{"id":"https://openalex.org/W2282554866","doi":null,"title":"Hypertrophic cardiomyopathy-linked alpha-cardiac actin mutations and their role on actomyosin interactions","display_name":"Hypertrophic cardiomyopathy-linked alpha-cardiac actin mutations and their role on actomyosin interactions","publication_year":2015,"publication_date":"2015-05-05","ids":{"openalex":"https://openalex.org/W2282554866","mag":"2282554866"},"language":"en","primary_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8801","pdf_url":"http://hdl.handle.net/10214/8801","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10214/8801","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091598201","display_name":"Maria Anillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Anillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091598201"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-alpha-actin","display_name":"alpha-cardiac actin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/actin-myosin-interaction","display_name":"actin-myosin interaction","score":0.902999997138977},{"id":"https://openalex.org/keywords/duty-cycle","display_name":"duty cycle","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sarcomeric-proteins","display_name":"sarcomeric proteins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardiac-muscle-contraction","display_name":"cardiac muscle contraction","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.7951867580413818},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.6457624435424805},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6054054498672485},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4841780960559845},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45419034361839294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40311428904533386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3279433846473694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.322738379240036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23008093237876892}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8801","pdf_url":"http://hdl.handle.net/10214/8801","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2282554866","doi":null,"is_oa":false,"landing_page_url":"https://atrium.lib.uoguelph.ca/xmlui/bitstream/handle/10214/8801/Anillo_Maria_201505_MSc.pdf;sequence=3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8801","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8801","pdf_url":"http://hdl.handle.net/10214/8801","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2282554866.pdf","grobid_xml":"https://content.openalex.org/works/W2282554866.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W3452360","https://openalex.org/W589975765","https://openalex.org/W599719449","https://openalex.org/W1484177930","https://openalex.org/W1517924156","https://openalex.org/W1538692246","https://openalex.org/W1553795439","https://openalex.org/W1573173148","https://openalex.org/W1824385938","https://openalex.org/W1901823973","https://openalex.org/W1962950334","https://openalex.org/W1963507186","https://openalex.org/W1964897783","https://openalex.org/W1965042960","https://openalex.org/W1966663172","https://openalex.org/W1968778374","https://openalex.org/W1968894591","https://openalex.org/W1969933847","https://openalex.org/W1975421284","https://openalex.org/W1976171313","https://openalex.org/W1976658184","https://openalex.org/W1977049048","https://openalex.org/W1980389907","https://openalex.org/W1980392151","https://openalex.org/W1982969737","https://openalex.org/W1984415904","https://openalex.org/W1984725648","https://openalex.org/W1984943062","https://openalex.org/W1997906151","https://openalex.org/W2000358630","https://openalex.org/W2001626522","https://openalex.org/W2002553862","https://openalex.org/W2002621138","https://openalex.org/W2003468593","https://openalex.org/W2005070668","https://openalex.org/W2011362038","https://openalex.org/W2014203816","https://openalex.org/W2026182775","https://openalex.org/W2031349613","https://openalex.org/W2036340138","https://openalex.org/W2036426310","https://openalex.org/W2036540440","https://openalex.org/W2037030280","https://openalex.org/W2037615332","https://openalex.org/W2039495884","https://openalex.org/W2040899301","https://openalex.org/W2042379041","https://openalex.org/W2042562951","https://openalex.org/W2043642289","https://openalex.org/W2044403474","https://openalex.org/W2044629144","https://openalex.org/W2045878687","https://openalex.org/W2053271991","https://openalex.org/W2056671887","https://openalex.org/W2062170165","https://openalex.org/W2062372050","https://openalex.org/W2062419041","https://openalex.org/W2062471801","https://openalex.org/W2068459121","https://openalex.org/W2073084279","https://openalex.org/W2076579909","https://openalex.org/W2078663666","https://openalex.org/W2079043315","https://openalex.org/W2082173027","https://openalex.org/W2082936028","https://openalex.org/W2086529412","https://openalex.org/W2086554842","https://openalex.org/W2087633651","https://openalex.org/W2090521614","https://openalex.org/W2093545737","https://openalex.org/W2099302775","https://openalex.org/W2100837269","https://openalex.org/W2112590743","https://openalex.org/W2113565284","https://openalex.org/W2115353136","https://openalex.org/W2118238916","https://openalex.org/W2119766339","https://openalex.org/W2121936157","https://openalex.org/W2129408645","https://openalex.org/W2129992226","https://openalex.org/W2132677514","https://openalex.org/W2133730954","https://openalex.org/W2135992267","https://openalex.org/W2137128469","https://openalex.org/W2137542902","https://openalex.org/W2139229287","https://openalex.org/W2139292873","https://openalex.org/W2139834186","https://openalex.org/W2140040046","https://openalex.org/W2145367033","https://openalex.org/W2146691714","https://openalex.org/W2149321230","https://openalex.org/W2149422196","https://openalex.org/W2153274079","https://openalex.org/W2154965092","https://openalex.org/W2158081637","https://openalex.org/W2159669366","https://openalex.org/W2159675291","https://openalex.org/W2167320958","https://openalex.org/W2171122741","https://openalex.org/W2313988373","https://openalex.org/W2411066716","https://openalex.org/W2418071088","https://openalex.org/W2474950595","https://openalex.org/W3030239592"],"related_works":["https://openalex.org/W2764138940","https://openalex.org/W2580633931","https://openalex.org/W1990314548","https://openalex.org/W2062419041","https://openalex.org/W2608059894","https://openalex.org/W2945300436","https://openalex.org/W2800742750","https://openalex.org/W7009858529","https://openalex.org/W2062471801","https://openalex.org/W4378528832"],"abstract_inverted_index":{"Mutations":[0],"in":[1,10,35,51,73],"genes":[2],"encoding":[3],"sarcomeric":[4],"proteins":[5],"are":[6,33],"linked":[7],"to":[8,96],"changes":[9],"the":[11,41,58,79,90,112,116,119,123,126,137,141],"myocardium":[12],"which":[13],"can":[14],"manifest":[15],"as":[16],"hypertrophic":[17],"cardiomyopathy":[18],"(HCM).":[19],"Three":[20],"\u03b1-cardiac":[21],"actin":[22,39,47,64,77,101],"(ACTC)":[23],"gene":[24],"mutations":[25,72],"(R95C,":[26],"F90\u0394,":[27],"and":[28,48,65,104],"H88Y)":[29],"associated":[30],"with":[31],"HCM,":[32],"located":[34],"subdomain":[36,74],"1":[37,75],"of":[38,60,76,118],"at":[40],"actomyosin":[42],"interface.":[43],"Cyclic":[44],"interactions":[45],"between":[46],"myosin":[49,66],"result":[50],"contraction.":[52],"The":[53,86],"duty":[54,80,87],"ratio,":[55],"r,":[56],"is":[57,70],"fraction":[59],"time":[61],"spent":[62],"by":[63,140],"interacting.":[67],"My":[68],"hypothesis":[69],"that":[71,111],"increase":[78],"ratio":[81,88],"allowing":[82],"for":[83,89,125],"HCM":[84,145],"development.":[85,146],"R95C":[91],"ACTC":[92,120,127,142],"variant":[93],"was":[94],"found":[95],"be":[97,130],"higher":[98],"than":[99],"bovine":[100],"while":[102],"F90\u0394":[103],"H88Y":[105],"were":[106],"lower.":[107],"Further":[108],"investigation":[109],"revealed":[110],"DNase-I":[113],"purification":[114],"affected":[115],"activity":[117],"variants.":[121],"Therefore,":[122],"r":[124],"variants":[128,143],"may":[129],"unreliable;":[131],"hence,":[132],"I":[133],"cannot":[134],"confidently":[135],"determine":[136],"mechanism":[138],"used":[139],"leading":[144]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}