{"id":"https://openalex.org/W2284884492","doi":null,"title":"Surface modified Polymeric Nanoparticles for Brain Targeted drug Delivery","display_name":"Surface modified Polymeric Nanoparticles for Brain Targeted drug Delivery","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2284884492","mag":"2284884492"},"language":"en","primary_location":{"id":"mag:2284884492","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Sunita_Lahkar/publication/258154290_Surface_modified_Polymeric_Nanoparticles_for_Brain_Targeted_drug_Delivery/links/0c96052724c837e4df000000.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S35776942","display_name":"Current Trends in Biotechnology and Pharmacy","issn_l":"0973-8916","issn":["0973-8916","2230-7303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Trends in Biotechnology and Pharmacy","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012486721","display_name":"Sunita Lahkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunita Lahkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024195200","display_name":"Malay K. Das","orcid":"https://orcid.org/0000-0001-7199-4143","observed_orcids":["https://orcid.org/0000-0001-7199-4143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malay K. Das","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7199-4143","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1124,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.38351978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"4","first_page":"914","last_page":"931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surface-modification","display_name":"surface modification","score":0.593999981880188},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.847000002861023},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biodegradable-nanoparticles","display_name":"biodegradable nanoparticles","score":0.796999990940094},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.5929999947547913},{"id":"https://openalex.org/keywords/p-glycoprotein-efflux","display_name":"P-glycoprotein efflux","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7570450901985168},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7400338649749756},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7077977657318115},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.6329532861709595},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5906581282615662},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.5801081657409668},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.5384950041770935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46377936005592346},{"id":"https://openalex.org/C3019069312","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Site of action","level":2,"score":0.46195435523986816},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.41597461700439453},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.38639163970947266},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.30828624963760376},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2580905556678772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24335941672325134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15569689869880676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07541868090629578}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2284884492","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Sunita_Lahkar/publication/258154290_Surface_modified_Polymeric_Nanoparticles_for_Brain_Targeted_drug_Delivery/links/0c96052724c837e4df000000.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S35776942","display_name":"Current Trends in Biotechnology and Pharmacy","issn_l":"0973-8916","issn":["0973-8916","2230-7303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Trends in Biotechnology and Pharmacy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W128151115","https://openalex.org/W161237599","https://openalex.org/W216495100","https://openalex.org/W965009743","https://openalex.org/W1484500142","https://openalex.org/W1488991280","https://openalex.org/W1526328115","https://openalex.org/W1764204891","https://openalex.org/W1839455002","https://openalex.org/W1871974660","https://openalex.org/W1879067067","https://openalex.org/W1945926377","https://openalex.org/W1965148833","https://openalex.org/W1967367130","https://openalex.org/W1968502849","https://openalex.org/W1969914493","https://openalex.org/W1981965779","https://openalex.org/W1988330716","https://openalex.org/W1989301056","https://openalex.org/W1997963236","https://openalex.org/W2000319670","https://openalex.org/W2004759520","https://openalex.org/W2005952956","https://openalex.org/W2014485768","https://openalex.org/W2018121350","https://openalex.org/W2021448244","https://openalex.org/W2023409826","https://openalex.org/W2025486324","https://openalex.org/W2025595011","https://openalex.org/W2026559466","https://openalex.org/W2027561558","https://openalex.org/W2028672439","https://openalex.org/W2034188938","https://openalex.org/W2041072417","https://openalex.org/W2042610050","https://openalex.org/W2044985875","https://openalex.org/W2053202725","https://openalex.org/W2068491059","https://openalex.org/W2069813447","https://openalex.org/W2074754374","https://openalex.org/W2075347200","https://openalex.org/W2077851646","https://openalex.org/W2086719948","https://openalex.org/W2088393400","https://openalex.org/W2090677413","https://openalex.org/W2090866080","https://openalex.org/W2094264010","https://openalex.org/W2095698264","https://openalex.org/W2101727103","https://openalex.org/W2105680795","https://openalex.org/W2106437384","https://openalex.org/W2112007587","https://openalex.org/W2115509480","https://openalex.org/W2127609760","https://openalex.org/W2136593164","https://openalex.org/W2144232916","https://openalex.org/W2146738959","https://openalex.org/W2165807036","https://openalex.org/W2167316144","https://openalex.org/W2170341619","https://openalex.org/W2172226636","https://openalex.org/W2186736572","https://openalex.org/W2257996213","https://openalex.org/W2284480688","https://openalex.org/W2286738179","https://openalex.org/W2353752869","https://openalex.org/W2415370583","https://openalex.org/W2482776162","https://openalex.org/W2485682973","https://openalex.org/W2974092518","https://openalex.org/W3082978145","https://openalex.org/W4299864469"],"related_works":["https://openalex.org/W3022008613","https://openalex.org/W7099104294","https://openalex.org/W3100741345","https://openalex.org/W2171802467","https://openalex.org/W4252325297","https://openalex.org/W2069667649","https://openalex.org/W4324128572","https://openalex.org/W2136348158","https://openalex.org/W2922512057","https://openalex.org/W2319328132"],"abstract_inverted_index":{"The":[0,98],"aim":[1],"of":[2,17,31],"any":[3],"drug":[4,13,62,73,110],"delivery":[5,111],"system":[6],"is":[7],"not":[8],"only":[9],"to":[10,14,21,46],"deliver":[11],"a":[12],"specific":[15],"site":[16],"action":[18],"but":[19],"also":[20,93],"maintain":[22],"its":[23],"therapeutic":[24],"concentration":[25,63],"at":[26],"the":[27,32,40,67,82,87,95,103,113],"targeted":[28],"site.":[29],"Most":[30],"drugs":[33],"used":[34],"in":[35,60,64,80,90,108],"CNS":[36],"disorders":[37],"cannot":[38],"cross":[39],"blood":[41,83,114],"brain":[42,71,84,91,115],"barrier":[43],"(BBB)":[44],"due":[45],"their":[47],"large":[48],"molecular":[49],"size,":[50],"less":[51],"lipid":[52],"solubility":[53],"and":[54,92],"p-glycoprotein":[55],"(p-gp)":[56],"efflux":[57],"mechanism":[58],"resulting":[59],"low":[61],"brain.":[65],"Among":[66],"current":[68],"strategies":[69],"for":[70],"targeting":[72],"delivery,":[74],"biodegradable":[75],"polymeric":[76,106],"nanoparticles":[77,107],"are":[78],"significant":[79],"delimiting":[81],"barrier,":[85],"increasing":[86],"loading":[88],"efficiency":[89],"reducing":[94],"peripheral":[96],"toxicity.":[97],"present":[99],"review":[100],"emphasizes":[101],"on":[102],"surface":[104],"modified":[105],"enhancing":[109],"across":[112],"barrier.":[116]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}