],"cell":[30,110,199,219],"types":[31,111],"which":[32,67,168,194],"express":[33],"both":[34,162],"C3aRs":[35],"C5aRs.":[37],"Activation":[38],"of":[39,63,89,98,131,148,175,180,204,217],"C3aR":[41,100,186],"is":[42,135,139,189,195,213],"often":[43],"transient":[44],"weak":[46],"compared":[47],"with":[48,96,141,197],"other":[49,109],"G\u2010protein":[50,206],"coupled":[51,207],"receptors.":[52],"In":[53,183],"MSCs":[54,93,188],"it":[55,138],"was,":[56],"however":[57],"prolonged":[58,87,198],"determined":[60],"by":[61,146],"phosphorylation":[62,147],"ERK1/2":[64,116],"Akt,":[66],"were":[68],"phosphorylated":[69],"for":[70,78],"up":[71],"to":[72,101,119,178,191],"one":[73],"hour":[74],"MSCs,":[76,105,123,155,167],"at":[79],"most":[80],"5":[81],"min":[82],"HEK293":[84,128,159],"cells.":[85,129,160],"This":[86],"activation":[88,143],"signaling":[90,114,133],"pathways":[91],"was":[94],"associated":[95,140,196],"translocation":[97],"nucleus":[103,121],"not":[107,157],"tested.":[112],"molecule":[115],"also":[117],"translocated":[118,190],"only":[125],"minimally":[126],"Translocation":[130],"these":[132],"molecules":[134],"important":[136],"because":[137],"transcriptional":[142],"reflected":[145],"transcription":[150],"factor":[151],"Elk":[152],"C3a\u2010stimulated":[154],"Functionally,":[161],"C3a":[163],"C5a":[165],"chemo\u2010attracted":[166],"may":[169],"be":[170],"an":[171],"vivo":[173],"mechanism":[174],"MSC":[176],"recruitment":[177],"areas":[179],"tissue":[181],"injury.":[182],"summary,":[184],"nucleus,":[193],"activation.":[200,220],"Such":[201],"distinct":[202],"trafficking":[203],"a":[205,214],"receptor":[208],"depending":[209],"on":[210],"cellular":[211],"context":[212],"novel":[215],"means":[216],"regulating":[218]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}