{"id":"https://openalex.org/W2285192552","doi":"https://doi.org/10.1152/ajpregu.2000.278.1.r263","title":"Interleukin-1\u03b2 deficiency results in reduced NF-\u03baB levels in pregnant mice","display_name":"Interleukin-1\u03b2 deficiency results in reduced NF-\u03baB levels in pregnant mice","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2285192552","doi":"https://doi.org/10.1152/ajpregu.2000.278.1.r263","mag":"2285192552","pmid":"https://pubmed.ncbi.nlm.nih.gov/10644648"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.2000.278.1.r263","doi":"https://doi.org/10.1152/ajpregu.2000.278.1.r263","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.2000.278.1.r263","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021537282","display_name":"Leonid L. Reznikov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonid L. Reznikov","raw_affiliation_strings":["Division of Infectious Diseases and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043499587","display_name":"Brian D. Shames","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian D. Shames","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060090431","display_name":"Hazel A. Barton","orcid":"https://orcid.org/0000-0001-8585-9997","observed_orcids":["https://orcid.org/0000-0001-8585-9997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hazel A. Barton","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031493840","display_name":"Craig H. Selzman","orcid":"https://orcid.org/0000-0001-9218-4764","observed_orcids":["https://orcid.org/0000-0001-9218-4764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig H. Selzman","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088316508","display_name":"Giamila Fantuzzi","orcid":"https://orcid.org/0000-0001-5334-0082","observed_orcids":["https://orcid.org/0000-0001-5334-0082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giamila Fantuzzi","raw_affiliation_strings":["Division of Infectious Diseases and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431002","display_name":"Soo Hyun Kim","orcid":"https://orcid.org/0000-0002-8391-3686","observed_orcids":["https://orcid.org/0000-0002-8391-3686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo-Hyun Kim","raw_affiliation_strings":["Division of Infectious Diseases and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111608333","display_name":"Sylene M. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylene M. Johnson","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028234430","display_name":"Charles Anthony Dinarello","orcid":"https://orcid.org/0000-0002-5073-8316","observed_orcids":["https://orcid.org/0000-0002-5073-8316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles A. Dinarello","raw_affiliation_strings":["Division of Infectious Diseases and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9513,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7490441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"278","issue":"1","first_page":"R263","last_page":"R270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.33719998598098755,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lipopolysaccharide-response","display_name":"lipopolysaccharide response","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/macrophage-inflammatory-protein-1-alpha","display_name":"macrophage inflammatory protein-1alpha","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":1.0},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.7929999828338623},{"id":"https://openalex.org/keywords/uterine-wall","display_name":"uterine wall","score":0.6970000267028809},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cytokine-regulation","display_name":"cytokine regulation","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37052565813064575}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.2000.278.1.r263","doi":"https://doi.org/10.1152/ajpregu.2000.278.1.r263","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.2000.278.1.r263","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:10644648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10644648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G508098258","display_name":null,"funder_award_id":"AI\u201115614","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6909620674","display_name":null,"funder_award_id":"CA-46943","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7414987332","display_name":null,"funder_award_id":"AI-2532359","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W319674832","https://openalex.org/W1500908560","https://openalex.org/W1515994079","https://openalex.org/W1534207743","https://openalex.org/W1535509219","https://openalex.org/W1547420341","https://openalex.org/W1549562401","https://openalex.org/W1561511271","https://openalex.org/W1575634297","https://openalex.org/W1602460865","https://openalex.org/W1609862856","https://openalex.org/W1661180389","https://openalex.org/W1826445668","https://openalex.org/W1904705252","https://openalex.org/W1920787626","https://openalex.org/W1940973248","https://openalex.org/W1965600364","https://openalex.org/W1967092468","https://openalex.org/W1969058122","https://openalex.org/W1976715882","https://openalex.org/W1982062664","https://openalex.org/W2001585029","https://openalex.org/W2001963326","https://openalex.org/W2002711392","https://openalex.org/W2005164305","https://openalex.org/W2016730049","https://openalex.org/W2024418426","https://openalex.org/W2045074773","https://openalex.org/W2046588493","https://openalex.org/W2052701260","https://openalex.org/W2055426473","https://openalex.org/W2065498716","https://openalex.org/W2070073216","https://openalex.org/W2076261469","https://openalex.org/W2105415988","https://openalex.org/W2105721964","https://openalex.org/W2115587787","https://openalex.org/W2120642988","https://openalex.org/W2129801898","https://openalex.org/W2132389105","https://openalex.org/W2144951566","https://openalex.org/W2159674010","https://openalex.org/W2168041453","https://openalex.org/W2189495881","https://openalex.org/W2209782291","https://openalex.org/W2402514215","https://openalex.org/W2411128568","https://openalex.org/W2414536178","https://openalex.org/W2443130105","https://openalex.org/W4313333659","https://openalex.org/W4313347768","https://openalex.org/W4313376320"],"related_works":["https://openalex.org/W2020076884","https://openalex.org/W2074798933","https://openalex.org/W1992841547","https://openalex.org/W1848733318","https://openalex.org/W2057017726","https://openalex.org/W3034738343","https://openalex.org/W2385431627","https://openalex.org/W1985554164","https://openalex.org/W2269573895","https://openalex.org/W1967092468"],"abstract_inverted_index":{"Interleukin":[0],"(IL)-1beta-deficient":[1],"(IL-1beta(-/-))":[2],"mice":[3,113,122],"were":[4,79],"assessed":[5],"for":[6],"cytokine":[7,63,101,126],"production":[8,64,127],"during":[9,159],"pregnancy.":[10,160],"A":[11],"significant":[12],"reduction":[13],"in":[14,23,55,62,81,103,111,130,139,142],"nuclear":[15],"factor":[16],"(NF)-kappaB":[17],"p65":[18,151],"protein":[19,152],"content":[20],"was":[21,116,136],"observed":[22],"the":[24,68,82],"uteri":[25],"and":[26,36,77,87,107],"spleens":[27],"of":[28,51,70,97],"pregnant":[29,56,93],"IL-1beta(-/-)":[30,57,108,112,140],"mice,":[31],"as":[32],"demonstrated":[33],"by":[34,66,156],"immunohistochemistry":[35],"Western":[37],"immunoblot":[38],"analysis.":[39],"In":[40],"addition,":[41],"electromobility":[42],"gel":[43],"shift":[44],"assay":[45],"revealed":[46],"less":[47],"DNA":[48],"binding":[49],"activity":[50],"NF-kappaB":[52,150],"p65-containing":[53],"complex":[54],"mice.":[58,94,144],"To":[59],"investigate":[60],"differences":[61],"regulated":[65,155],"NF-kappaB,":[67],"levels":[69,102],"tumor":[71],"necrosis":[72],"factor-alpha,":[73],"macrophage":[74],"inflammatory":[75],"protein-1alpha,":[76],"interferon-gamma":[78],"measured":[80],"uterine":[83],"wall,":[84],"spleen":[85,88],"homogenates,":[86],"cell":[89],"cultures":[90],"obtained":[91],"from":[92,120],"Endocervical":[95],"administration":[96],"lipopolysaccharide":[98],"(LPS)":[99],"increased":[100],"both":[104],"wild-type":[105],"(IL-1beta(+/+))":[106],"animals,":[109],"but":[110],"this":[114],"response":[115],"50-75%":[117],"lower.":[118],"Splenocytes":[119],"nonpregnant":[121],"exhibited":[123],"decreased":[124],"LPS-induced":[125],"when":[128],"primed":[129],"vitro":[131],"with":[132],"progesterone.":[133],"This":[134],"suppression":[135],"25%":[137],"greater":[138],"than":[141],"IL-1beta(+/+)":[143],"These":[145],"data":[146],"suggest":[147],"that":[148],"constitutive":[149],"synthesis":[153],"is":[154],"IL-1beta,":[157],"particularly":[158]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}