{"id":"https://openalex.org/W2282300994","doi":null,"title":"Cholesterol lowering effects of bovine serum immunoglobulin in human participants with mild hypercholesterolemia","display_name":"Cholesterol lowering effects of bovine serum immunoglobulin in human participants with mild hypercholesterolemia","publication_year":2006,"publication_date":"2006-10-30","ids":{"openalex":"https://openalex.org/W2282300994","mag":"2282300994"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/4153","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/4153","pdf_url":"https://hdl.handle.net/1969.1/4153","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1969.1/4153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021267960","display_name":"Melinda Lori Black","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melinda Lori Black","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021267960"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.3206000030040741,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.949999988079071},{"id":"https://openalex.org/keywords/cholesterol-lowering","display_name":"cholesterol lowering","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.46799999475479126},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.574999988079071},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.677986204624176},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.669222354888916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5678301453590393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5263682007789612},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4622914493083954},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45481714606285095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20544299483299255},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/4153","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/4153","pdf_url":"https://hdl.handle.net/1969.1/4153","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2282300994","doi":null,"is_oa":false,"landing_page_url":"http://oaktrust.library.tamu.edu/bitstream/handle/1969.1/4153/etd-tamu-2005B-NUTR-Safir.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/4153","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/4153","pdf_url":"https://hdl.handle.net/1969.1/4153","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2282300994.pdf","grobid_xml":"https://content.openalex.org/works/W2282300994.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W24840142","https://openalex.org/W62594355","https://openalex.org/W66416128","https://openalex.org/W68552834","https://openalex.org/W127956282","https://openalex.org/W149938039","https://openalex.org/W204166006","https://openalex.org/W1562430392","https://openalex.org/W1772398232","https://openalex.org/W1893040569","https://openalex.org/W1899698110","https://openalex.org/W1899810945","https://openalex.org/W1903634699","https://openalex.org/W1918045645","https://openalex.org/W1918987183","https://openalex.org/W1938124489","https://openalex.org/W1957663279","https://openalex.org/W1971383366","https://openalex.org/W1972000972","https://openalex.org/W1972110417","https://openalex.org/W1981237781","https://openalex.org/W1982596778","https://openalex.org/W1983844880","https://openalex.org/W1984058728","https://openalex.org/W1992597684","https://openalex.org/W1994691874","https://openalex.org/W1999043640","https://openalex.org/W2003839321","https://openalex.org/W2006911110","https://openalex.org/W2012952446","https://openalex.org/W2012990523","https://openalex.org/W2013161578","https://openalex.org/W2013698805","https://openalex.org/W2013932227","https://openalex.org/W2014243241","https://openalex.org/W2018865741","https://openalex.org/W2019114283","https://openalex.org/W2019570915","https://openalex.org/W2020255415","https://openalex.org/W2020821268","https://openalex.org/W2023216000","https://openalex.org/W2024018426","https://openalex.org/W2024674799","https://openalex.org/W2025650630","https://openalex.org/W2032804222","https://openalex.org/W2036787377","https://openalex.org/W2040137572","https://openalex.org/W2040281229","https://openalex.org/W2045065016","https://openalex.org/W2046523416","https://openalex.org/W2048474290","https://openalex.org/W2050804963","https://openalex.org/W2051905777","https://openalex.org/W2052725031","https://openalex.org/W2055054372","https://openalex.org/W2059078444","https://openalex.org/W2059189902","https://openalex.org/W2062039627","https://openalex.org/W2063722000","https://openalex.org/W2066264822","https://openalex.org/W2066281438","https://openalex.org/W2067394325","https://openalex.org/W2068596738","https://openalex.org/W2080711306","https://openalex.org/W2083980136","https://openalex.org/W2084613815","https://openalex.org/W2086228842","https://openalex.org/W2086705478","https://openalex.org/W2106184090","https://openalex.org/W2112815973","https://openalex.org/W2115762872","https://openalex.org/W2116404316","https://openalex.org/W2117928399","https://openalex.org/W2118080822","https://openalex.org/W2119767830","https://openalex.org/W2120093041","https://openalex.org/W2122977248","https://openalex.org/W2126128848","https://openalex.org/W2129963828","https://openalex.org/W2130171854","https://openalex.org/W2134013689","https://openalex.org/W2134854746","https://openalex.org/W2135568455","https://openalex.org/W2139352774","https://openalex.org/W2140174721","https://openalex.org/W2142656956","https://openalex.org/W2143220508","https://openalex.org/W2143484935","https://openalex.org/W2145756100","https://openalex.org/W2146902372","https://openalex.org/W2151312829","https://openalex.org/W2155303176","https://openalex.org/W2158460399","https://openalex.org/W2159281982","https://openalex.org/W2163895795","https://openalex.org/W2164892349","https://openalex.org/W2167949935","https://openalex.org/W2170048963","https://openalex.org/W2172216800","https://openalex.org/W2258744761","https://openalex.org/W2266811122","https://openalex.org/W2267118053","https://openalex.org/W2276251365","https://openalex.org/W2312331326","https://openalex.org/W2316376271","https://openalex.org/W2317184793","https://openalex.org/W2328390279","https://openalex.org/W2395913347","https://openalex.org/W2412081635","https://openalex.org/W2417362597","https://openalex.org/W2429267777","https://openalex.org/W2443858347","https://openalex.org/W2466168554","https://openalex.org/W2468891502","https://openalex.org/W2477872031","https://openalex.org/W2764517945","https://openalex.org/W4238451924","https://openalex.org/W4240069246","https://openalex.org/W4249825849","https://openalex.org/W4254413925","https://openalex.org/W4407364800"],"related_works":["https://openalex.org/W2159281982","https://openalex.org/W119471040","https://openalex.org/W2143484935","https://openalex.org/W2266811122","https://openalex.org/W2216324968","https://openalex.org/W2056091292","https://openalex.org/W2082338244","https://openalex.org/W2113237353","https://openalex.org/W2044305271","https://openalex.org/W2062423155"],"abstract_inverted_index":{"Hypercholesterolemia":[0],"is":[1],"a":[2,191],"major":[3,270],"risk":[4],"factor":[5],"for":[6,140,182],"cardiovascular":[7,263],"disease":[8],"(CVD).\\nInterestingly,":[9],"the":[10,32,79,127,195,199,236,249],"consumption":[11],"of":[12,24,35,45,66,81,93,126,134,178,194,266],"dairy":[13],"products,":[14],"namely":[15],"milk,":[16],"has":[17,29],"been":[18,30,40],"shown":[19],"to":[20,228,268],"lower\\ncholesterol.":[21],"The":[22,230],"mechanism":[23],"action":[25],"surrounding":[26],"this":[27],"observation":[28],"attributed\\nto":[31],"protein":[33,47,57,69],"fraction":[34,87],"milk.":[36],"While":[37],"there":[38],"have":[39,74],"many":[41],"studies":[42,53,63],"evaluating":[43],"the\\neffects":[44],"dietary":[46],"sources":[48],"on":[49,71,100],"cholesterol":[50,72,162],"concentrations,":[51],"few":[52],"have\\nevaluated":[54],"specific":[55],"animal":[56,67],"components":[58],"and":[59,108,152,159,169,187,190,217],"no":[60,245],"human":[61],"clinical":[62],"regarding\\nthe":[64],"effects":[65],"plasma":[68],"fractions":[70],"metabolism":[73],"been\\nconducted.":[75],"This":[76],"study":[77,243],"examined":[78],"effect":[80],"an":[82],"oral":[83],"serum":[84],"bovine":[85],"immunoglobulin\\nprotein":[86],"(bIg)":[88],"derived":[89],"from":[90],"US":[91],"Department":[92],"Agriculture":[94],"approved":[95],"beef":[96],"(aged":[97,110],"<\\n30":[98],"months)":[99],"lipid":[101,256,271],"indices":[102],"in":[103,144,150,184,205,248,253],"hypercholesterolemic":[104],"humans.\\nParticipants":[105],"included":[106],"men":[107],"women":[109],"25":[111],"\u2013":[112],"70":[113],"years)":[114],"with":[115,260,274],"mild\\nhypercholesterolemia":[116],"(5.44-6.99":[117],"mmol/L)":[118],"who":[119],"were":[120],"not":[121],"receiving":[122],"cholesterol-lowering\\nmedication.":[123],"Treatment":[124],"consisted":[125],"randomized,":[128],"double":[129],"blind,":[130],"parallel":[131],"group,\\nplacebo-controlled":[132],"administration":[133],"5":[135],"grams":[136],"(g)":[137],"bIg":[138],"daily":[139],"6":[141],"weeks":[142],"(W)":[143,209],"52\\nparticipants":[145],"(n":[146],"=":[147],"26":[148],"each":[149],"treatment":[151],"control":[153],"groups).":[154],"Mean":[155],"(\u00b1":[156],"SD)":[157],"baseline\\ntreatment":[158],"placebo":[160,237,250],"total":[161,185],"(TC)":[163],"was":[164],"6.33":[165],"\u00b1":[166,171,211,220],"0.1":[167],"mmol/L":[168],"6.16":[170],"0.1\\nmmol/L":[172],"respectively.":[173],"A":[174],"repeated-measures":[175],"multivariate":[176],"analysis":[177],"covariance":[179],"(MANCOVA)":[180],"covaried":[181],"change":[183],"energy":[186],"alcohol":[188],"intake,":[189],"Tukey":[192],"posthoc\\nexamination":[193],"data":[196],"showed":[197],"that":[198],"bIg-treated":[200],"group":[201,238,251],"demonstrated":[202],"a\\nsignificant":[203],"reduction":[204],"TC":[206],"at":[207],"3-week":[208],"(5.98":[210],"0.5":[212],"mmol/L;":[213,222],"P":[214,223],"<":[215,240],"0.05)":[216,225],"6-week":[218],"(W)\\n(5.97":[219],"0.7":[221],">":[224],"intervals":[226],"compared":[227],"baseline.":[229],"6W":[231],"concentration\\nwas":[232],"significantly":[233],"lower":[234,269],"than":[235],"(P":[239],"0.05).":[241],"Additionally,":[242],"findings\\ndisplayed":[244],"significant":[246],"changes":[247],"or":[252,262],"any":[254],"other":[255],"indexes":[257,272],"or\\nmarkers":[258],"associated":[259,273],"hepatorenal":[261],"health.":[264],"Consumption":[265],"bIg\\nappears":[267],"CVD.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}