{"id":"https://openalex.org/W2285186352","doi":null,"title":"Menopause increases the iron storage protein ferritin in skin.","display_name":"Menopause increases the iron storage protein ferritin in skin.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2285186352","mag":"2285186352","pmid":"https://pubmed.ncbi.nlm.nih.gov/23752032"},"language":"en","primary_location":{"id":"pmid:23752032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23752032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cosmetic science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063485910","display_name":"Edward Pelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Pelle","raw_affiliation_strings":["Department of Medicine and Environmental Medicine, New York University School of Medicine, NY, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Environmental Medicine, New York University School of Medicine, NY, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063440871","display_name":"Jinlong Jian","orcid":"https://orcid.org/0000-0002-7008-9659","observed_orcids":["https://orcid.org/0000-0002-7008-9659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinlong Jian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360401","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0003-0564-9215","observed_orcids":["https://orcid.org/0000-0003-0564-9215","https://orcid.org/0009-0005-3941-2824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007604384","display_name":"Neelam Muizzuddin","orcid":"https://orcid.org/0000-0001-7292-7399","observed_orcids":["https://orcid.org/0000-0001-7292-7399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neelam Muizzuddin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101545579","display_name":"Qing H. Yang","orcid":"https://orcid.org/0009-0001-1481-5265","observed_orcids":["https://orcid.org/0009-0001-1481-5265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021013323","display_name":"Jisen Dai","orcid":"https://orcid.org/0000-0002-1065-2219","observed_orcids":["https://orcid.org/0000-0002-1065-2219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jisen Dai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036496847","display_name":"Daniel H. Maes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Maes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071043766","display_name":"Nadine Pernodet","orcid":"https://orcid.org/0009-0005-9153-5645","observed_orcids":["https://orcid.org/0009-0005-9153-5645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadine Pernodet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015232791","display_name":"Daniel B. Yarosh","orcid":"https://orcid.org/0000-0002-0786-5985","observed_orcids":["https://orcid.org/0000-0002-0786-5985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel B Yarosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068136062","display_name":"Krystyna Frenkel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystyna Frenkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101605250","display_name":"Xi Huang","orcid":"https://orcid.org/0009-0008-5667-2662","observed_orcids":["https://orcid.org/0009-0008-5667-2662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6389,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.73879658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"64","issue":"3","first_page":"175","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.18569999933242798,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.09549999982118607,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.906000018119812},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.42100000381469727},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/epidermal-keratinocytes","display_name":"epidermal keratinocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.875},{"id":"https://openalex.org/keywords/photoaging","display_name":"photoaging","score":0.9210000038146973},{"id":"https://openalex.org/keywords/iron-excretion","display_name":"iron excretion","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.7975709438323975},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.7348974347114563},{"id":"https://openalex.org/C2776003677","wikidata":"https://www.wikidata.org/wiki/Q2738617","display_name":"Desquamation","level":2,"score":0.6649377346038818},{"id":"https://openalex.org/C2779771394","wikidata":"https://www.wikidata.org/wiki/Q12171","display_name":"Menstruation","level":2,"score":0.5582154989242554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5510351657867432},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5366802215576172},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4575272500514984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4479783773422241},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.4312211275100708},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.418948769569397},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.4160225987434387},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39720338582992554},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29420608282089233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26787155866622925},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23752032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23752032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cosmetic science","raw_type":"Journal Article"},{"id":"mag:2285186352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23752032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2523375882","https://openalex.org/W2013238343","https://openalex.org/W1992835764","https://openalex.org/W4413107323","https://openalex.org/W7048071678","https://openalex.org/W4385878909","https://openalex.org/W2885739783","https://openalex.org/W4401123756","https://openalex.org/W2331960294","https://openalex.org/W7123361044"],"abstract_inverted_index":{"Menstruation":[0],"and":[1,45,65,71,132,150],"desquamation":[2],"are":[3],"important":[4],"routes":[5],"for":[6],"humans":[7],"to":[8,108,143],"excrete":[9],"iron.":[10],"Because":[11],"menstruation":[12],"is":[13,126],"no":[14],"longer":[15],"available":[16],"in":[17,20,30,34,52,74,83,93,137],"postmenopausal":[18,31,47,75],"women,":[19],"the":[21,53,144],"present":[22],"study,":[23],"we":[24],"examined":[25],"whether":[26],"iron":[27,131,136],"accumulates":[28],"more":[29],"skin":[32,76,85,125,138,148],"than":[33,82],"premenopausal":[35,84],"skin.":[36],"Skin":[37],"biopsy":[38],"samples":[39],"were":[40,57,69],"obtained":[41],"from":[42],"six":[43,46],"pre-":[44],"Caucasian":[48],"women.":[49],"Iron":[50],"levels":[51,103],"form":[54],"of":[55,104,130,146],"ferritin":[56,105],"42%":[58],"higher,":[59],"but":[60],"vascular":[61],"endothelial":[62],"growth":[63],"factor":[64],"total":[66],"antioxidant":[67],"capacity":[68],"45%":[70],"34%":[72],"lower":[73],"(58.8":[77],"\u00b1":[78,87],"1.3":[79],"years":[80,89],"old)":[81],"(41.6":[86],"1.7":[88],"old),":[90],"respectively.":[91],"Moreover,":[92],"vitro":[94],"cultured":[95],"normal":[96],"human":[97,110,116],"epidermal":[98],"keratinocytes":[99],"had":[100],"surprisingly":[101],"high":[102],"when":[106],"compared":[107],"immortalized":[109],"breast":[111],"epithelial":[112],"MCF-10A":[113],"cells":[114],"or":[115],"liver":[117],"HepG2":[118],"cancer":[119],"cells.":[120],"Our":[121],"results":[122],"indicate":[123],"that":[124,133],"a":[127],"cellular":[128],"repository":[129],"menopause":[134],"increases":[135],"and,":[139],"thus,":[140],"may":[141],"contribute":[142],"manifestation":[145],"accelerated":[147],"aging":[149,152],"photo":[151],"after":[153],"menopause.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}