{"id":"https://openalex.org/W2285647247","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15509","title":"A new mechanism of estrogen action in prostate cancer: Inhibition of tissue androgen production and prostate cancer growth by Estradiol in androgen independent prostate cancer xenografts","display_name":"A new mechanism of estrogen action in prostate cancer: Inhibition of tissue androgen production and prostate cancer growth by Estradiol in androgen independent prostate cancer xenografts","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2285647247","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15509","mag":"2285647247"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.15509","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15509","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15509","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054590690","display_name":"Bruce Montgomery","orcid":"https://orcid.org/0000-0003-4459-0295","observed_orcids":["https://orcid.org/0000-0003-4459-0295"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Montgomery","raw_affiliation_strings":["University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067800417","display_name":"Peter S. Nelson","orcid":"https://orcid.org/0000-0002-5451-5726","observed_orcids":["https://orcid.org/0000-0002-5451-5726"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Nelson","raw_affiliation_strings":["University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079709333","display_name":"David L. Hess","orcid":"https://orcid.org/0000-0001-7869-6923","observed_orcids":["https://orcid.org/0000-0001-7869-6923"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Hess","raw_affiliation_strings":["University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108555436","display_name":"R L Vessella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Vessella","raw_affiliation_strings":["University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018745405","display_name":"Eva Corey","orcid":"https://orcid.org/0000-0002-9244-3807","observed_orcids":["https://orcid.org/0000-0002-9244-3807"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Corey","raw_affiliation_strings":["University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA; Oregon Health and Sciences University, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"15509","last_page":"15509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.722000002861023},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5740000009536743},{"id":"https://openalex.org/keywords/estrogen-receptor-independent-mechanism","display_name":"estrogen receptor-independent mechanism","score":0.6069999933242798},{"id":"https://openalex.org/keywords/steroidogenesis-inhibition","display_name":"steroidogenesis inhibition","score":0.7070000171661377},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.953000009059906},{"id":"https://openalex.org/keywords/orchiectomy","display_name":"orchiectomy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7635951638221741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7062727212905884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6922523975372314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6612051725387573},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.6393836736679077},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6026237607002258},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5963197350502014},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5912505984306335},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5731731057167053},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5431784987449646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5091802477836609},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.44528526067733765},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3651195168495178},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18872299790382385},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.1536342203617096}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.15509","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15509","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15509","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070193481","https://openalex.org/W2104046060","https://openalex.org/W2120743127","https://openalex.org/W2163029804","https://openalex.org/W2016449938","https://openalex.org/W7096210158","https://openalex.org/W1987222985","https://openalex.org/W2079047691","https://openalex.org/W2078167795","https://openalex.org/W2074562732"],"abstract_inverted_index":{"15509":[0],"Background:":[1],"Estrogens":[2],"are":[3,16,31],"effective":[4],"agents":[5],"in":[6,10,12,163,168,183,200],"treating":[7],"prostate":[8,29,37,230,262],"cancer":[9,30,38,231],"patients":[11],"which":[13],"serum":[14],"androgens":[15,167],"already":[17],"at":[18,106,212],"\u2018castrate\u2018":[19],"or":[20,61],"anorchid":[21],"levels.":[22],"The":[23,34,121],"mechanisms":[24],"whereby":[25],"estrogens":[26],"inhibit":[27],"\u2018androgen-independent\u2018":[28],"unclear.":[32],"Methods:":[33],"androgen-independent":[35,101],"human":[36,229],"xenograft":[39,232],"LuCaP":[40],"35V":[41],"was":[42],"implanted":[43],"into":[44],"orchiectomized":[45],"male":[46],"SCID":[47],"mice":[48],"and":[49,83,87,110,153,161,178,182,189,198,207,234,248],"established":[50],"tumors":[51],"were":[52,91,210],"treated":[53,164,170],"with":[54,63],"placebo":[55,169,206],"pellets,":[56],"17\u03b2-estradiol":[57],"(E2)":[58],"slow-release":[59],"pellets":[60],"E2":[62,79,96,130,149,155,222,242,255],"the":[64,146,226],"estrogen":[65,122,239],"receptor":[66,123,137,240],"antagonist":[67,124],"ICI":[68,125],"182,780":[69,126],"as":[70],"previously":[71],"described":[72],"(Clin":[73],"Cancer":[74],"Res":[75],"8:1003).":[76],"Effects":[77],"of":[78,100,113,132,140,148,158,196,225,254,259,267,272,284],"on":[80,150],"tumor":[81,114,133,141,159,245,274],"growth":[82,99,224,257],"tissue":[84,151,203,246,285],"testosterone":[85],"(T)":[86],"dihydrotestosterone":[88],"(DHT)":[89],"levels":[90,157],"evaluated":[92],"by":[93],"radioimmunoassay.":[94],"Results:":[95],"significantly":[97,243],"inhibited":[98],"LuCaP35V":[102,171,185],"(":[103],"\u223c35%":[104],"inhibition":[105,131,237,258,266],"4":[107],"weeks,":[108],"p=0.0047,":[109],"increased":[111],"survival":[112],"bearing":[115],"animals,":[116],"(p":[117],"trend":[118],"=0.03)":[119],".":[120],"did":[127],"not":[128],"block":[129],"growth,":[134],"suggesting":[135,250],"a":[136,251],"independent":[138,228,261],"mechanism":[139,253],"suppression.":[142],"We":[143,218],"then":[144],"examined":[145],"effect":[147],"T":[152,160,197,247],"DHT.":[154],"suppressed":[156,244],"DHT":[162,190,199,249],"tumors.":[165],"Tissue":[166],"xenografts":[172],"were;":[173],"T=1.21":[174],"(\u00b1":[175],"0.18)":[176],"pg/mg":[177,188],"DHT=3.54":[179],"(\u00b11.07)":[180],"pg/mg,":[181,193],"E2-treated":[184,208],"T=0.23":[186],"(\u00b10.09)":[187],"=0.44":[191],"(\u00b10.14)":[192],"(p<0.001).":[194],"Levels":[195],"control":[201],"liver":[202],"from":[204],"both":[205],"animals":[209],"equivalent,":[211],"less":[213],"than":[214],"0.2":[215],"pg/mg.":[216],"Conclusions:":[217],"have":[219],"shown":[220],"that":[221,235],"inhibits":[223],"androgen-":[227],"LuCaP35V,":[233],"this":[236],"is":[238],"independent.":[241],"new":[252],"mediated":[256],"androgen":[260,275],"cancer,":[263],"potentially":[264],"through":[265],"tumoral":[268],"steroidogenesis.":[269,286],"This":[270],"model":[271],"\u2018intracrine\u2018":[273],"production":[276],"can":[277],"be":[278],"used":[279],"to":[280,291],"evaluate":[281],"other":[282],"inhibitors":[283],"No":[287],"significant":[288],"financial":[289],"relationships":[290],"disclose.":[292]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}