{"id":"https://openalex.org/W2283119699","doi":null,"title":"Paradoxe Hirnembolie : Nachweis von Risikofaktoren f\u00fcr Rezidive und Strategien zur Sekund\u00e4rprophylaxe","display_name":"Paradoxe Hirnembolie : Nachweis von Risikofaktoren f\u00fcr Rezidive und Strategien zur Sekund\u00e4rprophylaxe","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2283119699","mag":"2283119699"},"language":"de","primary_location":{"id":"pmh:oai:publications.rwth-aachen.de:59625","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121394%22","pdf_url":"http://publications.rwth-aachen.de/record/59625/files/Lucas_Sabine.pdf","source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aachen : Publikationsserver der RWTH Aachen University 66 S. : Ill., graph. Darst. (2004). = Aachen, Techn. Hochsch., Diss., 2004","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://publications.rwth-aachen.de/record/59625/files/Lucas_Sabine.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013716716","display_name":"Sabine Lucas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040212868","display_name":"Christof Kl\u00f6tzsch","orcid":"https://orcid.org/0000-0003-2291-6979","observed_orcids":["https://orcid.org/0000-0003-2291-6979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christof Kl\u00f6tzsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patent-foramen-ovale","display_name":"patent foramen ovale","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cryptogenic-stroke","display_name":"cryptogenic stroke","score":0.9139999747276306},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.8259999752044678},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.6190000176429749},{"id":"https://openalex.org/keywords/transcatheter-closure","display_name":"transcatheter closure","score":0.8169999718666077},{"id":"https://openalex.org/keywords/surgical-closure","display_name":"surgical closure","score":0.7789999842643738},{"id":"https://openalex.org/keywords/medical-therapy","display_name":"medical therapy","score":0.5370000004768372},{"id":"https://openalex.org/keywords/shunt-size","display_name":"shunt size","score":0.7839999794960022},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2901357412338257}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:publications.rwth-aachen.de:59625","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121394%22","pdf_url":"http://publications.rwth-aachen.de/record/59625/files/Lucas_Sabine.pdf","source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aachen : Publikationsserver der RWTH Aachen University 66 S. : Ill., graph. Darst. (2004). = Aachen, Techn. Hochsch., Diss., 2004","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2283119699","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/59625","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:publications.rwth-aachen.de:59625","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121394%22","pdf_url":"http://publications.rwth-aachen.de/record/59625/files/Lucas_Sabine.pdf","source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aachen : Publikationsserver der RWTH Aachen University 66 S. : Ill., graph. Darst. (2004). = Aachen, Techn. Hochsch., Diss., 2004","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2283119699.pdf","grobid_xml":"https://content.openalex.org/works/W2283119699.grobid-xml"},"referenced_works_count":133,"referenced_works":["https://openalex.org/W20145613","https://openalex.org/W191436390","https://openalex.org/W1491588010","https://openalex.org/W1493823773","https://openalex.org/W1531281563","https://openalex.org/W1580143606","https://openalex.org/W1629077163","https://openalex.org/W1965387971","https://openalex.org/W1965641956","https://openalex.org/W1965788520","https://openalex.org/W1967884967","https://openalex.org/W1969410779","https://openalex.org/W1971196515","https://openalex.org/W1971313531","https://openalex.org/W1971343276","https://openalex.org/W1971941241","https://openalex.org/W1974049738","https://openalex.org/W1975769887","https://openalex.org/W1977494343","https://openalex.org/W1977747781","https://openalex.org/W1979857093","https://openalex.org/W1979943923","https://openalex.org/W1980996793","https://openalex.org/W1981820725","https://openalex.org/W1983409105","https://openalex.org/W1984108538","https://openalex.org/W1991070150","https://openalex.org/W1991655677","https://openalex.org/W1993371786","https://openalex.org/W1994445887","https://openalex.org/W1994580388","https://openalex.org/W1995474189","https://openalex.org/W1996930100","https://openalex.org/W1997599767","https://openalex.org/W1998971444","https://openalex.org/W1999593367","https://openalex.org/W2000830490","https://openalex.org/W2003187649","https://openalex.org/W2004262819","https://openalex.org/W2005961893","https://openalex.org/W2006348556","https://openalex.org/W2007303097","https://openalex.org/W2007491393","https://openalex.org/W2008564184","https://openalex.org/W2010050468","https://openalex.org/W2011465634","https://openalex.org/W2013446483","https://openalex.org/W2014797584","https://openalex.org/W2014824545","https://openalex.org/W2015664555","https://openalex.org/W2017710930","https://openalex.org/W2019224439","https://openalex.org/W2020956423","https://openalex.org/W2021556603","https://openalex.org/W2026554555","https://openalex.org/W2026580042","https://openalex.org/W2027538725","https://openalex.org/W2028910996","https://openalex.org/W2033239948","https://openalex.org/W2033459488","https://openalex.org/W2037434671","https://openalex.org/W2039999236","https://openalex.org/W2041866392","https://openalex.org/W2046491923","https://openalex.org/W2048092960","https://openalex.org/W2050839120","https://openalex.org/W2050856619","https://openalex.org/W2053519846","https://openalex.org/W2054213128","https://openalex.org/W2057279002","https://openalex.org/W2061835461","https://openalex.org/W2061995020","https://openalex.org/W2063324240","https://openalex.org/W2064131658","https://openalex.org/W2065624647","https://openalex.org/W2066404391","https://openalex.org/W2068246574","https://openalex.org/W2072850095","https://openalex.org/W2073184248","https://openalex.org/W2073408290","https://openalex.org/W2074246811","https://openalex.org/W2075139720","https://openalex.org/W2078656768","https://openalex.org/W2081036521","https://openalex.org/W2082975576","https://openalex.org/W2083142362","https://openalex.org/W2084847007","https://openalex.org/W2085057549","https://openalex.org/W2086604139","https://openalex.org/W2087439115","https://openalex.org/W2087860321","https://openalex.org/W2089933125","https://openalex.org/W2090474032","https://openalex.org/W2092010580","https://openalex.org/W2096629412","https://openalex.org/W2101734877","https://openalex.org/W2102245076","https://openalex.org/W2104024477","https://openalex.org/W2106587674","https://openalex.org/W2108658940","https://openalex.org/W2111543696","https://openalex.org/W2113386256","https://openalex.org/W2115938602","https://openalex.org/W2119731028","https://openalex.org/W2121187530","https://openalex.org/W2124679490","https://openalex.org/W2125283117","https://openalex.org/W2125421043","https://openalex.org/W2132946541","https://openalex.org/W2133714466","https://openalex.org/W2133878760","https://openalex.org/W2138259442","https://openalex.org/W2139885238","https://openalex.org/W2141991965","https://openalex.org/W2145809735","https://openalex.org/W2151720801","https://openalex.org/W2153456651","https://openalex.org/W2153488905","https://openalex.org/W2159245442","https://openalex.org/W2164374762","https://openalex.org/W2168055297","https://openalex.org/W2258503797","https://openalex.org/W2287151933","https://openalex.org/W2299063261","https://openalex.org/W2326526061","https://openalex.org/W2328547014","https://openalex.org/W2335681587","https://openalex.org/W2340957755","https://openalex.org/W2401928536","https://openalex.org/W2409604032","https://openalex.org/W3070147965","https://openalex.org/W3110813384","https://openalex.org/W3205926832"],"related_works":["https://openalex.org/W2313084802","https://openalex.org/W2153488905","https://openalex.org/W2128762165","https://openalex.org/W4232523060","https://openalex.org/W2000314855","https://openalex.org/W2287151933","https://openalex.org/W3147778655","https://openalex.org/W2063740149","https://openalex.org/W2163030676","https://openalex.org/W4283525367"],"abstract_inverted_index":{"Background:":[0],"It":[1],"is":[2,8,27,202,234],"unclear":[3],"what":[4],"kind":[5],"of":[6,32,46,57,97,112,121,143,153,189,212,222,232,252],"role":[7],"played":[9],"by":[10],"concomitant":[11],"risk":[12,85,188,205],"factors":[13,86],"in":[14,35,78,128,164,193,220,249],"stroke":[15,88,118,135,159],"recurrence":[16,31,89,119,136,160,177,211,217,219],"and":[17,74,84,108,150,166,215],"whether":[18],"medical":[19,198,223],"or":[20,23,171,199],"invasive":[21,200],"(surgical":[22],"catheter":[24],"interventional)":[25],"treatment":[26,224],"preferable":[28],"to":[29],"prevent":[30],"cerebral":[33,72],"ischemia":[34,73],"patients":[36,63,104,169,174,194,233],"with":[37,70,195],"patent":[38],"foramen":[39,114,254],"ovale":[40],"(PFO)":[41],"as":[42],"a":[43,50,54,95,146,151],"suspected":[44],"cause":[45],"stroke.":[47],"Methods:":[48],"During":[49],"prospective":[51],"follow-up":[52],"over":[53],"mean":[55],"time":[56],"52":[58],"\u00f1":[59,67],"32":[60],"months":[61],"124":[62],"(mean":[64],"age":[65],"51":[66],"15":[68],"years)":[69],"cryptogenic":[71],"PFO":[75,196],"were":[76,90,99,125,145],"included":[77],"this":[79],"study.":[80,130],"Recurrent":[81],"ischemic":[82],"events":[83,192],"for":[87],"analyzed.":[91],"Of":[92],"all":[93],"patients,":[94],"number":[96],"83":[98],"treated":[100,168],"purely":[101],"medically,":[102],"34":[103],"received":[105],"transcatheter":[106,179,247],"closure":[107,111,180,245,248],"7":[109],"surgical":[110],"the":[113,122,129,207,210,216,218,230,253],"ovale.":[115,255],"The":[116,132,157,186],"annual":[117,134,158],"rates":[120,161],"special":[123],"treatments":[124],"being":[126],"compared":[127],"Results:":[131],"general":[133],"rate":[137],"was":[138],"low":[139],"(2,1/year).":[140],"Significant":[141],"cofactors":[142],"recurrent":[144,190],"large":[147],"shunt":[148,208],"(p<0,05)":[149],"history":[152],"pulmonary":[154,213],"embolism":[155,214],"(p<0,01).":[156],"are":[162],"comparable":[163],"catheter-based":[165],"medically":[167],"(3,0/year":[170],"2,2/year).":[172],"Both":[173],"suffering":[175],"from":[176,243],"after":[178],"(n=2)":[181],"had":[182],"residual":[183],"shunts.":[184],"Conclusions:":[185],"absolute":[187],"cerebrovascular":[191],"receiving":[197],"therapy":[201],"low.":[203],"For":[204],"classification,":[206],"size,":[209],"spite":[221],"should":[225],"be":[226],"carefully":[227],"determined.":[228],"Although":[229],"majority":[231],"efficiently":[235],"medicaly":[236],"treated,":[237],"certain":[238],"high-risk":[239],"groups":[240],"may":[241],"benefit":[242],"definite":[244],"(priority":[246],"specialized":[250],"centers)":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}