{"id":"https://openalex.org/W2283484722","doi":null,"title":"New concepts in diabetes: how multihormonal regulation can improve glycemic control.","display_name":"New concepts in diabetes: how multihormonal regulation can improve glycemic control.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2283484722","mag":"2283484722","pmid":"https://pubmed.ncbi.nlm.nih.gov/23570175"},"language":"en","primary_location":{"id":"pmid:23570175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23570175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of managed care pharmacy : JMCP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070289715","display_name":"Lawrence Blonde","orcid":"https://orcid.org/0000-0003-0492-6698","observed_orcids":["https://orcid.org/0000-0003-0492-6698"]},"institutions":[{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Blonde","raw_affiliation_strings":["Ochsner Diabetes Clinical Research Unit, Section on Endocrinology, Diabetes and Metabolic Diseases, Ochsner Clinical Foundation, New Orleans, Louisiana 70121, USA. lblonde@ochsner.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ochsner Diabetes Clinical Research Unit, Section on Endocrinology, Diabetes and Metabolic Diseases, Ochsner Clinical Foundation, New Orleans, Louisiana 70121, USA. lblonde@ochsner.org","institution_ids":["https://openalex.org/I2799767083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029438179","display_name":"Danial E. Baker","orcid":"https://orcid.org/0000-0002-4605-3357","observed_orcids":["https://orcid.org/0000-0002-4605-3357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danial E Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080379883","display_name":"Stephen N. Davis","orcid":"https://orcid.org/0000-0001-8923-5209","observed_orcids":["https://orcid.org/0000-0001-8923-5209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen N Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081205041","display_name":"Robert E. Ratner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E Ratner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"6 Suppl B","first_page":"S3","last_page":"8; quiz S9, S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6930000185966492},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9710000157356262},{"id":"https://openalex.org/keywords/multihormonal-regulation","display_name":"multihormonal regulation","score":0.921999990940094},{"id":"https://openalex.org/keywords/glucoregulatory-hormones","display_name":"glucoregulatory hormones","score":0.9129999876022339},{"id":"https://openalex.org/keywords/amylin","display_name":"amylin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pramlintide","display_name":"pramlintide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/insulin-analogs","display_name":"insulin analogues","score":0.7229999899864197},{"id":"https://openalex.org/keywords/continuous-subcutaneous-insulin-infusion","display_name":"insulin pump therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7570000290870667},{"id":"https://openalex.org/keywords/antidiabetic-drug-development","display_name":"antidiabetic drug development","score":0.6230000257492065},{"id":"https://openalex.org/keywords/diabetes-costs","display_name":"diabetes costs","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8909355401992798},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.8029288649559021},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7049539685249329},{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.6060121655464172},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5990277528762817},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5536959171295166},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5219444632530212},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48204049468040466},{"id":"https://openalex.org/C2778848681","wikidata":"https://www.wikidata.org/wiki/Q6725716","display_name":"Macrovascular disease","level":4,"score":0.42683038115501404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4233427941799164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39385801553726196},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.16222664713859558},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008329","descriptor_name":"Managed Care Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017281","descriptor_name":"Cost of Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23570175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23570175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of managed care pharmacy : JMCP","raw_type":"Journal Article"},{"id":"mag:2283484722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23570175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1975588287","https://openalex.org/W2045554373","https://openalex.org/W2050456578","https://openalex.org/W2101718966","https://openalex.org/W2139075957","https://openalex.org/W2170378756","https://openalex.org/W2337454357"],"related_works":["https://openalex.org/W2070228656","https://openalex.org/W2003838322","https://openalex.org/W4253393552","https://openalex.org/W2793074282","https://openalex.org/W2417331304","https://openalex.org/W1965270239","https://openalex.org/W2134045800","https://openalex.org/W7099755498","https://openalex.org/W7214175425","https://openalex.org/W7096472620"],"abstract_inverted_index":{"It":[0,340],"is":[1,66,127,221,299,341],"estimated":[2],"that":[3,14,38,192,245,259,344],"18.2":[4],"million":[5],"Americans":[6],"are":[7,47],"currently":[8],"living":[9],"with":[10,76,155,162,227],"diabetes,":[11],"a":[12,121],"disease":[13],"continues":[15],"to":[16,57,68,85,129,261,305,313],"place":[17],"significant":[18],"economic":[19,319],"burdens":[20,320],"on":[21],"patients,":[22],"their":[23,230,255,262],"families,":[24],"health":[25,92],"plans,":[26],"systems,":[27],"and":[28,42,65,79,90,103,110,114,147,168,181,197,205,252,309,312,318],"society.":[29],"Recent":[30],"data":[31],"from":[32],"the":[33,39,59,70,83,124,131,138,142,163,187,209,247,250,276,283,315,337],"American":[34,139,143],"Diabetes":[35,140],"Association":[36],"indicates":[37,191],"annual":[40],"direct":[41],"indirect":[43],"costs":[44],"of":[45,61,72,88,108,123,145,165,189,211,235,237,249,267,271,285,321,324,336],"diabetes":[46,190,228,288,338],"rapidly":[48],"increasing.":[49],"Improved":[50],"glycemic":[51,134,231,307],"control--which":[52],"has":[53],"been":[54],"repeatedly":[55],"demonstrated":[56],"reduce":[58,69,91,314],"risk":[60,71,164],"developing":[62],"microvascular":[63],"complications":[64,74],"likely":[67,331],"macrovascular":[73],"associated":[75,161],"type":[77,80,286],"1":[78,287],"2":[81],"diabetes--has":[82],"potential":[84,279,301],"improve":[86,306],"quality":[87],"life":[89],"care":[93,346],"expenditures.":[94],"However,":[95],"despite":[96],"recent":[97],"advances":[98],"in":[99,208,224],"oral":[100],"antidiabetic":[101],"agents":[102,244,258,304],"insulin":[104,112,117,196,220,290],"management":[105],"(e.g.,":[106],"development":[107],"rapid-":[109],"long-acting":[111],"analogs":[113,236],"continuous":[115],"subcutaneous":[116],"infusion":[118],"[CSII]),":[119],"only":[120],"portion":[122],"patient":[125,226,310],"population":[126],"able":[128],"achieve":[130,229],"goals":[132],"for":[133,282,302],"control":[135,308],"recommended":[136],"by":[137],"Association,":[141],"College":[144],"Endocrinology,":[146],"other":[148],"guideline-setting":[149],"organizations.":[150],"Moreover,":[151],"improved":[152,268],"glycemia":[153],"achieved":[154],"present":[156],"therapeutic":[157],"modalities":[158],"may":[159,264],"be":[160],"hypoglycemic":[166],"events":[167],"undesired":[169],"weight":[170],"gain.":[171],"The":[172,233],"latter":[173],"can":[174],"negatively":[175],"affect":[176],"plasma":[177,212],"lipids,":[178],"blood":[179],"pressure,":[180],"therapy":[182],"adherence.":[183],"New":[184],"research":[185],"into":[186,217],"pathophysiology":[188],"multiple":[193],"hormones--not":[194],"just":[195],"glucagon":[198],"but":[199],"amylin,":[200],"GLP-1":[201],"(a":[202],"glucagon-like":[203],"peptide),":[204],"others--are":[206],"involved":[207],"regulation":[210],"glucose":[213],"levels,":[214],"providing":[215],"insight":[216],"why":[218],"even":[219],"often":[222],"ineffective":[223],"helping":[225],"goals.":[232],"use":[234],"these":[238,272,303,325],"newly":[239],"recognized,":[240],"important":[241,334,343],"glucoregulatory":[242,328],"hormones;":[243],"delay":[246],"degradation":[248],"hormones":[251],"therefore":[253,342],"raise":[254],"concentration;":[256],"and/or":[257],"bind":[260],"receptors":[263],"facilitate":[265],"achievement":[266],"glycemia.":[269],"One":[270],"agents,":[273],"pramlintide,":[274],"represents":[275],"first":[277],"new":[278],"antihyperglycemic":[280],"agent":[281],"treatment":[284],"since":[289],"was":[291],"introduced":[292],"more":[293],"than":[294],"80":[295],"years":[296],"ago.":[297],"There":[298],"substantial":[300],"outcomes":[311],"personal,":[316],"societal,":[317],"diabetes.":[322],"Some":[323],"novel":[326],"multihormonal":[327],"therapies":[329],"will":[330],"soon":[332],"become":[333],"components":[335],"armamentarium.":[339],"managed":[345],"pharmacy":[347],"decision":[348],"makers":[349],"learn":[350],"about":[351],"them.":[352]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}