{"id":"https://openalex.org/W2284667990","doi":"https://doi.org/10.1007/978-3-0348-8847-9_48","title":"Cell differentiation alters metallothionein expression in avian growth plate chondrocytes","display_name":"Cell differentiation alters metallothionein expression in avian growth plate chondrocytes","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2284667990","doi":"https://doi.org/10.1007/978-3-0348-8847-9_48","mag":"2284667990"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-0348-8847-9_48","doi":"https://doi.org/10.1007/978-3-0348-8847-9_48","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-8847-9_48","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallothionein IV","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4256081844","display_name":"Metallothionein IV"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071805375","display_name":"Glenn R. Sauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn R. Sauer","raw_affiliation_strings":["Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111685519","display_name":"Licia N.Y. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Licia N. Y. Wu","raw_affiliation_strings":["Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103355021","display_name":"Daotai Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daotai Nie","raw_affiliation_strings":["Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109997080","display_name":"Roy E. Wuthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy E. Wuthier","raw_affiliation_strings":["Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemistry & Biochemistry, University of South Carolina, Columbia, SC, 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"333","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.6809999942779541},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.7459999918937683},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.7099999785423279},{"id":"https://openalex.org/keywords/matrix-vesicles","display_name":"matrix vesicles","score":0.6949999928474426},{"id":"https://openalex.org/keywords/extracellular-matrix-calcification","display_name":"extracellular matrix calcification","score":0.7409999966621399},{"id":"https://openalex.org/keywords/metal-ion-metabolism","display_name":"metal ion metabolism","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7106712460517883},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6600431203842163},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.6457556486129761},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5539429187774658},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4902963936328888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.470418244600296},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46064239740371704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45971181988716125},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.43135398626327515},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.3727228045463562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2318631410598755},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19965872168540955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-0348-8847-9_48","doi":"https://doi.org/10.1007/978-3-0348-8847-9_48","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-8847-9_48","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallothionein IV","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1533065115","https://openalex.org/W1595556526","https://openalex.org/W1595972372","https://openalex.org/W1981966393","https://openalex.org/W1985109410","https://openalex.org/W1985185954","https://openalex.org/W1985394791","https://openalex.org/W2007904889","https://openalex.org/W2012793379","https://openalex.org/W2037296957","https://openalex.org/W2055667796","https://openalex.org/W2098118319","https://openalex.org/W2099931271","https://openalex.org/W2103461739","https://openalex.org/W2143417663","https://openalex.org/W2149439703","https://openalex.org/W2214671441","https://openalex.org/W2218661003","https://openalex.org/W4231713627","https://openalex.org/W4250221563"],"related_works":["https://openalex.org/W127979960","https://openalex.org/W1985185954","https://openalex.org/W2037296957","https://openalex.org/W2044276555","https://openalex.org/W2012793379","https://openalex.org/W1859770441","https://openalex.org/W2345595391","https://openalex.org/W2095932559","https://openalex.org/W2067224785","https://openalex.org/W1530516996"],"abstract_inverted_index":{"Endochondral":[0],"bone":[1,18],"formation":[2,117],"represents":[3],"the":[4,13,22,47,91,104,110,167,170,194,201,207],"primary":[5],"mechanism":[6],"of":[7,37,42,49,94,113,157,169],"vertebrate":[8],"skeletal":[9],"development":[10],"and":[11,53,75,81,108,137,140,181,191,200],"is":[12,44,131,198],"means":[14],"by":[15,46,71,189,193],"which":[16,43],"longitudinal":[17],"growth":[19,24,30,136,178],"occurs":[20],"in":[21,55,124,145,161,176],"epiphyseal":[23],"plate":[25,31,179],"[1].":[26],"During":[27],"this":[28,95],"process":[29,197],"chondrocytes":[32],"progress":[33],"through":[34,66],"a":[35,67,78,154],"series":[36],"distinct":[38],"developmental":[39,96],"stages,":[40],"each":[41],"characterized":[45,70],"expression":[48,168],"specific":[50],"marker":[51],"proteins":[52],"changes":[54],"electrolyte":[56],"metabolism.":[57],"This":[58,196],"progression":[59],"proceeds":[60],"from":[61,103],"an":[62,83,142],"early":[63],"resting":[64],"stage,":[65],"proliferative":[68],"stage":[69,80,87],"active":[72],"cell":[73,105,183],"division":[74],"matrix":[76,99,120,146],"synthesis,":[77],"hypertrophic":[79],"finally,":[82],"apoptotic":[84],"terminally":[85],"differentiated":[86],"[2,":[88],"3].":[89],"In":[90,150],"later":[92],"stages":[93],"cascade,":[97],"extracellular":[98],"vesicles":[100],"are":[101],"released":[102],"membrane":[106],"[4]":[107],"become":[109],"initial":[111],"sites":[112],"calcium":[114],"phosphate":[115],"mineral":[116],"thereby":[118],"triggering":[119],"calcification":[121],"[5].":[122],"Studies":[123],"our":[125],"laboratory":[126],"have":[127],"shown":[128],"that":[129],"zinc":[130],"essential":[132],"to":[133,152],"normal":[134],"chondrocyte":[135,182],"differentiation":[138],"[6]":[139],"plays":[141],"important":[143],"role":[144],"vesicle":[147],"mineralization":[148],"[7].":[149],"order":[151],"gain":[153],"better":[155],"understanding":[156],"metal":[158],"ion":[159],"metabolism":[160],"these":[162],"calcifying":[163],"cells,":[164],"we":[165],"examined":[166],"intracellular":[171],"Zn-binding":[172],"protein":[173],"metallothionein":[174],"(MT)":[175],"avian":[177],"tissue":[180],"cultures.":[184],"These":[185],"keywords":[186,202],"were":[187],"added":[188],"machine":[190],"not":[192],"authors.":[195],"experimental":[199],"may":[203],"be":[204],"updated":[205],"as":[206],"learning":[208],"algorithm":[209],"improves.":[210]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}