{"id":"https://openalex.org/W2282258393","doi":"https://doi.org/10.1152/ajprenal.1998.274.5.f946","title":"Nitric oxide increases the activity of the apical 70-pS K+channel in TAL of rat kidney","display_name":"Nitric oxide increases the activity of the apical 70-pS K+channel in TAL of rat kidney","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2282258393","doi":"https://doi.org/10.1152/ajprenal.1998.274.5.f946","mag":"2282258393","pmid":"https://pubmed.ncbi.nlm.nih.gov/9612333"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1998.274.5.f946","doi":"https://doi.org/10.1152/ajprenal.1998.274.5.f946","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1998.274.5.f946","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103426713","display_name":"Ming Wei Lu","orcid":"https://orcid.org/0009-0003-3910-8932","observed_orcids":["https://orcid.org/0009-0003-3910-8932"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Lu","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455467","display_name":"Xiaohong Wang","orcid":"https://orcid.org/0009-0000-6515-7621","observed_orcids":["https://orcid.org/0009-0000-6515-7621"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohong Wang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100370077","display_name":"Wen\u2010Hui Wang","orcid":"https://orcid.org/0000-0002-7503-9554","observed_orcids":["https://orcid.org/0000-0002-7503-9554"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenhui Wang","raw_affiliation_strings":["Department of Pharmacology, New York Medical College, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, New York Medical College, Valhalla, New York 10595","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":1.4535,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.81742549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"274","issue":"5","first_page":"F946","last_page":"F950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/apical-potassium-channels","display_name":"apical potassium channels","score":0.8230000138282776},{"id":"https://openalex.org/keywords/thick-ascending-limb","display_name":"thick ascending limb","score":0.972000002861023},{"id":"https://openalex.org/keywords/loop-of-henle","display_name":"loop of Henle","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/guanylate-cyclase","display_name":"guanylate cyclase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8669999837875366},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.5429999828338623},{"id":"https://openalex.org/keywords/potassium-channel-modulation","display_name":"potassium channel regulation","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2779997099","wikidata":"https://www.wikidata.org/wiki/Q7547253","display_name":"Snap","level":2,"score":0.8147460222244263},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7628748416900635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6693700551986694},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5805083513259888},{"id":"https://openalex.org/C2778827303","wikidata":"https://www.wikidata.org/wiki/Q7558945","display_name":"Soluble guanylyl cyclase","level":4,"score":0.4907854497432709},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.46114829182624817},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4493206739425659},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4414274990558624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4202340841293335},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.4071057438850403},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4010533094406128},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27672165632247925},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23230469226837158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16952389478683472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07713377475738525},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008138","descriptor_name":"Loop of Henle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.1998.274.5.f946","doi":"https://doi.org/10.1152/ajprenal.1998.274.5.f946","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1998.274.5.f946","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:9612333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9612333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2170044055","display_name":"HORMONAL REGULATION OF BLOOD PRESSURE","funder_award_id":"P01HL034300","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2191624845","display_name":null,"funder_award_id":"DK 47402","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W48314888","https://openalex.org/W1560310146","https://openalex.org/W1753116283","https://openalex.org/W1898513650","https://openalex.org/W1918955785","https://openalex.org/W1993351925","https://openalex.org/W1998033989","https://openalex.org/W2024919412","https://openalex.org/W2044009697","https://openalex.org/W2060243949","https://openalex.org/W2063874865","https://openalex.org/W2065991901","https://openalex.org/W2085107746","https://openalex.org/W2153406598","https://openalex.org/W2157809041","https://openalex.org/W2184842339","https://openalex.org/W2260927379","https://openalex.org/W2283921235","https://openalex.org/W2339489110","https://openalex.org/W2350706484","https://openalex.org/W2411219465","https://openalex.org/W2412915627","https://openalex.org/W2417892838","https://openalex.org/W2424274959","https://openalex.org/W2428189951","https://openalex.org/W2472948405","https://openalex.org/W2473010778"],"related_works":["https://openalex.org/W2084366543","https://openalex.org/W2339489110","https://openalex.org/W2040478155","https://openalex.org/W2153406598","https://openalex.org/W2152338458","https://openalex.org/W2327548685","https://openalex.org/W2240031290","https://openalex.org/W2167808720","https://openalex.org/W2184908421","https://openalex.org/W1969738234"],"abstract_inverted_index":{"We":[0,214],"have":[1],"previously":[2],"shown":[3],"that":[4,216],"nitric":[5,85],"oxide":[6,86],"(NO)":[7],"mediates":[8],"the":[9,16,22,31,36,41,46,51,65,90,102,119,124,131,146,151,164,171,186,199,222,225,231,234],"stimulatory":[10],"effect":[11,98,117,125,165,187],"of":[12,27,30,48,56,74,84,99,104,126,133,140,148,166,182,188,198,224,233],"angiotensin":[13],"II":[14],"on":[15,50,118],"apical":[17,226],"70-pS":[18,52,227],"K+":[19,53,228],"channel":[20,66,91,120,229],"in":[21,68,130,179,220,230],"thick":[23],"ascending":[24],"limb":[25],"(TAL)":[26],"Henle's":[28],"loop":[29],"rat":[32,235],"kidney":[33],"(12).":[34],"In":[35,71,122],"present":[37],"study,":[38],"we":[39],"used":[40],"patch-clamp":[42],"technique":[43],"to":[44,206],"examine":[45],"effects":[47],"NO":[49,62,167,217],"channel.":[54],"Addition":[55],"10":[57,141,191],"microM":[58,76,142,192],"S-nitroso-N-acetylpenicillamine":[59],"(SNAP),":[60],"a":[61],"donor,":[63],"increased":[64,195],"activity":[67,92,223],"cell-attached":[69],"patches.":[70],"contrast,":[72],"application":[73],"100":[75],"N":[77],"omega-nitro-L-arginine":[78],"methyl":[79],"ester":[80],"(L-NAME),":[81],"an":[82],"inhibitor":[83],"synthase":[87],"(NOS),":[88],"reduced":[89],"by":[93,138,157,170,177],"75":[94],"+/-":[95],"7%.":[96],"The":[97],"L-NAME":[100,127],"was":[101,128,154],"result":[103],"inhibiting":[105],"NOS,":[106],"since":[107],"D-NAME,":[108],"which":[109,180],"does":[110],"not":[111],"block":[112],"NOS":[113],"activity,":[114],"had":[115],"no":[116],"activity.":[121],"addition,":[123],"abolished":[129,185],"presence":[132],"1":[134],"mM":[135],"L-arginine":[136],"or":[137],"addition":[139],"SNAP,":[143],"further":[144],"supporting":[145],"role":[147],"NO.":[149],"Finally,":[150,190],"L-NAME-induced":[152],"inhibition":[153,181],"also":[155,175],"reversed":[156],"adding":[158],"8-bromoguanosine":[159],"3',5'-cyclic":[160],"monophosphate":[161],"(8-BrcGMP).":[162],"That":[163],"is":[168,174,218],"mediated":[169],"cGMP-dependent":[172],"pathway":[173],"suggested":[176],"experiments":[178],"guanylate":[183],"cyclase":[184],"SNAP.":[189],"SNAP":[193],"significantly":[194],"cGMP":[196],"concentration":[197],"medullary":[200],"TAL":[201,232],"from":[202],"12.4":[203],"fM/microgram":[204,208],"protein":[205],"38.9":[207],"protein,":[209],"as":[210],"measured":[211],"with":[212],"ELISA.":[213],"conclude":[215],"involved":[219],"regulating":[221],"kidney.":[236]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}