{"id":"https://openalex.org/W2285530557","doi":null,"title":"Regulation of the mechanism of interference with Quorum sensing in Escherichia coli","display_name":"Regulation of the mechanism of interference with Quorum sensing in Escherichia coli","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2285530557","mag":"2285530557"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/6464","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/6464","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/6464","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053358836","display_name":"Paulo Jos\u00e9 Braz Correia Correia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paulo Jos\u00e9 Braz Correia Correia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053358836"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.9909999966621399},{"id":"https://openalex.org/keywords/autoinducer-2","display_name":"autoinducer-2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8510000109672546},{"id":"https://openalex.org/keywords/phosphoenolpyruvate-dependent-phosphotransferase-system","display_name":"phosphoenolpyruvate-dependent phosphotransferase system","score":0.9649999737739563},{"id":"https://openalex.org/keywords/platinum-silicide","display_name":"platinum silicide","score":0.8009999990463257},{"id":"https://openalex.org/keywords/suppressor-screen","display_name":"suppressor screen","score":0.6959999799728394},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.9511008858680725},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7323700189590454},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7123390436172485},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.5956342816352844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38338178396224976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2909311056137085},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.14499935507774353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14489731192588806},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11446267366409302},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.07414290308952332},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05167004466056824},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/6464","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/6464","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2285530557","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ul.pt/handle/10451/6464","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/6464","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/6464","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1501727668","https://openalex.org/W1560753515","https://openalex.org/W1593038806","https://openalex.org/W1603665563","https://openalex.org/W1603944953","https://openalex.org/W1713646499","https://openalex.org/W1829245089","https://openalex.org/W1851276803","https://openalex.org/W1903601716","https://openalex.org/W1924356139","https://openalex.org/W1934181521","https://openalex.org/W1943112463","https://openalex.org/W1959548112","https://openalex.org/W1969638357","https://openalex.org/W1972435034","https://openalex.org/W1975383233","https://openalex.org/W1987038145","https://openalex.org/W1988874714","https://openalex.org/W1993616876","https://openalex.org/W1994462493","https://openalex.org/W1996135784","https://openalex.org/W2000106451","https://openalex.org/W2000930830","https://openalex.org/W2001773648","https://openalex.org/W2002276562","https://openalex.org/W2002317558","https://openalex.org/W2004280279","https://openalex.org/W2005076869","https://openalex.org/W2009929728","https://openalex.org/W2018093936","https://openalex.org/W2022959719","https://openalex.org/W2026056595","https://openalex.org/W2027104262","https://openalex.org/W2035999312","https://openalex.org/W2038683612","https://openalex.org/W2044878310","https://openalex.org/W2052255348","https://openalex.org/W2057601066","https://openalex.org/W2057624222","https://openalex.org/W2061257637","https://openalex.org/W2065492641","https://openalex.org/W2069228394","https://openalex.org/W2071123327","https://openalex.org/W2071563418","https://openalex.org/W2074726414","https://openalex.org/W2082062328","https://openalex.org/W2083489645","https://openalex.org/W2088970163","https://openalex.org/W2098159838","https://openalex.org/W2099529971","https://openalex.org/W2100964796","https://openalex.org/W2103359264","https://openalex.org/W2103547456","https://openalex.org/W2104941420","https://openalex.org/W2105005778","https://openalex.org/W2107069650","https://openalex.org/W2111967267","https://openalex.org/W2115335630","https://openalex.org/W2115682970","https://openalex.org/W2118521369","https://openalex.org/W2118721916","https://openalex.org/W2120468912","https://openalex.org/W2121264393","https://openalex.org/W2125448911","https://openalex.org/W2130394726","https://openalex.org/W2130718208","https://openalex.org/W2131725857","https://openalex.org/W2131869707","https://openalex.org/W2134153749","https://openalex.org/W2138776000","https://openalex.org/W2138956739","https://openalex.org/W2144640625","https://openalex.org/W2145299726","https://openalex.org/W2149332722","https://openalex.org/W2166342754","https://openalex.org/W2166374078","https://openalex.org/W2167637231"],"related_works":["https://openalex.org/W7014303497","https://openalex.org/W2090291762","https://openalex.org/W2519997677","https://openalex.org/W7214868348","https://openalex.org/W7042587815","https://openalex.org/W1568927532","https://openalex.org/W7120760137","https://openalex.org/W2224686062","https://openalex.org/W2240530066","https://openalex.org/W796140950"],"abstract_inverted_index":{"Quorum":[0],"sensing":[1],"is":[2,29,42,147,173,304,329],"a":[3,21,181,223,229,274],"cell-to-cell":[4],"signaling":[5],"mechanism":[6,190,313],"in":[7,47,60,105,115,160,219,222],"which":[8,84,315],"bacteria":[9,33,55,322],"collectively":[10],"control":[11],"gene":[12],"expression":[13,68,241],"and":[14,34,44,57,78,132,235,254,292,295,323],"therefore":[15],"synchronize":[16],"behaviors":[17],"only":[18],"productive":[19],"at":[20],"high":[22],"population":[23],"density.":[24],"The":[25,139,267],"autoinducer-2":[26],"(AI-2)":[27],"signal":[28,327],"produced":[30],"by":[31,80,199],"many":[32],"enables":[35],"inter-species":[36],"communication.":[37],"In":[38,178],"Escherichia":[39,220],"coli,":[40],"AI-2":[41,51,131,161,169,176,195,326],"synthesized":[43],"secreted,":[45],"accumulating":[46],"the":[48,67,81,90,96,106,110,116,125,136,151,154,157,188,192,203,244,249,255,287,301,307,311,318],"extracellular":[49,130],"medium.":[50],"concentration":[52],"rises":[53],"as":[54],"divide":[56],"decreases":[58],"rapidly":[59],"early":[61],"stationary":[62],"phase":[63],"partially":[64],"due":[65],"to":[66,167,186,263],"of":[69,109,124,145,153,156,191,194,202,212,215,248,321,325],"an":[70,102],"ATP-binding":[71],"cassette":[72],"transporter,":[73],"named":[74],"Lsr":[75,111,268,302],"(for":[76],"LuxS-regulated)":[77],"encoded":[79],"lsrACDB":[82],"operon,":[83],"imports":[85],"AI-2,":[86],"removing":[87],"it":[88],"from":[89],"environment.":[91],"Recent":[92],"work":[93,141],"showed":[94,142],"that":[95,143,206],"phosphoenolpyruvate-dependent":[97],"phosphotransferase":[98],"system":[99],"(PTS)":[100],"plays":[101],"important":[103,148],"role":[104],"regulatory":[107],"network":[108],"transporter.":[112],"Specifically,":[113],"mutants":[114,238,258],"ptsI":[117,158,204,224,250],"gene,":[118],"encoding":[119],"for":[120,149,175,237],"Enzyme":[121],"I":[122],"(EI)":[123],"PTS,":[126,308],"do":[127,133],"not":[128,134,166],"internalize":[129],"activate":[135],"lsr":[137],"operon.":[138],"present":[140],"phosphorylation":[144],"EI":[146,198],"enabling":[150],"recovery":[152],"defect":[155],"mutation":[159],"internalization":[162,196],"but":[163],"most":[164,256],"likely":[165],"phosphorylate":[168],"since":[170],"LsrK":[171],"kinase":[172],"required":[174],"processing.":[177],"this":[179],"study":[180],"genetic":[182],"screen":[183],"was":[184,233,270],"performed":[185],"determine":[187],"molecular":[189,312],"regulation":[193,269,324],"via":[197],"identifying":[200],"suppressors":[201],"mutant":[205,251],"can":[207,309],"incorporate":[208],"AI-2.":[209],"A":[210],"library":[211],"single-gene":[213],"deletions":[214],"all":[216],"non-essential":[217],"genes":[218],"coli":[221],"deletion":[225],"background":[226],"strain":[227],"carrying":[228],"lsr-lacZ":[230,240],"promoter":[231],"fusion":[232],"generated":[234],"screened":[236],"with":[239,286],"higher":[242],"than":[243],"parent":[245],"strain.":[246],"Suppressors":[247],"were":[252,284,297],"identified":[253],"interesting":[257],"are":[259],"currently":[260],"being":[261],"analyzed":[262],"understand":[264],"their":[265,293],"role.":[266],"also":[271],"studied":[272],"using":[273],"new":[275],"tool:":[276],"green":[277],"fluorescent":[278],"protein":[279],"(gfp)":[280],"reporter":[281],"fusions.":[282],"These":[283],"compared":[285],"commonly":[288],"used":[289],"promoter-lacZ":[290],"fusions":[291],"benefits":[294],"drawbacks":[296],"accessed.":[298],"Understanding":[299],"how":[300],"transport":[303],"dependent":[305],"on":[306],"reveal":[310],"through":[314],"information":[316],"about":[317],"physiological":[319],"state":[320],"uptake":[328],"integrated.":[330]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
