{"id":"https://openalex.org/W2281587014","doi":null,"title":"Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.","display_name":"Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2281587014","mag":"2281587014","pmid":"https://pubmed.ncbi.nlm.nih.gov/2317204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131169"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:4425357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131169","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004846648","display_name":"Quang K. Nguyen","orcid":"https://orcid.org/0000-0002-9171-2526","observed_orcids":["https://orcid.org/0000-0002-9171-2526"]},"institutions":[{"id":"https://openalex.org/I2802125861","display_name":"Shriners Hospitals for Children - Canada","ror":"https://ror.org/01z1dtf94","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802125861","https://openalex.org/I4210144267"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Q Nguyen","raw_affiliation_strings":["Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2802125861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085462956","display_name":"John S. Mort","orcid":"https://orcid.org/0000-0001-8434-2101","observed_orcids":["https://orcid.org/0000-0001-8434-2101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Mort","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109871366","display_name":"Peter J. Roughley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Roughley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3109,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.89000719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"266","issue":"2","first_page":"569","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.1137000024318695,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":1.0},{"id":"https://openalex.org/keywords/proteoglycan-aggregates","display_name":"proteoglycan aggregates","score":0.8420000076293945},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.968999981880188},{"id":"https://openalex.org/keywords/link-protein","display_name":"link protein","score":0.6959999799728394},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9129999876022339},{"id":"https://openalex.org/keywords/proteolytic-cleavage-sites","display_name":"proteolytic cleavage sites","score":0.906000018119812},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/proteoglycan-degradation","display_name":"proteoglycan degradation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cartilage-proteolysis","display_name":"cartilage proteolysis","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.8498030304908752},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.6741378307342529},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5825726985931396},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.5767554640769958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5399979948997498},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5354322195053101},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.534148633480072},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.504513144493103},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.4841693043708801},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4776645600795746},{"id":"https://openalex.org/C81216549","wikidata":"https://www.wikidata.org/wiki/Q18022191","display_name":"Cathepsin L1","level":4,"score":0.44161704182624817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3504433035850525},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2287384271621704},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.10174381732940674},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.057457298040390015},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099249","descriptor_name":"Proteoglycan Link Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056668","descriptor_name":"Cathepsin L","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:4425357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1131169","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131169","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:2317204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2317204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"mag:2281587014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2317204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4425357","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W27304192","https://openalex.org/W118641700","https://openalex.org/W127220886","https://openalex.org/W128448010","https://openalex.org/W178753903","https://openalex.org/W1265146923","https://openalex.org/W1484675846","https://openalex.org/W1484740986","https://openalex.org/W1537453899","https://openalex.org/W1544761069","https://openalex.org/W1560831298","https://openalex.org/W1564763556","https://openalex.org/W1668019041","https://openalex.org/W1764993432","https://openalex.org/W1842293499","https://openalex.org/W1842433572","https://openalex.org/W1867458054","https://openalex.org/W1932052686","https://openalex.org/W1974828587","https://openalex.org/W2018289835","https://openalex.org/W2040602277","https://openalex.org/W2040648848","https://openalex.org/W2058381769","https://openalex.org/W2060780211","https://openalex.org/W2066286282","https://openalex.org/W2080140978","https://openalex.org/W2087211553","https://openalex.org/W2092048925","https://openalex.org/W2093392535","https://openalex.org/W2101108802","https://openalex.org/W2103749562","https://openalex.org/W2110270062","https://openalex.org/W2114447963","https://openalex.org/W2278193200","https://openalex.org/W2287255813","https://openalex.org/W2293647140","https://openalex.org/W2341624020","https://openalex.org/W2341720846","https://openalex.org/W2415927568","https://openalex.org/W2441188394","https://openalex.org/W2466499246"],"related_works":["https://openalex.org/W1272499475","https://openalex.org/W2093392535","https://openalex.org/W110173727","https://openalex.org/W2096464236","https://openalex.org/W2410828041","https://openalex.org/W2063035603","https://openalex.org/W1867458054","https://openalex.org/W2232304638","https://openalex.org/W2074459649","https://openalex.org/W7055141786"],"abstract_inverted_index":{"The":[0],"degradative":[1],"actions":[2],"of":[3,39,47,70,127,138,163,175],"cathepsins":[4,95],"L":[5,16,96],"and":[6,44,62,91,97,109,122],"B":[7,26,80,98],"on":[8,87,105,160],"human":[9,75,106,148,176],"articular-cartilage":[10],"proteoglycan":[11,29,89],"aggregates":[12],"were":[13],"examined.":[14],"Cathepsin":[15],"was":[17],"found":[18],"to":[19,37,68,153,171,180],"be":[20],"much":[21,83],"more":[22,84],"extensive":[23],"than":[24],"cathepsin":[25,79],"in":[27,51,73,116,147,151],"degrading":[28],"aggregates.":[30],"It":[31],"released":[32],"products":[33],"with":[34],"size":[35],"similar":[36,65],"that":[38,154],"single":[40],"chondroitin":[41],"sulphate":[42],"chains,":[43],"a":[45,82,139,161],"series":[46],"degraded":[48],"link-protein":[49,58,92,130],"fragments":[50,71],"the":[52,110,117,136,164,173],"digestion":[53],"mixtures.":[54],"These":[55],"proteolytically":[56],"modified":[57,129],"components":[59,131],"(Mr":[60],"25,000":[61],"33,000)":[63],"have":[64,113],"Mr":[66],"values":[67],"those":[69],"observed":[72],"adult":[74],"cartilage.":[76],"In":[77],"contrast,":[78],"exhibited":[81],"limited":[85],"degradation":[86],"both":[88],"subunits":[90],"components.":[93],"Both":[94],"generate":[99],"multiple":[100],"but":[101],"distinct":[102],"cleavage":[103],"sites":[104],"link":[107,149,165,177],"proteins,":[108,150],"hydrolysed":[111],"bonds":[112],"been":[114],"identified":[115],"region":[118],"between":[119],"residues":[120],"18":[121],"29.":[123],"Protein":[124],"sequencing":[125],"analysis":[126],"these":[128],"also":[132],"provided":[133],"evidence":[134],"for":[135],"location":[137],"second":[140],"N-linked":[141],"glycosylation":[142],"site":[143],"at":[144,157],"residue":[145,158,181],"41":[146],"addition":[152],"previously":[155],"described":[156],"6":[159],"proportion":[162],"proteins.":[166],"Furthermore,":[167],"it":[168],"allows":[169],"us":[170],"report":[172],"sequence":[174],"protein":[178],"up":[179],"65.":[182]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}