{"id":"https://openalex.org/W2283616663","doi":"https://doi.org/10.1007/s00198-015-3402-9","title":"Assessment of off-label use of denosumab 60 mg injection during the early postmarketing period using health insurance claims data","display_name":"Assessment of off-label use of denosumab 60 mg injection during the early postmarketing period using health insurance claims data","publication_year":2015,"publication_date":"2015-11-11","ids":{"openalex":"https://openalex.org/W2283616663","doi":"https://doi.org/10.1007/s00198-015-3402-9","mag":"2283616663","pmid":"https://pubmed.ncbi.nlm.nih.gov/26558380"},"language":"en","primary_location":{"id":"doi:10.1007/s00198-015-3402-9","doi":"https://doi.org/10.1007/s00198-015-3402-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00198-015-3402-9","pdf_url":null,"source":{"id":"https://openalex.org/S170889201","display_name":"Osteoporosis International","issn_l":"0937-941X","issn":["0937-941X","1433-2965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoporosis International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082099394","display_name":"Veena Hoffman","orcid":"https://orcid.org/0000-0003-4932-0892","observed_orcids":["https://orcid.org/0000-0003-4932-0892"]},"institutions":[{"id":"https://openalex.org/I4210124242","display_name":"Optum (United States)","ror":"https://ror.org/0370sjj75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124242"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V. Hoffman","raw_affiliation_strings":["Epidemiology, Optum , Ann Arbor, MI, USA. veena.hoffman@optum.com","Epidemiology, Optum , Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, Optum , Ann Arbor, MI, USA. veena.hoffman@optum.com","institution_ids":[]},{"raw_affiliation_string":"Epidemiology, Optum , Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I4210124242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089710591","display_name":"Fei Xue","orcid":"https://orcid.org/0000-0001-7047-8497","observed_orcids":["https://orcid.org/0000-0001-7047-8497"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Xue","raw_affiliation_strings":["Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039924006","display_name":"Betsey M. Gardstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124242","display_name":"Optum (United States)","ror":"https://ror.org/0370sjj75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Gardstein","raw_affiliation_strings":["Epidemiology, Optum , Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, Optum , Waltham, MA, USA","institution_ids":["https://openalex.org/I4210124242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016773260","display_name":"Kathleen Skerry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124242","display_name":"Optum (United States)","ror":"https://ror.org/0370sjj75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Skerry","raw_affiliation_strings":["Epidemiology, Optum , Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, Optum , Waltham, MA, USA","institution_ids":["https://openalex.org/I4210124242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108390714","display_name":"Cathy W. Critchlow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. W. Critchlow","raw_affiliation_strings":["Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029506986","display_name":"Cheryl L. Enger","orcid":"https://orcid.org/0000-0002-1007-851X","observed_orcids":["https://orcid.org/0000-0002-1007-851X"]},"institutions":[{"id":"https://openalex.org/I4210124242","display_name":"Optum (United States)","ror":"https://ror.org/0370sjj75","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Enger","raw_affiliation_strings":["Epidemiology, Optum , Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, Optum , Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I4210124242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082099394"],"corresponding_institution_ids":["https://openalex.org/I4210124242"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.3371,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.69141587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"4","first_page":"1653","last_page":"1658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.1492999941110611,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9089999794960022},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.9639999866485596},{"id":"https://openalex.org/keywords/rankl-inhibition","display_name":"RANKL inhibition","score":0.7200000286102295},{"id":"https://openalex.org/keywords/osteoclastic-bone-resorption","display_name":"osteoclast resorption","score":0.6850000023841858},{"id":"https://openalex.org/keywords/medical-record-review","display_name":"medical records review","score":0.6930000185966492},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.6850000023841858},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.7039999961853027},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.43299999833106995},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/health-insurance-claims","display_name":"health insurance claims","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.9632421135902405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8937820196151733},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5249519348144531},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.5169991254806519},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5064109563827515},{"id":"https://openalex.org/C188313352","wikidata":"https://www.wikidata.org/wiki/Q119697","display_name":"Off-label use","level":2,"score":0.4311537742614746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38198474049568176},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2114894688129425}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004363","descriptor_name":"Drug Utilization","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007348","descriptor_name":"Insurance, Health","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017723","descriptor_name":"Drug Utilization Review","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D056687","descriptor_name":"Off-Label Use","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00198-015-3402-9","doi":"https://doi.org/10.1007/s00198-015-3402-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00198-015-3402-9","pdf_url":null,"source":{"id":"https://openalex.org/S170889201","display_name":"Osteoporosis International","issn_l":"0937-941X","issn":["0937-941X","1433-2965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoporosis International","raw_type":"journal-article"},{"id":"pmid:26558380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26558380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1538467883","https://openalex.org/W1576988357","https://openalex.org/W1608931031","https://openalex.org/W1987726368","https://openalex.org/W2004547921","https://openalex.org/W2028200045","https://openalex.org/W2044511370","https://openalex.org/W2083282685","https://openalex.org/W2099385877","https://openalex.org/W2121487587","https://openalex.org/W2143382895","https://openalex.org/W2154789738","https://openalex.org/W2160005424","https://openalex.org/W2166145588","https://openalex.org/W2171595133","https://openalex.org/W2171709369","https://openalex.org/W2482202957","https://openalex.org/W4226079456"],"related_works":["https://openalex.org/W2921231364","https://openalex.org/W2322219091","https://openalex.org/W1576988357","https://openalex.org/W2419474786","https://openalex.org/W7097737706","https://openalex.org/W2969312520","https://openalex.org/W2884939923","https://openalex.org/W3166368938","https://openalex.org/W1916448504","https://openalex.org/W2185249748"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}