{"id":"https://openalex.org/W2282270705","doi":null,"title":"Non-canonical signaling mode of the epidermal growth factor receptor family.","display_name":"Non-canonical signaling mode of the epidermal growth factor receptor family.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2282270705","mag":"2282270705","pmid":"https://pubmed.ncbi.nlm.nih.gov/26693051","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656722"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3652776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656722","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074529344","display_name":"Heng\u2010Huan Lee","orcid":"https://orcid.org/0000-0002-7813-1292","observed_orcids":["https://orcid.org/0000-0002-7813-1292"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng-Huan Lee","raw_affiliation_strings":["Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston 77030, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston 77030, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064884375","display_name":"Ying\u2010Nai Wang","orcid":"https://orcid.org/0000-0002-5275-6729","observed_orcids":["https://orcid.org/0000-0002-5275-6729"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Ying-Nai Wang","raw_affiliation_strings":["Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston 77030, TX, USA ; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston 77030, TX, USA ; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076834432","display_name":"Mien\u2010Chie Hung","orcid":"https://orcid.org/0000-0003-4317-4740","observed_orcids":["https://orcid.org/0000-0003-4317-4740"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Mien-Chie Hung","raw_affiliation_strings":["Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston 77030, TX, USA ; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan ; The University of Texas Graduate School of Biomedical Sciences at Houston Houston 77030, TX, USA ; Department of Biotechnology, Asia University Taichung 413, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston 77030, TX, USA ; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan ; The University of Texas Graduate School of Biomedical Sciences at Houston Houston 77030, TX, USA ; Department of Biotechnology, Asia University Taichung 413, Taiwan","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I143578492","https://openalex.org/I184693016"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4438,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.94852254,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"10","first_page":"2944","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.953000009059906},{"id":"https://openalex.org/keywords/erbb-receptors","display_name":"ErbB receptors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/non-canonical-signaling","display_name":"non-canonical signaling","score":0.8600000143051147},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.9419999718666077},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7338513731956482},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.6364588141441345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6281623840332031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6009373664855957},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5848170518875122},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.48519042134284973},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42747679352760315},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4048539400100708},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2988407611846924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2392420470714569},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.06528332829475403}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3652776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26693051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26693051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4656722","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4656722/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:2282270705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26693051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3652776","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3893293991","display_name":"Tumor Progression of Nuclear EGFR in Breast Cancer","funder_award_id":"R01CA109311","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7043661956","display_name":"Growth Factor Receptor in Breast Cancer Progression and Metabolic Regulation","funder_award_id":"P01CA099031","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W48782725","https://openalex.org/W68029993","https://openalex.org/W104237097","https://openalex.org/W136994090","https://openalex.org/W201779591","https://openalex.org/W967487999","https://openalex.org/W1490526451","https://openalex.org/W1508835219","https://openalex.org/W1674052188","https://openalex.org/W1878799800","https://openalex.org/W1915536483","https://openalex.org/W1932563524","https://openalex.org/W1947442001","https://openalex.org/W1963878229","https://openalex.org/W1964232997","https://openalex.org/W1965710516","https://openalex.org/W1967591176","https://openalex.org/W1968366677","https://openalex.org/W1969607893","https://openalex.org/W1971595657","https://openalex.org/W1972586311","https://openalex.org/W1972587317","https://openalex.org/W1977692564","https://openalex.org/W1979430724","https://openalex.org/W1981420342","https://openalex.org/W1983499602","https://openalex.org/W1984557698","https://openalex.org/W1986321004","https://openalex.org/W1987604193","https://openalex.org/W1988106671","https://openalex.org/W1989223905","https://openalex.org/W1990369070","https://openalex.org/W1991390602","https://openalex.org/W1992508309","https://openalex.org/W1994861590","https://openalex.org/W1996275566","https://openalex.org/W1996894304","https://openalex.org/W1997799423","https://openalex.org/W1998802762","https://openalex.org/W2002710687","https://openalex.org/W2004305401","https://openalex.org/W2004681650","https://openalex.org/W2006257247","https://openalex.org/W2006413644","https://openalex.org/W2007744599","https://openalex.org/W2013121282","https://openalex.org/W2015222608","https://openalex.org/W2019350196","https://openalex.org/W2023578257","https://openalex.org/W2023648132","https://openalex.org/W2024213130","https://openalex.org/W2025974334","https://openalex.org/W2026320744","https://openalex.org/W2027784514","https://openalex.org/W2027877482","https://openalex.org/W2029935304","https://openalex.org/W2030701238","https://openalex.org/W2033042382","https://openalex.org/W2033395428","https://openalex.org/W2037506213","https://openalex.org/W2043346845","https://openalex.org/W2044151404","https://openalex.org/W2051570504","https://openalex.org/W2052858451","https://openalex.org/W2053306406","https://openalex.org/W2054727624","https://openalex.org/W2054799018","https://openalex.org/W2055313665","https://openalex.org/W2055598450","https://openalex.org/W2061324224","https://openalex.org/W2063508984","https://openalex.org/W2066432115","https://openalex.org/W2070522144","https://openalex.org/W2070528611","https://openalex.org/W2071457560","https://openalex.org/W2072167135","https://openalex.org/W2073066468","https://openalex.org/W2073310925","https://openalex.org/W2074156609","https://openalex.org/W2075233606","https://openalex.org/W2080373512","https://openalex.org/W2080418767","https://openalex.org/W2086722873","https://openalex.org/W2087032518","https://openalex.org/W2087402693","https://openalex.org/W2087487150","https://openalex.org/W2087624913","https://openalex.org/W2090235590","https://openalex.org/W2090800692","https://openalex.org/W2093742580","https://openalex.org/W2094882473","https://openalex.org/W2095931710","https://openalex.org/W2097091656","https://openalex.org/W2098513996","https://openalex.org/W2100647031","https://openalex.org/W2101335870","https://openalex.org/W2101428201","https://openalex.org/W2102850350","https://openalex.org/W2105288740","https://openalex.org/W2105568907","https://openalex.org/W2107008239","https://openalex.org/W2108375854","https://openalex.org/W2109126978","https://openalex.org/W2109399507","https://openalex.org/W2109564400","https://openalex.org/W2111623065","https://openalex.org/W2111693820","https://openalex.org/W2111778115","https://openalex.org/W2112238332","https://openalex.org/W2115308806","https://openalex.org/W2116075954","https://openalex.org/W2116168356","https://openalex.org/W2116443070","https://openalex.org/W2120239384","https://openalex.org/W2121354606","https://openalex.org/W2123242713","https://openalex.org/W2127806881","https://openalex.org/W2127902440","https://openalex.org/W2131817933","https://openalex.org/W2135513925","https://openalex.org/W2137317814","https://openalex.org/W2137513862","https://openalex.org/W2139577140","https://openalex.org/W2140777225","https://openalex.org/W2140910902","https://openalex.org/W2141003137","https://openalex.org/W2141484215","https://openalex.org/W2142521148","https://openalex.org/W2147524392","https://openalex.org/W2154889628","https://openalex.org/W2155366992","https://openalex.org/W2159278398","https://openalex.org/W2160557950","https://openalex.org/W2167038248","https://openalex.org/W2167398987","https://openalex.org/W2167495106","https://openalex.org/W2168031418","https://openalex.org/W2170725294","https://openalex.org/W2236412615","https://openalex.org/W2409298088","https://openalex.org/W2409668309","https://openalex.org/W7098072643"],"related_works":["https://openalex.org/W2128420846","https://openalex.org/W136994090","https://openalex.org/W2898347886","https://openalex.org/W2095931710","https://openalex.org/W2134850272","https://openalex.org/W2767336741","https://openalex.org/W4405999351","https://openalex.org/W4410459046","https://openalex.org/W1976559908","https://openalex.org/W4246072446"],"abstract_inverted_index":{"Epidermal":[0],"growth":[1],"factor":[2,112],"receptor":[3,35,83,176],"(EGFR)":[4],"and":[5,15,30,39,48,88,113,126,161],"its":[6,137],"family":[7,61,133,157],"members":[8],"are":[9,21],"key":[10],"players":[11],"in":[12,58,91,117,187],"both":[13],"physiological":[14],"pathological":[16],"settings":[17],"for":[18,26],"which":[19],"they":[20],"well":[22,64,179],"recognized":[23],"as":[24,41,66,109,178,180],"models":[25],"investigating":[27],"the":[28,55,59,75,105,118,131,140,151,155,165,175,181,188],"functions":[29,57,167],"regulations":[31],"of":[32,54,70,98,104,150,154,168,183],"other":[33],"membrane":[34,77,169],"tyrosine":[36],"kinases":[37],"(RTKs)":[38],"serve":[40],"therapeutic":[42,185],"targets":[43],"critical":[44],"to":[45,78,120],"clinical":[46],"need":[47],"fundamental":[49],"research.":[50],"The":[51,147],"canonical":[52],"view":[53],"pivotal":[56],"EGFR":[60,106,132,156],"has":[62],"been":[63],"documented":[65],"being":[67],"an":[68,159],"initiator":[69],"signaling":[71],"amplification":[72],"cascades":[73],"from":[74],"plasma":[76],"different":[79],"subcellular":[80],"compartments":[81],"via":[82],"endocytic":[84],"trafficking,":[85],"intermolecular":[86],"interaction,":[87],"kinase-substrate":[89],"reaction":[90],"a":[92,110,114],"temporalspatial":[93],"manner.":[94],"However,":[95],"several":[96],"lines":[97],"evidence":[99],"have":[100],"identified":[101],"non-canonical":[102,152],"roles":[103,153],"family,":[107],"acting":[108],"transcriptional":[111],"chromatin":[115],"regulator":[116],"nucleus":[119],"regulate":[121],"gene":[122],"expression,":[123],"DNA":[124,127],"replication,":[125],"damage":[128],"repair.":[129],"Moreover,":[130],"can":[134],"even":[135],"exert":[136],"impact":[138],"outside":[139],"host":[141],"cell":[142],"through":[143],"exosomal":[144],"vesicle":[145],"secretion.":[146],"emerging":[148],"concept":[149],"reveals":[158],"astonishing":[160],"elaborate":[162],"scheme":[163],"on":[164],"molecular":[166],"RTKs,":[170],"offering":[171],"new":[172],"insights":[173],"into":[174],"biology":[177],"development":[182],"comprehensive":[184],"strategies":[186],"future.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}