{"id":"https://openalex.org/W2281440424","doi":null,"title":"ENHANCEMENT OF HIV PERSISTENCE BY ADIPOSE TISSUE","display_name":"ENHANCEMENT OF HIV PERSISTENCE BY ADIPOSE TISSUE","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2281440424","mag":"2281440424"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1648","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041155597","display_name":"Jacob P. Couturier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacob Couturier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041155597"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-persistence","display_name":"HIV persistence","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.7990000247955322},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.9309999942779541},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hiv-replication","display_name":"HIV replication","score":0.8870000243186951},{"id":"https://openalex.org/keywords/stromal-vascular-fraction","display_name":"stromal vascular fraction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.5699999928474426},{"id":"https://openalex.org/keywords/integrin-ligands","display_name":"integrin ligands","score":0.8629999756813049},{"id":"https://openalex.org/keywords/common-gamma-chain-cytokines","display_name":"common gamma chain cytokines","score":0.9679999947547913},{"id":"https://openalex.org/keywords/antiretroviral-drug-resistance","display_name":"antiretroviral resistance","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chronic-immune-activation","display_name":"chronic immune activation","score":0.671999990940094},{"id":"https://openalex.org/keywords/hiv-eradication","display_name":"HIV eradication","score":0.7049999833106995},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.847000002861023},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.667992115020752},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.5856788754463196},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.49150073528289795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34188973903656006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23315772414207458},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.17382892966270447},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.11490356922149658},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1648","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:2281440424","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1648&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1648","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/612","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2281440424.pdf","grobid_xml":"https://content.openalex.org/works/W2281440424.grobid-xml"},"referenced_works_count":164,"referenced_works":["https://openalex.org/W22414062","https://openalex.org/W49920453","https://openalex.org/W1514146705","https://openalex.org/W1536536278","https://openalex.org/W1541696647","https://openalex.org/W1563727852","https://openalex.org/W1590709474","https://openalex.org/W1596578598","https://openalex.org/W1631101137","https://openalex.org/W1675699936","https://openalex.org/W1777882158","https://openalex.org/W1900874324","https://openalex.org/W1924240621","https://openalex.org/W1939446637","https://openalex.org/W1965079305","https://openalex.org/W1967632729","https://openalex.org/W1969274526","https://openalex.org/W1969412791","https://openalex.org/W1970698189","https://openalex.org/W1974760797","https://openalex.org/W1980005768","https://openalex.org/W1980225051","https://openalex.org/W1982206175","https://openalex.org/W1982886401","https://openalex.org/W1984999783","https://openalex.org/W1986234750","https://openalex.org/W1987189896","https://openalex.org/W1989222449","https://openalex.org/W1990522629","https://openalex.org/W1990988855","https://openalex.org/W1991037689","https://openalex.org/W1995289825","https://openalex.org/W1995994688","https://openalex.org/W1996312325","https://openalex.org/W2000379000","https://openalex.org/W2004010450","https://openalex.org/W2005674407","https://openalex.org/W2007130444","https://openalex.org/W2008150005","https://openalex.org/W2008153212","https://openalex.org/W2008869160","https://openalex.org/W2009365923","https://openalex.org/W2011816810","https://openalex.org/W2012042482","https://openalex.org/W2013051750","https://openalex.org/W2013388724","https://openalex.org/W2015207903","https://openalex.org/W2015333667","https://openalex.org/W2015519467","https://openalex.org/W2016935482","https://openalex.org/W2019113684","https://openalex.org/W2021631452","https://openalex.org/W2022074240","https://openalex.org/W2022098233","https://openalex.org/W2022712113","https://openalex.org/W2025312536","https://openalex.org/W2025346994","https://openalex.org/W2025665987","https://openalex.org/W2025866303","https://openalex.org/W2026547100","https://openalex.org/W2028780773","https://openalex.org/W2029679352","https://openalex.org/W2030844138","https://openalex.org/W2031325112","https://openalex.org/W2032729612","https://openalex.org/W2034858284","https://openalex.org/W2042007762","https://openalex.org/W2044676910","https://openalex.org/W2046314233","https://openalex.org/W2046700010","https://openalex.org/W2047300635","https://openalex.org/W2047442471","https://openalex.org/W2049653440","https://openalex.org/W2051122335","https://openalex.org/W2052955118","https://openalex.org/W2053329660","https://openalex.org/W2053701857","https://openalex.org/W2057187544","https://openalex.org/W2057812330","https://openalex.org/W2059652342","https://openalex.org/W2062057951","https://openalex.org/W2064140898","https://openalex.org/W2064953244","https://openalex.org/W2065708749","https://openalex.org/W2067416157","https://openalex.org/W2072830090","https://openalex.org/W2076264917","https://openalex.org/W2076610142","https://openalex.org/W2077258201","https://openalex.org/W2079264461","https://openalex.org/W2082354489","https://openalex.org/W2082595913","https://openalex.org/W2082848536","https://openalex.org/W2088968901","https://openalex.org/W2091869250","https://openalex.org/W2092412131","https://openalex.org/W2093019166","https://openalex.org/W2095250058","https://openalex.org/W2097473216","https://openalex.org/W2098021336","https://openalex.org/W2098260170","https://openalex.org/W2099311529","https://openalex.org/W2099782613","https://openalex.org/W2100647507","https://openalex.org/W2100859269","https://openalex.org/W2101282227","https://openalex.org/W2101353031","https://openalex.org/W2102033291","https://openalex.org/W2104214690","https://openalex.org/W2105448220","https://openalex.org/W2105874826","https://openalex.org/W2108763477","https://openalex.org/W2111815518","https://openalex.org/W2111966641","https://openalex.org/W2112569342","https://openalex.org/W2113347258","https://openalex.org/W2114413003","https://openalex.org/W2114862491","https://openalex.org/W2115580899","https://openalex.org/W2116556589","https://openalex.org/W2117013048","https://openalex.org/W2117211286","https://openalex.org/W2117971406","https://openalex.org/W2119080021","https://openalex.org/W2120480222","https://openalex.org/W2122204312","https://openalex.org/W2123530170","https://openalex.org/W2124058652","https://openalex.org/W2124369899","https://openalex.org/W2124905372","https://openalex.org/W2125524975","https://openalex.org/W2128446740","https://openalex.org/W2128970130","https://openalex.org/W2129785124","https://openalex.org/W2130666948","https://openalex.org/W2132008472","https://openalex.org/W2135724418","https://openalex.org/W2141356493","https://openalex.org/W2141632305","https://openalex.org/W2143936288","https://openalex.org/W2144211575","https://openalex.org/W2144912209","https://openalex.org/W2148378054","https://openalex.org/W2149024774","https://openalex.org/W2149412083","https://openalex.org/W2150484278","https://openalex.org/W2153520524","https://openalex.org/W2154502881","https://openalex.org/W2155675552","https://openalex.org/W2156075763","https://openalex.org/W2156877200","https://openalex.org/W2157729384","https://openalex.org/W2158853388","https://openalex.org/W2162572769","https://openalex.org/W2164350084","https://openalex.org/W2164466050","https://openalex.org/W2165379440","https://openalex.org/W2167204431","https://openalex.org/W2168795464","https://openalex.org/W2168952458","https://openalex.org/W2170161832","https://openalex.org/W2171516424","https://openalex.org/W2317583984","https://openalex.org/W2419233734"],"related_works":["https://openalex.org/W2792698713","https://openalex.org/W2312340658","https://openalex.org/W2141913238","https://openalex.org/W2739833481","https://openalex.org/W2989684144","https://openalex.org/W2342786251","https://openalex.org/W2028780773","https://openalex.org/W2127225068","https://openalex.org/W2902853210","https://openalex.org/W4404119175"],"abstract_inverted_index":{"A":[0],"major":[1,56,90,274],"challenge":[2],"for":[3,19,59,125,135,214,229,283,304,312],"HIV":[4,60,80,118,136,155,162,176,215,285,305],"eradication":[5],"is":[6],"the":[7,38,44,131,181,199,238,281],"persistence":[8,216],"of":[9,40,92,133,203,221,242,290,298],"cellular":[10,17,240],"and":[11,25,48,52,70,89,94,100,110,120,167,175,196,224,234,251,261,268,287,292,302,306],"anatomic":[12],"viral":[13,33,200,235,275,313],"reservoirs.":[14,277],"The":[15,55],"primary":[16,146],"reservoirs":[18,58],"HIV,":[20],"memory":[21,139,230,247],"CD4":[22,106,140,231,248],"T":[23,98,107,141,172,193,232,249],"cells":[24,99,142,233,250],"macrophages,":[26],"traffic":[27],"into":[28],"various":[29],"tissues":[30,63,76,84,88,220,244,289],"where":[31],"most":[32],"replication":[34,119,177],"occurs,":[35],"or":[36,188],"in":[37,148,178,217,256],"case":[39],"virally-suppressed":[41],"antiretroviral-treated":[42],"patients,":[43],"virus":[45],"becomes":[46],"dormant":[47],"protected":[49],"from":[50],"drugs":[51],"immune":[53,95,127,300],"responses.":[54],"tissue":[57,104,276],"include":[61],"lymphoid":[62,72],"such":[64],"as":[65,81,122],"lymph":[66],"nodes,":[67],"bone":[68],"marrow,":[69],"gastrointestinal":[71],"tissues,":[73],"but":[74,164],"adipose":[75,103,210,219,243,288],"could":[77],"potentially":[78],"harbor":[79],"well.":[82],"Adipose":[83],"are":[85,212],"ubiquitous":[86,182],"connective":[87],"sites":[91,213,297],"infiltration":[93],"activity":[96],"by":[97],"macrophages.":[101],"As":[102],"regulates":[105],"cell":[108,173,194],"migration":[109],"functions,":[111],"we":[112],"hypothesized":[113],"that":[114],"adipocytes":[115,134,147,153,279],"may":[116],"affect":[117,161],"serve":[121],"a":[123],"reservoir":[124],"infected":[126,222,258],"cells.":[128],"To":[129,207],"study":[130],"role":[132],"infection,":[137],"HIV-infected":[138],"were":[143,227,253],"cocultured":[144],"with":[145,180],"vitro":[149],"to":[150,272,295],"determine":[151,208],"if":[152,209],"influence":[154],"replication.":[156],"Adipocytes":[157,190],"alone":[158],"did":[159,170],"not":[160],"replication,":[163,286],"via":[165],"IL6":[166],"integrin":[168],"ligands,":[169],"enhance":[171],"activation":[174,301],"cooperation":[179],"common":[183],"gamma-chain":[184],"cytokines,":[185],"IL2,":[186],"IL7,":[187],"IL15.":[189],"further":[191],"enhanced":[192],"viability":[195],"even":[197],"mitigated":[198],"suppressive":[201],"effects":[202],"some":[204],"antiretroviral":[205],"drugs.":[206],"depots":[211],"vivo,":[218],"humans":[223,259,291],"rhesus":[225,262],"macaques":[226,263],"examined":[228],"DNA.":[236],"Within":[237],"stromal-vascular-fraction":[239],"component":[241],"(AT-SVF),":[245],"activated":[246],"provirus":[252],"readily":[254],"detectable":[255],"all":[257],"(n=5)":[260],"(n=8)":[264],"so":[265],"far":[266],"examined,":[267],"at":[269],"frequencies":[270],"comparable":[271],"other":[273],"Thus,":[278],"have":[280],"capacity":[282],"promoting":[284],"monkeys":[293],"appear":[294],"be":[296],"chronic":[299],"sanctuaries":[303],"SIV,":[307],"which":[308],"pose":[309],"additional":[310],"obstacles":[311],"eradication.":[314]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}