{"id":"https://openalex.org/W2285718604","doi":null,"title":"\u00c0 propos d'une s\u00e9rie r\u00e9trospective de cancers du sein diagnostiqu\u00e9s aupr\u00e8s de patientes pr\u00e9sentant une mutation constitutionnelle des g\u00e8nes BRCA1 ou BRCA2: traitement et suivi \u00e0 long terme","display_name":"\u00c0 propos d'une s\u00e9rie r\u00e9trospective de cancers du sein diagnostiqu\u00e9s aupr\u00e8s de patientes pr\u00e9sentant une mutation constitutionnelle des g\u00e8nes BRCA1 ou BRCA2: traitement et suivi \u00e0 long terme","publication_year":2015,"publication_date":"2015-10-08","ids":{"openalex":"https://openalex.org/W2285718604","mag":"2285718604"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:dumas-01223886v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01223886","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine humaine et pathologie. 2015","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dumas.ccsd.cnrs.fr/dumas-01223886","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044112371","display_name":"Margaux Artiguenave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marie Artiguenave","raw_affiliation_strings":["Universite De Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite De Bordeaux","institution_ids":["https://openalex.org/I15057530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044112371"],"corresponding_institution_ids":["https://openalex.org/I15057530"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"111","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/brca2-mutation","display_name":"BRCA2 mutation","score":1.0},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/contralateral-breast-cancer","display_name":"contralateral breast cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ipsilateral-breast-tumor-recurrence","display_name":"ipsilateral breast tumor recurrence","score":0.8140000104904175},{"id":"https://openalex.org/keywords/prophylactic-oophorectomy","display_name":"prophylactic oophorectomy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/contralateral-prophylactic-mastectomy","display_name":"contralateral prophylactic mastectomy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/breast-conserving-therapy","display_name":"breast-conserving therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mutation-carriers","display_name":"mutation carriers","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.845307469367981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7560446262359619}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:dumas-01223886v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01223886","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine humaine et pathologie. 2015","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2285718604","doi":null,"is_oa":false,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01223886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:dumas-01223886v1","doi":null,"is_oa":true,"landing_page_url":"https://dumas.ccsd.cnrs.fr/dumas-01223886","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine humaine et pathologie. 2015","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W12608455","https://openalex.org/W174839820","https://openalex.org/W227417487","https://openalex.org/W277215578","https://openalex.org/W1480061914","https://openalex.org/W1520606981","https://openalex.org/W1563439685","https://openalex.org/W1591944655","https://openalex.org/W1605263017","https://openalex.org/W1817692493","https://openalex.org/W1828494712","https://openalex.org/W1850777108","https://openalex.org/W1879999340","https://openalex.org/W1883413549","https://openalex.org/W1919403884","https://openalex.org/W1927697689","https://openalex.org/W1936766016","https://openalex.org/W1945350395","https://openalex.org/W1967964280","https://openalex.org/W1970305438","https://openalex.org/W1970379686","https://openalex.org/W1971911973","https://openalex.org/W1973081257","https://openalex.org/W1973268287","https://openalex.org/W1973683234","https://openalex.org/W1975803034","https://openalex.org/W1981064091","https://openalex.org/W1981231327","https://openalex.org/W1982603317","https://openalex.org/W1989223339","https://openalex.org/W1991216698","https://openalex.org/W1994262858","https://openalex.org/W1999197880","https://openalex.org/W1999676128","https://openalex.org/W2002419036","https://openalex.org/W2002561481","https://openalex.org/W2002568301","https://openalex.org/W2005351661","https://openalex.org/W2009007206","https://openalex.org/W2009074196","https://openalex.org/W2009258470","https://openalex.org/W2009681618","https://openalex.org/W2010871781","https://openalex.org/W2011515749","https://openalex.org/W2011960226","https://openalex.org/W2012506200","https://openalex.org/W2013945615","https://openalex.org/W2017860169","https://openalex.org/W2018022325","https://openalex.org/W2020877141","https://openalex.org/W2022785606","https://openalex.org/W2023630115","https://openalex.org/W2027472658","https://openalex.org/W2027713510","https://openalex.org/W2035720645","https://openalex.org/W2038793520","https://openalex.org/W2042161739","https://openalex.org/W2044438803","https://openalex.org/W2044459640","https://openalex.org/W2045216597","https://openalex.org/W2046809735","https://openalex.org/W2048747088","https://openalex.org/W2049944849","https://openalex.org/W2055414597","https://openalex.org/W2057250471","https://openalex.org/W2059064246","https://openalex.org/W2062367399","https://openalex.org/W2065042932","https://openalex.org/W2066100838","https://openalex.org/W2070331010","https://openalex.org/W2070355942","https://openalex.org/W2071194784","https://openalex.org/W2072613861","https://openalex.org/W2072876845","https://openalex.org/W2072964995","https://openalex.org/W2073129224","https://openalex.org/W2073863214","https://openalex.org/W2081943419","https://openalex.org/W2085377566","https://openalex.org/W2087025655","https://openalex.org/W2089454614","https://openalex.org/W2090740451","https://openalex.org/W2094608707","https://openalex.org/W2096250359","https://openalex.org/W2096864872","https://openalex.org/W2097216790","https://openalex.org/W2098383175","https://openalex.org/W2100860810","https://openalex.org/W2101603546","https://openalex.org/W2101699473","https://openalex.org/W2103700689","https://openalex.org/W2106806709","https://openalex.org/W2107243201","https://openalex.org/W2108565008","https://openalex.org/W2108830626","https://openalex.org/W2108979944","https://openalex.org/W2109465247","https://openalex.org/W2110017381","https://openalex.org/W2110166017","https://openalex.org/W2110742140","https://openalex.org/W2112187879","https://openalex.org/W2114153887","https://openalex.org/W2116554987","https://openalex.org/W2121117374","https://openalex.org/W2122589024","https://openalex.org/W2124189233","https://openalex.org/W2125153509","https://openalex.org/W2133429162","https://openalex.org/W2133878799","https://openalex.org/W2133959685","https://openalex.org/W2136889891","https://openalex.org/W2137086763","https://openalex.org/W2137167442","https://openalex.org/W2138929540","https://openalex.org/W2139892288","https://openalex.org/W2142230152","https://openalex.org/W2143730928","https://openalex.org/W2143924924","https://openalex.org/W2147058464","https://openalex.org/W2149994587","https://openalex.org/W2150111967","https://openalex.org/W2151807981","https://openalex.org/W2151836927","https://openalex.org/W2152217620","https://openalex.org/W2153579158","https://openalex.org/W2154356111","https://openalex.org/W2157507405","https://openalex.org/W2159026044","https://openalex.org/W2160324074","https://openalex.org/W2162096542","https://openalex.org/W2162110703","https://openalex.org/W2162148675","https://openalex.org/W2162272563","https://openalex.org/W2166734873","https://openalex.org/W2167674154","https://openalex.org/W2168879581","https://openalex.org/W2172211152","https://openalex.org/W2195779187","https://openalex.org/W2312752082","https://openalex.org/W2464601339","https://openalex.org/W2496499584","https://openalex.org/W2593526662","https://openalex.org/W2772971838","https://openalex.org/W3144692184"],"related_works":["https://openalex.org/W2914478693","https://openalex.org/W2114153887","https://openalex.org/W2073129224","https://openalex.org/W2121904146","https://openalex.org/W2124189233","https://openalex.org/W2116554987","https://openalex.org/W2300514338","https://openalex.org/W2002561481","https://openalex.org/W2331235243","https://openalex.org/W2062367399"],"abstract_inverted_index":{"Introduction:":[0],"Prophylactic":[1],"measures":[2],"proposed":[3],"to":[4,171,240],"BRCA1/2":[5,99,199],"mutation":[6,56,100,110,200],"carriers":[7],"are":[8,97,238],"well":[9],"codified":[10],"and":[11,28,41,93,115,122,139,150,163,206,223,226],"based":[12],"on":[13,244],"probability,":[14],"in":[15,174],"the":[16,49,71,85,95,109,116,158,209,218],"course":[17],"of":[18,20,45,73,87,134,160,211,220],"life,":[19],"breast":[21,46,64,78,82,136,178,192],"or":[22,60,89],"ovarian":[23],"cancer.":[24,65],"Bilateral":[25],"prophylactic":[26,215],"mastectomy":[27,231],"oophorectomy":[29,88,216],"practiced":[30],"at":[31],"a":[32,38,42,55,105],"young":[33],"age":[34],"have":[35],"clearly":[36],"demonstrated":[37,113],"survival":[39,181],"benefit":[40,86],"reduced":[43],"risk":[44,76,133,159,194,210,219],"events.":[47],"However,":[48],"treatment":[50,62,203],"is":[51,57,70,128,145,195],"less":[52],"obvious":[53],"when":[54],"discovered":[58],"during":[59],"after":[61,77,142,187],"for":[63,198],"In":[66],"this":[67],"case,":[68],"there":[69],"question":[72],"ipsilateral":[74,135],"recurrence":[75,138],"conservative":[79],"treatment,":[80],"contralateral":[81,90,140,164,221,233],"cancer":[83,141,165,179,193,222],"risk,":[84],"mastectomy.":[91],"Material":[92],"Methods:":[94],"patients":[96,103],"103":[98],"carriers,":[101],"these":[102],"had":[104],"unilateral":[106],"non-metastatic":[107],"tumor,":[108],"has":[111],"been":[112],"retrospectively":[114],"assumption":[117],"was":[118,182],"made":[119],"between":[120],"1993":[121],"2013.":[123],"Results:":[124],"The":[125,132,177,214],"median":[126],"follow-up":[127],"116.8":[129],"months":[130],"[107.1-41.1].":[131],"tumor":[137,162],"10":[143,188],"years":[144],"10.4%":[146],"(95%":[147,152,184],"CI:":[148,153,185],"4.8-21.9)":[149],"32.8%":[151],"21.8-47.4).":[154],"Univariate":[155],"analyses":[156],"regarding":[157],"locoregional":[161],"do":[166],"not":[167],"provide":[168],"information":[169],"as":[170],"prognostic":[172],"factor":[173],"our":[175],"series.":[176],"specific":[180,228,245],"87.8%":[183],"77.4-93.6)":[186],"years.":[189],"Conclusion:":[190],"Contralateral":[191,230],"high":[196],"(3%/year)":[197],"carriers.":[201],"Conservative":[202],"including":[204],"radiotherapy":[205],"chemotherapy":[207],"reduces":[208],"local":[212,224],"relapse.":[213],"lowers":[217],"relapse,":[225],"increases":[227],"survival.":[229,246],"avoids":[232],"cancer,":[234],"but":[235],"further":[236],"studies":[237],"needed":[239],"show":[241],"its":[242],"impact":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}