{"id":"https://openalex.org/W2283961973","doi":"https://doi.org/10.1111/jsr.12394","title":"Percentage of REM sleep is associated with overnight change in leptin","display_name":"Percentage of REM sleep is associated with overnight change in leptin","publication_year":2016,"publication_date":"2016-02-26","ids":{"openalex":"https://openalex.org/W2283961973","doi":"https://doi.org/10.1111/jsr.12394","mag":"2283961973","pmid":"https://pubmed.ncbi.nlm.nih.gov/26919408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4980172"},"language":"en","primary_location":{"id":"doi:10.1111/jsr.12394","doi":"https://doi.org/10.1111/jsr.12394","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jsr.12394","pdf_url":null,"source":{"id":"https://openalex.org/S123151105","display_name":"Journal of Sleep Research","issn_l":"0962-1105","issn":["0962-1105","1365-2869"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Sleep Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4980172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102873512","display_name":"Christy A. Olson","orcid":"https://orcid.org/0000-0002-4203-8475","observed_orcids":["https://orcid.org/0000-0002-4203-8475"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christy A. Olson","raw_affiliation_strings":["Department of Psychiatry and Human Behavior University of Wisconsin School of Medicine and Public Health Madison WI USA","Division of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester MN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Human Behavior University of Wisconsin School of Medicine and Public Health Madison WI USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027384039","display_name":"Nancy A. Hamilton","orcid":"https://orcid.org/0000-0001-8424-3859","observed_orcids":["https://orcid.org/0000-0001-8424-3859"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy A. Hamilton","raw_affiliation_strings":["Department of Psychology University of Kansas Lawrence KS USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology University of Kansas Lawrence KS USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084645609","display_name":"Virend Kristen Somers","orcid":"https://orcid.org/0000-0003-4045-4341","observed_orcids":["https://orcid.org/0000-0003-4045-4341"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virend K. Somers","raw_affiliation_strings":["Division of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester MN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102873512"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074"],"apc_list":{"value":4340,"currency":"USD","value_usd":4340},"apc_paid":null,"fwci":2.1437,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85407927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"4","first_page":"419","last_page":"425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.75},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sleep-stages","display_name":"sleep stages","score":0.6629999876022339},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.3840000033378601},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9195457100868225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7192139625549316},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6777937412261963},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.6749392747879028},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6518465280532837},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.5852699279785156},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.5388045310974121},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.526431679725647},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.5105613470077515},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5058140754699707},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.49372348189353943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49167782068252563},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.44763243198394775},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.4369202256202698},{"id":"https://openalex.org/C2910364982","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep Stages","level":4,"score":0.4247048497200012},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3452731966972351},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.2643468677997589},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.07766753435134888},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/jsr.12394","doi":"https://doi.org/10.1111/jsr.12394","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jsr.12394","pdf_url":null,"source":{"id":"https://openalex.org/S123151105","display_name":"Journal of Sleep Research","issn_l":"0962-1105","issn":["0962-1105","1365-2869"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Sleep Research","raw_type":"journal-article"},{"id":"pmid:26919408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26919408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of sleep research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4374702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4980172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4980172","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4980172/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Sleep Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4374702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4980172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3676659082","display_name":"Disease Mechanisms in Sleep Apnea","funder_award_id":"R01HL065176","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5033994758","display_name":"Interactions Between Obesity Risk and Insufficient Sleep","funder_award_id":"R01HL114024","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8216177471","display_name":"Sleep Restriction and Augmented Vascular Risk in Prehypertension","funder_award_id":"R01HL114676","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1591122824","https://openalex.org/W1793127045","https://openalex.org/W1967260085","https://openalex.org/W1970593689","https://openalex.org/W1971511738","https://openalex.org/W1972925546","https://openalex.org/W1987049214","https://openalex.org/W1994476196","https://openalex.org/W2007482590","https://openalex.org/W2009037172","https://openalex.org/W2014163208","https://openalex.org/W2015084556","https://openalex.org/W2023103882","https://openalex.org/W2035662131","https://openalex.org/W2041904172","https://openalex.org/W2050003210","https://openalex.org/W2055915794","https://openalex.org/W2056554779","https://openalex.org/W2057483830","https://openalex.org/W2057554134","https://openalex.org/W2103610654","https://openalex.org/W2113087631","https://openalex.org/W2113211629","https://openalex.org/W2115505164","https://openalex.org/W2125510262","https://openalex.org/W2130357926","https://openalex.org/W2146716098","https://openalex.org/W2149295638","https://openalex.org/W2161553389","https://openalex.org/W2162055998","https://openalex.org/W2188676055","https://openalex.org/W2260387628","https://openalex.org/W2525537354","https://openalex.org/W3022302886","https://openalex.org/W4321429268"],"related_works":["https://openalex.org/W2113087631","https://openalex.org/W2115505164","https://openalex.org/W4393353605","https://openalex.org/W2057554134","https://openalex.org/W3137661528","https://openalex.org/W1964615628","https://openalex.org/W7099505126","https://openalex.org/W1591122824","https://openalex.org/W2149295638","https://openalex.org/W2138330700"],"abstract_inverted_index":{"Sleep":[0],"contributes":[1],"importantly":[2],"to":[3,33,123,156],"energy":[4,210],"homeostasis,":[5],"and":[6,25,55,72,82,105,138,173,207],"may":[7,63],"impact":[8],"hormones":[9],"regulating":[10],"appetite,":[11],"such":[12],"as":[13],"leptin,":[14],"an":[15],"adipocyte-derived":[16],"hormone.":[17],"There":[18],"is":[19,47],"increasing":[20],"evidence":[21],"that":[22,111],"sleep":[23,46,56,62,71,86,119,137,153,163,175,184,202],"duration,":[24],"reduced":[26],"rapid":[27,59,83,116,134,150,181,199],"eye":[28,60,84,117,135,151,182,200],"movement":[29,61,85,118,136,152,183,201],"sleep,":[30],"are":[31,214],"linked":[32],"obesity.":[34,73],"Leptin":[35,101],"has":[36],"central":[37],"neural":[38],"effects":[39,196],"beyond":[40],"modulation":[41],"of":[42,90,115,133,149,180,197],"appetite":[43],"alone.":[44],"As":[45],"not":[48],"a":[49,65,88,112,157],"unifrom":[50],"process,":[51],"interactions":[52],"between":[53,70,79,131],"leptin":[54,81,125,139,161,205],"stages":[57],"including":[58],"play":[64],"role":[66],"in":[67,87,160,191,212],"the":[68,77,195],"relationship":[69,78,130],"This":[74],"study":[75],"examined":[76],"serum":[80],"sample":[89],"healthy":[91,96],"adults.":[92],"Participants":[93],"were":[94],"58":[95],"adults":[97],"who":[98],"underwent":[99],"polysomnography.":[100],"was":[102,109,140,154,185],"measured":[103],"before":[104],"after":[106],"sleep.":[107,128],"It":[108],"hypothesized":[110],"lower":[113,124],"percentage":[114,132,148,179],"would":[120],"be":[121],"related":[122,155],"levels":[126],"during":[127,162],"The":[129],"analysed":[141],"using":[142],"hierarchical":[143],"linear":[144],"regression.":[145],"An":[146],"increased":[147],"greater":[158,178],"reduction":[159],"even":[164],"when":[165],"controlling":[166],"for":[167],"age,":[168],"gender,":[169],"percent":[170],"body":[171],"fat":[172],"total":[174],"time.":[176],"A":[177],"accompanied":[186],"by":[187],"more":[188],"marked":[189],"reductions":[190],"leptin.":[192],"Studies":[193],"examining":[194],"selective":[198],"deprivation":[203],"on":[204,209],"levels,":[206],"hence":[208],"homeostasis":[211],"humans,":[213],"needed.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}