{"id":"https://openalex.org/W228337244","doi":null,"title":"Medullar expression of type-A natriuretic peptide receptor in an animal model of hypertension induced by renal mass ablation.","display_name":"Medullar expression of type-A natriuretic peptide receptor in an animal model of hypertension induced by renal mass ablation.","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W228337244","mag":"228337244","pmid":"https://pubmed.ncbi.nlm.nih.gov/16869207"},"language":"en","primary_location":{"id":"pmid:16869207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16869207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033176750","display_name":"Carla Santos-Ara\u00fajo","orcid":"https://orcid.org/0000-0002-6166-7074","observed_orcids":["https://orcid.org/0000-0002-6166-7074"]},"institutions":[{"id":"https://openalex.org/I4405254375","display_name":"Unidade de Investiga\u00e7\u00e3o e Desenvolvimento de Nefrologia","ror":"https://ror.org/01r3j2c85","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405254375"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carla Santos Ara\u00fajo","raw_affiliation_strings":["Unidade de Investiga\u00e7\u00e3o e Desenvolvimento de Nefrologia, Faculdade de Medicina, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidade de Investiga\u00e7\u00e3o e Desenvolvimento de Nefrologia, Faculdade de Medicina, Porto, Portugal","institution_ids":["https://openalex.org/I4405254375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084089641","display_name":"Roberto Roncon\u2010Albuquerque","orcid":"https://orcid.org/0000-0002-2966-2943","observed_orcids":["https://orcid.org/0000-0002-2966-2943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Roncon Albuquerque","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016099768","display_name":"M\u00f3nica Rodrigues","orcid":"https://orcid.org/0000-0002-7932-9460","observed_orcids":["https://orcid.org/0000-0002-7932-9460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00f3nica Moreira Rodrigues","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064433527","display_name":"Benedita Sampaio\u2010Maia","orcid":"https://orcid.org/0000-0001-9368-8075","observed_orcids":["https://orcid.org/0000-0001-9368-8075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benedita Sampaio Maia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065137829","display_name":"Adelino F Leite Moreira","orcid":"https://orcid.org/0000-0001-7808-3596","observed_orcids":["https://orcid.org/0000-0001-7808-3596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adelino F Leite Moreira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046122152","display_name":"Manuel Pestana","orcid":"https://orcid.org/0000-0003-1482-2024","observed_orcids":["https://orcid.org/0000-0003-1482-2024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Pestana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"4","first_page":"419","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.29760000109672546,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.29760000109672546,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.28999999165534973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.875},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5370000004768372},{"id":"https://openalex.org/keywords/partial-nephrectomy","display_name":"partial nephrectomy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/natriuretic-peptide-system","display_name":"natriuretic peptide system","score":0.8849999904632568},{"id":"https://openalex.org/keywords/remnant-kidney","display_name":"remnant kidney","score":0.6399999856948853},{"id":"https://openalex.org/keywords/fractional-excretion-of-sodium","display_name":"fractional excretion of sodium","score":0.8289999961853027},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.6510000228881836},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6951521635055542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6452934741973877},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6338587999343872},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.6249403953552246},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5722506046295166},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5692012310028076},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.5565621852874756},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5154693722724915},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4843972325325012},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4748677909374237},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3879280686378479}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017461","descriptor_name":"Receptors, Atrial Natriuretic Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16869207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16869207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1964757249","https://openalex.org/W1984893737","https://openalex.org/W1993247232","https://openalex.org/W1997779855","https://openalex.org/W2007112807","https://openalex.org/W2014431983","https://openalex.org/W2027960056","https://openalex.org/W2044813579","https://openalex.org/W2053998186","https://openalex.org/W2082400577","https://openalex.org/W2135925833","https://openalex.org/W2139515152","https://openalex.org/W2170616939","https://openalex.org/W2415534077"],"related_works":["https://openalex.org/W2158562346","https://openalex.org/W2170616939","https://openalex.org/W2256509973","https://openalex.org/W7035263729","https://openalex.org/W2424642011","https://openalex.org/W2083863414","https://openalex.org/W1973286153","https://openalex.org/W2075973145","https://openalex.org/W2091326467","https://openalex.org/W2319266906"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,143],"biological":[2],"activity":[3,42],"of":[4,23,69,88,91,145,159,239,245],"the":[5,13,20,27,29,37,48,66,92,133,156,160,205,219,237,242,246,269,279],"natriuretic":[6,30],"peptide":[7,31],"(NP)":[8],"system":[9],"is":[10,36,44,57,249,262],"dependent":[11],"on":[12],"balance":[14],"between":[15],"NP":[16,41,55],"tissue":[17],"levels":[18,56,217],"and":[19,43,103,120,127,132,173,191,201,228],"local":[21],"expression":[22,68,238],"their":[24],"receptors.":[25],"In":[26,234],"kidney,":[28],"receptor":[32,39],"type":[33],"A":[34],"(NPR-A)":[35],"principal":[38],"mediating":[40],"mainly":[45],"expressed":[46,149],"in":[47,53,60,75,150,174,189,198,214,218,241,272,283],"renal":[49,62,67,125,220,243,280],"medulla.":[50],"An":[51],"increase":[52,271],"circulating":[54],"well":[58,276],"documented":[59],"chronic":[61],"failure":[63],"(CRF);":[64],"however,":[65],"NPR-A":[70,137,215,240],"has":[71],"not":[72],"been":[73],"evaluated":[74,131],"this":[76,265],"condition.":[77],"METHODS:":[78],"Wistar-Han":[79],"rats":[80,200],"were":[81,98,115,130],"submitted":[82],"to":[83,107,256,268,278],"right":[84],"nephrectomy":[85],"plus":[86],"ablation":[87],"both":[89],"poles":[90],"left":[93],"kidney":[94,248],"(3/4nx;":[95],"n=27)":[96],"or":[97],"sham":[99],"operated":[100],"(Sham;":[101],"n=22)":[102],"followed":[104],"for":[105,136,167],"up":[106,255],"26":[108,121,180,229,257],"weeks":[109,122,170,181,230,254,258],"post":[110,231,259],"surgery.":[111,232,260],"Blood":[112],"pressure":[113,195],"measurements":[114],"performed":[116],"weekly.":[117],"Two,":[118],"10":[119,227],"after":[123,165,171,182],"surgery,":[124],"sodium":[126,177,185],"creatinine":[128],"excretion":[129,178],"kidneys":[134],"removed":[135],"mRNA":[138,146,216],"quantification":[139,147],"by":[140,210],"real-time":[141],"PCR.":[142],"results":[144],"are":[148],"arbitrary":[151],"units":[152],"(AU)":[153],"set":[154],"as":[155,275,277],"mean":[157],"value":[158],"Sham":[161,192],"group":[162],"(Sham=1":[163],"AU),":[164],"normalization":[166],"GAPDH":[168],"(p<0.05).":[169],"surgery)":[172],"elevated":[175],"fractional":[176],"(+270%,":[179],"surgery).":[183],"Although":[184],"intake":[186],"was":[187,196,208],"similar":[188],"3/4nx":[190,199,223,235,284],"rats,":[193,236],"blood":[194,273],"higher":[197],"increased":[202],"progressively":[203],"throughout":[204],"study.":[206],"This":[207],"accompanied":[209],"a":[211],"marked":[212],"decrease":[213],"medulla":[221,244],"from":[222,252],"animals":[224],"at":[225],"2,":[226],"CONCLUSION:":[233],"remnant":[247],"markedly":[250],"reduced":[251],"2":[253],"It":[261],"suggested":[263],"that":[264],"may":[266],"contribute":[267],"progressive":[270],"pressure,":[274],"fibrosis":[281],"observed":[282],"rats.":[285]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}