{"id":"https://openalex.org/W22856308","doi":null,"title":"Mechanism of Hic-5/ARA55 action, a novel stromal-specific nuclear receptor coactivator","display_name":"Mechanism of Hic-5/ARA55 action, a novel stromal-specific nuclear receptor coactivator","publication_year":2005,"publication_date":"2005-12-20","ids":{"openalex":"https://openalex.org/W22856308","mag":"22856308"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10428","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/10428/1/Thesis.pdf","pdf_url":"https://d-scholarship.pitt.edu/10428/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091669192","display_name":"Marjet D. Heitzer","orcid":"https://orcid.org/0009-0005-3896-191X","observed_orcids":["https://orcid.org/0009-0005-3896-191X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marjet D. Heitzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091669192"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-receptor-coactivators","display_name":"nuclear receptor coactivators","score":0.8840000033378601},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ncor","display_name":"NCoR","score":0.609000027179718},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.5199999809265137},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.5249999761581421},{"id":"https://openalex.org/keywords/leptomycin-b","display_name":"leptomycin B","score":0.6790000200271606},{"id":"https://openalex.org/keywords/prostatic-stroma","display_name":"prostate stroma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.6480000019073486},{"id":"https://openalex.org/keywords/lim-domain-proteins","display_name":"LIM domain proteins","score":0.5929999947547913},{"id":"https://openalex.org/keywords/transcriptional-coactivation","display_name":"transcriptional coactivation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.5249999761581421},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.3569999933242798},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.7732897996902466},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6758456230163574},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6530882120132446},{"id":"https://openalex.org/C124170894","wikidata":"https://www.wikidata.org/wiki/Q14914591","display_name":"Nuclear receptor coactivator 2","level":5,"score":0.6439940333366394},{"id":"https://openalex.org/C203966977","wikidata":"https://www.wikidata.org/wiki/Q14914599","display_name":"Nuclear receptor coactivator 3","level":5,"score":0.6421502828598022},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.5207338333129883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5018124580383301},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.48584577441215515},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47290027141571045},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4708661139011383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38516777753829956},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.3688402771949768},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537141978740692},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.23245388269424438},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.17916139960289001},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.14392048120498657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0732167661190033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07253652811050415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10428","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/10428/1/Thesis.pdf","pdf_url":"https://d-scholarship.pitt.edu/10428/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:22856308","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10428/1/Thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":150,"referenced_works":["https://openalex.org/W24211996","https://openalex.org/W93756624","https://openalex.org/W158811859","https://openalex.org/W1501286679","https://openalex.org/W1529553588","https://openalex.org/W1533310838","https://openalex.org/W1589166971","https://openalex.org/W1594826552","https://openalex.org/W1640813462","https://openalex.org/W1646199134","https://openalex.org/W1840303296","https://openalex.org/W1894633050","https://openalex.org/W1896007356","https://openalex.org/W1899637312","https://openalex.org/W1948931726","https://openalex.org/W1959606306","https://openalex.org/W1969997861","https://openalex.org/W1970316586","https://openalex.org/W1970318111","https://openalex.org/W1972158913","https://openalex.org/W1972729228","https://openalex.org/W1976319508","https://openalex.org/W1977455794","https://openalex.org/W1978231657","https://openalex.org/W1980344333","https://openalex.org/W1983624471","https://openalex.org/W1985063313","https://openalex.org/W1986384054","https://openalex.org/W1990573232","https://openalex.org/W1990988819","https://openalex.org/W1992515328","https://openalex.org/W1993635973","https://openalex.org/W1996127793","https://openalex.org/W1999837736","https://openalex.org/W2000287016","https://openalex.org/W2000736584","https://openalex.org/W2003833483","https://openalex.org/W2003955264","https://openalex.org/W2003964366","https://openalex.org/W2003985632","https://openalex.org/W2004988279","https://openalex.org/W2005205814","https://openalex.org/W2005658600","https://openalex.org/W2006479274","https://openalex.org/W2007699624","https://openalex.org/W2007772649","https://openalex.org/W2007985526","https://openalex.org/W2008498145","https://openalex.org/W2009402948","https://openalex.org/W2010142538","https://openalex.org/W2011119018","https://openalex.org/W2011803766","https://openalex.org/W2012155675","https://openalex.org/W2013671870","https://openalex.org/W2016002890","https://openalex.org/W2021859995","https://openalex.org/W2021894566","https://openalex.org/W2022502406","https://openalex.org/W2022635468","https://openalex.org/W2024894627","https://openalex.org/W2025639750","https://openalex.org/W2026022568","https://openalex.org/W2031146912","https://openalex.org/W2031849324","https://openalex.org/W2034112780","https://openalex.org/W2036054914","https://openalex.org/W2038119818","https://openalex.org/W2038807372","https://openalex.org/W2039253501","https://openalex.org/W2039539461","https://openalex.org/W2041170984","https://openalex.org/W2042030331","https://openalex.org/W2043408634","https://openalex.org/W2043631674","https://openalex.org/W2048844582","https://openalex.org/W2050018959","https://openalex.org/W2050115029","https://openalex.org/W2055069711","https://openalex.org/W2057360439","https://openalex.org/W2058818042","https://openalex.org/W2059089773","https://openalex.org/W2059140386","https://openalex.org/W2060128629","https://openalex.org/W2064418360","https://openalex.org/W2064956340","https://openalex.org/W2068113812","https://openalex.org/W2069532898","https://openalex.org/W2070303233","https://openalex.org/W2072518443","https://openalex.org/W2072793384","https://openalex.org/W2078704234","https://openalex.org/W2080852072","https://openalex.org/W2085412371","https://openalex.org/W2085797277","https://openalex.org/W2087240811","https://openalex.org/W2091210876","https://openalex.org/W2094328082","https://openalex.org/W2094838095","https://openalex.org/W2096496280","https://openalex.org/W2096760781","https://openalex.org/W2096958727","https://openalex.org/W2099703259","https://openalex.org/W2100343976","https://openalex.org/W2102892939","https://openalex.org/W2106054588","https://openalex.org/W2107340243","https://openalex.org/W2110530587","https://openalex.org/W2111194763","https://openalex.org/W2111683138","https://openalex.org/W2111868926","https://openalex.org/W2117325725","https://openalex.org/W2118578196","https://openalex.org/W2118934341","https://openalex.org/W2124223766","https://openalex.org/W2125090627","https://openalex.org/W2125553911","https://openalex.org/W2128242821","https://openalex.org/W2129433937","https://openalex.org/W2129750923","https://openalex.org/W2129800178","https://openalex.org/W2129938127","https://openalex.org/W2130110320","https://openalex.org/W2130831637","https://openalex.org/W2133208346","https://openalex.org/W2134055375","https://openalex.org/W2135666845","https://openalex.org/W2136819543","https://openalex.org/W2137344766","https://openalex.org/W2137658990","https://openalex.org/W2141628779","https://openalex.org/W2141724343","https://openalex.org/W2142864334","https://openalex.org/W2147894248","https://openalex.org/W2149442384","https://openalex.org/W2150127705","https://openalex.org/W2152885380","https://openalex.org/W2153997727","https://openalex.org/W2155249164","https://openalex.org/W2156575042","https://openalex.org/W2159759132","https://openalex.org/W2159762082","https://openalex.org/W2170656238","https://openalex.org/W2172032447","https://openalex.org/W2412225035","https://openalex.org/W2417067056","https://openalex.org/W2419293391","https://openalex.org/W2419506035","https://openalex.org/W2442297962","https://openalex.org/W2466951418","https://openalex.org/W2994374683"],"related_works":["https://openalex.org/W2102058704","https://openalex.org/W2004305725","https://openalex.org/W2092604740","https://openalex.org/W71074821","https://openalex.org/W1990573232","https://openalex.org/W1998976356","https://openalex.org/W2159762082","https://openalex.org/W2150127705","https://openalex.org/W6964164658","https://openalex.org/W7099440334"],"abstract_inverted_index":{"Hydrogen":[0],"peroxide":[1],"inducible":[2],"clone-5/Androgen":[3],"Receptor":[4],"Activator":[5],"55":[6],"(Hic-5/ARA55)":[7],"is":[8,218,304,319],"a":[9,28,79,135,289,329],"group":[10],"III":[11],"LIM":[12],"domain":[13],"protein":[14],"that":[15,241,293,303,317,331],"functions":[16],"at":[17,92,263,337],"focal":[18,93],"adhesion":[19,94],"complexes":[20,95,196,262,336],"as":[21,23,27,134],"well":[22],"in":[24,43,51,78,197,230,248,271,310],"the":[25,33,36,71,75,98,109,156,159,165,175,224,245,249,285,311],"nucleus":[26],"nuclear":[29,110,122,181],"receptor":[30,38,182,194],"coactivator.":[31],"Because":[32],"interaction":[34],"of":[35,74,104,121,153,158,168,192,202,223,251,267,273,288],"androgen":[37,299],"(AR)":[39],"with":[40,124,244,259],"Hic-5/ARA55":[41,49,66,88,105,133,179,184,203,217,242,257,268,318],"results":[42,315],"enhanced":[44],"androgen-induced":[45],"transcription,":[46],"we":[47,173],"analyzed":[48],"expression":[50,67,204,269,325],"prostate":[52,60,81],"tissue":[53],"sections":[54],"from":[55,236],"normal":[56],"human":[57,80],"donors":[58],"and":[59,96,111,140,227,276],"cancer":[61,171],"patients.":[62],"In":[63],"each":[64],"sample,":[65],"was":[68,89,117,185],"confined":[69],"to":[70,106,155,187,220,232,279],"stromal":[72,82,160],"compartment":[73],"prostate.":[76,312],"Furthermore,":[77,145,313],"cell":[83,308],"line":[84],"(i.e.":[85],"WPMY-1":[86,115],"cells)":[87],"localized":[90],"both":[91,138,274],"within":[97,114],"soluble":[99],"cytoplasmic":[100,112],"compartment.":[101],"The":[102],"ability":[103],"shuttle":[107],"between":[108],"compartments":[113],"cells":[116,199],"revealed":[118],"upon":[119,254],"inhibition":[120],"export":[123],"leptomycin":[125],"B":[126],"(LMB).":[127],"siRNA":[128],"ablation":[129,201],"experiments":[130],"established":[131,240],"endogenous":[132,141],"coactivator":[136,292,335],"for":[137,306,321],"viral":[139],"cellular":[142],"AR-regulated":[143],"genes.":[144],"chromatin":[146],"immunoprecipitation":[147],"(ChIP)":[148],"analysis":[149],"showed":[150],"androgen-dependent":[151],"recruitment":[152,278],"Hic-/ARA55":[154],"promoter":[157],"androgen-responsive":[161],"KGF":[162],"gene.":[163],"Using":[164],"A1-2":[166,198],"derivative":[167],"T47D":[169],"breast":[170],"cells,":[172],"examined":[174],"mechanism":[176],"by":[177,205,214,327],"which":[178],"potentiates":[180],"transactivation.":[183,211],"found":[186],"be":[188],"an":[189,295,298],"important":[190],"component":[191],"glucocorticoid":[193,233,255],"(GR)-coactivator":[195],"since":[200],"RNA":[206],"interference-mediated":[207],"silencing":[208],"reduced":[209],"GR":[210],"As":[212],"shown":[213],"ChIP":[215,238],"assays,":[216],"recruited":[219],"glucocorticoid-responsive":[221,280],"promoters":[222],"MMTV,":[225],"c-fos,":[226],"p21":[228],"genes":[229],"response":[231],"treatment.":[234],"Results":[235],"sequential":[237],"assays":[239],"associates":[243],"corepressor,":[246],"NCoR,":[247],"absence":[250],"glucocorticoids.":[252],"However,":[253],"stimulation,":[256],"interacts":[258],"GR-coactivator":[260],"containing":[261],"these":[264,314],"promoters.":[265,281,340],"Ablation":[266],"resulted":[270],"reduction":[272],"TIF-2":[275],"p300":[277],"These":[282],"data":[283],"provide":[284],"first":[286],"demonstration":[287],"stromal-specific":[290],"AR":[291],"has":[294],"impact":[296],"on":[297],"regulated":[300],"growth":[301],"factor":[302],"essential":[305],"stromal/epithelial":[307],"communication":[309],"suggest":[316],"required":[320],"optimal":[322],"GR-mediated":[323],"gene":[324],"possibly":[326],"providing":[328],"scaffold":[330],"organizes":[332],"or":[333],"stabilizes":[334],"some":[338],"hormone-responsive":[339]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}