{"id":"https://openalex.org/W2283173335","doi":null,"title":"Humoral immunodeficiency in recurrent upper respiratory tract infections. Some basic, clinical and therapeutic features.","display_name":"Humoral immunodeficiency in recurrent upper respiratory tract infections. Some basic, clinical and therapeutic features.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2283173335","mag":"2283173335","pmid":"https://pubmed.ncbi.nlm.nih.gov/11082774"},"language":"en","primary_location":{"id":"pmid:11082774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11082774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-rhino-laryngologica Belgica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079655134","display_name":"Jacques Daele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Daele","raw_affiliation_strings":["ENT Dept., CHR Citadelle, Li\u00e8ge, Belgium. Daele@village.uunet.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ENT Dept., CHR Citadelle, Li\u00e8ge, Belgium. Daele@village.uunet.be","institution_ids":["https://openalex.org/I4210159123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083640448","display_name":"A F Zicot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A F Zicot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1133,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.41626678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"3","first_page":"373","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-deficiency","display_name":"antibody deficiency","score":0.9860000014305115},{"id":"https://openalex.org/keywords/recurrent-upper-respiratory-tract-infections","display_name":"recurrent upper respiratory tract infections","score":0.9810000061988831},{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.8960000276565552},{"id":"https://openalex.org/keywords/secretory-igm","display_name":"secretory IgM","score":0.8619999885559082},{"id":"https://openalex.org/keywords/igg-deficiency","display_name":"IgG deficiency","score":0.7609999775886536},{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/immunoglobulin-replacement-therapy","display_name":"immunoglobulin replacement therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytokine-therapy","display_name":"cytokine therapy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ciliary-function","display_name":"ciliary function","score":0.800000011920929},{"id":"https://openalex.org/keywords/mucociliary-clearance","display_name":"mucociliary clearance","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7482286691665649},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6564201712608337},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.6165162920951843},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.5689281225204468},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.5639575123786926},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.5408037900924683},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5209556818008423},{"id":"https://openalex.org/C2776433325","wikidata":"https://www.wikidata.org/wiki/Q1472818","display_name":"Common variable immunodeficiency","level":3,"score":0.5144820213317871},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5081343650817871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4535830616950989},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.4228357970714569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3629039525985718},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3276849389076233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11017829179763794}],"mesh":[{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002925","descriptor_name":"Ciliary Motility Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002925","descriptor_name":"Ciliary Motility Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017098","descriptor_name":"IgA Deficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017098","descriptor_name":"IgA Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017099","descriptor_name":"IgG Deficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017099","descriptor_name":"IgG Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11082774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11082774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oto-rhino-laryngologica Belgica","raw_type":"Journal Article"},{"id":"mag:2283173335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11082774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4235548009","https://openalex.org/W2106518276","https://openalex.org/W2044444136","https://openalex.org/W2420370591","https://openalex.org/W1980791060","https://openalex.org/W2145710378","https://openalex.org/W2314695115","https://openalex.org/W2073324717","https://openalex.org/W2988101420","https://openalex.org/W2889804155"],"abstract_inverted_index":{"Adequate":[0],"surface":[1],"protection":[2],"of":[3,65,72,103,113,151],"the":[4,73,107,142,148,152],"upper":[5,74,108],"airway":[6],"tract":[7,110],"depends":[8],"on":[9],"intimate":[10],"co-operation":[11],"between":[12],"natural":[13],"non":[14],"specific":[15,31,139],"defence":[16],"mechanisms":[17],"such":[18],"as":[19,47,49],"ciliary":[20],"function":[21],"and":[22,40,53,94,137],"acquired":[23],"adaptative":[24],"immunity.":[25],"The":[26,120],"latter":[27],"is":[28,131],"mediated":[29],"by":[30,50],"antibodies":[32],"mainly":[33,118],"belonging":[34],"to":[35,41,84,99],"secretory":[36,44],"immunoglobulin":[37,124],"A":[38],"(SIgA)":[39],"lesser":[42],"extent":[43],"IgM":[45],"(SigM)":[46],"well":[48],"serum":[51],"derived":[52],"locally":[54],"produced":[55],"IgG.":[56],"Immunoglobulin's":[57],"deficiency":[58],"may":[59],"exist":[60],"in":[61],"a":[62,138],"significant":[63],"percentage":[64],"patients":[66,85],"with":[67,133],"chronic":[68],"or":[69,111,126],"recurrent":[70],"infections":[71],"respiratory":[75,109],"tract.":[76],"So":[77],"an":[78,135],"immunologic":[79],"screening":[80],"should":[81],"be":[82],"extended":[83],"who":[86],"have":[87],"persistent":[88],"sinus":[89],"infection,":[90],"despite":[91],"normal":[92],"mucocilary":[93],"ventilation":[95],"patterns,":[96],"inadequate":[97],"response":[98],"antimicrobial":[100],"therapy,":[101],"culture":[102],"unusual":[104],"pathogens":[105],"from":[106],"history":[112],"infection":[114],"at":[115],"other":[116],"side,":[117],"bronchopulmonary.":[119],"therapeutic":[121],"aspects":[122],"include":[123],"replacement":[125],"mucosal":[127],"immunogens":[128],"whose":[129],"efficacy":[130],"related":[132],"both":[134],"unspecific":[136],"way.":[140],"In":[141],"future,":[143],"cytokines":[144],"will":[145],"probably":[146],"become":[147],"strongest":[149],"therapy":[150],"immunoglobulin's":[153],"deficiency.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
