{"id":"https://openalex.org/W2280943180","doi":null,"title":"Cell mediated therapeutics for cancer treatment: tumor homing cells as therapeutic delivery vehicles","display_name":"Cell mediated therapeutics for cancer treatment: tumor homing cells as therapeutic delivery vehicles","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2280943180","mag":"2280943180"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.839.9707","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.839.9707","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://krex.k-state.edu/dspace/bitstream/handle/2097/16890/SivasaiBalivada2013.pdf%3Bjsessionid%3DAB54455E3ECC40571B1FD804B51F8BEB?sequence%3D1","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055671744","display_name":"Sivasai Balivada","orcid":"https://orcid.org/0000-0002-7852-4627","observed_orcids":["https://orcid.org/0000-0002-7852-4627"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sivasai Balivada","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7852-4627","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055671744"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-mediated-drug-delivery","display_name":"cell-mediated drug delivery","score":0.8410000205039978},{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"magnetic nanoparticles","score":0.9620000123977661},{"id":"https://openalex.org/keywords/magnetic-hyperthermia","display_name":"magnetic hyperthermia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alternating-magnetic-field","display_name":"alternating magnetic field","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/monocytes-macrophages","display_name":"monocytes/macrophages","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-targeted-therapy","display_name":"tumor-targeted therapy","score":0.49399998784065247},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.8220000267028809},{"id":"https://openalex.org/keywords/surface-engineering","display_name":"surface engineering","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.7793077230453491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46539390087127686},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38255631923675537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22903048992156982},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.839.9707","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.839.9707","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://krex.k-state.edu/dspace/bitstream/handle/2097/16890/SivasaiBalivada2013.pdf%3Bjsessionid%3DAB54455E3ECC40571B1FD804B51F8BEB?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:krex.k-state.edu:2097/16890","doi":null,"is_oa":false,"landing_page_url":"https://krex.k-state.edu/bitstreams/131e0e7f-733c-436a-9a7d-b0513b8b1d6e/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2280943180","doi":null,"is_oa":false,"landing_page_url":"https://ui.adsabs.harvard.edu/abs/2013PhDT.......356B/abstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306522422","display_name":"PhDT","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PhDT","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":165,"referenced_works":["https://openalex.org/W159782486","https://openalex.org/W1484368999","https://openalex.org/W1488835948","https://openalex.org/W1513231719","https://openalex.org/W1513954632","https://openalex.org/W1534679825","https://openalex.org/W1587942505","https://openalex.org/W1598061310","https://openalex.org/W1621557262","https://openalex.org/W1626967392","https://openalex.org/W1927732700","https://openalex.org/W1930162478","https://openalex.org/W1966538775","https://openalex.org/W1966886925","https://openalex.org/W1970430753","https://openalex.org/W1972461780","https://openalex.org/W1976797458","https://openalex.org/W1977030367","https://openalex.org/W1980441719","https://openalex.org/W1982027307","https://openalex.org/W1984250533","https://openalex.org/W1985017153","https://openalex.org/W1987329424","https://openalex.org/W1988217845","https://openalex.org/W1988405508","https://openalex.org/W1990900025","https://openalex.org/W1993412993","https://openalex.org/W1993454337","https://openalex.org/W1993886792","https://openalex.org/W2001593006","https://openalex.org/W2001679453","https://openalex.org/W2003183488","https://openalex.org/W2007144923","https://openalex.org/W2010117024","https://openalex.org/W2011012675","https://openalex.org/W2011271265","https://openalex.org/W2014220492","https://openalex.org/W2014351925","https://openalex.org/W2016901692","https://openalex.org/W2017382169","https://openalex.org/W2018762035","https://openalex.org/W2020794309","https://openalex.org/W2023158524","https://openalex.org/W2023505847","https://openalex.org/W2024786578","https://openalex.org/W2025531782","https://openalex.org/W2029547209","https://openalex.org/W2033013378","https://openalex.org/W2035387970","https://openalex.org/W2035628044","https://openalex.org/W2035765497","https://openalex.org/W2035816996","https://openalex.org/W2036186447","https://openalex.org/W2036226019","https://openalex.org/W2036670812","https://openalex.org/W2037393203","https://openalex.org/W2038062002","https://openalex.org/W2040294604","https://openalex.org/W2041932145","https://openalex.org/W2042018154","https://openalex.org/W2043106681","https://openalex.org/W2043228552","https://openalex.org/W2044143966","https://openalex.org/W2046065581","https://openalex.org/W2047744526","https://openalex.org/W2048136402","https://openalex.org/W2048657818","https://openalex.org/W2048678124","https://openalex.org/W2049789508","https://openalex.org/W2050922685","https://openalex.org/W2053004997","https://openalex.org/W2054438521","https://openalex.org/W2054609442","https://openalex.org/W2054626405","https://openalex.org/W2054990794","https://openalex.org/W2056132768","https://openalex.org/W2056299800","https://openalex.org/W2059690381","https://openalex.org/W2060197999","https://openalex.org/W2060906205","https://openalex.org/W2062875878","https://openalex.org/W2065470163","https://openalex.org/W2067052556","https://openalex.org/W2069713478","https://openalex.org/W2072062887","https://openalex.org/W2072365921","https://openalex.org/W2075117403","https://openalex.org/W2075733006","https://openalex.org/W2076243979","https://openalex.org/W2077060302","https://openalex.org/W2078594804","https://openalex.org/W2081754685","https://openalex.org/W2083013139","https://openalex.org/W2084438624","https://openalex.org/W2084708998","https://openalex.org/W2084936473","https://openalex.org/W2090453278","https://openalex.org/W2092059846","https://openalex.org/W2093759755","https://openalex.org/W2093807603","https://openalex.org/W2094614028","https://openalex.org/W2096676113","https://openalex.org/W2099814623","https://openalex.org/W2099886521","https://openalex.org/W2102603826","https://openalex.org/W2104692415","https://openalex.org/W2105848229","https://openalex.org/W2105927926","https://openalex.org/W2106360889","https://openalex.org/W2107940486","https://openalex.org/W2109021322","https://openalex.org/W2110454656","https://openalex.org/W2110735056","https://openalex.org/W2113046540","https://openalex.org/W2113435552","https://openalex.org/W2113614699","https://openalex.org/W2115517178","https://openalex.org/W2115844597","https://openalex.org/W2115993724","https://openalex.org/W2116558467","https://openalex.org/W2117692326","https://openalex.org/W2118852328","https://openalex.org/W2121058206","https://openalex.org/W2121744182","https://openalex.org/W2123647020","https://openalex.org/W2123885452","https://openalex.org/W2125793635","https://openalex.org/W2125865280","https://openalex.org/W2127734192","https://openalex.org/W2127771136","https://openalex.org/W2129872035","https://openalex.org/W2130474357","https://openalex.org/W2133707964","https://openalex.org/W2133897272","https://openalex.org/W2135212691","https://openalex.org/W2136232291","https://openalex.org/W2136422556","https://openalex.org/W2137104454","https://openalex.org/W2143022774","https://openalex.org/W2144466990","https://openalex.org/W2144837068","https://openalex.org/W2148278891","https://openalex.org/W2148643283","https://openalex.org/W2149782991","https://openalex.org/W2155318379","https://openalex.org/W2155413956","https://openalex.org/W2156124327","https://openalex.org/W2160829031","https://openalex.org/W2163326536","https://openalex.org/W2164330601","https://openalex.org/W2167454336","https://openalex.org/W2168631000","https://openalex.org/W2170558349","https://openalex.org/W2220278592","https://openalex.org/W2288689888","https://openalex.org/W2314348637","https://openalex.org/W2331692002","https://openalex.org/W2339752618","https://openalex.org/W2401866239","https://openalex.org/W2404338614","https://openalex.org/W2406111407","https://openalex.org/W2408464576","https://openalex.org/W2413422741","https://openalex.org/W2418241912","https://openalex.org/W2530014580"],"related_works":["https://openalex.org/W2316910892","https://openalex.org/W4318346608","https://openalex.org/W1969197853","https://openalex.org/W2583857841","https://openalex.org/W2479990614","https://openalex.org/W2333079136","https://openalex.org/W2081430133","https://openalex.org/W3114286780","https://openalex.org/W3024585939","https://openalex.org/W3214696488"],"abstract_inverted_index":{"Many":[0],"cell":[1,232,239,256],"types":[2],"were":[3,116,282,291],"known":[4,162],"to":[5,85,119,132,163],"have":[6,15,169],"migratory":[7],"properties":[8],"towards":[9,121],"tumors":[10,204,219],"and":[11,45,89,167,248,286,296,306],"different":[12],"research":[13],"groups":[14],"shown":[16,118],"reliable":[17],"results":[18],"regarding":[19],"cells":[20,80,113,298,312],"as":[21,50,342],"delivery":[22,40,144],"vehicles":[23],"of":[24,34,41,145,177,193,213,288,308,326,332,340],"therapeutics":[25],"for":[26,36,68,318,323,337,345],"targeted":[27,46,69,143],"cancer":[28,52,59,70,223,238,255,319,328],"treatment.":[29],"Present":[30],"report":[31,334],"discusses":[32],"proof":[33],"concept":[35],"1.":[37,77],"Cell":[38],"mediated":[39,304],"Magnetic":[42,47],"nanoparticles":[43],"(MNPs)":[44],"hyperthermia":[48],"(MHT)":[49],"a":[51,152,190,343],"treatment":[53,71,224],"by":[54,72,147,228],"using":[55,73],"in":[56,74,151,155,271,293,299],"vivo":[57],"mouse":[58,191],"models,":[60],"2.":[61,221],"Cells":[62],"surface":[63],"engineering":[64,229],"with":[65,129,187,234],"chimeric":[66,267,276],"proteins":[67,290],"vitro":[75],"models.":[76],"Tumor":[78],"homing":[79,231],"can":[81,173],"carry":[82],"MNPs":[83,130,146,188],"specifically":[84],"the":[86,142,148,211],"tumor":[87,90,156,165,230,235],"site":[88],"burden":[91],"will":[92],"decrease":[93,154],"after":[94,206],"alternating":[95,137],"magnetic":[96,138],"field":[97,139],"(AMF)":[98,140],"exposure.":[99],"To":[100,179,244],"test":[101,180,245],"this":[102],"hypothesis,":[103],"first":[104],"we":[105,183],"loaded":[106,128,186],"Fe/Fe3O4":[107],"bi-magnetic":[108],"NPs":[109],"into":[110,189],"neural":[111],"progenitor":[112],"(NPCs),":[114],"which":[115,172],"previously":[117],"migrate":[120],"melanoma":[122,134],"tumors.":[123,135],"We":[124,197],"observed":[125,198],"that":[126,199],"NPCs":[127,149],"travel":[131],"subcutaneous":[133],"After":[136],"exposure,":[141],"resulted":[150],"mild":[153],"size":[157],"(Chapter-2).":[158],"Monocytes/macrophages":[159],"(Mo/Ma)":[160],"are":[161,321],"infiltrate":[164],"sites,":[166],"also":[168],"phagocytic":[170],"activity":[171,287],"increase":[174],"their":[175],"uptake":[176],"MNPs.":[178],"Mo/Ma-mediated":[181],"MHT":[182],"transplanted":[184],"Mo/Ma":[185,201,295],"model":[192,344],"pancreatic":[194,203,218],"peritoneal":[195],"carcinomatosis.":[196],"MNP-loaded":[200],"infiltrated":[202],"and,":[205],"AMF":[207],"treatment,":[208],"significantly":[209],"prolonged":[210],"lives":[212],"mice":[214],"bearing":[215],"disseminated":[216],"intraperitoneal":[217],"(Chapter-3).":[220],"Targeted":[222],"could":[225],"be":[226],"achieved":[227],"surfaces":[233],"proteases":[236],"cleavable,":[237],"specific":[240,251,258],"recombinant":[241],"therapeutic":[242],"proteins.":[243],"this,":[246],"Urokinase":[247,302],"Calpain":[249],"(tumor":[250],"proteases)":[252],"cleavable;":[253],"prostate":[254],"(CaP)":[257],"(CaP1":[259],"targeting":[260],"peptide);":[261],"apoptosis":[262],"inducible":[263],"(Caspase3":[264],"V266ED3)-":[265],"rCasp3V266ED3":[266,309],"protein":[268,277],"was":[269,313],"designed":[270,289],"silico.":[272],"Hypothesized":[273],"membrane":[274],"anchored":[275],"(rCasp3V266ED3,":[278],"rMcherry":[279],"red)":[280],"plasmids":[281],"constructed.":[283],"Membrane":[284],"anchoring":[285],"analyzed":[292],"RAW264.7":[294],"HEK293":[297],"vitro.":[300],"Further,":[301],"(uPA)":[303],"cleavage":[305],"release":[307],"from":[310],"engineered":[311],"tested":[314],"(Chapter-4).":[315],"Animal":[316],"models":[317],"therapy":[320],"invaluable":[322],"preclinical":[324],"testing":[325],"potential":[327],"treatments.":[329],"Final":[330],"chapter":[331],"present":[333],"shows":[335],"evidence":[336],"immune-deficient":[338],"line":[339],"pigs":[341],"human":[346],"cancers":[347],"(Chapter-5)":[348]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
