{"id":"https://openalex.org/W2284313982","doi":null,"title":"Avalia\u00e7\u00e3o Pr\u00e9-cl\u00ednica da Farmacocin\u00e9tica e da Toxicidade Aguda em Roedores do Candidato a F\u00e1rmaco Antitumoral LaSOM 65","display_name":"Avalia\u00e7\u00e3o Pr\u00e9-cl\u00ednica da Farmacocin\u00e9tica e da Toxicidade Aguda em Roedores do Candidato a F\u00e1rmaco Antitumoral LaSOM 65","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2284313982","mag":"2284313982"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3180186","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/60378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071062777","display_name":"Bruna Gaelzer Silva Torres","orcid":"https://orcid.org/0000-0003-2410-4448","observed_orcids":["https://orcid.org/0000-0003-2410-4448"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bruna Gaelzer Silva Torres","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2410-4448","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071062777"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.2538999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.2538999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.20739999413490295,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.10670000314712524,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-candidates","display_name":"anticancer drug candidates","score":0.722000002861023},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.984000027179718},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6359999775886536},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.6809999942779541},{"id":"https://openalex.org/keywords/linear-pharmacokinetics","display_name":"linear pharmacokinetics","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.4490000009536743},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.5839999914169312},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.5270000100135803},{"id":"https://openalex.org/keywords/preclinical-drug-development","display_name":"preclinical drug development","score":0.5370000004768372},{"id":"https://openalex.org/keywords/tissue-homogenization","display_name":"tissue homogenization","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4202331304550171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32768428325653076},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.24372470378875732}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:americanae.aecid.es:3180186","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:lume.ufrgs.br:10183/60378","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60378","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/60378","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60378","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2284313982","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/bitstream/handle/10183/60378/000862373.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3180186","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W69856591","https://openalex.org/W1143179928","https://openalex.org/W1482818782","https://openalex.org/W1498155822","https://openalex.org/W1567784973","https://openalex.org/W1967416134","https://openalex.org/W1979013550","https://openalex.org/W1985701763","https://openalex.org/W1993784371","https://openalex.org/W2004637463","https://openalex.org/W2004934711","https://openalex.org/W2010433606","https://openalex.org/W2020246613","https://openalex.org/W2028421166","https://openalex.org/W2029178312","https://openalex.org/W2031894327","https://openalex.org/W2032721707","https://openalex.org/W2040228024","https://openalex.org/W2044197183","https://openalex.org/W2046218393","https://openalex.org/W2049103009","https://openalex.org/W2052957185","https://openalex.org/W2058946848","https://openalex.org/W2060807305","https://openalex.org/W2067491763","https://openalex.org/W2077056852","https://openalex.org/W2086081719","https://openalex.org/W2095542113","https://openalex.org/W2101018764","https://openalex.org/W2114500428","https://openalex.org/W2120863112","https://openalex.org/W2130134612","https://openalex.org/W2148323023","https://openalex.org/W2165836181","https://openalex.org/W2234738778","https://openalex.org/W2403245025","https://openalex.org/W2408748341","https://openalex.org/W2501923200","https://openalex.org/W2791114118","https://openalex.org/W3206650004"],"related_works":["https://openalex.org/W7119280238","https://openalex.org/W2076192771","https://openalex.org/W2944816361","https://openalex.org/W7119264142","https://openalex.org/W7120469678","https://openalex.org/W2338032277","https://openalex.org/W7101062814","https://openalex.org/W1536765416","https://openalex.org/W784583690","https://openalex.org/W2967328396"],"abstract_inverted_index":{"Objetivo:":[0],"Contribuir":[1],"para":[2,157,236,318,369],"o":[3,109,276,319,370],"desenvolvimento":[4,360],"do":[5,32],"candidato":[6],"a":[7,39,87,158,178,210,267,278,304],"antitumoral":[8],"(LaSOM":[9],"65)":[10],"atrav\u00e9s":[11],"da":[12,29],"avalia\u00e7\u00e3o":[13,28,159],"farmacocin\u00e9tica":[14,170],"pr\u00e9-cl\u00ednica":[15],"em":[16,73],"roedores":[17],"de":[18,44,94,99,106,111,116,130,138,145,160,174,176,212,254,270,344,372],"diferentes":[19],"doses":[20,43],"pelas":[21],"vias":[22],"i.v.,":[23,296],"p.o":[24],"e":[25,27,53,57,59,76,86,119,123,126,148,150,165,183,202,223,241,244,246,275,286,330,340],"i.p.":[26,62,215],"toxicidade":[30,112,345],"aguda":[31],"composto.":[33],"Metodologia:":[34],"LaSOM":[35,131,167,320,323],"65":[36,132,168,324],"foi":[37,82,90,133,229,253,309],"administrado":[38],"ratos":[40],"Wistar":[41],"nas":[42],"1":[45,100,177],"mg/kg":[46,55,61,101,121,128,180,214],"i.v.":[47,98,122,187,336],"bolus":[48],"(n":[49,63,102],"=":[50,64,103,191,197,204,273,281],"8),":[51],"10":[52],"30":[54,58,179],"p.o.":[56,129,182,243],"90":[60,213],"6/grupo).":[65],"As":[66],"concentra\u00e7\u00f5es":[67],"plasm\u00e1ticas":[68],"foram":[69,155,288],"quantificadas":[70],"por":[71,84,92,347],"CL-UV":[72],"m\u00e9todo":[74],"desenvolvido":[75],"validado.":[77],"A":[78,249,354],"liga\u00e7\u00e3o":[79,250],"\u00e0s":[80,251],"prote\u00ednas":[81,252],"determinada":[83],"ultrafiltra\u00e7\u00e3o":[85],"distribui\u00e7\u00e3o":[88,328],"tecidual":[89,329],"avaliada":[91],"homogeneizado":[93],"tecido":[95],"ap\u00f3s":[96,294,300,334],"administra\u00e7\u00e3o":[97,335],"3":[104,301],"animais/ponto":[105],"coleta).":[107],"Para":[108,209,303],"ensaio":[110],"aguda,":[113],"dose":[114,175,186,211],"\u00fanica":[115],"1,":[117],"2,5":[118],"5":[120],"50,":[124],"100":[125],"150":[127],"administrada":[134],"aos":[135],"animais.":[136],"Ganho":[137],"peso,":[139],"massa":[140],"relativa":[141],"dos":[142],"tecidos,":[143],"determina\u00e7\u00e3o":[144],"par\u00e2metros":[146],"bioqu\u00edmicos":[147],"hematol\u00f3gicos":[149],"uma":[151,326,331,341],"observa\u00e7\u00e3o":[152],"cl\u00ednica":[153],"detalhada":[154],"realizados":[156],"poss\u00edveis":[161],"efeitos":[162,316],"t\u00f3xicos.":[163],"Resultados":[164],"Discuss\u00e3o:":[166],"apresentou":[169,188,233],"linear":[171],"na":[172],"faixa":[173],"(i.v.,":[181],"i.p.).":[184,248],"Ap\u00f3s":[185],"um":[189,216],"CL":[190],"0,85":[192],"\u00b1":[193,199,206,221,226,256],"0,18":[194],"L/h/kg,":[195],"t1/2":[196,224],"1,8":[198],"0,7":[200],"h":[201],"Vd":[203,219],"1,76":[205],"0,24":[207],"L/kg.":[208],"aumento":[217],"no":[218,265,361],"(3,2":[220],"0,8L/Kg)":[222],"(2,9":[225],"0,9":[227],"h)":[228],"observado.":[230],"O":[231,258],"composto":[232,259],"boa":[234,338],"biodisponibilidade":[235,339],"as":[237],"administra\u00e7\u00f5es":[238,295],"extravasculares":[239],"(58":[240],"50%":[242],"73":[245],"61%":[247],"84,7":[255],"1,6%.":[257],"distribuiu-se":[260],"nos":[261],"tecidos":[262],"investigados":[263],"tendo":[264],"pulm\u00e3o":[266],"maior":[268],"taxa":[269],"penetra\u00e7\u00e3o":[271,356],"(ASCtecido/plasma":[272,280],"2,7)":[274],"c\u00e9rebro":[277],"menor":[279],"0,4).":[282],"Piloere\u00e7\u00e3o,":[283],"diarr\u00e9ia,":[284],"letargia":[285],"dispneia":[287],"os":[289,297],"sinais":[290],"cl\u00ednicos":[291],"observados":[292],"imediatamente":[293],"quais":[298],"regrediram":[299],"h.":[302],"via":[305,349],"oral":[306],"nenhuma":[307],"altera\u00e7\u00e3o":[308],"observada.":[310],"Nenhum":[311],"outro":[312],"par\u00e2metro":[313],"avaliado":[314],"demonstrou":[315,325],"tociol\u00f3gicos":[317],"65.":[321],"Conclus\u00f5es:":[322],"r\u00e1pida":[327,332],"elimina\u00e7\u00e3o":[333],"Sua":[337],"poss\u00edvel":[342],"aus\u00eancia":[343],"apresentada":[346],"esta":[348],"permitem":[350],"seu":[351,367],"uso":[352,368],"oral.":[353],"baixa":[355],"cerebral":[357],"sugere":[358],"que":[359],"\u00e2mbito":[362],"farmacot\u00e9cnico":[363],"ser\u00e1":[364],"necess\u00e1rio":[365],"visando":[366],"tratamento":[371],"gliomas.":[373]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}