{"id":"https://openalex.org/W2282103272","doi":"https://doi.org/10.1152/ajplung.2001.281.5.l1106","title":"Genes other than TLR4 are involved in the response to inhaled LPS","display_name":"Genes other than TLR4 are involved in the response to inhaled LPS","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2282103272","doi":"https://doi.org/10.1152/ajplung.2001.281.5.l1106","mag":"2282103272","pmid":"https://pubmed.ncbi.nlm.nih.gov/11597901"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.2001.281.5.l1106","doi":"https://doi.org/10.1152/ajplung.2001.281.5.l1106","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.2001.281.5.l1106","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020863829","display_name":"Eva Lorenz","orcid":"https://orcid.org/0000-0002-6057-0078","observed_orcids":["https://orcid.org/0000-0002-6057-0078"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Lorenz","raw_affiliation_strings":["Department of Medicine and","Department of Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa 52242; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa 52242; and","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071291501","display_name":"Michael Jones","orcid":"https://orcid.org/0000-0003-0565-4938","observed_orcids":["https://orcid.org/0000-0003-0565-4938","https://orcid.org/0000-0001-7793-327X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Jones","raw_affiliation_strings":["Biostatistics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007051495","display_name":"Christine Wohlford-Lenane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Wohlford-Lenane","raw_affiliation_strings":["Departments of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112769624","display_name":"Nicole C. Meyer","orcid":"https://orcid.org/0000-0003-1461-2879","observed_orcids":["https://orcid.org/0000-0003-1461-2879"]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Meyer","raw_affiliation_strings":["Departments of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112252033","display_name":"Kathy L. Frees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathy L. Frees","raw_affiliation_strings":["Departments of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021807174","display_name":"Nancy C. Arbour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy C. Arbour","raw_affiliation_strings":["Departments of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376759","display_name":"David A. Schwartz","orcid":"https://orcid.org/0000-0001-6743-8443","observed_orcids":["https://orcid.org/0000-0001-6743-8443","https://orcid.org/0000-0001-5352-069X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Schwartz","raw_affiliation_strings":["Department of Medicine and","Department of Veterans Affairs Medical Center, Duke University Medical Center, Durham, North Carolina 27710","Department of Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa 52242; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa 52242; and","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4052,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.89565108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"281","issue":"5","first_page":"L1106","last_page":"L1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mouse-strain-differences","display_name":"mouse strain differences","score":0.6129999756813049},{"id":"https://openalex.org/keywords/c3h-hej-mice","display_name":"C3H/HeJ mice","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.9070005416870117},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6990925669670105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6193087100982666},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5936826467514038},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5678116083145142},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5668190717697144},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.5253162384033203},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4919757544994354},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4403139054775238},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4327908754348755},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3577660322189331},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29031431674957275},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2686898708343506},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.18710803985595703},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010993","descriptor_name":"Plethysmography, Whole Body","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016085","descriptor_name":"Bronchoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019570","descriptor_name":"Inhalation Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.2001.281.5.l1106","doi":"https://doi.org/10.1152/ajplung.2001.281.5.l1106","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.2001.281.5.l1106","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:11597901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11597901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2415645824","display_name":"Biological Determinants of Environmental Airway Injury","funder_award_id":"R01ES007498","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4100514286","display_name":"Mouse Models for Heart, Lung and Blood Disease","funder_award_id":"U01HL066611","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4115029918","display_name":"HOST DETERMINANTS OF ORGANIC DUST INDUCED AIRWAY DISEASE","funder_award_id":"R01HL062628","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G617936626","display_name":"CENTER FOR ENVIRONMENTAL GENOMICS","funder_award_id":"U19ES011375","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6485797958","display_name":"MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMA","funder_award_id":"U01HL066604","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6633739245","display_name":"AIRWAY DISEASE IN CHILDREN FROM RURAL COMMUNITIES","funder_award_id":"P01ES009607","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1520365933","https://openalex.org/W1522842079","https://openalex.org/W1525464385","https://openalex.org/W1677119557","https://openalex.org/W1864179398","https://openalex.org/W1968134126","https://openalex.org/W1973138645","https://openalex.org/W1978926805","https://openalex.org/W1988815437","https://openalex.org/W1993930516","https://openalex.org/W1996120614","https://openalex.org/W2000759052","https://openalex.org/W2012589576","https://openalex.org/W2020389505","https://openalex.org/W2050802901","https://openalex.org/W2066011467","https://openalex.org/W2084225449","https://openalex.org/W2091713887","https://openalex.org/W2095833996","https://openalex.org/W2129319296","https://openalex.org/W2138156029","https://openalex.org/W2147038697","https://openalex.org/W2167059596","https://openalex.org/W2184432439"],"related_works":["https://openalex.org/W1520365933","https://openalex.org/W2001760737","https://openalex.org/W1993246463","https://openalex.org/W2008166250","https://openalex.org/W2110827592","https://openalex.org/W1978926805","https://openalex.org/W7096069049","https://openalex.org/W1978917087","https://openalex.org/W1985772890","https://openalex.org/W2013397493"],"abstract_inverted_index":{"For":[0],"several":[1],"decades,":[2],"the":[3,40,58,70,100,106,110,148,159,165,168,206,217],"mouse":[4],"strains":[5,51,65,72,88,101,142,151,161,170],"C3H/HeJ":[6,152],"and":[7,44,56,60,80,153,182,219],"C57BL/10ScNCr":[8,154],"have":[9,27],"been":[10,28],"known":[11],"to":[12,15,30,35,46,66,125,185,202,222],"be":[13,200],"hyporesponsive":[14,126],"endotoxin":[16],"or":[17],"lipopolysaccharide":[18],"(LPS).":[19],"Recently,":[20],"mutations":[21,83,94,163,172,198],"in":[22,84,95,109,164,179,205,215,225],"Toll-like":[23],"receptor":[24],"(TLR)":[25],"4":[26],"shown":[29],"underlie":[31],"this":[32],"aberrant":[33],"response":[34,108,208],"LPS.":[36,68,187],"To":[37],"further":[38],"determine":[39],"relationship":[41],"between":[42],"TLR4":[43,55,79,90,149,166,174,197],"responsiveness":[45],"LPS,":[47],"we":[48],"genotyped":[49],"18":[50,71],"of":[52,63,115,131,136,190],"mice":[53],"for":[54,78,104,145,173],"evaluated":[57],"physiological":[59,181,218],"biological":[61,183,220],"responses":[62,184,221],"these":[64],"inhaled":[67,186,223],"Of":[69,86],"tested,":[73],"6":[74],"were":[75,155],"wild":[76,102,143],"type":[77,103,144],"12":[81],"had":[82,93],"TLR4.":[85,146],"those":[87],"with":[89,162,171],"mutations,":[91],"nine":[92],"highly":[96],"conserved":[97],"residues.":[98],"Among":[99],"TLR4,":[105],"inflammatory":[107],"airway":[111,132],"induced":[112],"by":[113],"inhalation":[114,135],"LPS":[116,137,207,224],"showed":[117],"a":[118,176,203],"phenotype":[119],"ranging":[120],"from":[121,158],"very":[122],"sensitive":[123],"(DBA/2)":[124],"(C57BL/6).":[127],"A":[128],"broad":[129,177],"spectrum":[130],"hyperreactivity":[133],"after":[134],"was":[138],"also":[139],"observed":[140],"among":[141],"Although":[147],"mutant":[150],"phenotypically":[156],"distinct":[157],"other":[160,169],"gene,":[167],"demonstrated":[175],"distribution":[178],"their":[180],"The":[188],"results":[189],"our":[191],"study":[192],"indicate":[193],"that":[194],"although":[195],"certain":[196],"can":[199],"linked":[201],"change":[204],"phenotype,":[209],"additional":[210],"genes":[211],"are":[212],"clearly":[213],"involved":[214],"determining":[216],"mammals.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}