{"id":"https://openalex.org/W2282989802","doi":null,"title":"The first step towards the development of an electrophoretic prion detector","display_name":"The first step towards the development of an electrophoretic prion detector","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2282989802","mag":"2282989802"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-08082011-162258","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-08082011-162258","pdf_url":"https://harvest.usask.ca/bitstreams/2749b6d3-bbe3-4183-b0fc-6093e62f1d4b/download","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://harvest.usask.ca/bitstreams/2749b6d3-bbe3-4183-b0fc-6093e62f1d4b/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112378659","display_name":"Claudia Avis Madampage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claudia Madampage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112378659"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-hemolysin","display_name":"alpha-hemolysin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/prion-detection","display_name":"prion detection","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bovine-prion-protein","display_name":"bovine prion protein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-translocation","display_name":"protein translocation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/peptide-translocation","display_name":"peptide translocation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.6819999814033508},{"id":"https://openalex.org/keywords/folding-intermediates","display_name":"folding intermediates","score":0.921999990940094},{"id":"https://openalex.org/keywords/single-molecule-detection","display_name":"single-molecule detection","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4343518614768982}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/etd-08082011-162258","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-08082011-162258","pdf_url":"https://harvest.usask.ca/bitstreams/2749b6d3-bbe3-4183-b0fc-6093e62f1d4b/download","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/etd-08082011-162258","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/etd-08082011-162258","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2282989802","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/bitstream/10388/etd-08082011-162258/1/Thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-08082011-162258","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-08082011-162258","pdf_url":"https://harvest.usask.ca/bitstreams/2749b6d3-bbe3-4183-b0fc-6093e62f1d4b/download","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2282989802.pdf","grobid_xml":"https://content.openalex.org/works/W2282989802.grobid-xml"},"referenced_works_count":479,"referenced_works":["https://openalex.org/W88508911","https://openalex.org/W103986698","https://openalex.org/W146253285","https://openalex.org/W164022543","https://openalex.org/W370260827","https://openalex.org/W638709276","https://openalex.org/W1225403746","https://openalex.org/W1481296411","https://openalex.org/W1492262300","https://openalex.org/W1492349014","https://openalex.org/W1495221297","https://openalex.org/W1504267511","https://openalex.org/W1508564334","https://openalex.org/W1518293840","https://openalex.org/W1527047915","https://openalex.org/W1531180332","https://openalex.org/W1534728973","https://openalex.org/W1538230865","https://openalex.org/W1546470600","https://openalex.org/W1557182452","https://openalex.org/W1557724928","https://openalex.org/W1561445208","https://openalex.org/W1563909688","https://openalex.org/W1566848521","https://openalex.org/W1573809350","https://openalex.org/W1573955539","https://openalex.org/W1575128625","https://openalex.org/W1583440911","https://openalex.org/W1585073473","https://openalex.org/W1598796342","https://openalex.org/W1606920356","https://openalex.org/W1619710608","https://openalex.org/W1624018543","https://openalex.org/W1633149113","https://openalex.org/W1658649599","https://openalex.org/W1678350171","https://openalex.org/W1704732331","https://openalex.org/W1733593391","https://openalex.org/W1774320314","https://openalex.org/W1817087919","https://openalex.org/W1830282454","https://openalex.org/W1839118167","https://openalex.org/W1878693307","https://openalex.org/W1933863182","https://openalex.org/W1964627321","https://openalex.org/W1964730348","https://openalex.org/W1964752817","https://openalex.org/W1966535643","https://openalex.org/W1968307266","https://openalex.org/W1968485623","https://openalex.org/W1969190984","https://openalex.org/W1969615033","https://openalex.org/W1970231182","https://openalex.org/W1970611074","https://openalex.org/W1970987171","https://openalex.org/W1971200038","https://openalex.org/W1971212710","https://openalex.org/W1971880089","https://openalex.org/W1972074942","https://openalex.org/W1972720178","https://openalex.org/W1972777213","https://openalex.org/W1973078413","https://openalex.org/W1975966604","https://openalex.org/W1976133898","https://openalex.org/W1976397183","https://openalex.org/W1976951513","https://openalex.org/W1977514567","https://openalex.org/W1978525961","https://openalex.org/W1978663383","https://openalex.org/W1978941223","https://openalex.org/W1979187940","https://openalex.org/W1981260293","https://openalex.org/W1982280799","https://openalex.org/W1982288739","https://openalex.org/W1982534182","https://openalex.org/W1982651400","https://openalex.org/W1982898268","https://openalex.org/W1983750916","https://openalex.org/W1983861942","https://openalex.org/W1985001321","https://openalex.org/W1985155893","https://openalex.org/W1985315884","https://openalex.org/W1985829798","https://openalex.org/W1986553396","https://openalex.org/W1987268193","https://openalex.org/W1987566729","https://openalex.org/W1987847765","https://openalex.org/W1988744922","https://openalex.org/W1988901585","https://openalex.org/W1989150559","https://openalex.org/W1989241675","https://openalex.org/W1989531795","https://openalex.org/W1989838784","https://openalex.org/W1989918649","https://openalex.org/W1990084184","https://openalex.org/W1990112908","https://openalex.org/W1990264812","https://openalex.org/W1990391869","https://openalex.org/W1990623935","https://openalex.org/W1991039509","https://openalex.org/W1991674727","https://openalex.org/W1992084965","https://openalex.org/W1993820504","https://openalex.org/W1994660369","https://openalex.org/W1995522769","https://openalex.org/W1996513738","https://openalex.org/W1997119515","https://openalex.org/W1997139797","https://openalex.org/W1997725693","https://openalex.org/W1998345991","https://openalex.org/W1999069908","https://openalex.org/W2000057317","https://openalex.org/W2000262724","https://openalex.org/W2001091850","https://openalex.org/W2002189507","https://openalex.org/W2002320632","https://openalex.org/W2002645252","https://openalex.org/W2002852647","https://openalex.org/W2003156002","https://openalex.org/W2003474735","https://openalex.org/W2003671997","https://openalex.org/W2004994031","https://openalex.org/W2005566671","https://openalex.org/W2005693512","https://openalex.org/W2006540966","https://openalex.org/W2006810449","https://openalex.org/W2006907498","https://openalex.org/W2006947113","https://openalex.org/W2007093034","https://openalex.org/W2007126425","https://openalex.org/W2007504230","https://openalex.org/W2007989713","https://openalex.org/W2008096642","https://openalex.org/W2008209736","https://openalex.org/W2009025716","https://openalex.org/W2009083349","https://openalex.org/W2009292770","https://openalex.org/W2009667219","https://openalex.org/W2009886994","https://openalex.org/W2011180058","https://openalex.org/W2011562647","https://openalex.org/W2011989202","https://openalex.org/W2012128918","https://openalex.org/W2012405730","https://openalex.org/W2012541956","https://openalex.org/W2012694433","https://openalex.org/W2013679718","https://openalex.org/W2014742609","https://openalex.org/W2015566874","https://openalex.org/W2015701671","https://openalex.org/W2015811557","https://openalex.org/W2016196561","https://openalex.org/W2016247254","https://openalex.org/W2016776155","https://openalex.org/W2016857135","https://openalex.org/W2017014906","https://openalex.org/W2017216510","https://openalex.org/W2017267009","https://openalex.org/W2017621244","https://openalex.org/W2018009677","https://openalex.org/W2018407130","https://openalex.org/W2019950598","https://openalex.org/W2020199691","https://openalex.org/W2020258831","https://openalex.org/W2020449159","https://openalex.org/W2020522725","https://openalex.org/W2021054607","https://openalex.org/W2021871166","https://openalex.org/W2022392367","https://openalex.org/W2022614447","https://openalex.org/W2022735447","https://openalex.org/W2022878400","https://openalex.org/W2023178515","https://openalex.org/W2023290470","https://openalex.org/W2023338142","https://openalex.org/W2023529808","https://openalex.org/W2023918463","https://openalex.org/W2024293507","https://openalex.org/W2024441578","https://openalex.org/W2025445118","https://openalex.org/W2025583382","https://openalex.org/W2025658533","https://openalex.org/W2026459175","https://openalex.org/W2026613451","https://openalex.org/W2026912511","https://openalex.org/W2027009369","https://openalex.org/W2027397937","https://openalex.org/W2027854802","https://openalex.org/W2028038575","https://openalex.org/W2028271728","https://openalex.org/W2028345570","https://openalex.org/W2029440340","https://openalex.org/W2030505387","https://openalex.org/W2030683115","https://openalex.org/W2030809838","https://openalex.org/W2030970284","https://openalex.org/W2031245531","https://openalex.org/W2032530512","https://openalex.org/W2032648665","https://openalex.org/W2032711662","https://openalex.org/W2032825857","https://openalex.org/W2034045875","https://openalex.org/W2034156336","https://openalex.org/W2034797921","https://openalex.org/W2035004702","https://openalex.org/W2035611358","https://openalex.org/W2035922686","https://openalex.org/W2036105970","https://openalex.org/W2037257326","https://openalex.org/W2037724790","https://openalex.org/W2038964762","https://openalex.org/W2039525761","https://openalex.org/W2041867303","https://openalex.org/W2041998593","https://openalex.org/W2042169196","https://openalex.org/W2042368222","https://openalex.org/W2042978244","https://openalex.org/W2045439785","https://openalex.org/W2047060525","https://openalex.org/W2047132654","https://openalex.org/W2047510784","https://openalex.org/W2048041842","https://openalex.org/W2048166729","https://openalex.org/W2048339382","https://openalex.org/W2048556815","https://openalex.org/W2048667237","https://openalex.org/W2049003730","https://openalex.org/W2049055716","https://openalex.org/W2049320468","https://openalex.org/W2049622201","https://openalex.org/W2050369906","https://openalex.org/W2051193695","https://openalex.org/W2051524724","https://openalex.org/W2051540079","https://openalex.org/W2051815061","https://openalex.org/W2052024288","https://openalex.org/W2052706468","https://openalex.org/W2052733154","https://openalex.org/W2053290111","https://openalex.org/W2053457342","https://openalex.org/W2054138964","https://openalex.org/W2054260887","https://openalex.org/W2054886377","https://openalex.org/W2054904323","https://openalex.org/W2055188598","https://openalex.org/W2056182522","https://openalex.org/W2057293794","https://openalex.org/W2057448845","https://openalex.org/W2057579163","https://openalex.org/W2058411875","https://openalex.org/W2058659733","https://openalex.org/W2058766976","https://openalex.org/W2059205219","https://openalex.org/W2059804089","https://openalex.org/W2060025547","https://openalex.org/W2060423946","https://openalex.org/W2060452207","https://openalex.org/W2060541402","https://openalex.org/W2061056467","https://openalex.org/W2061232909","https://openalex.org/W2061627162","https://openalex.org/W2061657355","https://openalex.org/W2061952239","https://openalex.org/W2062743922","https://openalex.org/W2063553621","https://openalex.org/W2063984934","https://openalex.org/W2064127944","https://openalex.org/W2064722614","https://openalex.org/W2065533951","https://openalex.org/W2065640711","https://openalex.org/W2066756249","https://openalex.org/W2066881913","https://openalex.org/W2067531824","https://openalex.org/W2067689618","https://openalex.org/W2068602112","https://openalex.org/W2070651788","https://openalex.org/W2070764974","https://openalex.org/W2070813536","https://openalex.org/W2071021036","https://openalex.org/W2071599250","https://openalex.org/W2072296425","https://openalex.org/W2072303997","https://openalex.org/W2072350671","https://openalex.org/W2075648677","https://openalex.org/W2075776126","https://openalex.org/W2075777353","https://openalex.org/W2076146345","https://openalex.org/W2076567649","https://openalex.org/W2076633565","https://openalex.org/W2077403248","https://openalex.org/W2078320842","https://openalex.org/W2078365170","https://openalex.org/W2079538521","https://openalex.org/W2080053124","https://openalex.org/W2080433158","https://openalex.org/W2082197002","https://openalex.org/W2082843999","https://openalex.org/W2082872027","https://openalex.org/W2082998566","https://openalex.org/W2083540358","https://openalex.org/W2083642579","https://openalex.org/W2084249759","https://openalex.org/W2084646890","https://openalex.org/W2084774024","https://openalex.org/W2084946341","https://openalex.org/W2085336728","https://openalex.org/W2085431407","https://openalex.org/W2085714100","https://openalex.org/W2086183656","https://openalex.org/W2086426300","https://openalex.org/W2086780152","https://openalex.org/W2086782779","https://openalex.org/W2087102081","https://openalex.org/W2087116956","https://openalex.org/W2088321333","https://openalex.org/W2090807504","https://openalex.org/W2090924278","https://openalex.org/W2091539334","https://openalex.org/W2092042046","https://openalex.org/W2092063619","https://openalex.org/W2093101754","https://openalex.org/W2094095233","https://openalex.org/W2094537242","https://openalex.org/W2094947144","https://openalex.org/W2095100443","https://openalex.org/W2095358223","https://openalex.org/W2095898308","https://openalex.org/W2096678988","https://openalex.org/W2097337121","https://openalex.org/W2099026571","https://openalex.org/W2099691647","https://openalex.org/W2101247857","https://openalex.org/W2102453092","https://openalex.org/W2102801175","https://openalex.org/W2102940047","https://openalex.org/W2103270514","https://openalex.org/W2103352856","https://openalex.org/W2103468162","https://openalex.org/W2103556163","https://openalex.org/W2103971664","https://openalex.org/W2104311920","https://openalex.org/W2104463631","https://openalex.org/W2104672342","https://openalex.org/W2104949076","https://openalex.org/W2105131059","https://openalex.org/W2105784500","https://openalex.org/W2106093671","https://openalex.org/W2107240568","https://openalex.org/W2107323267","https://openalex.org/W2107749044","https://openalex.org/W2107919301","https://openalex.org/W2108058966","https://openalex.org/W2108180175","https://openalex.org/W2110584587","https://openalex.org/W2111400509","https://openalex.org/W2111469645","https://openalex.org/W2111518775","https://openalex.org/W2111832767","https://openalex.org/W2112705133","https://openalex.org/W2113231874","https://openalex.org/W2113752368","https://openalex.org/W2114283841","https://openalex.org/W2114880494","https://openalex.org/W2114886185","https://openalex.org/W2116988453","https://openalex.org/W2117016125","https://openalex.org/W2118579429","https://openalex.org/W2118608964","https://openalex.org/W2119794733","https://openalex.org/W2120350230","https://openalex.org/W2121611717","https://openalex.org/W2121615663","https://openalex.org/W2122062385","https://openalex.org/W2122062639","https://openalex.org/W2122541606","https://openalex.org/W2123086824","https://openalex.org/W2123275492","https://openalex.org/W2124692732","https://openalex.org/W2125021618","https://openalex.org/W2125991606","https://openalex.org/W2126111700","https://openalex.org/W2127104838","https://openalex.org/W2127407003","https://openalex.org/W2127555797","https://openalex.org/W2128048423","https://openalex.org/W2128661804","https://openalex.org/W2128944252","https://openalex.org/W2129234254","https://openalex.org/W2129427144","https://openalex.org/W2129979528","https://openalex.org/W2131477676","https://openalex.org/W2131973852","https://openalex.org/W2133538960","https://openalex.org/W2134462664","https://openalex.org/W2134958632","https://openalex.org/W2135301408","https://openalex.org/W2135487357","https://openalex.org/W2136356270","https://openalex.org/W2136442838","https://openalex.org/W2136565736","https://openalex.org/W2136959524","https://openalex.org/W2137774806","https://openalex.org/W2138468217","https://openalex.org/W2138498069","https://openalex.org/W2138823948","https://openalex.org/W2138948398","https://openalex.org/W2139875839","https://openalex.org/W2140059341","https://openalex.org/W2140415834","https://openalex.org/W2141663125","https://openalex.org/W2141796158","https://openalex.org/W2141820674","https://openalex.org/W2141848451","https://openalex.org/W2141993669","https://openalex.org/W2142844453","https://openalex.org/W2142929893","https://openalex.org/W2142962840","https://openalex.org/W2143797894","https://openalex.org/W2143847761","https://openalex.org/W2144622957","https://openalex.org/W2144825332","https://openalex.org/W2147276565","https://openalex.org/W2148130200","https://openalex.org/W2148139858","https://openalex.org/W2149723426","https://openalex.org/W2149858731","https://openalex.org/W2151176009","https://openalex.org/W2153896793","https://openalex.org/W2154027377","https://openalex.org/W2154143507","https://openalex.org/W2154224094","https://openalex.org/W2154247440","https://openalex.org/W2154336998","https://openalex.org/W2155168718","https://openalex.org/W2156629890","https://openalex.org/W2157114632","https://openalex.org/W2157629307","https://openalex.org/W2157784883","https://openalex.org/W2157980298","https://openalex.org/W2158208080","https://openalex.org/W2158483456","https://openalex.org/W2158676848","https://openalex.org/W2158797055","https://openalex.org/W2160385421","https://openalex.org/W2164123708","https://openalex.org/W2164960448","https://openalex.org/W2165186407","https://openalex.org/W2165946906","https://openalex.org/W2167404530","https://openalex.org/W2167441750","https://openalex.org/W2167503783","https://openalex.org/W2167517570","https://openalex.org/W2167788333","https://openalex.org/W2167969358","https://openalex.org/W2168323480","https://openalex.org/W2168701047","https://openalex.org/W2168864377","https://openalex.org/W2170150611","https://openalex.org/W2171037304","https://openalex.org/W2171089945","https://openalex.org/W2171560184","https://openalex.org/W2171861123","https://openalex.org/W2172118867","https://openalex.org/W2172212022","https://openalex.org/W2185551856","https://openalex.org/W2278407379","https://openalex.org/W2314502625","https://openalex.org/W2321080235","https://openalex.org/W2325854321","https://openalex.org/W2327641970","https://openalex.org/W2408079270","https://openalex.org/W2413433335","https://openalex.org/W2432963219","https://openalex.org/W2440013949","https://openalex.org/W2467984685","https://openalex.org/W2476716000","https://openalex.org/W2494402508","https://openalex.org/W2798979737","https://openalex.org/W2886987336"],"related_works":["https://openalex.org/W1976397183","https://openalex.org/W2095100443","https://openalex.org/W1530761405","https://openalex.org/W2024755652","https://openalex.org/W1979187940","https://openalex.org/W4319931933","https://openalex.org/W77962473","https://openalex.org/W1989367572","https://openalex.org/W4406690654","https://openalex.org/W2467984685"],"abstract_inverted_index":{"In":[0,262],"nanopore":[1,243,265,286],"analysis,":[2],"peptides":[3,42,46,141,236,311],"and":[4,88,110,129,144,170,234,237,291,302,308,339],"proteins":[5,238],"can":[6,239,266],"be":[7,240],"detected":[8,241],"by":[9,242],"the":[10,29,59,67,98,114,117,127,132,150,254,275,279,289,292,296,305,316,325,336],"change":[11],"in":[12,23,58,113,224],"current":[13,188],"when":[14],"single":[15,269],"molecules":[16,259],"interact":[17,312],"with":[18,85,142,164,185,210,313,346],"an":[19,62,222],"\u03b1-hemolysin":[20,165],"pore":[21],"embedded":[22],"a":[24,56,104,186,264,268,282,321,343],"lipid":[25],"membrane.":[26],"Studies":[27],"into":[28,342],"effects":[30],"of":[31,55,61,69,76,119,131,139,159,178,189,207,281,328,352],"fluorenylmethoxycarbonyl":[32],"(Fmoc),":[33],"acetylation":[34],"or":[35,81,215],"proline":[36,57],"modification":[37],"to":[38,72,97,149,227,251,298,320,350],"negatively":[39],"charged":[40],"\u03b1-helical":[41,87,143],"showed":[43,166,198,212],"that":[44,153,180,199,213,335],"Fmoc":[45],"give":[47],"more":[48],"translocations":[49,70,95,111,120],"than":[50],"acetylated":[51,63],"peptides.":[52],"The":[53,74,91,100,157,205,245,285],"addition":[54],"middle":[60],"peptide":[64,77,116],"further":[65],"reduces":[66],"number":[68],"compared":[71,96],"Fmoc.":[73],"effect":[75],"conformation":[78,345],"on":[79],"translocation":[80,225],"intercalation":[82],"was":[83,121],"studied":[84],"small":[86],"\u03b2-sheet":[89],"hairpins.":[90],"capped":[92],"\u03b2-hairpin":[93],"increased":[94],"uncapped.":[99],"Fmoc-\u03b1-helical":[101],"hairpin,":[102],"containing":[103],"disulfide":[105],"link,":[106],"displayed":[107],"both":[108,167],"bumping":[109,168],"whereas":[112,253],"unlinked":[115],"proportion":[118],"greater.":[122],"Prion":[123],"diseases":[124],"arise":[125],"from":[126],"misfolding":[128],"aggregation":[130],"normal":[133],"cellular":[134],"prion":[135,140,161,235,283,306],"protein.":[136],"Nanopore":[137,196],"analysis":[138,197],"\u03b2-strand":[145],"sequences":[146],"show":[147],"changes":[148],"event":[151,255,317,347],"parameters":[152,256,348],"help":[154],"distinguish":[155,299],"them.":[156],"interaction":[158,206],"bovine":[160],"protein":[162,337],"(bPrP),":[163],"(type-I)":[169],"intercalation/translocation":[171],"(type-II)":[172],"events.":[173],"There":[174],"are":[175,260],"several":[176],"lines":[177],"evidence":[179],"indicate":[181],"these":[182],"type-II":[183],"events":[184,202,226],"blockade":[187],"-65":[190],"pA":[191],"for":[192,257],"bPrP,":[193],"represent":[194],"translocations.":[195,204,218],"about":[200,228],"37%":[201],"were":[203],"metal":[208],"ions":[209],"bPrP":[211,314,329],"Cu(II)":[214],"Zn(II)":[216],"reduced":[217],"Surprisingly,":[219],"Mn(II)":[220],"caused":[221],"increase":[223],"64%.":[229],"Complex":[230],"formation":[231],"between":[232,300],"antibodies":[233,293],"analysis.":[244],"PrP/antibody":[246],"complex":[247],"is":[248],"too":[249],"large":[250],"translocate":[252],"unbound":[258],"unchanged.":[261],"principle,":[263],"detect":[267],"molecule;":[270],"thus,":[271],"this":[272],"work":[273],"represents":[274],"first":[276],"step":[277],"towards":[278],"development":[280],"detector.":[284],"will":[287,294],"provide":[288,295],"sensitivity":[290],"specificity":[297],"PrPC":[301],"PrPSc.":[303],"Also,":[304],"N-":[307],"C-terminal":[309],"signal":[310],"changing":[315],"parameters,":[318],"relating":[319],"new":[322],"mechanism.":[323],"Finally,":[324],"folding":[326],"intermediates":[327],"at":[330],"0.86":[331],"M":[332],"Gdn-HCl":[333],"suggests":[334],"unfolds":[338],"then":[340],"refolds":[341],"different":[344],"similar":[349],"those":[351],"bPrP.":[353]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}