{"id":"https://openalex.org/W2284349265","doi":"https://doi.org/10.1128/jvi.02976-15","title":"New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor \u03b21 Production through Glucose-Regulated Protein 94","display_name":"New Mechanism of Hepatic Fibrogenesis: Hepatitis C Virus Infection Induces Transforming Growth Factor \u03b21 Production through Glucose-Regulated Protein 94","publication_year":2015,"publication_date":"2015-12-31","ids":{"openalex":"https://openalex.org/W2284349265","doi":"https://doi.org/10.1128/jvi.02976-15","mag":"2284349265","pmid":"https://pubmed.ncbi.nlm.nih.gov/26719248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4810663"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.02976-15","doi":"https://doi.org/10.1128/jvi.02976-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02976-15","pdf_url":"https://jvi.asm.org/content/jvi/90/6/3044.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/90/6/3044.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041684150","display_name":"Min Hyeok Jee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Hyeok Jee","raw_affiliation_strings":["POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087870336","display_name":"Ka Young Hong","orcid":"https://orcid.org/0000-0002-6079-8259","observed_orcids":["https://orcid.org/0000-0002-6079-8259"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ka Young Hong","raw_affiliation_strings":["POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042010713","display_name":"Ji Hoon Park","orcid":"https://orcid.org/0000-0002-6794-4909","observed_orcids":["https://orcid.org/0000-0002-6794-4909"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Hoon Park","raw_affiliation_strings":["POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694895","display_name":"Jae Seung Lee","orcid":"https://orcid.org/0000-0002-8421-3155","observed_orcids":["https://orcid.org/0000-0002-8421-3155"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Seung Lee","raw_affiliation_strings":["Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046153563","display_name":"Hee Sun Kim","orcid":"https://orcid.org/0000-0002-7698-8794","observed_orcids":["https://orcid.org/0000-0002-7698-8794"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Sun Kim","raw_affiliation_strings":["Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021521418","display_name":"Song Hee Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Song Hee Lee","raw_affiliation_strings":["POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030924151","display_name":"Sung Key Jang","orcid":"https://orcid.org/0000-0001-6620-8881","observed_orcids":["https://orcid.org/0000-0001-6620-8881"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Key Jang","raw_affiliation_strings":["POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"POSTECH Biotech Center, Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123900574"],"apc_list":null,"apc_paid":null,"fwci":1.8651,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86315965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"6","first_page":"3044","last_page":"3055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.08079999685287476,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8259999752044678},{"id":"https://openalex.org/keywords/glucose-regulated-protein-94","display_name":"glucose-regulated protein 94","score":0.953000009059906},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7270570397377014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7175821661949158},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6278716325759888},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5919206738471985},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5660719275474548},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5273005962371826},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.5187051892280579},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5134447813034058},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.48227789998054504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4630013108253479},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3893265724182129},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3458348214626312},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2918410301208496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21384349465370178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16488614678382874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1322648823261261},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.02976-15","doi":"https://doi.org/10.1128/jvi.02976-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02976-15","pdf_url":"https://jvi.asm.org/content/jvi/90/6/3044.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4810663","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4810663","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:26719248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26719248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:oasis.postech.ac.kr:2014.oak/29894","doi":null,"is_oa":false,"landing_page_url":"https://oasis.postech.ac.kr/handle/2014.oak/29894","pdf_url":null,"source":{"id":"https://openalex.org/S4306401965","display_name":"Open Access System for Information Sharing (Pohang University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123900574","host_organization_name":"Pohang University of Science and Technology","host_organization_lineage":["https://openalex.org/I123900574"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2584692527","doi":null,"is_oa":false,"landing_page_url":"https://jvi.asm.org/content/early/2015/12/28/JVI.02976-15.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1128/jvi.02976-15","doi":"https://doi.org/10.1128/jvi.02976-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02976-15","pdf_url":"https://jvi.asm.org/content/jvi/90/6/3044.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2284349265.pdf","grobid_xml":"https://content.openalex.org/works/W2284349265.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W126365190","https://openalex.org/W130223727","https://openalex.org/W163630733","https://openalex.org/W1520391110","https://openalex.org/W1565816762","https://openalex.org/W1956469105","https://openalex.org/W1963575114","https://openalex.org/W1967113037","https://openalex.org/W1967716194","https://openalex.org/W1971094896","https://openalex.org/W1973165481","https://openalex.org/W1973350436","https://openalex.org/W1975605578","https://openalex.org/W1985133515","https://openalex.org/W1990733264","https://openalex.org/W1994369106","https://openalex.org/W1995278959","https://openalex.org/W1995516336","https://openalex.org/W2005641431","https://openalex.org/W2013163515","https://openalex.org/W2014613718","https://openalex.org/W2015192989","https://openalex.org/W2015336471","https://openalex.org/W2016981683","https://openalex.org/W2023453643","https://openalex.org/W2026208522","https://openalex.org/W2032645764","https://openalex.org/W2034667224","https://openalex.org/W2036607998","https://openalex.org/W2038090008","https://openalex.org/W2047142125","https://openalex.org/W2052969362","https://openalex.org/W2070011813","https://openalex.org/W2092222191","https://openalex.org/W2093862280","https://openalex.org/W2096544389","https://openalex.org/W2104140554","https://openalex.org/W2104193042","https://openalex.org/W2106792841","https://openalex.org/W2113649995","https://openalex.org/W2126232334","https://openalex.org/W2127807231","https://openalex.org/W2128229698","https://openalex.org/W2129825724","https://openalex.org/W2147713131","https://openalex.org/W2159401975","https://openalex.org/W2161068946","https://openalex.org/W2168515791","https://openalex.org/W2413694353","https://openalex.org/W2604337567","https://openalex.org/W4243729710"],"related_works":["https://openalex.org/W2103071509","https://openalex.org/W7100522622","https://openalex.org/W2624853097","https://openalex.org/W1487503477","https://openalex.org/W2013163515","https://openalex.org/W2005641431","https://openalex.org/W2002690860","https://openalex.org/W2032745614","https://openalex.org/W1963575114","https://openalex.org/W2406660701"],"abstract_inverted_index":{"UNLABELLED:":[0],"Hepatitis":[1],"C":[2,178],"virus":[3,179],"(HCV)":[4],"is":[5,36,128,168,182],"one":[6],"of":[7,11,41,70,93,99,153,160,212,218,242,261,296],"the":[8,68,97,136,151,209,216,240,258,294],"leading":[9],"causes":[10],"chronic":[12],"liver":[13,26,91,137,173,192,297,310],"inflammatory":[14],"disease":[15],"(hepatitis),":[16],"which":[17],"often":[18],"leads":[19],"to":[20,63,111,130,250,293],"more":[21],"severe":[22],"diseases,":[23],"such":[24],"as":[25],"fibrosis,":[27,33],"cirrhosis,":[28],"and":[29,44,89,271,301],"hepatocellular":[30],"carcinoma.":[31],"Liver":[32],"in":[34,54,83,87,90,101,104,135,140,172,215,234,264,312],"particular,":[35],"a":[37,51,132,169,303],"major":[38],"pathogenic":[39],"consequence":[40],"HCV":[42,58,94,141,147,219,223,229,269,280,300,313],"infection,":[43],"transforming":[45],"growth":[46],"factor":[47],"\u03b21":[48],"(TGF-\u03b21)":[49],"plays":[50],"key":[52,133],"role":[53,134],"its":[55],"pathogenesis.":[56],"Several":[57],"proteins":[59],"have":[60,197],"been":[61],"suggested":[62,198],"either":[64],"augment":[65],"or":[66],"suppress":[67],"expression":[69],"TGF-\u03b21":[71,79,100,123,154,213,232,243,262,283],"by":[72,125,155,176,245,299],"HCV-infected":[73,84,106,126,156,200,246,265],"cells.":[74,255],"Here,":[75,206],"we":[76,144,207,226,237,267,277],"report":[77],"that":[78,122,146,185,199,228,239,279],"levels":[80,214],"are":[81],"elevated":[82],"hepatocytes":[85,107,127,201,217,247],"cultured":[86],"vitro":[88],"tissue":[92],"patients.":[95,142,220,314],"Notably,":[96],"level":[98],"media":[102],"from":[103,118],"vitro-cultured":[105],"was":[108,248],"high":[109],"enough":[110],"activate":[112,251],"primary":[113,252],"hepatic":[114,253],"stellate":[115,254],"cells":[116,157],"isolated":[117],"rats.":[119],"This":[120,290],"indicates":[121],"secreted":[124,244],"likely":[129],"play":[131],"fibrosis":[138,167,298],"observed":[139],"Moreover,":[143],"showed":[145,227],"E2":[148,281],"protein":[149,162],"triggers":[150],"production":[152,233,263],"through":[158],"overproduction":[159],"glucose-regulated":[161],"94":[163],"(GRP94).":[164],"IMPORTANCE:":[165],"Hepatic":[166],"critical":[170],"step":[171],"cirrhosis":[174,311],"caused":[175],"hepatitis":[177],"infection.":[180],"It":[181],"already":[183],"known":[184],"immune":[186],"cells,":[187,190],"including":[188],"Kupffer":[189],"mediate":[191],"fibrosis.":[193],"Recently,":[194],"several":[195],"papers":[196],"also":[202],"significantly":[203],"produce":[204],"TGF-\u03b21.":[205],"provide":[208],"first":[210],"examination":[211],"Using":[221],"an":[222],"culture":[224],"system,":[225],"infection":[230],"increases":[231],"hepatocytes.":[235],"Furthermore,":[236],"confirmed":[238],"amount":[241],"sufficient":[249],"To":[256],"understand":[257],"molecular":[259],"basis":[260],"hepatocytes,":[266],"used":[268],"replicons":[270],"various":[272],"stable":[273],"cell":[274],"lines.":[275],"Finally,":[276],"elucidated":[278],"triggered":[282],"secretion":[284],"via":[285],"GRP94":[286],"mediated":[287],"NF-\u03baB":[288],"activation.":[289],"study":[291],"contributes":[292],"understanding":[295],"suggests":[302],"new":[304],"potential":[305],"target":[306],"(GRP94)":[307],"for":[308],"blocking":[309]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
