{"id":"https://openalex.org/W2284578529","doi":null,"title":"Genetics of HIV-associated sensory neuropathy in black Southern Africans","display_name":"Genetics of HIV-associated sensory neuropathy in black Southern Africans","publication_year":2014,"publication_date":"2014-02-18","ids":{"openalex":"https://openalex.org/W2284578529","mag":"2284578529"},"language":"en","primary_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/13831","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net10539/13831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043589991","display_name":"Liesl M. Hendry","orcid":"https://orcid.org/0000-0002-0538-2023","observed_orcids":["https://orcid.org/0000-0002-0538-2023"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liesl M. Hendry","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0538-2023","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043589991"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.15610000491142273,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-sensory-neuropathy","display_name":"HIV-associated sensory neuropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8840000033378601},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tag-snps","display_name":"tag SNPs","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/il12b","display_name":"IL12B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.800000011920929},{"id":"https://openalex.org/keywords/il1b","display_name":"IL1B","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":1.0},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.7540000081062317},{"id":"https://openalex.org/keywords/african-ancestry","display_name":"African ancestry","score":0.4650000035762787},{"id":"https://openalex.org/keywords/population-specific-genetic-association","display_name":"population-specific genetic association","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2908603061","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Sensory neuropathy","level":2,"score":0.8117073774337769},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4918854236602783},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.46495044231414795},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.464641809463501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37213167548179626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3565976321697235},{"id":"https://openalex.org/C53553401","wikidata":"https://www.wikidata.org/wiki/Q47307","display_name":"Genealogy","level":1,"score":0.335917592048645},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2422352135181427},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.1621074378490448},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.15418565273284912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1530567705631256}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:wiredspace.wits.ac.za:10539/13831","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net10539/13831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2284578529","doi":null,"is_oa":false,"landing_page_url":"https://wiredspace.wits.ac.za/handle/10539/13831","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W1491990920","https://openalex.org/W1495885844","https://openalex.org/W1497954397","https://openalex.org/W1499500424","https://openalex.org/W1549097303","https://openalex.org/W1607270055","https://openalex.org/W1612226764","https://openalex.org/W1661652663","https://openalex.org/W1841237986","https://openalex.org/W1959229569","https://openalex.org/W1965771641","https://openalex.org/W1969554594","https://openalex.org/W1974297138","https://openalex.org/W1975155294","https://openalex.org/W1977889303","https://openalex.org/W1978130724","https://openalex.org/W1978286026","https://openalex.org/W1978515480","https://openalex.org/W1978678208","https://openalex.org/W1978725214","https://openalex.org/W1978902758","https://openalex.org/W1979100111","https://openalex.org/W1980977100","https://openalex.org/W1982982131","https://openalex.org/W1983473854","https://openalex.org/W1987594513","https://openalex.org/W1988209540","https://openalex.org/W1988502367","https://openalex.org/W1993285878","https://openalex.org/W1994292108","https://openalex.org/W1997093375","https://openalex.org/W1997343220","https://openalex.org/W1998717100","https://openalex.org/W2000498382","https://openalex.org/W2000814289","https://openalex.org/W2006576432","https://openalex.org/W2010591910","https://openalex.org/W2015756509","https://openalex.org/W2019562479","https://openalex.org/W2027641132","https://openalex.org/W2028892759","https://openalex.org/W2029023661","https://openalex.org/W2030541760","https://openalex.org/W2032204511","https://openalex.org/W2032628817","https://openalex.org/W2033743981","https://openalex.org/W2033823503","https://openalex.org/W2036969218","https://openalex.org/W2037890420","https://openalex.org/W2039170389","https://openalex.org/W2042823677","https://openalex.org/W2042969691","https://openalex.org/W2043487230","https://openalex.org/W2044639383","https://openalex.org/W2044921400","https://openalex.org/W2045586900","https://openalex.org/W2045592358","https://openalex.org/W2049015703","https://openalex.org/W2049871886","https://openalex.org/W2050822001","https://openalex.org/W2055353922","https://openalex.org/W2058401000","https://openalex.org/W2060491215","https://openalex.org/W2062415421","https://openalex.org/W2063274987","https://openalex.org/W2066023492","https://openalex.org/W2066110072","https://openalex.org/W2066845489","https://openalex.org/W2067212451","https://openalex.org/W2069333051","https://openalex.org/W2069971071","https://openalex.org/W2071917546","https://openalex.org/W2071973495","https://openalex.org/W2073527744","https://openalex.org/W2073739597","https://openalex.org/W2075400749","https://openalex.org/W2076580743","https://openalex.org/W2079395838","https://openalex.org/W2081881569","https://openalex.org/W2082556460","https://openalex.org/W2084040734","https://openalex.org/W2087214422","https://openalex.org/W2087333063","https://openalex.org/W2088163920","https://openalex.org/W2088189953","https://openalex.org/W2089157910","https://openalex.org/W2089405771","https://openalex.org/W2089844538","https://openalex.org/W2090196236","https://openalex.org/W2092108597","https://openalex.org/W2092460680","https://openalex.org/W2092595668","https://openalex.org/W2094162828","https://openalex.org/W2095905661","https://openalex.org/W2106012138","https://openalex.org/W2109599974","https://openalex.org/W2111374432","https://openalex.org/W2117478646","https://openalex.org/W2117682276","https://openalex.org/W2118094114","https://openalex.org/W2118525034","https://openalex.org/W2118582599","https://openalex.org/W2128016314","https://openalex.org/W2128399345","https://openalex.org/W2129316818","https://openalex.org/W2131090034","https://openalex.org/W2135540915","https://openalex.org/W2136588877","https://openalex.org/W2139231561","https://openalex.org/W2139743596","https://openalex.org/W2139898757","https://openalex.org/W2140026462","https://openalex.org/W2141820415","https://openalex.org/W2142672496","https://openalex.org/W2144722464","https://openalex.org/W2147079101","https://openalex.org/W2148732309","https://openalex.org/W2148987122","https://openalex.org/W2149479217","https://openalex.org/W2149756965","https://openalex.org/W2151291137","https://openalex.org/W2151345855","https://openalex.org/W2152269778","https://openalex.org/W2152579567","https://openalex.org/W2155412494","https://openalex.org/W2156364336","https://openalex.org/W2156564520","https://openalex.org/W2161633633","https://openalex.org/W2162530578","https://openalex.org/W2170756333","https://openalex.org/W2217809488","https://openalex.org/W2322798515","https://openalex.org/W2398077306","https://openalex.org/W2400861285","https://openalex.org/W2442995036","https://openalex.org/W4293384371"],"related_works":["https://openalex.org/W2618040105","https://openalex.org/W1978919566","https://openalex.org/W1985532708","https://openalex.org/W2071908346","https://openalex.org/W6921052074","https://openalex.org/W6958295599","https://openalex.org/W1491990920","https://openalex.org/W2068127809","https://openalex.org/W6920738344","https://openalex.org/W2299116123"],"abstract_inverted_index":{"HIV-associated":[0],"sensory":[1],"neuropathy":[2],"(HIV-SN)":[3],"is":[4,19,291],"a":[5,78,153,268],"common":[6,15],"complication":[7],"associated":[8,86,207],"with":[9,87,127,156,180,195,208,237],"human":[10],"immunodeficiency":[11],"virus":[12],"(HIV)-infection.":[13],"A":[14],"symptom":[16],"of":[17,49,61,67,83,134,142,176,189,232,261,267,274,307],"HIV-SN":[18,37,91,184,209],"pain.":[20],"Variation":[21],"at":[22],"specific":[23],"loci":[24],"within":[25],"certain":[26],"candidate":[27],"genes":[28,84,95,136,205],"has":[29,240],"been":[30,57,241],"suggested":[31],"to":[32,35,43,72,89,131,172,182,297],"alter":[33],"susceptibility":[34,42,88,102,181,210,214],"developing":[36,44,90,183],"as":[38,40],"well":[39],"the":[41,47,50,68,123,135,174,177,204,233,262,265,272,287,305],"pain":[45,51,101,115,186,190,213,223],"and":[46,93,96,98,103,110,159,185,187,201,220,229,280,286],"intensity":[48,104,191,224],"experienced.":[52],"Few":[53],"studies,":[54],"however,":[55],"have":[56],"conducted":[58],"in":[59,77,100,112,122,137,192,203,243,246,283,312],"individuals":[60],"black":[62,79],"African":[63,81,139,294],"ancestry.":[64],"The":[65],"aim":[66],"current":[69],"research":[70],"was":[71,149],"conduct":[73],"an":[74,138,164],"in-depth":[75],"study,":[76],"Southern":[80,293],"population,":[82],"previously":[85,143],"(TNFA":[92,211,215,225],"surrounding":[94],"IL12B)":[97],"variations":[99],"(GCH1,":[105],"KCNS1,":[106,218,227],"IL1B,":[107],"IL6,":[108],"CCL2":[109],"CCR2)":[111,221],"other":[113],"neuropathic":[114],"states.":[116],"Single":[117],"nucleotide":[118],"polymorphisms":[119],"(SNPs)":[120],"identified":[121],"literature":[124],"were":[125,161,169,235],"supplemented":[126],"population":[128,295],"appropriate":[129],"tagSNPs":[130],"improve":[132],"assessment":[133],"population.":[140],"Genotyping":[141],"collected":[144],"deoxyribonucleic":[145],"acid":[146],"(DNA)":[147],"samples":[148],"carried":[150],"out":[151],"using":[152],"GoldenGate":[154],"assay":[155],"VeraCode":[157],"microbeads":[158],"data":[160],"read":[162],"on":[163],"Illumina":[165],"BeadXpress":[166],"Reader.":[167],"Data":[168],"statistically":[170],"analysed":[171],"assess":[173],"association":[175,310],"genetic":[178,309],"variants":[179],"variability":[188],"those":[193],"patients":[194],"painful":[196],"HIV-SN.":[197],"Although":[198],"some":[199,284],"SNPs":[200],"haplotypes":[202],"investigated":[206],"region),":[212],"region,":[216,226],"IL12B,":[217],"IL6":[219],"or":[222,258],"IL1B":[228],"IL6),":[230],"none":[231],"results":[234],"consistent":[236],"that":[238,254,289],"which":[239],"found":[242],"previous":[244],"studies":[245,311],"non-African":[247],"populations.":[248],"Reasons":[249],"for":[250,299],"this":[251],"may":[252],"be":[253],"associations":[255],"are":[256],"population-specific":[257],"model-specific.":[259],"Limitations":[260],"study":[263],"included":[264],"\\nuse":[266],"relatively":[269],"small":[270],"sample,":[271],"method":[273],"sampling":[275],"(convenience":[276],"sampling),":[277],"genotyping":[278],"failure":[279],"tagging":[281],"inefficiency":[282],"instances,":[285],"fact":[288],"there":[290],"no":[292],"dataset":[296],"use":[298],"tagSNP":[300],"selection.":[301],"My":[302],"findings":[303],"emphasise":[304],"importance":[306],"conducting":[308],"separate":[313],"ethnic":[314],"groups.":[315]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
