{"id":"https://openalex.org/W2282022376","doi":null,"title":"Colloidal gold nanoparticles for cancer therapy: effects of particle size on treatment efficacy, toxicology, and biodistribution","display_name":"Colloidal gold nanoparticles for cancer therapy: effects of particle size on treatment efficacy, toxicology, and biodistribution","publication_year":2011,"publication_date":"2011-03-29","ids":{"openalex":"https://openalex.org/W2282022376","mag":"2282022376"},"language":"en","primary_location":{"id":"pmh:oai:smartech.gatech.edu:1853/43640","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/43640","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058931668","display_name":"Kate Y. J. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kate Y. J. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058931668"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colloidal-gold-nanoparticles","display_name":"colloidal gold nanoparticles","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cancer-nanotherapy","display_name":"cancer nanotherapy","score":0.875},{"id":"https://openalex.org/keywords/nanoparticle-size-effects","display_name":"nanoparticle size effects","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nanoparticle-clearance","display_name":"nanoparticle clearance","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.9126668572425842},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.7534955739974976},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7213141918182373},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6156611442565918},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.4937206208705902},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47654634714126587},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4706510603427887},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46842941641807556},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39919713139533997},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.39391404390335083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26801973581314087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06735321879386902},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06558731198310852}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:smartech.gatech.edu:1853/43640","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/43640","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2282022376","doi":null,"is_oa":false,"landing_page_url":"https://oatd.org/oatd/record?record=handle%5C%3A1853%5C%2F43640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W356713039","https://openalex.org/W1556801875","https://openalex.org/W1570773027","https://openalex.org/W1594063460","https://openalex.org/W1672766972","https://openalex.org/W1679270262","https://openalex.org/W1844565319","https://openalex.org/W1871308790","https://openalex.org/W1899397722","https://openalex.org/W1963675773","https://openalex.org/W1963797031","https://openalex.org/W1965097716","https://openalex.org/W1966562377","https://openalex.org/W1967043259","https://openalex.org/W1967221930","https://openalex.org/W1969043210","https://openalex.org/W1969471545","https://openalex.org/W1970592466","https://openalex.org/W1971237107","https://openalex.org/W1972326854","https://openalex.org/W1972582749","https://openalex.org/W1974261801","https://openalex.org/W1975900423","https://openalex.org/W1976041621","https://openalex.org/W1979260070","https://openalex.org/W1979884986","https://openalex.org/W1980422006","https://openalex.org/W1980495221","https://openalex.org/W1981855264","https://openalex.org/W1982411174","https://openalex.org/W1985477303","https://openalex.org/W1985858988","https://openalex.org/W1986347816","https://openalex.org/W1988950753","https://openalex.org/W1989195046","https://openalex.org/W1989867115","https://openalex.org/W1991240946","https://openalex.org/W1991891900","https://openalex.org/W1994025696","https://openalex.org/W1996139192","https://openalex.org/W1996908429","https://openalex.org/W1996993122","https://openalex.org/W1998017874","https://openalex.org/W1998490237","https://openalex.org/W1998534594","https://openalex.org/W2000209103","https://openalex.org/W2001851003","https://openalex.org/W2002516695","https://openalex.org/W2004255859","https://openalex.org/W2005408885","https://openalex.org/W2006165138","https://openalex.org/W2007987609","https://openalex.org/W2009153130","https://openalex.org/W2009629825","https://openalex.org/W2009909078","https://openalex.org/W2010036027","https://openalex.org/W2010183849","https://openalex.org/W2011148933","https://openalex.org/W2011370547","https://openalex.org/W2011610178","https://openalex.org/W2012548810","https://openalex.org/W2013918333","https://openalex.org/W2013980860","https://openalex.org/W2016156919","https://openalex.org/W2017371967","https://openalex.org/W2017631057","https://openalex.org/W2017861164","https://openalex.org/W2018107585","https://openalex.org/W2023147957","https://openalex.org/W2024576374","https://openalex.org/W2024787650","https://openalex.org/W2025036947","https://openalex.org/W2026494961","https://openalex.org/W2026883056","https://openalex.org/W2027137358","https://openalex.org/W2027292955","https://openalex.org/W2029228838","https://openalex.org/W2029749273","https://openalex.org/W2030858244","https://openalex.org/W2034168948","https://openalex.org/W2034269086","https://openalex.org/W2035147329","https://openalex.org/W2035419569","https://openalex.org/W2036117763","https://openalex.org/W2037035743","https://openalex.org/W2038529358","https://openalex.org/W2040332674","https://openalex.org/W2040958578","https://openalex.org/W2041110417","https://openalex.org/W2041671919","https://openalex.org/W2043009832","https://openalex.org/W2043590679","https://openalex.org/W2043710568","https://openalex.org/W2044794349","https://openalex.org/W2045723481","https://openalex.org/W2047387436","https://openalex.org/W2047855476","https://openalex.org/W2047922146","https://openalex.org/W2050019054","https://openalex.org/W2054455969","https://openalex.org/W2054992180","https://openalex.org/W2055713782","https://openalex.org/W2056688534","https://openalex.org/W2057056863","https://openalex.org/W2057427618","https://openalex.org/W2059999322","https://openalex.org/W2061841287","https://openalex.org/W2062470136","https://openalex.org/W2063318887","https://openalex.org/W2063338965","https://openalex.org/W2065484582","https://openalex.org/W2067389663","https://openalex.org/W2068222275","https://openalex.org/W2070029422","https://openalex.org/W2070622052","https://openalex.org/W2070838947","https://openalex.org/W2071470947","https://openalex.org/W2073229232","https://openalex.org/W2074034082","https://openalex.org/W2074544404","https://openalex.org/W2076024443","https://openalex.org/W2076033276","https://openalex.org/W2076895064","https://openalex.org/W2077228161","https://openalex.org/W2077707599","https://openalex.org/W2077780592","https://openalex.org/W2078211790","https://openalex.org/W2078416857","https://openalex.org/W2078516817","https://openalex.org/W2078820160","https://openalex.org/W2079884685","https://openalex.org/W2080181785","https://openalex.org/W2080376276","https://openalex.org/W2080511631","https://openalex.org/W2080742616","https://openalex.org/W2081451527","https://openalex.org/W2084380099","https://openalex.org/W2086696748","https://openalex.org/W2087236666","https://openalex.org/W2088614204","https://openalex.org/W2089915138","https://openalex.org/W2091588319","https://openalex.org/W2093141302","https://openalex.org/W2093279818","https://openalex.org/W2097535374","https://openalex.org/W2101312385","https://openalex.org/W2102947851","https://openalex.org/W2104009735","https://openalex.org/W2104814850","https://openalex.org/W2105547623","https://openalex.org/W2106270682","https://openalex.org/W2106600662","https://openalex.org/W2112101570","https://openalex.org/W2112719371","https://openalex.org/W2114135715","https://openalex.org/W2115318943","https://openalex.org/W2115533786","https://openalex.org/W2115797520","https://openalex.org/W2115830594","https://openalex.org/W2116415775","https://openalex.org/W2116810900","https://openalex.org/W2119423559","https://openalex.org/W2119591285","https://openalex.org/W2120103427","https://openalex.org/W2120593162","https://openalex.org/W2121170935","https://openalex.org/W2122124176","https://openalex.org/W2123605247","https://openalex.org/W2124158735","https://openalex.org/W2125430310","https://openalex.org/W2125753084","https://openalex.org/W2129569338","https://openalex.org/W2134304198","https://openalex.org/W2136456461","https://openalex.org/W2137335948","https://openalex.org/W2142159584","https://openalex.org/W2143208806","https://openalex.org/W2143856400","https://openalex.org/W2144714372","https://openalex.org/W2145238798","https://openalex.org/W2145921425","https://openalex.org/W2149148587","https://openalex.org/W2149952617","https://openalex.org/W2150146274","https://openalex.org/W2154218023","https://openalex.org/W2154773020","https://openalex.org/W2156969927","https://openalex.org/W2157863085","https://openalex.org/W2158138220","https://openalex.org/W2158734599","https://openalex.org/W2159142469","https://openalex.org/W2161744546","https://openalex.org/W2162956025","https://openalex.org/W2163051842","https://openalex.org/W2164394173","https://openalex.org/W2165704116","https://openalex.org/W2166806803","https://openalex.org/W2166926604","https://openalex.org/W2167428677","https://openalex.org/W2168321305","https://openalex.org/W2170829363","https://openalex.org/W2170952917","https://openalex.org/W2171227711","https://openalex.org/W2172298636","https://openalex.org/W2313357530","https://openalex.org/W2333038355","https://openalex.org/W2469323193","https://openalex.org/W2948127148","https://openalex.org/W3131593014"],"related_works":["https://openalex.org/W2020525105","https://openalex.org/W2944287852","https://openalex.org/W2144551975","https://openalex.org/W2296154238","https://openalex.org/W4285737815","https://openalex.org/W4308896385","https://openalex.org/W3201696498","https://openalex.org/W2145921425","https://openalex.org/W2059999322","https://openalex.org/W2967852315"],"abstract_inverted_index":{"Gold":[0],"nanoparticle":[1,79,106,126,138,176],"has":[2],"emerged":[3],"as":[4,107,139,200],"an":[5,85,108,206,243],"attractive":[6],"platform":[7],"for":[8,46,113,157,210,220,250,254],"drug":[9,16,26,91,141,187,221,251],"delivery":[10,17,27,36,92,111,142,222,252],"applications":[11],"by":[12,241],"complementing":[13],"the":[14,34,47,52,56,72,100,158,162,186,189,195,211,216,234],"existing":[15],"carriers.":[18],"Currently,":[19],"only":[20,184],"a":[21,42,90,140,179,246],"few":[22],"gold":[23,78,105,125,137,150,218],"nanoparticle-based":[24],"anticancer":[25,109],"systems":[28],"have":[29],"been":[30],"reported,":[31],"compared":[32],"to":[33,70,129,188],"polymer-based":[35],"systems.":[37],"Additionally,":[38],"there":[39],"is":[40,61,69,239],"still":[41],"lack":[43],"of":[44,51,66,76,102,115,123,134,149],"understanding":[45,133],"behavior":[48,75,198],"and":[49,80,121,153,167,202],"fate":[50],"gold-drug":[53],"conjugate":[54],"in":[55,73,84,89,132,169,182,196],"body":[57],"that":[58,175],"further":[59,130],"attention":[60],"required.":[62],"The":[63],"overall":[64],"goal":[65],"this":[67,96],"thesis":[68],"investigate":[71],"vivo":[74,197],"colloidal":[77,104,124,136],"its":[81],"therapeutic":[82,163],"efficacy":[83],"animal":[86],"model,":[87],"especially":[88],"application.":[93],"To":[94],"achieve":[95],"goal,":[97],"we":[98,213],"investigated":[99,156],"feasibility":[101],"using":[103,135],"agent":[110],"vehicle":[112],"treatment":[114],"cancer.":[116],"Then,":[117],"long-term":[118],"clearance,":[119],"toxicity,":[120,165],"biodistribution":[122,201],"were":[127,155],"studied":[128],"aid":[131],"platform.":[143],"In":[144],"particular,":[145],"two":[146],"representative":[147],"sizes":[148],"nanoparticles,":[151],"5nm":[152],"60nm,":[154],"size":[159,177,208],"effect":[160],"on":[161,245],"efficacy,":[164],"biodistribution,":[166],"clearance":[168,232],"cancer":[170,255],"nanotherapy.":[171,256],"\\n":[172],"\\nWe":[173],"believe":[174],"plays":[178],"critical":[180],"role":[181],"not":[183],"delivering":[185],"target":[190],"site":[191],"but":[192],"also":[193,225],"determining":[194],"such":[199],"clearance.":[203],"By":[204],"choosing":[205],"appropriate":[207],"scale":[209],"system,":[212],"successfully":[214],"used":[215],"small-sized":[217],"nanoparticles":[219],"applications,":[223],"which":[224],"displayed":[226],"no":[227],"apparent":[228],"toxicity":[229],"with":[230],"desirable":[231],"from":[233],"biological":[235],"system.":[236],"This":[237],"work":[238],"significant":[240],"providing":[242],"insight":[244],"potential":[247],"ideal":[248],"candidate":[249],"carrier":[253]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}