{"id":"https://openalex.org/W2283594609","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.4649","title":"Comprehensive analysis of ERCC, XPD, and XRCC polymorphisms: Association with clinical outcomes in patients with advanced gastric cancer","display_name":"Comprehensive analysis of ERCC, XPD, and XRCC polymorphisms: Association with clinical outcomes in patients with advanced gastric cancer","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2283594609","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.4649","mag":"2283594609"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.4649","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.4649","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.4649","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080295544","display_name":"Bhumsuk Keam","orcid":"https://orcid.org/0000-0001-8196-4247","observed_orcids":["https://orcid.org/0000-0001-8196-4247","https://orcid.org/0000-0002-2974-675X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"B. Keam","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045836897","display_name":"H. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H. Kim","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Im","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. Im","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110316881","display_name":"Hyun Seok Ham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H. Ham","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109391762","display_name":"Sangjun Han","orcid":"https://orcid.org/0009-0009-7133-2428","observed_orcids":["https://orcid.org/0009-0009-7133-2428"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. Han","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010330750","display_name":"E. Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"E. Cho","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027168888","display_name":"J. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J. Lee","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"D. Oh","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011249694","display_name":"T. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"T. Kim","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050684671","display_name":"Yung\u2010Jue Bang","orcid":"https://orcid.org/0000-0001-6000-4597","observed_orcids":["https://orcid.org/0000-0001-6000-4597"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]},{"id":"https://openalex.org/I4210110313","display_name":"JS Link (South Korea)","ror":"https://ror.org/023cpc062","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210110313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Y. Bang","raw_affiliation_strings":["Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Seoul, Republic of Korea; Seoul National University College of Medicine, Seoul, Republic of Korea; DNA Link Inc, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210110313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"4649","last_page":"4649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ercc1","display_name":"ERCC1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ercc2","display_name":"XPD","score":0.9860000014305115},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9950000047683716},{"id":"https://openalex.org/keywords/haplotype-blocks","display_name":"haplotype blocks","score":0.6600000262260437},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.875},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":1.0},{"id":"https://openalex.org/keywords/folfox6","display_name":"FOLFOX6","score":0.925000011920929},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.7590000033378601},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/platinum-dna-adducts","display_name":"platinum-DNA adducts","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7916799783706665},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.6118869185447693},{"id":"https://openalex.org/C177580304","wikidata":"https://www.wikidata.org/wiki/Q1147298","display_name":"International HapMap Project","level":5,"score":0.5847459435462952},{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.5732013583183289},{"id":"https://openalex.org/C2779309665","wikidata":"https://www.wikidata.org/wiki/Q17917256","display_name":"ERCC1","level":5,"score":0.5108975768089294},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.5075732469558716},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.4907163381576538},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.48094338178634644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47655799984931946},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.45802199840545654},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.44825479388237},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44339612126350403},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.36924800276756287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30248910188674927},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.24994876980781555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1974988579750061}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.4649","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.4649","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.4649","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050244347","https://openalex.org/W2389778455","https://openalex.org/W1984720118","https://openalex.org/W2146666789","https://openalex.org/W2122800597","https://openalex.org/W2969684798","https://openalex.org/W2427875213","https://openalex.org/W2461682901","https://openalex.org/W2010796937","https://openalex.org/W2342817047"],"abstract_inverted_index":{"4649":[0],"Background:":[1],"Platinum-DNA":[2],"adducts":[3],"are":[4],"repaired":[5],"by":[6,93,123],"nucleotide":[7,49],"excision":[8,17],"repair":[9,18,29],"(NER)":[10],"pathway,":[11],"in":[12,66,158,162,166,192,201,210,299],"which":[13],"genes":[14,54,78],"of":[15,39,52,62,75,81,149,226,239,256,280],"the":[16,45,56,82,105,113,119,147,150,222],"cross-complementation":[19],"1":[20],"(ERCC1),":[21],"xeroderma":[22],"pigmentosum":[23],"group":[24,31],"D":[25],"(XPD)":[26],"and":[27,55,64,88,96,118,141,180,188,197,206,216,253,283,288],"X-ray":[28],"cross-complementing":[30],"(XRCC)":[32],"have":[33],"an":[34],"important":[35],"role.":[36],"The":[37],"purpose":[38],"this":[40],"study":[41],"was":[42,110,121],"to":[43,59,182,290],"investigate":[44],"relationship":[46],"between":[47],"single":[48],"polymorphisms":[50],"(SNPs)":[51],"these":[53],"clinical":[57,219,235,297],"outcomes":[58],"combination":[60],"chemotherapy":[61,140],"5-FU":[63],"oxaliplatin":[65],"advanced":[67],"gastric":[68],"cancer":[69],"(AGC).":[70],"Methods:":[71],"We":[72,168],"searched":[73],"SNPs":[74,87,157,161,165,172,187,196,205,213,225,279],"NER":[76,227],"pathway":[77,228],"from":[79,104,112],"database":[80,148],"International":[83,151],"Hapmap":[84,152],"Project.":[85],"Tagging":[86,212],"halpotype":[89],"blocks":[90,200],"were":[91,102,142,214],"founded":[92],"linakage":[94],"disequilibrium":[95,287],"haplotype":[97,183,190,199,208,291],"analysis.":[98],"Whole":[99],"blood":[100,115],"samples":[101],"obtained":[103],"patients":[106,132,301],"before":[107],"chemotherapy.":[108],"DNA":[109],"extracted":[111],"peripheral":[114],"mononuclear":[116],"cells":[117],"genotyping":[120],"performed":[122],"SNaPshot":[124],"methods.":[125],"Seventy":[126],"three":[127],"metastatic":[128],"or":[129,259,270],"relapsed":[130],"AGC":[131,300],"received":[133],"modified":[134,304],"FOLFOX-6":[135,305],"as":[136,176],"a":[137,174,177],"first-line":[138],"palliative":[139],"analyzed.":[143],"Results:":[144],"By":[145],"searching":[146],"Project,":[153],"we":[154],"found":[155,169],"17":[156],"ERCC,":[159,193,281],"69":[160],"XPD,":[163,202],"78":[164],"XRCC.":[167],"that":[170,277],"some":[171,278],"played":[173],"role":[175],"tagging":[178,224],"SNP":[179,232,295],"belonged":[181,289],"block":[184,191,209],"(5":[185],"tapping":[186,195,204],"one":[189],"8":[194],"two":[198,207],"9":[203],"XRCC).":[211],"analyzed":[215],"matched":[217],"with":[218,303],"significance.":[220],"Among":[221],"22":[223],"genes,":[229],"only":[230],"XPD-C156A":[231,294],"(rs238406)":[233],"showed":[234,242,285,296],"correlation.":[236],"AA":[237],"genotype":[238],"XPD":[240,282],"C156A":[241],"higher":[243],"response":[244],"rate":[245],"(CC:":[246,261],"CA:":[247,262],"AA=":[248,263],"29.2%:":[249],"43.3%:":[250],"63.2%,":[251],"p=0.083)":[252],"toxicities":[254],"(neutropenia":[255],"grade":[257],"3":[258],"4)":[260],"4.3%:":[264],"3.2%:":[265],"21.1%,":[266],"p=0.060)":[267],"than":[268],"CC":[269],"CA":[271],"genotypes.":[272],"Conclusions:":[273],"Our":[274],"results":[275],"suggest":[276],"XRCC":[284],"linkage":[286],"blocks.":[292],"And":[293],"correlation":[298],"treated":[302],"regimen.":[306],"These":[307],"findings":[308],"require":[309],"independent":[310],"prospective":[311],"confirmation.":[312],"[Table:":[313],"see":[314],"text]":[315]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}