{"id":"https://openalex.org/W2285004359","doi":null,"title":"Phenotypics study of mutant embryos for the gene ADTK1 in mice","display_name":"Phenotypics study of mutant embryos for the gene ADTK1 in mice","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2285004359","mag":"2285004359"},"language":"en","primary_location":{"id":"pmh:oai:sapientia.ualg.pt:10400.1/3026","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.1/3026","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.1/3026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Cunha, N\u00eddia Sofia Maltez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cunha, N\u00eddia Sofia Maltez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.6060000061988831},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.984000027179718},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.7260000109672546},{"id":"https://openalex.org/keywords/anterior-visceral-endoderm","display_name":"anterior visceral endoderm","score":0.8429999947547913},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.847000002861023},{"id":"https://openalex.org/keywords/neural-tube-closure","display_name":"neural tube closure","score":0.9179999828338623},{"id":"https://openalex.org/keywords/limb-shortening","display_name":"limb shortening","score":0.6639999747276306},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6815212368965149},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5751956701278687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5520843267440796},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5235483050346375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.472128689289093}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:sapientia.ualg.pt:10400.1/3026","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.1/3026","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:sapientia.ualg.pt:10400.1/3026","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.1/3026","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W11653250","https://openalex.org/W1487181994","https://openalex.org/W1495114372","https://openalex.org/W1596549154","https://openalex.org/W1607201914","https://openalex.org/W1659265739","https://openalex.org/W1829700783","https://openalex.org/W1862089070","https://openalex.org/W1873268238","https://openalex.org/W1919667732","https://openalex.org/W1964494064","https://openalex.org/W1970857759","https://openalex.org/W1971230349","https://openalex.org/W1971238657","https://openalex.org/W1971689970","https://openalex.org/W1972063584","https://openalex.org/W1973537879","https://openalex.org/W1974467793","https://openalex.org/W1980616032","https://openalex.org/W1981810931","https://openalex.org/W1982499214","https://openalex.org/W1986135099","https://openalex.org/W1986958859","https://openalex.org/W1987566228","https://openalex.org/W1987655927","https://openalex.org/W1989244336","https://openalex.org/W1990498979","https://openalex.org/W1991923928","https://openalex.org/W1993593819","https://openalex.org/W1995394709","https://openalex.org/W1996273412","https://openalex.org/W1996416783","https://openalex.org/W2002614726","https://openalex.org/W2002815733","https://openalex.org/W2003028861","https://openalex.org/W2003951674","https://openalex.org/W2004881965","https://openalex.org/W2007389030","https://openalex.org/W2008777486","https://openalex.org/W2014541403","https://openalex.org/W2015125668","https://openalex.org/W2016429896","https://openalex.org/W2016727307","https://openalex.org/W2017177010","https://openalex.org/W2018313817","https://openalex.org/W2020165802","https://openalex.org/W2024215958","https://openalex.org/W2025604314","https://openalex.org/W2026126802","https://openalex.org/W2027322371","https://openalex.org/W2029908327","https://openalex.org/W2031721857","https://openalex.org/W2032894029","https://openalex.org/W2034273860","https://openalex.org/W2039542136","https://openalex.org/W2044083143","https://openalex.org/W2046966887","https://openalex.org/W2049980919","https://openalex.org/W2051998916","https://openalex.org/W2052543379","https://openalex.org/W2053071361","https://openalex.org/W2057375692","https://openalex.org/W2061909097","https://openalex.org/W2063537682","https://openalex.org/W2063778808","https://openalex.org/W2064199615","https://openalex.org/W2064208027","https://openalex.org/W2066484100","https://openalex.org/W2068801415","https://openalex.org/W2071999620","https://openalex.org/W2074292609","https://openalex.org/W2075526364","https://openalex.org/W2076812266","https://openalex.org/W2077765163","https://openalex.org/W2080404126","https://openalex.org/W2082584428","https://openalex.org/W2086259825","https://openalex.org/W2086485207","https://openalex.org/W2088601923","https://openalex.org/W2089360680","https://openalex.org/W2095643982","https://openalex.org/W2095762981","https://openalex.org/W2097966523","https://openalex.org/W2098890132","https://openalex.org/W2099587996","https://openalex.org/W2100175343","https://openalex.org/W2102665272","https://openalex.org/W2104158696","https://openalex.org/W2106118490","https://openalex.org/W2106174831","https://openalex.org/W2107141327","https://openalex.org/W2108946209","https://openalex.org/W2109052299","https://openalex.org/W2110457654","https://openalex.org/W2113998165","https://openalex.org/W2114011703","https://openalex.org/W2116070901","https://openalex.org/W2117287510","https://openalex.org/W2118311923","https://openalex.org/W2121228024","https://openalex.org/W2124852687","https://openalex.org/W2131074211","https://openalex.org/W2134894529","https://openalex.org/W2141638474","https://openalex.org/W2143973293","https://openalex.org/W2146111652","https://openalex.org/W2148440651","https://openalex.org/W2150094887","https://openalex.org/W2155187025","https://openalex.org/W2158058087","https://openalex.org/W2168350703","https://openalex.org/W2170185182","https://openalex.org/W4235104968"],"related_works":["https://openalex.org/W2026040363","https://openalex.org/W1976384802","https://openalex.org/W2427484234","https://openalex.org/W1977667441","https://openalex.org/W7096933151","https://openalex.org/W2109518192","https://openalex.org/W2051209896","https://openalex.org/W2097563852","https://openalex.org/W2168147607","https://openalex.org/W2113588019"],"abstract_inverted_index":{"A":[0,105],"differential":[1],"screening":[2],"conducted":[3],"to":[4,16],"identify":[5],"novel":[6],"genes":[7],"expressed":[8],"in":[9,88,112,132],"the":[10,17,55,71,84,96,102],"anterior":[11],"visceral":[12],"endoderm":[13],"(AVE)":[14],"led":[15],"isolation/identification":[18],"of":[19,37,73,98,109,127],"Adtk1,":[20],"a":[21,25,133],"gene":[22,100],"coding":[23],"for":[24],"protein":[26],"with":[27,63,145],"tyrosine":[28],"and":[29,47,60],"serine/threonine":[30],"kinase":[31],"domains.":[32],"The":[33],"analysis":[34,108,126],"at":[35],"birth":[36],"generated":[38],"Adtk1":[39,81,129],"mouse":[40],"mutants":[41,56],"has":[42],"been":[43],"reported":[44],"by":[45,92],"our":[46],"other":[48],"laboratories.":[49],"Several":[50],"defects":[51,143],"were":[52,57],"identified,":[53],"namely":[54],"slightly":[58],"smaller":[59],"had":[61],"limbs":[62],"shortened":[64],"long":[65],"bones":[66],"than":[67],"wild-type":[68],"littermates.":[69],"In":[70],"course":[72],"this":[74,99,110],"thesis":[75],"it":[76],"was":[77],"observed":[78],"that":[79,117,139],"inbreeding":[80],"mutation":[82,111],"into":[83],"C57Bl6":[85],"background":[86,114,136],"resulted":[87],"embryonic":[89,103],"death":[90],"identified":[91],"genotyped":[93],"conceptus,":[94],"suggesting":[95],"importance":[97],"along":[101],"development.":[104],"more":[106],"in-depth":[107],"mixed":[113],"(C57Bl6/DBA)":[115],"revealed":[116,138],"Adtk1-/-":[118],"animals":[119],"also":[120],"presented":[121],"kidney":[122],"defects.":[123],"Furthermore,":[124],"preliminary":[125],"E9.5":[128],"KO":[130],"embryos":[131],"pure":[134],"inbred":[135],"(C57Bl6)":[137],"they":[140],"display":[141],"severe":[142],"associated":[144],"neural":[146],"tube":[147],"closure.":[148]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
