{"id":"https://openalex.org/W2285387657","doi":null,"title":"Transcriptional and epigenetic regulation of gene expression by arsenic in cancer and normal cells","display_name":"Transcriptional and epigenetic regulation of gene expression by arsenic in cancer and normal cells","publication_year":2016,"publication_date":"2016-02-18","ids":{"openalex":"https://openalex.org/W2285387657","mag":"2285387657"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26914336","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Transcriptional_and_epigenetic_regulation_of_gene_expression_by_arsenic_in_cancer_and_normal_cells/26914336","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/45016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049554722","display_name":"Angeliki Pournara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Angeliki Pournara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049554722"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.1776999980211258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inorganic-arsenic","display_name":"inorganic arsenic","score":0.8759999871253967},{"id":"https://openalex.org/keywords/arsenic-toxicity","display_name":"arsenic toxicity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/maml1","display_name":"MAML1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.859000027179718},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.921999990940094},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.6790000200271606},{"id":"https://openalex.org/keywords/h3k9me3","display_name":"H3K9me3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/h3k9ac","display_name":"H3K9ac","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/t-lymphoblasts","display_name":"T lymphoblasts","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.886502742767334},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5385452508926392},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.529943585395813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48041844367980957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4448450207710266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4419747591018677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4308212101459503},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42914247512817383},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36580705642700195},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3281984031200409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16932538151741028},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26914336","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Transcriptional_and_epigenetic_regulation_of_gene_expression_by_arsenic_in_cancer_and_normal_cells/26914336","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/45016","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/45016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2285387657","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/45016/Thesis_Angeliki_Pournara.pdf;sequence=3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/45016","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/45016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":163,"referenced_works":["https://openalex.org/W81465174","https://openalex.org/W128718553","https://openalex.org/W134743188","https://openalex.org/W192794212","https://openalex.org/W899590184","https://openalex.org/W1162354494","https://openalex.org/W1481575941","https://openalex.org/W1490231232","https://openalex.org/W1504303645","https://openalex.org/W1508234976","https://openalex.org/W1516234656","https://openalex.org/W1521333964","https://openalex.org/W1537298049","https://openalex.org/W1543546710","https://openalex.org/W1553135333","https://openalex.org/W1574848475","https://openalex.org/W1658305954","https://openalex.org/W1913106188","https://openalex.org/W1964032340","https://openalex.org/W1971328346","https://openalex.org/W1971571526","https://openalex.org/W1973549360","https://openalex.org/W1977080726","https://openalex.org/W1977258749","https://openalex.org/W1977875971","https://openalex.org/W1979019066","https://openalex.org/W1979397879","https://openalex.org/W1979737424","https://openalex.org/W1980002433","https://openalex.org/W1980974420","https://openalex.org/W1982353442","https://openalex.org/W1984808083","https://openalex.org/W1987557775","https://openalex.org/W1988697030","https://openalex.org/W1989296869","https://openalex.org/W1989704161","https://openalex.org/W1990374273","https://openalex.org/W1992356296","https://openalex.org/W1992499209","https://openalex.org/W1992892752","https://openalex.org/W1994194752","https://openalex.org/W1998707352","https://openalex.org/W1999648969","https://openalex.org/W2000145238","https://openalex.org/W2001156156","https://openalex.org/W2004451606","https://openalex.org/W2004582746","https://openalex.org/W2007834782","https://openalex.org/W2008127692","https://openalex.org/W2009774822","https://openalex.org/W2012674858","https://openalex.org/W2014235860","https://openalex.org/W2014999300","https://openalex.org/W2015416439","https://openalex.org/W2016547637","https://openalex.org/W2018163822","https://openalex.org/W2019028138","https://openalex.org/W2020820075","https://openalex.org/W2025034500","https://openalex.org/W2027644456","https://openalex.org/W2031153505","https://openalex.org/W2033171078","https://openalex.org/W2034244244","https://openalex.org/W2037579319","https://openalex.org/W2039797666","https://openalex.org/W2041850769","https://openalex.org/W2041935553","https://openalex.org/W2043355394","https://openalex.org/W2044626217","https://openalex.org/W2045823138","https://openalex.org/W2046300477","https://openalex.org/W2049534901","https://openalex.org/W2049856484","https://openalex.org/W2051347752","https://openalex.org/W2051384809","https://openalex.org/W2052547550","https://openalex.org/W2053405779","https://openalex.org/W2056310758","https://openalex.org/W2056771307","https://openalex.org/W2058071169","https://openalex.org/W2058261185","https://openalex.org/W2059553622","https://openalex.org/W2061120018","https://openalex.org/W2061459507","https://openalex.org/W2061939832","https://openalex.org/W2064216912","https://openalex.org/W2064340999","https://openalex.org/W2064844197","https://openalex.org/W2065036890","https://openalex.org/W2065782380","https://openalex.org/W2067423114","https://openalex.org/W2067700416","https://openalex.org/W2068120083","https://openalex.org/W2069624136","https://openalex.org/W2070777085","https://openalex.org/W2072375912","https://openalex.org/W2075596346","https://openalex.org/W2075737968","https://openalex.org/W2077518922","https://openalex.org/W2078184125","https://openalex.org/W2081184407","https://openalex.org/W2081538622","https://openalex.org/W2082066702","https://openalex.org/W2085033409","https://openalex.org/W2085864324","https://openalex.org/W2086677653","https://openalex.org/W2089037794","https://openalex.org/W2090381051","https://openalex.org/W2095397411","https://openalex.org/W2098780853","https://openalex.org/W2105405045","https://openalex.org/W2107295567","https://openalex.org/W2107447544","https://openalex.org/W2113724558","https://openalex.org/W2115063820","https://openalex.org/W2115680369","https://openalex.org/W2116407381","https://openalex.org/W2118151336","https://openalex.org/W2118466825","https://openalex.org/W2125922899","https://openalex.org/W2127808543","https://openalex.org/W2127967852","https://openalex.org/W2128160901","https://openalex.org/W2128481501","https://openalex.org/W2131190398","https://openalex.org/W2135113756","https://openalex.org/W2136707087","https://openalex.org/W2139842301","https://openalex.org/W2140357331","https://openalex.org/W2141533864","https://openalex.org/W2141587967","https://openalex.org/W2142077671","https://openalex.org/W2142584816","https://openalex.org/W2145492248","https://openalex.org/W2145757364","https://openalex.org/W2146053741","https://openalex.org/W2146721090","https://openalex.org/W2147524392","https://openalex.org/W2149602337","https://openalex.org/W2149875120","https://openalex.org/W2150496093","https://openalex.org/W2152033157","https://openalex.org/W2154221402","https://openalex.org/W2155080972","https://openalex.org/W2155507961","https://openalex.org/W2158021558","https://openalex.org/W2158188390","https://openalex.org/W2160911021","https://openalex.org/W2163666912","https://openalex.org/W2163798555","https://openalex.org/W2167076734","https://openalex.org/W2169518540","https://openalex.org/W2170964470","https://openalex.org/W2184391500","https://openalex.org/W2207991208","https://openalex.org/W2232663846","https://openalex.org/W2261133602","https://openalex.org/W2267712628","https://openalex.org/W2276218090","https://openalex.org/W2289845601","https://openalex.org/W2290581479","https://openalex.org/W2480873744","https://openalex.org/W2496662343"],"related_works":["https://openalex.org/W2143070196","https://openalex.org/W2347863587","https://openalex.org/W2770920574","https://openalex.org/W4409820886","https://openalex.org/W2792719021","https://openalex.org/W2405610832","https://openalex.org/W2056771307","https://openalex.org/W2030624202","https://openalex.org/W2176846237","https://openalex.org/W2053469236"],"abstract_inverted_index":{"Inorganic":[0],"arsenic":[1,21,46,68,79,189,224,245,251,293,330,342],"is":[2,60,106,163,215],"a":[3,322],"toxic":[4],"metalloid":[5],"that":[6,66,151,160,200,223,314,324,341],"occurs":[7,233],"naturally":[8],"on":[9,39,80,191,246,357],"the":[10,41,56,63,71,76,133,139,144,210,242,247,256,292,352,368,385,455],"earth\u2019s":[11],"crust.":[12],"Millions":[13],"of":[14,45,52,78,173,209,244,371,389,450],"people":[15],"worldwide":[16],"are":[17,155,318],"exposed":[18,268,294,306],"to":[19,94,117,127,239,255,307,380],"inorganic":[20],"via":[22,29,157,234,320],"drinking":[23],"water,":[24],"and":[25,82,88,113,120,143,146,159,167,183,194,205,229,262,296,331,347,373,409,443,454,477,491],"more":[26],"recently":[27],"also":[28,176,326,350,362],"contaminated":[30],"food,":[31],"in":[32,86,108,180,217,253,264,273,275,283,287,298,300,301,332,375,384,487,489,492],"particular":[33],"rice.":[34],"Many":[35],"studies":[36],"have":[37],"focused":[38],"exploring":[40],"adverse":[42,381],"health":[43,382],"effects":[44,77,243,383],"as":[47,49,103,186,188,270,272],"well":[48,187,271],"its":[50],"mode":[51],"action":[53],"once":[54],"entering":[55],"body.":[57],"Still,":[58],"little":[59],"known":[61],"about":[62],"intracellular":[64],"processes":[65,84,119,131,365],"drive":[67],"toxicity.":[69],"In":[70,92,237,309],"present":[72],"thesis":[73],"we":[74,137,175,230,249,339],"investigated":[75,177],"transcriptional":[81,100,140,359,456],"epigenetic":[83,184,218,285,364],"both":[85,207],"normal":[87],"cancer":[89],"cell":[90,181,196,227,276,353,452],"lines.":[91],"order":[93,238],"understand":[95,128],"how":[96],"exogenous":[97],"compounds":[98],"affect":[99],"regulators":[101],"such":[102],"MAML1,":[104],"which":[105,129,214,377],"involved":[107,216],"many":[109],"different":[110],"signaling":[111,354],"pathways":[112,355],"has":[114],"been":[115],"related":[116],"developmental":[118],"human":[121,386],"diseases":[122],"(e.g.":[123],"cancer),":[124],"it\u2019s":[125],"important":[126],"cellular":[130],"regulate":[132],"protein":[134,153,316,345],"levels.":[135],"Consequently,":[136],"studied":[138,250],"co-activator":[141],"MAML1":[142,152,178,192,201,235,315,344,358],"ubiquitination":[145,158],"degradation":[147],"process.":[148],"We":[149,198,220,279],"show":[150,199],"levels":[154,317,346,370],"regulated":[156,319],"this":[161,232,333],"process":[162,323],"enhanced":[164],"by":[165,169,329,366],"p300":[166],"repressed":[168],"N1ICD.":[170],"On":[171],"top":[172],"that,":[174],"involvement":[179],"proliferation":[182,228,453],"regulation":[185],"effect":[190],"expression":[193],"kidney":[195,226,451],"proliferation.":[197],"interacts":[202],"with":[203],"DNMT1":[204],"PCNA,":[206],"members":[208],"DNMT1-PCNA-HDAC2":[211],"repressive":[212],"complex,":[213],"regulation.":[219],"further":[221,240],"report":[222,280],"decreases":[225],"suggest":[231,313,340],"downregulation.":[236],"explore":[241],"epigenome,":[248],"exposure":[252],"relation":[254],"post-translational":[257],"histone":[258,485],"modifications":[259,486],"(PTHMs)":[260],"H3K9me3":[261,284,372],"H3K9Ac":[263,299,374],"lymphocytes":[265,289,488],"isolated":[266,290],"from":[267,291],"individuals":[269,295],"vitro":[274,302,490],"culture":[277],"system.":[278],"arsenic-related":[281],"changes":[282,297],"mark":[286],"CD4+":[288],"cultured":[303],"T":[304],"lymphoblasts":[305],"arsenic.":[308],"conclusion,":[310],"our":[311],"data":[312],"ubiquitination,":[321],"could":[325,348,378],"be":[327],"targeted":[328],"way":[334],"influence":[335,351],"gene":[336],"expression.":[337],"Moreover,":[338],"regulates":[343],"thereby":[349],"depending":[356],"activity.":[360],"Arsenic":[361,482],"targets":[363],"altering":[367],"global":[369,484],"lymphocytes,":[376],"lead":[379],"population.":[387],"List":[388],"scientific":[390],"papers":[391],"I.":[392],"M.":[393,395,437,441,466,473],"Farshbaf,":[394],"J.":[396,410],"Lindberg,":[397],"A.":[398,404,406,429,444,464,478],"Truong,":[399],"Z.":[400],"Bevens,":[401],"E.":[402,407,445,479],"Chambers,":[403],"Pournara,":[405,430,465],"Wallberg":[408,446,480],"B.":[411],"White":[412],"(2015).":[413],"Mastermind-Like":[414],"1":[415],"Is":[416],"Ubiquitinated:":[417],"Functional":[418],"Consequences":[419],"for":[420],"Notch":[421],"Signaling.":[422],"PLoS":[423],"One,":[424],"10,":[425],"e0134013.":[426],"https://doi.org/10.1371/journal.pone.0134013":[427],"II.":[428],"T.":[431,468],"Holmlund,":[432,469],"Y.":[433],"Lu,":[434],"R.":[435,439,471],"Ceder,":[436],"Putnik,":[438],"Grafstrom,":[440],"Vahter":[442],"(2014).":[447],"Arsenic-induced":[448],"suppression":[449],"coregulator":[457],"MAML1.":[458],"Metallomics,":[459],"6,":[460],"498-504.":[461],"https://doi.org/10.1039/c3mt00333g":[462],"III.":[463],"Kippler,":[467],"R.Ceder,":[470],"Grafstro\u0308m,":[472],"Vahter,":[474],"K.":[475],"Broberg":[476],"(2016).":[481],"alters":[483],"vivo.":[493],"[Manuscript]":[494]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
