{"id":"https://openalex.org/W2283775893","doi":"https://doi.org/10.1152/ajprenal.1985.249.1.f107","title":"Juxtamedullary nephrons during acute metabolic alkalosis in the rat","display_name":"Juxtamedullary nephrons during acute metabolic alkalosis in the rat","publication_year":1985,"publication_date":"1985-07-01","ids":{"openalex":"https://openalex.org/W2283775893","doi":"https://doi.org/10.1152/ajprenal.1985.249.1.f107","mag":"2283775893","pmid":"https://pubmed.ncbi.nlm.nih.gov/2990237"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1985.249.1.f107","doi":"https://doi.org/10.1152/ajprenal.1985.249.1.f107","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1985.249.1.f107","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. P. Frommer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. P. Frommer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. E. Wesson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002593275","display_name":"Melvin E. Laski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. E. Laski","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112036212","display_name":"Neil A. Kurtzman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. A. Kurtzman","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9667,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.76292335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"249","issue":"1","first_page":"F107","last_page":"F116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juxtamedullary-nephron","display_name":"juxtamedullary nephron","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bicarbonate-reabsorption","display_name":"bicarbonate reabsorption","score":0.8420000076293945},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.8429087400436401},{"id":"https://openalex.org/C2779539245","wikidata":"https://www.wikidata.org/wiki/Q1428362","display_name":"Metabolic alkalosis","level":2,"score":0.7813503742218018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6820161938667297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6621415615081787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.607776403427124},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5863170027732849},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.5759185552597046},{"id":"https://openalex.org/C158171629","wikidata":"https://www.wikidata.org/wiki/Q6998414","display_name":"Net acid excretion","level":3,"score":0.548954963684082},{"id":"https://openalex.org/C2777068682","wikidata":"https://www.wikidata.org/wiki/Q512654","display_name":"Alkalosis","level":3,"score":0.5456138849258423},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.38536766171455383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25724613666534424},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.1775791049003601}],"mesh":[{"descriptor_ui":"D000471","descriptor_name":"Alkalosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005021","descriptor_name":"Ethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007671","descriptor_name":"Kidney Concentrating Ability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017693","descriptor_name":"Sodium Bicarbonate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.1985.249.1.f107","doi":"https://doi.org/10.1152/ajprenal.1985.249.1.f107","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1985.249.1.f107","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:2990237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2990237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4578448178","display_name":null,"funder_award_id":"AM-21070","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7327989058","display_name":"NEPHRONAL SITES OF DIVALENT ION TRANSPORT","funder_award_id":"5r01am021394-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097642480","https://openalex.org/W2011923581","https://openalex.org/W2167759319","https://openalex.org/W2021053546","https://openalex.org/W2279260453","https://openalex.org/W2410696169","https://openalex.org/W2042403734","https://openalex.org/W2409887329","https://openalex.org/W2339429817","https://openalex.org/W2412121734"],"abstract_inverted_index":{"The":[0,115,154,168],"renal":[1],"handling":[2],"of":[3,27,46,66,89,117,183,194,199,214],"bicarbonate":[4,22,67,134,195,215],"during":[5,223],"acute":[6,21,224],"metabolic":[7,225],"alkalosis":[8,226],"was":[9,39,95,188],"examined":[10],"in":[11,196,227],"Munich-Wistar":[12],"rats":[13,75,125],"using":[14],"micropuncture":[15],"techniques.":[16],"Group":[17],"I":[18],"received":[19],"an":[20],"load,":[23],"and":[24,70,93,97,175],"fractional":[25,192],"delivery":[26],"total":[28],"CO2":[29],"(tCO2)":[30],"(FDtCO2)":[31],"to":[32,43,123,219],"the":[33,44,47,163,180,191,197,200,220,228],"superficial":[34,217],"late":[35],"distal":[36,133],"tubule":[37],"(LD)":[38],"significantly":[40],"lower":[41],"than":[42,61,113,216],"base":[45],"papillary":[48],"collecting":[49],"duct":[50],"(B)":[51],"(18.4":[52],"+/-":[53,57,104,109,144,149],"1.7":[54],"vs.":[55,106,146],"22.9":[56],"1.5%;":[58],"P":[59,111,151],"less":[60,112],"0.01),":[62],"indicating":[63],"net":[64,87,98],"addition":[65,88,140],"between":[68,91,173],"LD":[69,92,174,187],"B.":[71],"When":[72],"acutely":[73],"bicarbonate-loaded":[74],"had":[76],"their":[77],"deep":[78],"nephrons":[79,209,218],"destroyed":[80],"with":[81,127,190],"bromoethylamine":[82],"hydrobromide":[83],"(BEA)":[84],"(group":[85,129,160],"II),":[86],"tCO2":[90],"B":[94,176],"abolished":[96],"reabsorption":[99,135],"uncovered":[100],"(FDtCO2":[101,141],"LD:":[102,142],"28.0":[103],"3.6":[105],"B:":[107,147],"17.5":[108],"2.5%;":[110],"0.01).":[114],"infusion":[116],"amiloride":[118],"(2.5":[119],"mg/kg":[120],"body":[121],"wt)":[122],"alkalotic":[124],"treated":[126],"BEA":[128],"III)":[130],"completely":[131],"inhibited":[132],"but":[136],"did":[137],"not":[138],"reestablish":[139],"27.6":[143],"1.6":[145],"26.1":[148],"3.7%;":[150],"=":[152],"NS).":[153],"values":[155],"obtained":[156],"for":[157,165,179],"sham-operated":[158],"animals":[159,184],"IV)":[161],"were":[162,171,177],"same":[164],"group":[166],"I.":[167],"patterns":[169],"that":[170,207],"observed":[172],"reproduced":[178],"four":[181],"groups":[182],"when":[185],"FDtCO2":[186],"compared":[189],"excretion":[193],"urine":[198,222],"intact":[201],"contralateral":[202],"kidney.":[203],"These":[204],"studies":[205],"suggest":[206],"juxtamedullary":[208],"contribute":[210],"a":[211],"higher":[212],"load":[213],"final":[221],"rat.":[229]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}