{"id":"https://openalex.org/W2285533697","doi":null,"title":"Estrat\u00e9gias utilizadas para o incremento da solubilidade do f\u00e1rmaco antiretroviral classe II: Efavirenz","display_name":"Estrat\u00e9gias utilizadas para o incremento da solubilidade do f\u00e1rmaco antiretroviral classe II: Efavirenz","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2285533697","mag":"2285533697"},"language":"pt","primary_location":{"id":"pmh:oai:doaj.org/article:7f6d76fe33d04b39affa16858d0af298","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f6d76fe33d04b39affa16858d0af298","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eauticas B\u00e1sica e Aplicada, Vol 36, Iss 2 (2015)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/7f6d76fe33d04b39affa16858d0af298","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019958883","display_name":"Tarcyla Andrade Gomes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tarcyla Andrade Gomes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079247333","display_name":"Salvana Priscylla Manso Costa","orcid":"https://orcid.org/0000-0003-0055-1219","observed_orcids":["https://orcid.org/0000-0003-0055-1219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvana Priscylla Manso Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038310796","display_name":"Giovanna Christinne Rocha de Medeiros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanna Christinne Rocha de Medeiros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038231264","display_name":"Cristov\u00e3o Rodrigues da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristov\u00e3o  Rodrigues da Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006089922","display_name":"Magaly Andreza Marques de Lyra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magaly Andreza Marques de Lyra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060119164","display_name":"Keyla Emanuelle Ramos da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keyla Emanuelle Ramos da Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393891","display_name":"Miracy Muniz de Albuquerque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Miracy Muniz de Albuquerque","raw_affiliation_strings":["National Council for Scientific and Technological Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Council for Scientific and Technological Development","institution_ids":["https://openalex.org/I11385950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004881942","display_name":"Rosali Maria Ferreira da Silva","orcid":"https://orcid.org/0000-0002-4139-6035","observed_orcids":["https://orcid.org/0000-0002-4139-6035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosali Maria Ferreira da Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082729574","display_name":"Pedr\u00f3 Jos\u00e9 Rolim Neto","orcid":"https://orcid.org/0000-0003-0723-2587","observed_orcids":["https://orcid.org/0000-0003-0723-2587"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Jos\u00e9  Rolim Neto","raw_affiliation_strings":["National Council for Scientific and Technological Development"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Council for Scientific and Technological Development","institution_ids":["https://openalex.org/I11385950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2002,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.48789644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.8519999980926514},{"id":"https://openalex.org/keywords/solubility-enhancement","display_name":"solubility enhancement","score":0.8259999752044678},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.9279999732971191},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.7689999938011169},{"id":"https://openalex.org/keywords/inclusion-complexes","display_name":"inclusion complexes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/multicomponent-systems","display_name":"multicomponent systems","score":0.9160000085830688},{"id":"https://openalex.org/keywords/particulate-systems","display_name":"particulate systems","score":0.8859999775886536},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.8330000042915344},{"id":"https://openalex.org/keywords/biopharmaceutics-classification-system-class-ii","display_name":"Biopharmaceutics Classification System class II","score":0.8230000138282776},{"id":"https://openalex.org/keywords/water-solubility","display_name":"water solubility","score":0.796999990940094},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hiv-treatment","display_name":"HIV treatment","score":0.48899999260902405},{"id":"https://openalex.org/keywords/drug-formulation-technology","display_name":"drug formulation technology","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2781432083","wikidata":"https://www.wikidata.org/wiki/Q422645","display_name":"Efavirenz","level":5,"score":0.8030463457107544},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.37585771083831787},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.32765528559684753},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3226364254951477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2528037428855896},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.21008214354515076},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.20877191424369812},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.18643665313720703},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.030831128358840942}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:7f6d76fe33d04b39affa16858d0af298","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f6d76fe33d04b39affa16858d0af298","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eauticas B\u00e1sica e Aplicada, Vol 36, Iss 2 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d5e2aeba9da941c0aa94e139b118931d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d5e2aeba9da941c0aa94e139b118931d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eauticas B\u00e1sica e Aplicada, Vol 36, Iss 2 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:7f6d76fe33d04b39affa16858d0af298","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f6d76fe33d04b39affa16858d0af298","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista de Ci\u00eancias Farmac\u00eauticas B\u00e1sica e Aplicada, Vol 36, Iss 2 (2015)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1497362429","https://openalex.org/W1515288612","https://openalex.org/W1523211161","https://openalex.org/W1776418785","https://openalex.org/W1973791844","https://openalex.org/W1975615618","https://openalex.org/W1977234717","https://openalex.org/W1977423002","https://openalex.org/W1981515967","https://openalex.org/W1986744233","https://openalex.org/W1999366282","https://openalex.org/W2001902661","https://openalex.org/W2002116756","https://openalex.org/W2004091098","https://openalex.org/W2011751565","https://openalex.org/W2022846728","https://openalex.org/W2033799761","https://openalex.org/W2034043510","https://openalex.org/W2036138053","https://openalex.org/W2039704550","https://openalex.org/W2045465776","https://openalex.org/W2050648235","https://openalex.org/W2056434768","https://openalex.org/W2065279002","https://openalex.org/W2066160097","https://openalex.org/W2071236160","https://openalex.org/W2075623509","https://openalex.org/W2077250336","https://openalex.org/W2077697763","https://openalex.org/W2079204076","https://openalex.org/W2079640624","https://openalex.org/W2097831508","https://openalex.org/W2104804170","https://openalex.org/W2119904380","https://openalex.org/W2142604597","https://openalex.org/W2151823004","https://openalex.org/W2156829937","https://openalex.org/W2165243510","https://openalex.org/W2182248758","https://openalex.org/W2182494711","https://openalex.org/W2187427806","https://openalex.org/W2187884692","https://openalex.org/W2189251303","https://openalex.org/W2208621510","https://openalex.org/W2289899484","https://openalex.org/W2900497031","https://openalex.org/W2921400557"],"related_works":["https://openalex.org/W7120540755","https://openalex.org/W7009144124","https://openalex.org/W4362671415","https://openalex.org/W6986166692","https://openalex.org/W2572141420","https://openalex.org/W2289899484","https://openalex.org/W6893004179","https://openalex.org/W2758679006","https://openalex.org/W2189604846","https://openalex.org/W2188290317"],"abstract_inverted_index":{"O":[0],"efavirenz":[1],"(EFZ)":[2,226],"\u00e9":[3,19,89,163],"considerado":[4,90],"um":[5,48,92,108],"dos":[6,17,93,182],"f\u00e1rmacos":[7,84],"anti-":[8],"HIV":[9],"mais":[10,61,94],"utilizados,":[11],"por\u00e9m,":[12],"como":[13,21,91,105],"a":[14,44,154,161,246,273,335,388],"grande":[15,178],"maioria":[16],"antirretrovirais,":[18],"classificado":[20],"f\u00e1rmaco":[22,49,198],"de":[23,29,47,73,83,100,131,151,156,169,184,203,218],"classe":[24],"II,":[25],"segundo":[26],"o":[27,70,192,201],"Sistema":[28],"Classifica\u00e7\u00e3o":[30],"Biofarmac\u00eautica":[31],"(SCB),":[32],"por":[33,180],"apresentar":[34],"baixa":[35],"solubilidade":[36,45],"e":[37,113,135,168,188,199],"alta":[38],"permeabilidade.":[39],"\u00c9":[40],"bem":[41],"conhecido":[42],"que":[43,176,190,200],"aquosa":[46,78,196],"constitui":[50],"requisito":[51],"pr\u00e9vio":[52],"\u00e0":[53,64],"absor\u00e7\u00e3o":[54],"e,":[55,79],"assim,":[56],"se":[57],"faz":[58],"uma":[59,165,209],"das":[60],"importantes":[62],"barreiras":[63],"efic\u00e1cia":[65],"do":[66,124],"medicamento.":[67],"Desta":[68,172],"forma,":[69,173],"aumento,":[71],"atrav\u00e9s":[72],"tecnologias":[74],"farmac\u00eauticas,":[75],"da":[76,81,110,122,194],"dissolu\u00e7\u00e3o":[77,123,195],"conseq\u00fcentemente,":[80],"biodisponibilidade":[82],"pouco":[85],"sol\u00faveis":[86],"em":[87],"\u00e1gua":[88],"desafiantes":[95],"aspectos":[96],"no":[97,120,426],"desenvolvimento":[98,202],"moderno":[99],"f\u00e1rmacos.":[101],"Este":[102],"trabalho":[103],"tem":[104],"objetivo":[106],"realizar":[107],"levantamento":[109,146],"literatura":[111],"cientifica":[112],"discuss\u00e3o":[114],"sobre":[115],"as":[116,245],"principais":[117],"t\u00e9cnicas":[118],"aplicadas":[119],"melhoramento":[121,193],"EFZ,":[125,352],"dentre":[126],"elas:":[127],"dispers\u00f5es":[128,157,204],"s\u00f3lidas,":[129,158],"complexos":[130],"inclus\u00e3o,":[132],"sistemas":[133,136],"multicomponentes":[134],"particulados":[137],"nos":[138],"\u00faltimos":[139],"10":[140,366],"anos":[141],"(2004":[142],"\u2013":[143],"2014).":[144],"Ap\u00f3s":[145],"bibliogr\u00e1fico,":[147],"verificou-se":[148],"maior":[149],"n\u00famero":[150],"publica\u00e7\u00f5es":[152],"empregando":[153],"t\u00e9cnica":[155,166],"provavelmente,":[159],"porque":[160],"mesma":[162],"considerada":[164],"simples":[167],"baixo":[170],"custo.":[171],"ficou":[174],"claro":[175],"h\u00e1":[177],"interesse,":[179],"parte":[181],"pesquisadores,":[183],"desenvolver":[185],"m\u00e9todos":[186],"eficientes":[187],"econ\u00f4micos":[189],"visam":[191],"deste":[197],"s\u00f3lidas":[205],"\u00e9,":[206],"sem":[207],"d\u00favida,":[208],"solu\u00e7\u00e3o":[210],"interessante.":[211],"Palavras-chave:":[212],"Efavirenz.":[213,432],"Solubilidade.":[214],"Dispers\u00f5es":[215],"S\u00f3lidas.":[216],"Complexos":[217],"Inclus\u00e3o.":[219],"Sistemas":[220,222],"Multicomponentes.":[221],"Particulados.":[223],"ABSTRACT":[224],"Efavirenz":[225],"is":[227,243,266,275,312,386,395,399],"considered":[228,387],"one":[229,283],"of":[230,272,284,291,296,304,338,351,372,377,416,422],"the":[231,238,252,269,276,285,289,294,297,302,315,324,339,343,349,364,375,413,420],"most":[232],"used":[233],"anti-HIV":[234],"drugs.":[235],"However,":[236],"like":[237],"others":[239],"anti-retroviral":[240],"drugs,":[241],"it":[242,385,394],"classified":[244],"class":[247],"II":[248],"drug,":[249],"according":[250],"to":[251,258,288,333,404],"Biopharmaceutics":[253],"Classification":[254],"System":[255],"(BCS),":[256],"due":[257],"its":[259,279],"low":[260],"solubility":[261,271],"and":[262,281,359,390,407,418],"high":[263],"permeability.":[264],"It":[265],"well-known":[267],"that":[268,306,397,419],"aqueous":[270,298,414],"drug":[274,326],"prerequisite":[277],"for":[278],"absorption":[280],"becomes":[282],"major":[286],"barriers":[287],"effectiveness":[290],"it.":[292],"Thus,":[293],"improvement":[295],"dissolution":[299,350,415],"and,":[300],"therefore,":[301],"bioavailability":[303],"drugs":[305],"are":[307,320],"poorly":[308],"soluble":[309],"in":[310,323,347,363],"water,":[311],"pursued":[313],"by":[314],"pharmaceutical":[316],"technology,":[317],"once":[318],"they":[319],"challenging":[321],"aspects":[322],"modern":[325],"development.":[327],"This":[328],"paper":[329],"aims,":[330],"besides":[331],"discussing,":[332],"perform":[334],"systematic":[336],"review":[337],"scientific":[340],"literature":[341],"regarding":[342],"main":[344],"techniques":[345],"applied":[346],"improving":[348,412],"including:":[353],"solid":[354,378],"dispersions,":[355],"inclusion":[356],"complexes,":[357],"systems":[358],"multicomponent":[360],"particulate":[361],"systems;":[362],"last":[365],"years":[367],"(2004-2014).":[368],"A":[369],"greater":[370],"number":[371],"publications":[373],"using":[374],"technique":[376],"dispersions":[379],"(SD)":[380],"were":[381],"found,":[382],"probably":[383],"because":[384],"simple":[389],"inexpensive":[391],"technique.":[392],"Therefore":[393],"clear":[396],"there":[398],"great":[400],"interest":[401],"from":[402],"researchers":[403],"develop":[405],"efficient":[406],"economical":[408],"methods":[409],"aimed":[410],"at":[411],"EFZ":[417],"development":[421],"SD":[423],"is,":[424],"with":[425],"doubt,":[427],"an":[428],"interesting":[429],"solution.":[430],"Keywords:":[431],"Solubility.":[433],"Solid":[434],"dispersions.":[435],"Inclusion":[436],"Complexes.":[437],"Multicomponent":[438],"systems.":[439,441],"Particulate":[440]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2016-06-24T00:00:00"}
