{"id":"https://openalex.org/W2283230010","doi":"https://doi.org/10.15436/2378-6914/15/010","title":"Impaired Coronary Endothelial Vasorelaxation in a Preclinical Model of Peripheral Arterial Insufficiency","display_name":"Impaired Coronary Endothelial Vasorelaxation in a Preclinical Model of Peripheral Arterial Insufficiency","publication_year":2015,"publication_date":"2015-06-29","ids":{"openalex":"https://openalex.org/W2283230010","doi":"https://doi.org/10.15436/2378-6914/15/010","mag":"2283230010","pmid":"https://pubmed.ncbi.nlm.nih.gov/26726316","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4696773"},"language":"en","primary_location":{"id":"doi:10.15436/2378-6914/15/010","doi":"https://doi.org/10.15436/2378-6914/15/010","is_oa":true,"landing_page_url":"https://doi.org/10.15436/2378-6914/15/010","pdf_url":"https://www.ommegaonline.org/articles/publishimages/10747_Impaired-Coronary-Endothelial-Vasorelaxation-in-a-Preclinical-Model-of-Peripheral-Arterial-Insufficiency.pdf","source":{"id":"https://openalex.org/S4210167690","display_name":"JOURNAL OF HEART AND CARDIOLOGY","issn_l":"2378-6914","issn":["2378-6914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL OF HEART AND CARDIOLOGY","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.ommegaonline.org/articles/publishimages/10747_Impaired-Coronary-Endothelial-Vasorelaxation-in-a-Preclinical-Model-of-Peripheral-Arterial-Insufficiency.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070390150","display_name":"Arturo A. Arce\u2010Esquivel","orcid":"https://orcid.org/0000-0002-9246-5213","observed_orcids":["https://orcid.org/0000-0002-9246-5213"]},"institutions":[{"id":"https://openalex.org/I221716585","display_name":"The University of Texas at Tyler","ror":"https://ror.org/01azfw069","country_code":"US","type":"education","lineage":["https://openalex.org/I221716585"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arce Esquive","raw_affiliation_strings":["Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri ; Department of Health and Kinesiology, The University of Texas at Tyler, Tyler, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri ; Department of Health and Kinesiology, The University of Texas at Tyler, Tyler, Texas","institution_ids":["https://openalex.org/I221716585","https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070390150"],"corresponding_institution_ids":["https://openalex.org/I221716585","https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":0.2456,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64934786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"2","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.22030000388622284,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/coronary-endothelial-dysfunction","display_name":"coronary endothelial dysfunction","score":0.8899999856948853},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.7459999918937683},{"id":"https://openalex.org/keywords/femoral-artery-occlusion","display_name":"femoral artery occlusion","score":0.847000002861023},{"id":"https://openalex.org/keywords/coronary-vasomotor-function","display_name":"coronary vasomotor function","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/adenosine-diphosphate","display_name":"adenosine diphosphate","score":0.9509999752044678},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.4129999876022339},{"id":"https://openalex.org/keywords/yucatan-miniature-swine","display_name":"Yucatan miniature swine","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C126707884","wikidata":"https://www.wikidata.org/wiki/Q305876","display_name":"sed","level":2,"score":0.7313500642776489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7299290299415588},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6271336078643799},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5729827284812927},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.5611264705657959},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.5167038440704346},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.510646402835846},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.4915090501308441},{"id":"https://openalex.org/C2778088351","wikidata":"https://www.wikidata.org/wiki/Q429285","display_name":"Right coronary artery","level":4,"score":0.4552958011627197},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38595467805862427},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.16881558299064636},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.16063624620437622},{"id":"https://openalex.org/C3019004856","wikidata":"https://www.wikidata.org/wiki/Q42297149","display_name":"Coronary angiography","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.15436/2378-6914/15/010","doi":"https://doi.org/10.15436/2378-6914/15/010","is_oa":true,"landing_page_url":"https://doi.org/10.15436/2378-6914/15/010","pdf_url":"https://www.ommegaonline.org/articles/publishimages/10747_Impaired-Coronary-Endothelial-Vasorelaxation-in-a-Preclinical-Model-of-Peripheral-Arterial-Insufficiency.pdf","source":{"id":"https://openalex.org/S4210167690","display_name":"JOURNAL OF HEART AND CARDIOLOGY","issn_l":"2378-6914","issn":["2378-6914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL OF HEART AND CARDIOLOGY","raw_type":"journal-article"},{"id":"pmid:26726316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26726316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of heart and cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3666023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4696773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4696773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4696773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Heart Cardiol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.780.8274","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.780.8274","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5a/2f/nihms708649.PMC4696773.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.15436/2378-6914/15/010","doi":"https://doi.org/10.15436/2378-6914/15/010","is_oa":true,"landing_page_url":"https://doi.org/10.15436/2378-6914/15/010","pdf_url":"https://www.ommegaonline.org/articles/publishimages/10747_Impaired-Coronary-Endothelial-Vasorelaxation-in-a-Preclinical-Model-of-Peripheral-Arterial-Insufficiency.pdf","source":{"id":"https://openalex.org/S4210167690","display_name":"JOURNAL OF HEART AND CARDIOLOGY","issn_l":"2378-6914","issn":["2378-6914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOURNAL OF HEART AND CARDIOLOGY","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3309575514","display_name":"Exercise & Health Integration from Molecule to Patient","funder_award_id":"T32AR048523","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8259420954","display_name":"Training-Muscle Blood Flow and Capillary Dynamics","funder_award_id":"R01HL036088","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2283230010.pdf","grobid_xml":"https://content.openalex.org/works/W2283230010.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1513003420","https://openalex.org/W1830359444","https://openalex.org/W1851866395","https://openalex.org/W1945450223","https://openalex.org/W1964400122","https://openalex.org/W1968645315","https://openalex.org/W1976950263","https://openalex.org/W1979252626","https://openalex.org/W1983602530","https://openalex.org/W1986364550","https://openalex.org/W1995568914","https://openalex.org/W2001659937","https://openalex.org/W2008202040","https://openalex.org/W2011278613","https://openalex.org/W2021952948","https://openalex.org/W2033641090","https://openalex.org/W2042560919","https://openalex.org/W2051767272","https://openalex.org/W2054583260","https://openalex.org/W2061005453","https://openalex.org/W2062900721","https://openalex.org/W2063756400","https://openalex.org/W2069490874","https://openalex.org/W2072051531","https://openalex.org/W2074718841","https://openalex.org/W2075082242","https://openalex.org/W2077397160","https://openalex.org/W2077519675","https://openalex.org/W2078649731","https://openalex.org/W2081219450","https://openalex.org/W2087252312","https://openalex.org/W2087277843","https://openalex.org/W2093037267","https://openalex.org/W2100757481","https://openalex.org/W2119635674","https://openalex.org/W2122274177","https://openalex.org/W2125823894","https://openalex.org/W2131048176","https://openalex.org/W2133050385","https://openalex.org/W2153986804","https://openalex.org/W2165389773","https://openalex.org/W2229261006","https://openalex.org/W2320229168","https://openalex.org/W2404576446","https://openalex.org/W2565726191","https://openalex.org/W2887712073","https://openalex.org/W4243714509"],"related_works":["https://openalex.org/W2008917340","https://openalex.org/W2094007475","https://openalex.org/W2062900721","https://openalex.org/W2054921327","https://openalex.org/W1988785129","https://openalex.org/W1550597325","https://openalex.org/W3142022097","https://openalex.org/W2044178530","https://openalex.org/W2275470915","https://openalex.org/W2316301882"],"abstract_inverted_index":{"The":[0,93],"present":[1],"study":[2],"was":[3,141,175],"designed":[4],"to":[5,34,57,107,124,139,155,167,188,195,243,262],"determine":[6],"whether":[7],"adult":[8],"swine":[9,53],"with":[10,276],"peripheral":[11,277],"artery":[12,96,278],"insufficiency":[13],"(PAI)":[14],"would":[15],"exhibit":[16],"vascular":[17,226,259,263],"dysfunction":[18,227,264],"in":[19,45,119,136,143,177,228,238,253,265,274,290],"vessels":[20,230],"distinct":[21,231],"from":[22,145,179,232],"the":[23,27,36,168,213,222,233,254,266,287,291],"affected":[24,234],"distal":[25],"limbs,":[26],"coronary":[28,42,102,240,267,292],"conduit":[29,229],"arteries.":[30,293],"Moreover,":[31],"we":[32],"sought":[33],"evaluate":[35],"effect":[37],"of":[38,221,256],"exercise":[39,60,191],"training":[40],"on":[41,86],"vasomotor":[43],"function":[44],"PAI.":[46],"Eighteen":[47],"female":[48],"healthy":[49],"young":[50],"Yucatan":[51],"miniature":[52],"were":[54,81,104,117,134,208],"randomly":[55],"assigned":[56],"either":[58],"occluded":[59],"trained":[61,83],"(Occl-Ex,":[62],"n":[63,69],"=":[64,70],"7),":[65],"or":[66,72],"occluded-sedentary":[67],"(Occl-Sed,":[68],"5),":[71],"non-occluded,":[73],"non-exercised":[74],"control":[75],"(Non-Occl-Con,":[76],"n=6)":[77],"groups.":[78,171,214],"Occl-Ex":[79,148,159,180],"pigs":[80,149,160,183],"progressively":[82],"by":[84],"running":[85],"a":[87],"treadmill":[88],"(5":[89],"days/week,":[90],"12":[91],"weeks).":[92],"left":[94,99],"descending":[95],"(LAD)":[97],"and":[98,113,131,147,181,190,205,245],"circumflex":[100],"(LCX)":[101],"arteries":[103,224,268],"harvested.":[105],"Vasorelaxation":[106,138],"adenosine":[108],"diphosphate":[109],"(ADP),":[110],"bradykinin":[111],"(BK),":[112],"sodium":[114],"nitroprusside":[115],"(SNP)":[116],"assessed":[118,135],"LAD\u2019s;":[120],"while":[121],"constrictor":[122],"responses":[123,194,207,242],"phenylephrine":[125],"(PE),":[126],"angiotensin":[127],"II":[128],"(Ang":[129],"II),":[130],"endothelin-1":[132],"(ET-1)":[133],"LCX\u2019s.":[137],"ADP":[140,244],"reduced":[142,176],"LADs":[144,178],"Occl-Sed":[146,182],"(P":[150,164,184,197],"<":[151,185],"0.001)":[152],"as":[153,236],"compared":[154,187],"Non-Occl-Con":[156],"pigs;":[157],"however,":[158],"exhibited":[161],"partial":[162],"recovery":[163],"<0.001)":[165],"intermediate":[166],"other":[169],"two":[170],"BK":[172,196],"induced":[173],"relaxation":[174],"0.001),":[186],"Non-Occl-Con,":[189],"modestly":[192],"increased":[193],"<0.05).":[198],"In":[199],"addition,":[200],"SNP,":[201],"PE,":[202],"Ang":[203],"II,":[204],"ET-1":[206],"not":[209],"significantly":[210],"different":[211],"among":[212],"Our":[215],"results":[216],"indicate":[217],"that":[218,250,269],"\u2018simple\u2019":[219],"occlusion":[220],"femoral":[223],"induces":[225],"hindlimbs,":[235],"evident":[237],"blunted":[239],"vasorelaxation":[241],"BK.":[246],"These":[247],"findings":[248],"imply":[249],"PAI,":[251],"even":[252],"absence":[255],"frank":[257],"atherogenic":[258],"disease,":[260],"contributes":[261],"could":[270],"exacerbate":[271],"disease":[272],"outcome":[273],"patients":[275],"disease.":[279],"Further,":[280],"regular":[281],"daily":[282],"physical":[283],"activity":[284],"partially":[285],"recovered":[286],"deficit":[288],"observed":[289]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
