{"id":"https://openalex.org/W2284028583","doi":null,"title":"Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water.","display_name":"Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W2284028583","mag":"2284028583","pmid":"https://pubmed.ncbi.nlm.nih.gov/23749905"},"language":"en","primary_location":{"id":"pmid:23749905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23749905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G Subba Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Subba Rao","raw_affiliation_strings":["Global Technology Resource Center, Streamwood, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Technology Resource Center, Streamwood, IL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109347898","display_name":"Harukuni Tokuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harukuni Tokuda","raw_affiliation_strings":["2Department of Complementary and Alternative Medicine, Clinical Research and Development, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Complementary and Alternative Medicine, Clinical Research and Development, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021060939","display_name":"Eiichiro Ichiishi","orcid":"https://orcid.org/0000-0002-3493-6152","observed_orcids":["https://orcid.org/0000-0002-3493-6152"]},"institutions":[{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiichiro Ichiishi","raw_affiliation_strings":["3Department of Internal Medicine, International University of Health and Welfare, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Internal Medicine, International University of Health and Welfare, Tochigi, Japan","institution_ids":["https://openalex.org/I79072001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111453735","display_name":"Midori Takasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180048034","display_name":"Chiba Institute of Science","ror":"https://ror.org/05hfpw879","country_code":"JP","type":"education","lineage":["https://openalex.org/I180048034"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Midori Takasaki","raw_affiliation_strings":["4Deaprtment of Pharmacology, Laboratory of Medicinal Resources, Chiba Institute of Science, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Deaprtment of Pharmacology, Laboratory of Medicinal Resources, Chiba Institute of Science, Chiba, Japan","institution_ids":["https://openalex.org/I180048034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113553041","display_name":"Akira Iida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Iida","raw_affiliation_strings":["5Faculty of Agriculture, School of Agriculture, Kinki University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Faculty of Agriculture, School of Agriculture, Kinki University, Nara, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071996788","display_name":"Nobutaka Suzuki","orcid":"https://orcid.org/0000-0002-7542-3097","observed_orcids":["https://orcid.org/0000-0002-7542-3097"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutaka Suzuki","raw_affiliation_strings":["2Department of Complementary and Alternative Medicine, Clinical Research and Development, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Complementary and Alternative Medicine, Clinical Research and Development, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021694021","display_name":"Takao Konoshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180048034","display_name":"Chiba Institute of Science","ror":"https://ror.org/05hfpw879","country_code":"JP","type":"education","lineage":["https://openalex.org/I180048034"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Konoshima","raw_affiliation_strings":["4Deaprtment of Pharmacology, Laboratory of Medicinal Resources, Chiba Institute of Science, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Deaprtment of Pharmacology, Laboratory of Medicinal Resources, Chiba Institute of Science, Chiba, Japan","institution_ids":["https://openalex.org/I180048034"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109991774","display_name":"Govind J. Kapadia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Govind J Kapadia","raw_affiliation_strings":["6Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington, DC, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, Washington, DC, U.S.A","institution_ids":["https://openalex.org/I137853757"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3513,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59701725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"33","issue":"6","first_page":"2535","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-cancer-chemoprevention","display_name":"skin cancer chemoprevention","score":0.9580000042915344},{"id":"https://openalex.org/keywords/two-stage-skin-carcinogenesis","display_name":"two-stage skin carcinogenesis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nor-1","display_name":"NOR-1","score":0.8080000281333923},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9559999704360962},{"id":"https://openalex.org/keywords/skin-papilloma","display_name":"skin papilloma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5099999904632568},{"id":"https://openalex.org/keywords/drinking-water","display_name":"drinking water","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.8063527941703796},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.6794849038124084},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6162862777709961},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5625935792922974},{"id":"https://openalex.org/C2778279444","wikidata":"https://www.wikidata.org/wiki/Q409482","display_name":"Benzophenone","level":2,"score":0.5188085436820984},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4876331388950348},{"id":"https://openalex.org/C2776350393","wikidata":"https://www.wikidata.org/wiki/Q912796","display_name":"Papilloma","level":2,"score":0.47523951530456543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4710533320903778},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4259825050830841},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4237369894981384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3347877860069275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27273881435394287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.252826452255249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2220470905303955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1578490436077118},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001577","descriptor_name":"Benzophenones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001577","descriptor_name":"Benzophenones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008812","descriptor_name":"Mice, Hairless","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013473","descriptor_name":"Sunscreening Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013473","descriptor_name":"Sunscreening Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060766","descriptor_name":"Drinking Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23749905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23749905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2284028583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23749905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W299755261","https://openalex.org/W1547570107","https://openalex.org/W1569771987","https://openalex.org/W1702654012","https://openalex.org/W1964551619","https://openalex.org/W1969281224","https://openalex.org/W1977267367","https://openalex.org/W1986299517","https://openalex.org/W1992768845","https://openalex.org/W2015373177","https://openalex.org/W2018515502","https://openalex.org/W2021837487","https://openalex.org/W2026140133","https://openalex.org/W2034845334","https://openalex.org/W2035751656","https://openalex.org/W2036066012","https://openalex.org/W2038143862","https://openalex.org/W2040252091","https://openalex.org/W2046704995","https://openalex.org/W2054602937","https://openalex.org/W2056581742","https://openalex.org/W2057603612","https://openalex.org/W2065277475","https://openalex.org/W2068808747","https://openalex.org/W2071926434","https://openalex.org/W2073405097","https://openalex.org/W2073733750","https://openalex.org/W2083096531","https://openalex.org/W2090978578","https://openalex.org/W2098519872","https://openalex.org/W2100503716","https://openalex.org/W2102722391","https://openalex.org/W2104248434","https://openalex.org/W2110372729","https://openalex.org/W2111475094","https://openalex.org/W2113648497","https://openalex.org/W2127729384","https://openalex.org/W2135800512","https://openalex.org/W2139794269","https://openalex.org/W2141850989","https://openalex.org/W2146480809","https://openalex.org/W2150417381","https://openalex.org/W2160778065","https://openalex.org/W2165269110","https://openalex.org/W2170309317","https://openalex.org/W2235570046","https://openalex.org/W2341001743","https://openalex.org/W2410105688","https://openalex.org/W2502887514","https://openalex.org/W2506771043"],"related_works":["https://openalex.org/W1971433750","https://openalex.org/W2071926434","https://openalex.org/W2033278677","https://openalex.org/W2138597160","https://openalex.org/W2019874145","https://openalex.org/W3153564564","https://openalex.org/W2122437817","https://openalex.org/W2318914769","https://openalex.org/W7096371966","https://openalex.org/W2011047085"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sunscreen":[1],"compounds":[2,143],"with":[3],"added":[4],"benefit":[5],"of":[6,34,45,47,88,108,115,126,178,198,231,253,271],"skin":[7,30,68,131,179,232,249],"cancer":[8,31,250],"prevention":[9],"have":[10],"both":[11,183],"public":[12],"and":[13,61,76,95,163,185,194,202,205,211,259,273],"commercial":[14],"interests.":[15],"Our":[16],"earlier":[17],"study":[18],"using":[19,71],"the":[20,40,48,55,65,176,219,248],"Epstein-Barr":[21],"virus":[22],"early":[23],"antigen":[24],"in":[25,41,54,56,64,112,123,191,257,262],"vitro":[26,57],"assay":[27],"reported":[28],"on":[29],"chemoprevention":[32,251],"potential":[33,252],"benzophenone":[35,49,255],"sunscreens.":[36],"We":[37],"now":[38],"report":[39],"vivo":[42],"antitumor":[43],"activity":[44,242],"two":[46],"sunscreens":[50,256],"which":[51,238],"tested":[52],"positively":[53],"assay,":[58],"octabenzone":[59],"(UV-1)":[60],"dioxybenzone":[62],"(UV-2),":[63],"two-stage":[66],"mouse":[67],"carcinogenesis":[69],"model":[70],"(\u00b1)-(E)-4-methyl-2-[-(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide":[72],"(NOR-1)":[73],"as":[74,79,137],"inducer":[75],"12-O-tetradecanoyl-phorbol-13-acetate":[77],"(TPA)":[78],"promoter.":[80,140],"MATERIALS":[81],"AND":[82],"METHODS:":[83],"Pathogen-free,":[84],"female":[85],"hairless":[86],"mice":[87,152,258],"HOS:HR-1":[89],"strain,":[90],"15":[91],"animals":[92,171],"per":[93],"control":[94,221],"test":[96,142],"groups,":[97],"were":[98,102,147,172,214],"used.":[99],"Skin":[100],"tumors":[101],"induced":[103],"by":[104,269],"a":[105,139,188,227],"single":[106],"dose":[107],"NOR-1":[109],"(390":[110],"nmol":[111,122],"100":[113,124],"\u03bcl":[114,125],"acetone).":[116],"One":[117],"week":[118,160,166],"later,":[119],"TPA":[120],"(1.7":[121],"acetone)":[127],"was":[128,226],"applied":[129],"to":[130,151,162,218,264],"twice":[132],"weekly":[133,174],"for":[134,175],"20":[135],"weeks":[136],"tumor":[138,168,192,199,206,233],"The":[141,245],"UV-I":[144],"or":[145],"UV-2":[146,223],"administered":[148],"at":[149],"0.0025%":[150],"through":[153],"drinking":[154],"water":[155],"ad":[156],"libitum,":[157],"starting":[158],"one":[159,165],"prior":[161],"stopping":[164],"after":[167],"initiation.":[169],"All":[170],"examined":[173],"development":[177],"papillomas.":[180],"RESULTS:":[181],"In":[182],"UV-1-":[184],"UV-2-treated":[186],"mice,":[187],"two-week":[189],"delay":[190],"appearance,":[193],"significant":[195],"inhibition":[196],"(p<0.001)":[197],"incidence":[200],"(50%":[201],"60%,":[203],"respectively)":[204,213],"burden":[207],"(papilloma":[208],"inhibition/mouse,":[209],"50%":[210],"70%,":[212],"observed":[215],"when":[216],"compared":[217],"positive":[220],"group.":[222],"(dihydroxy":[224],"derivative)":[225],"more":[228],"potent":[229],"inhibitor":[230],"than":[234],"UV-1":[235],"(monohydroxy":[236],"derivative),":[237],"followed":[239],"their":[240],"antioxidant":[241],"ranking.":[243],"CONCLUSION:":[244],"results":[246],"affirm":[247],"orally-ingested":[254],"warrant":[260],"studies":[261],"humans":[263],"validate":[265],"synergistic":[266],"protection":[267],"achievable":[268],"complementation":[270],"oral":[272],"topical":[274],"sunscreen":[275],"usage.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
