{"id":"https://openalex.org/W2280803473","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.58","title":"High levels of dietary homocysteine (Hcy) accelerate impulse propagation across the murine atrioventricular node (AVN)","display_name":"High levels of dietary homocysteine (Hcy) accelerate impulse propagation across the murine atrioventricular node (AVN)","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2280803473","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.58","mag":"2280803473"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.2_supplement.58","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.58","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.2_supplement.58","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072860296","display_name":"Claudio J. Maldonado","orcid":"https://orcid.org/0000-0002-2034-2273","observed_orcids":["https://orcid.org/0000-0002-2034-2273"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio Maldonado","raw_affiliation_strings":["Physiology and Biophysics, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111873397","display_name":"Karni Singh Moshal","orcid":"https://orcid.org/0000-0002-7191-8818","observed_orcids":["https://orcid.org/0000-0002-7191-8818","https://orcid.org/0009-0004-9859-021X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karni Moshal","raw_affiliation_strings":["Physiology and Biophysics, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058779856","display_name":"Nathaniel Todnem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel D Todnem","raw_affiliation_strings":["Physiology and Biophysics, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chirag V Soni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chirag V Soni","raw_affiliation_strings":["Physiology and Biophysics, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005647791","display_name":"Sathnur Basappa Pushpakumar","orcid":"https://orcid.org/0000-0002-5984-166X","observed_orcids":["https://orcid.org/0000-0002-5984-166X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sathnur B Pushpakumar","raw_affiliation_strings":["Physiology and Biophysics, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101420583","display_name":"Suresh C. Tyagi","orcid":"https://orcid.org/0000-0002-7341-8227","observed_orcids":["https://orcid.org/0000-0002-7341-8227","https://orcid.org/0000-0002-4574-4850"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh C Tyagi","raw_affiliation_strings":["Physiology and Biophysics, University of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics, University of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S2","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/atrioventricular-node","display_name":"atrioventricular node","score":0.9330000281333923},{"id":"https://openalex.org/keywords/impulse-propagation","display_name":"impulse propagation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cardiac-conduction","display_name":"cardiac conduction","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pr-interval","display_name":"PR interval","score":0.8379999995231628},{"id":"https://openalex.org/keywords/atrial-tachyarrhythmia","display_name":"atrial tachyarrhythmia","score":0.765999972820282},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"ventricular tachycardia","score":0.925000011920929},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.8809999823570251},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7545778155326843},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6879125833511353},{"id":"https://openalex.org/C80093799","wikidata":"https://www.wikidata.org/wiki/Q366155","display_name":"Intracardiac injection","level":2,"score":0.6841102838516235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6283053755760193},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.4304021894931793},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39076870679855347}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.2_supplement.58","doi":"https://doi.org/10.1096/fasebj.22.2_supplement.58","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.2_supplement.58","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W198203420","https://openalex.org/W2284287207","https://openalex.org/W2234902081","https://openalex.org/W2133757149","https://openalex.org/W114253730","https://openalex.org/W2100774579","https://openalex.org/W2008019554","https://openalex.org/W117494188","https://openalex.org/W2041511855","https://openalex.org/W2008240978"],"abstract_inverted_index":{"Patients":[0],"with":[1],"elevated":[2],"levels":[3,83,148],"of":[4,14,41,62,84,102,149,165],"Hcy":[5,45,53,85,151],"have":[6],"been":[7],"reported":[8],"to":[9,65,114,129,157],"be":[10],"at":[11],"greater":[12],"risk":[13],"developing":[15],"cardiac":[16,20],"arrhythmias":[17,29,167],"and":[18,44],"sudden":[19],"death":[21],"(SCD).":[22],"However,":[23,118],"the":[24,39,58,66,143],"mechanism":[25,162],"that":[26,52,74,146],"initiates":[27],"Hcy\u2010induced":[28],"is":[30,36],"unknown.":[31],"Since":[32],"intracellular":[33],"Ca":[34,47],"2+":[35,48],"important":[37],"in":[38,75,93,105,135,168],"modulation":[40],"AVN":[42,59],"conduction":[43,56,61,111,120,164],"regulates":[46],"transients,":[49],"we":[50,72],"hypothesize":[51],"increases":[54],"impulse":[55,153],"across":[57],"facilitating":[60],"atrial":[63],"tachyarrhythmias":[64],"ventricles.":[67],"Using":[68],"intracardiac":[69,103],"electrophysiologic":[70],"techniques,":[71],"report":[73],"diet":[76],"induced":[77,130],"hyperhomocysteinemic":[78],"(HHcy)":[79],"C57BL/6":[80],"mice,":[81],"high":[82,147],"elicited":[86],"significantly":[87],"shorter":[88],"PR":[89],"intervals":[90],"(P=.0056)":[91],"than":[92],"mice":[94,107],"on":[95],"a":[96,127,160],"regular":[97],"diet.":[98],"The":[99],"AH":[100],"interval":[101],"electrograms":[104],"HHcy":[106,136,169],"revealed":[108],"an":[109],"accelerated":[110],"(32.4\u00b16.0msec)":[112],"compared":[113],"controls":[115],"(44.0\u00b17.3msec,":[116],"P=.0069).":[117],"HV":[119],"remained":[121],"unchanged.":[122],"Ventricular":[123],"programmed":[124],"stimulation":[125],"demonstrated":[126],"trend":[128],"non\u2010sustained":[131],"ventricular":[132],"tachycardia":[133],"(VT)":[134],"mice.":[137,170],"Our":[138],"preliminary":[139],"results":[140],"demonstrate":[141],"for":[142,163],"first":[144],"time":[145],"dietary":[150],"increase":[152],"propagation":[154],"from":[155],"atria":[156],"ventricles":[158],"suggesting":[159],"potential":[161],"supraventricular":[166]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}